Phenotype and polarization of autologous T cells by biomaterial-treated dendritic cells

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 1, 2015, Pages 170-184

  Park, Jaehyung ^a   Gerber, Michael H ^a   Babensee, Julia E ^a  

^a Emory University   (United States)

Author keywords

biomaterial; dendritic cells; immunotherapy; polarization; T cells

Indexed keywords

BIOMATERIALS; CELLS; COPOLYMERS; CYTOLOGY; HYALURONIC ACID; POLARIZATION;

CO-CULTURE SYSTEM; DENDRITIC CELLS; DENDRITIC CELLS (DCS); HUMAN PERIPHERAL BLOOD; IMMUNO MODULATIONS; IMMUNOTHERAPY; POLY(LACTIC-CO-GLYCOLIC ACID); T-CELL RESPONSE;

T-CELLS;

ALGINIC ACID; BIOMATERIAL; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CHITOSAN; GAMMA INTERFERON; HYALURONIC ACID; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; OVALBUMIN; POLYGLACTIN; TRANSCRIPTION FACTOR FOXP3; BIOLOGICAL MARKER;

ANTIGEN EXPRESSION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; COCULTURE; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONOCYTE; PHENOTYPE; POLARIZATION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; CELL POLARITY; CYTOLOGY; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM;

BIOCOMPATIBLE MATERIALS; BIOMARKERS; CELL POLARITY; COCULTURE TECHNIQUES; DENDRITIC CELLS; HUMANS; IMMUNOPHENOTYPING; T-LYMPHOCYTES;

EID: 84912561549     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35150     Document Type: Article

References (91)

1. Seferian P, Martinez M,. Immune stimulating activity of two new chitosan containing adjuvant formulations. Vaccine 2000; 19: 661-668.
2. Ajdary S, Dobakhti F, Taghikhani M, Riazi-Rad F, Rafiei S, Rafiee-Tehrani M,. Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB/c mice. Vaccine 2007; 25: 4595-4601.
3. Liman M, Peiser L, Zimmer G, Prosting M, Naim HY, Rautenschlein S,. A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(D,L-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumovirus. Vaccine 2007; 25: 7914-7926.
4. Li W, Tuan R,. Polymeric scaffolds for cartilage tissue engineering. Macromol Symp 2005; 227: 65-75.
5. Hutmacher D, Goh J, Teoh S,. An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singap 2001; 30: 183-191.
6. Hunziker E,. Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartilage 2002; 10: 432-463.
7. Fragonas E, Valente M, Pozzi-Mucelli M, Toffanin R, Rizzo R, Silvestri F, Vittur F,. Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate. Biomaterials 2000; 21: 795-801.
8. Fukumoto T, Sperling JW, Sanyal A, Fitzsimmons JS, Reinholz GG, Conover CA, O'Driscoll SW,. Combined effects of insulin-like growth factor-1 and transforming growth factor-beta 1 on periosteal mesenchymal cells during chondrogenesis in vitro. Osteoarthr Cartilage 2003; 11: 55-64.
9. Huang CYC, Reuben PM, D'Ippolito G, Schiller PC, Cheung HS,. Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture. Anat Rec Part A 2004; 278A: 428-436.
10. Mauck RL, Soltz MA, Wang CCB, Wong DD, Chao PHG, Valhmu WB, Hung CT, Ateshian GA,. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng-T Asme 2000; 122: 252-260.
11. Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP, Walter E,. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J Control Release 2001; 76: 59-71.
12. Yoshida M, Babensee J,. Differential effects of agarose and poly(lactic-co-glycolic acid) on dendritic cell maturation. J Biomed Mater Res A 2006; 79A: 393-408.
13. Rogers TH, Babensee JE,. The role of integrins in the recognition and response of dendritic cells to biomaterials. Biomaterials 2011; 32: 1270-1279.
14. Park J, Babensee JE,. Differential functional effects of biomaterials on dendritic cell maturation. Acta Biomater 2012; 8: 3606-3617.
15. Shankar SP, Chen II, Keselowsky BG, Garcia AJ, Babensee JE,. Profiles of carbohydrate ligands associated with adsorbed proteins on self-assembled monolayers of defined chemistries. J Biomed Mater Res A 2010; 92A: 1329-1342.
16. Kou PM, Schwartz Z, Boyan BD, Babensee JE,. Dendritic cell responses to surface properties of clinical titanium surfaces. Acta Biomater 2011; 7: 1354-1363.
17. Banchereau J, Steinman R,. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
18. Sallusto F, Lanzavecchia A,. Efficient Presentation of soluble-antigen by cultured human dendritic cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin-4 and down-regulated by tumor-necrosis-factor-alpha. J Exp Med 1994; 179: 1109-1118.
19. Triozzi PL, Aldrich W,. Phenotypic and functional differences between human dendritic cells derived in vitro from hematopoietic progenitors and from monocytes macrophages. J Leukocyte Biol 1997; 61: 600-608.
20. Setum CM, Serie JR, Hegre OD,. Comparative-analysis of potency of splenic dendritic and adherent cells (macrophages) as alloantigen presenters invivo. Diabetes 1991; 40: 1719-1724.
21. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YT, Pulendran B, Palucka K,. Immunobiology of dendritic cells. Ann Rev Immunol 2000; 18: 767-811.
22. Piemonti L, Monti P, Allavena P, Leone BE, Caputo A, Di Carlo V,. Glucocorticoids increase the endocytic activity of human dendritic cells. Int Immunol 1999; 11: 1519-1526.
23. Kalinski P, Hilkens CMU, Wierenga EA, Kapsenberg ML,. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal. Immunol Today 1999; 20: 561-567.
24. Lanzavecchia A, Sallusto F,. Regulation of T cell immunity by dendritic cells. Cell 2001; 106: 263-266.
25. Moser M, Murphy KM,. Dendritic cell regulation of T(H)1-T(H)2 development. Nat Immunol 2000; 1: 199-205.
26. Kapsenberg ML,. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003; 3: 984-993.
27. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KHG,. Interleukin-1 and IL-23 induce innate IL-17 production from gamma delta T Cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31: 331-341.
28. Sakaguchi S,. Naturally arising Foxp3-expressing CD25(+) CD4(+) regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-352.
29. Matzelle M, Babensee J,. Humoral immune responses to model antigen co-delivered with biomaterials used in tissue engineering. Biomaterials 2004; 25: 295-304.
30. Bennewitz N, Babensee J,. The effect of the physical form of poly(lactic-co-glycolic acid) carriers on the humoral immune response to co-delivered antigen. Biomaterials 2005; 26: 2991-2999.
31. Norton LW, Park J, Babensee JE,. Biomaterial adjuvant effect is attenuated by anti-inflammatory drug delivery or material selection. J Control Release 2010; 146: 341-348.
32. Yoshida M, Babensee J,. Poly(lactic-co-glycolic acid) enhances maturation of human monocyte-derived dendritic cells. J Biomed Mater Res A 2004; 71A: 45-54.
33. Babensee JE,. Interaction of dendritic cells with biomaterials. Semin Immunol 2008; 20: 101-108.
34. Lisby S, Hansen LH, Menn T, Baadsgaard O,. Nickel-induced proliferation of both memory and naive T cells in patch test-negative individuals. Clin Exp Immunol 1999; 117: 217-222.
35. Waddell SJ, Popper SJ, Rubins KH, Griffiths MJ, Brown PO, Levin M, Relman DA,. Dissecting interferon-induced transcriptional programs in human peripheral blood cells. Plos One 2010; 5: e9753.
36. Romagnani S, Del Prete GF, Maggi E, Bosi A, Bernardi F, Ponticelli P, Di Lollo S, Ricci M,. Displacement of T lymphocytes with the 'Helper/Inducer' phenotype from peripheral blood to lymphoid organs in untreated patients with Hodgkin's disease. Scand J Haematol 1983; 31: 305-314.
37. Pockaj BA, Basu GD, Pathangey LB, Gray RJ, Hernandez JL, Gendler SJ, Mukherjee P,. Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E-2 secretion in patients with breast cancer. Ann Surg Oncol 2004; 11: 328-339.
38. Schnurr M, Galambos P, Scholz C, Then F, Dauer M, Endres S, Eigler A,. Tumor cell lysate-pulsed human dendritic cells induce a T-cell response against pancreatic carcinoma cells: An in vitro model for the assessment of tumor vaccines. Cancer Res 2001; 61: 6445-6450.
39. Shilyansky J, Jacobs P, Doffek K, Sugg SL,. Induction of cytolytic T Lymphocytes against pediatric solid tumors in vitro using autologous dendritic cells pulsed with necrotic primary tumor. J Pediatr Surg 2007; 42: 54-61.
40. Goto S, Sato M, Kaneko R, Itoh M, Sato S, Takeuchi S,. Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients. Cancer Immunol Immunother 1999; 48: 435-442.
41. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP,. Preparation and characterization of poly(l-lactic acid) foams. Polymer 1994; 35: 1068-1077.
42. Lahiji A, Sohrabi A, Hungerford DS, Frondoza CG,. Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes. J Biomed Mater Res 2000; 51: 586-595.
43. Papas KK, Long RC, Sambanis A, Constantinidis I,. Development of a bioartificial pancreas: II. Effects of oxygen on long-term entrapped beta TC3 cell cultures. Biotech Bioeng 1999; 66: 231-237.
44. Tomihata K, Ikada Y,. Crosslinking of hyaluronic acid with water-soluble carbodiimide. J Biomed Mater Res 1997; 37: 243-251.
45. Tun T, Inoue K, Hayashi H, Aung T, Gu YJ, Doi R, Kaji H, Echigo Y, Wang WJ, Setoyama H, Imamura M, Maetani S, Morikawa N, Iwata H, Ikada Y,. A newly developed three-layer agarose microcapsule for a promising biohybrid artificial pancreas: Rat to mouse xenotransplantation. Cell Transplant 1996; 5: S59-S63.
46. Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A,. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005; 6: 769-776.
47. Bender A, Sapp M, Schuler G, Steinman RM, Bhardwaj N,. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods 1996; 196: 121-135.
48. Romani N, Reider D, Heuer M, Ebner S, Kampgen E, Eibl B, Niederwieser D, Schuler G,. Generation of mature dendritic cells from human blood-An improved method with special regard to clinical applicability. J Immunol Methods 1996; 196: 137-151.
49. Zou GM, Tam YK,. Cytokines in the generation and maturation of dendritic cells: Recent advances. Eur Cytokine Netw 2002; 13: 186-199.
50. Machy P, Serre K, Leserman L,. Class I-restricted presentation of exogenous antigen acquired by Fc gamma receptor-mediated endocytosis is regulated in dendritic cells. Eur J Immunol 2000; 30: 848-857.
51. Nakahara T, Uchi H, Urabe K, Chen QJ, Furue M, Moroi Y,. Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int Immunol 2004; 16: 1701-1709.
52. Delluc S, Ravot G, Maillere B,. Quantitative analysis of the CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors. FASEB J 2011; 25: 2040-2048.
53. Baxevanis CN, Reclos GJ, Panneerselvam C, Papamichail M,. Enhancement of human T lymphocyte functions by prothymosin alpha. I. Augmentation of mixed lymphocyte culture reactions and soluble protein-induced proliferative responses. Immunopharmacology 1988; 15: 73-84.
54. Babensee J, Paranjpe A,. Differential levels of dendritic cell maturation on different biomaterials used in combination products. J Biomed Mater Res A 2005; 74A: 503-510.
55. Smith KA,. Interleukin-2: Inception, impact, and implications. Science 1988; 240: 1169-1176.
56. Rathmell JC, Farkash EA, Gao W, Thompson CB,. IL-7 enhances the survival and maintains the size of naive T cells. J Immunol 2001; 167: 6869-6876.
57. Tran DQ, Ramsey H, Shevach EM,. Induction of FOXP3 expression in naive human CD4(+)FOXP3(-) T cells by T-cell receptor stimulation is transforming growth factor-beta-dependent but does not confer a regulatory phenotype. Blood 2007; 110: 2983-2990.
58. Todorovic M, Mesiano G, Gammaitoni L, Leuci V, Giraudo Diego L, Cammarata C, Jordaney N, Carnevale-Schianca F, Gallo S, Fagioli F, Piacibello W, Elia AR, Pignochino Y, Dellaglio C, Grignani G, Cignetti A, Aglietta M, Sangiolo D,. Ex vivo allogeneic stimulation significantly improves expansion of cytokine-induced killer cells without increasing their alloreactivity across HLA barriers. J Immunother 2012; 35: 579-586.
59. Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR,. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med 2011; 3: 83ra41.
60. Weiss L, Roux A, Garcia S, Demouchy C, Haeffner-Cavaillon N, Kazatchkine MD, Gougeon ML,. Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha. J Infect Dis 1998; 178: 1158-1162.
61. Nascimbeni M, Shin EC, Chiriboga L, Kleiner DE, Rehermann B,. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood 2004; 104: 478-486.
62. Levings MK, Sangregorio R, Roncarolo MG,. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295-1302.
63. Musabak U, Sengul A, Oktenli C, Pay S, Yesilova Z, Kenar L, Sanisoglu SY, Inal A, Tuzun A, Erdil A, Baqci S,. Does immune activation continue during an attack-free period in familial Mediterranean fever? Clin Exp Immunol 2004; 138: 526-533.
64. Hueman MT, Stojadinovic A, Storrer CE, Foley RJ, Gurney JM, Shriver CD, Ponniah S, Peoples GE,. Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine. Breast Cancer Res Treat 2006; 98: 17-29.
65. Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI,. Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells. Blood 2001; 98: 2736-2744.
66. Kulhankova K, Rouse T, Nasr ME, Field EH,. Dendritic cells control CD4+CD25+ Treg cell suppressor function in vitro through juxtacrine delivery of IL-2. Plos One 2012; 7: e43609.
67. Blue ML, Daley JF, Levine H, Schlossman SF,. Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol 1985; 134: 2281-2286.
68. Ortolani C, Forti E, Radin E, Cibin R, Cossarizza A,. Cytofluorimetric identification of two populations of double positive (CD4+,CD8+) T lymphocytes in human peripheral blood. Biochem Biophys Res Commun 1993; 191: 601-609.
69. Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH,. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 1285-1294.
70. Tonutti E, Sala P, Feruglio C, Yin Z, Colombatti A,. Phenotypic heterogeneity of persistent expansions of CD4+ CD8+ T cells. Clin Immunol Immunopathol 1994; 73: 312-320.
71. West MA, Wallin RPA, Matthews SP, Svensson HG, Zaru R, Ljunggren HG, Prescott AR, Watts C,. Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science 2004; 305: 1153-1157.
72. Termeer C, Averbeck M, Hara H, Eibel H, Herrlich P, Sleeman J, Simon JC,. Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4(+) T-helper cells by induction of FAS-independent T-cell apoptosis. Immunology 2003; 109: 32-40.
73. Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, Akbar AN,. Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population. Eur J Immunol 2001; 31: 1122-1131.
74. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G,. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303-1310.
75. Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJ, Bickham KL, Lerner H, Goldstein M, Sykes M, Kato T, Farber DL,. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 2013; 38: 187-197.
76. Zou W,. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006; 6: 295-307.
77. Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W,. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol 2004; 173: 4433-4442.
78. Rothoeft T, Balkow S, Krummen M, Beissert S, Varga G, Loser K, Oberbanscheidt P, van den Boom F, Grabbe S,. Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state. Eur J Immunol 2006; 36: 3105-3117.
79. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EEM, Trinchieri G, Caux C, Garrone P,. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 2005; 201: 1435-1446.
80. Bromberg JS,. Il-10 Immunosuppression in transplantation. Curr Opin Immunol 1995; 7: 639-643.
81. Kleinbeck KR, Faucher LD, Kao WJ,. Biomaterials modulate interleukin-8 and other inflammatory proteins during reepithelialization in cutaneous partial-thickness wounds in pigs. Wound Repair Regen 2010; 18: 486-498.
82. Whiteside TL, Odoux C,. Dendritic cell biology and cancer therapy. Cancer Immunol Immunother 2004; 53: 240-248.
83. Stax AM, Crul C, Kamerling SWA, Schlagwein N, van der Geest RN, Woltman AM, van Kooten C,. CD40L stimulation of rat dendritic cells specifically favors the IL-12/IL-10 ratio resulting in a strong T cell stimulatory capacity. Mol Immunol 2008; 45: 2641-2650.
84. Hunter TB, Alsarraj M, Gladue RP, Bedian V, Antonia SJ,. An agonist antibody specific for CD40 induces dendritic cell maturation and promotes autologous anti-tumour T-cell responses in an in vitro mixed autologous tumour cell/lymph node cell model. Scand J Immunol 2007; 65: 479-486.
85. Sokolovska A, Hem SL, HogenEsch H,. Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants. Vaccine 2007; 25: 4575-4585.
86. Cunningham AJ, Lafferty KJ,. Simple, conservative explanation of H-2 restriction of interactions between lymphocytes. Scand J Immunol 1977; 6: 1-6.
87. Lenschow DJ, Walunas TL, Bluestone JA,. CD28/B7 system of T cell costimulation. Ann Rev Immunol 1996; 14: 233-258.
88. Ghosh TK, Mickelson DJ, Fink J, Solberg JC, Inglefield JR, Hook D, Gupta SK, Gibson S, Alkan SS,. Toll-like receptor (TLR) 2-9 agonists-induced cytokines and chemokines: I. Comparison with T cell receptor-induced responses. Cell Immunol 2006; 243: 48-57.
89. Ng KW, Lima EG, Bian L, O'Conor CJ, Jayabalan PS, Stoker AM, Kuroki K, Cook CR, Ateshian GA, Cook JL, Hung CT,. Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: A canine model. Tissue Eng A 2010; 16: 1041-1051.
90. Gazda LS, Vinerean HV, Laramore MA, Diehl CH, Hall RD, Rubin AL, Smith BH,. Encapsulation of porcine islets permits extended culture time and insulin independence in spontaneously diabetic BB rats. Cell Transplant 2007; 16: 609-620.
91. Emans PJ, van Rhijn LW, Welting TJ, Cremers A, Wijnands N, Spaapen F, Voncken JW, Shastri VP,. Autologous engineering of cartilage. Proc Natl Acad Sci USA 2010; 107: 3418-3423.