메뉴 건너뛰기




Volumn 9, Issue 1, 2017, Pages 45-51

The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?

Author keywords

Abscopal effect; Breast cancer; Immunotherapy; Radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CD135 ANTIGEN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DOXORUBICIN; DURVALUMAB; GALUNISERTIB; IMIQUIMOD; INTERLEUKIN 2; MEDI 6469; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 85014090264     PISSN: 19434588     EISSN: 19434596     Source Type: Journal    
DOI: 10.1007/s12609-017-0234-y     Document Type: Review
Times cited : (128)

References (57)
  • 1
    • 0013071190 scopus 로고
    • Whole body irradiation; radiobiology or medicine?
    • COI: 1:STN:280:DyaG3s%2Fms1yrug%3D%3D, PID: 13042090
    • Mole RH. Whole body irradiation; radiobiology or medicine? Br J Radiol. 1953;26:234–41.
    • (1953) Br J Radiol , vol.26 , pp. 234-241
    • Mole, R.H.1
  • 2
    • 84937640449 scopus 로고    scopus 로고
    • The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant
    • PID: 25872878
    • Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev. 2015;41:503–10.
    • (2015) Cancer Treat Rev , vol.41 , pp. 503-510
    • Reynders, K.1    Illidge, T.2    Siva, S.3    Chang, J.Y.4    De Ruysscher, D.5
  • 4
    • 0020321584 scopus 로고
    • Radiation sensitivity of human erythropoietic and granulopoietic progenitor cells in the blood and in the bone marrow
    • COI: 1:STN:280:DyaL3s%2Fgs1aitQ%3D%3D, PID: 6981622
    • Grilli G, Nothdurft W, Fliedner TM. Radiation sensitivity of human erythropoietic and granulopoietic progenitor cells in the blood and in the bone marrow. Int J Radiat Biol Relat Stud Phys Chem Med. 1982;41(6):685–7.
    • (1982) Int J Radiat Biol Relat Stud Phys Chem Med , vol.41 , Issue.6 , pp. 685-687
    • Grilli, G.1    Nothdurft, W.2    Fliedner, T.M.3
  • 5
    • 0022831791 scopus 로고
    • Marrow transplantation for acute nonlymphoblastic leukemia in first remission: toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation
    • COI: 1:STN:280:DyaL1M%2FgtFemsg%3D%3D, PID: 3332129
    • Deeg HJ, Sullivan KM, Buckner CD, Storb R, Appelbaum FR, Clift RA, et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission: toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation. Bone Marrow Transplant. 1986;1(2):151–7.
    • (1986) Bone Marrow Transplant , vol.1 , Issue.2 , pp. 151-157
    • Deeg, H.J.1    Sullivan, K.M.2    Buckner, C.D.3    Storb, R.4    Appelbaum, F.R.5    Clift, R.A.6
  • 6
    • 84933050304 scopus 로고    scopus 로고
    • The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
    • COI: 1:CAS:528:DC%2BC2MXhtFaiu7bK, PID: 26105538
    • Barker HE, Paget JT, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015;15:409–25.
    • (2015) Nat Rev Cancer , vol.15 , pp. 409-425
    • Barker, H.E.1    Paget, J.T.2    Khan, A.A.3    Harrington, K.J.4
  • 7
    • 84896724517 scopus 로고    scopus 로고
    • Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
    • PID: 24480782
    • Gameiro SR, Jammeh ML, Wattenberg MM, Tsang KY, Ferrone S, Hodge JW. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. Oncotarget. 2014;5:403–16.
    • (2014) Oncotarget , vol.5 , pp. 403-416
    • Gameiro, S.R.1    Jammeh, M.L.2    Wattenberg, M.M.3    Tsang, K.Y.4    Ferrone, S.5    Hodge, J.W.6
  • 8
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • COI: 1:CAS:528:DC%2BD2sXhvFWisw%3D%3D, PID: 17187072
    • Obeid M, Tesniere A, Ghiringhelli F, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13:54–61.
    • (2007) Nat Med , vol.13 , pp. 54-61
    • Obeid, M.1    Tesniere, A.2    Ghiringhelli, F.3
  • 9
    • 0034698830 scopus 로고    scopus 로고
    • High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    • COI: 1:CAS:528:DC%2BD3cXlvFemsL0%3D, PID: 10952726
    • Andersson U, Wang H, Palmblad K, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med. 2000;192:565–70.
    • (2000) J Exp Med , vol.192 , pp. 565-570
    • Andersson, U.1    Wang, H.2    Palmblad, K.3
  • 10
    • 35748942876 scopus 로고    scopus 로고
    • The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
    • COI: 1:CAS:528:DC%2BD2sXhsVKgtr3L, PID: 17979839
    • Apetoh L, Ghiringhelli F, Tesniere A, et al. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev. 2007;220:47–59.
    • (2007) Immunol Rev , vol.220 , pp. 47-59
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 11
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • COI: 1:CAS:528:DC%2BD2sXhtVSgtr3E, PID: 17704786
    • Apetoh L, Ghiringhelli F, Tesniere A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 2007;13:1050–9.
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 12
    • 85015032786 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 7 agonist, cyclophosphamide, and radiotherapy for breast cancer with skin metastases
    • Toll-like receptor (TLR) 7 agonist, cyclophosphamide, and radiotherapy for breast cancer with skin metastases. 2016. at https://clinicaltrials.gov/ct2/show/NCT01421017
    • (2016)
  • 13
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • COI: 1:CAS:528:DC%2BD1MXhtFGjt7rK, PID: 19767732
    • Ghiringhelli F, Apetoh L, Tesniere A, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170–8.
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3
  • 14
    • 84912128872 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
    • COI: 1:CAS:528:DC%2BC2cXhvFOitrbM, PID: 25517616
    • Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity. 2014;41:843–52.
    • (2014) Immunity , vol.41 , pp. 843-852
    • Deng, L.1    Liang, H.2    Xu, M.3
  • 15
    • 0037942745 scopus 로고    scopus 로고
    • Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    • COI: 1:CAS:528:DC%2BD3sXktlKrtbw%3D, PID: 12794167
    • Chakraborty M, Abrams SI, Camphausen K, et al. Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol. 2003;170:6338–47.
    • (2003) J Immunol , vol.170 , pp. 6338-6347
    • Chakraborty, M.1    Abrams, S.I.2    Camphausen, K.3
  • 16
    • 7444258053 scopus 로고    scopus 로고
    • Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
    • COI: 1:CAS:528:DC%2BD2cXptFels7s%3D, PID: 15520206
    • Garnett CT, Palena C, Chakraborty M, Tsang KY, Schlom J, Hodge JW. Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res. 2004;64:7985–94.
    • (2004) Cancer Res , vol.64 , pp. 7985-7994
    • Garnett, C.T.1    Palena, C.2    Chakraborty, M.3    Tsang, K.Y.4    Schlom, J.5    Hodge, J.W.6
  • 17
    • 0029803150 scopus 로고    scopus 로고
    • Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium
    • COI: 1:CAS:528:DyaK28XntFOnu7k%3D, PID: 8912850
    • Hallahan D, Kuchibhotla J, Wyble C. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res. 1996;56:5150–5.
    • (1996) Cancer Res , vol.56 , pp. 5150-5155
    • Hallahan, D.1    Kuchibhotla, J.2    Wyble, C.3
  • 18
    • 45449090985 scopus 로고    scopus 로고
    • Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity
    • COI: 1:CAS:528:DC%2BD1cXit1Oks7g%3D, PID: 18292536
    • Lugade AA, Sorensen EW, Gerber SA, Moran JP, Frelinger JG, Lord EM. Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol. 2008;180:3132–9.
    • (2008) J Immunol , vol.180 , pp. 3132-3139
    • Lugade, A.A.1    Sorensen, E.W.2    Gerber, S.A.3    Moran, J.P.4    Frelinger, J.G.5    Lord, E.M.6
  • 19
    • 51549088023 scopus 로고    scopus 로고
    • Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    • COI: 1:CAS:528:DC%2BD1cXhtVSiu7vM, PID: 18713980
    • Matsumura S, Wang B, Kawashima N, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008;181:3099–107.
    • (2008) J Immunol , vol.181 , pp. 3099-3107
    • Matsumura, S.1    Wang, B.2    Kawashima, N.3
  • 20
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    • COI: 1:CAS:528:DC%2BD28XkvFWiurc%3D, PID: 16636135
    • Reits EA, Hodge JW, Herberts CA, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med. 2006;203:1259–71.
    • (2006) J Exp Med , vol.203 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3
  • 21
    • 84867182261 scopus 로고    scopus 로고
    • Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects
    • COI: 1:CAS:528:DC%2BC38XhsV2it7%2FO, PID: 22945631
    • Ruocco MG, Pilones KA, Kawashima N, et al. Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest. 2012;122:3718–30.
    • (2012) J Clin Invest , vol.122 , pp. 3718-3730
    • Ruocco, M.G.1    Pilones, K.A.2    Kawashima, N.3
  • 22
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • COI: 1:CAS:528:DC%2BD38Xit1KhurY%3D, PID: 11888921
    • Ganss R, Ryschich E, Klar E, Arnold B, Hammerling GJ. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 2002;62:1462–70.
    • (2002) Cancer Res , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hammerling, G.J.5
  • 23
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXhs1yqtrzL, PID: 24209604
    • Klug F, Prakash H, Huber PE, et al. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell. 2013;24:589–602.
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1    Prakash, H.2    Huber, P.E.3
  • 25
    • 84861618640 scopus 로고    scopus 로고
    • Infiltrating macrophages in extratumoural tissues after brachytherapy of uveal melanoma
    • PID: 20809904
    • Toivonen P, Kivela T. Infiltrating macrophages in extratumoural tissues after brachytherapy of uveal melanoma. Acta Ophthalmol. 2012;90:341–9.
    • (2012) Acta Ophthalmol , vol.90 , pp. 341-349
    • Toivonen, P.1    Kivela, T.2
  • 26
    • 34249014905 scopus 로고    scopus 로고
    • The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas
    • PID: 17509220
    • Julow J, Szeifert GT, Balint K, Nyary I, Nemes Z. The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas. Neurol Res. 2007;29:233–8.
    • (2007) Neurol Res , vol.29 , pp. 233-238
    • Julow, J.1    Szeifert, G.T.2    Balint, K.3    Nyary, I.4    Nemes, Z.5
  • 27
    • 84919489041 scopus 로고    scopus 로고
    • Myeloid-derived cells in tumors: effects of radiation
    • PID: 25481262
    • Vatner RE, Formenti SC. Myeloid-derived cells in tumors: effects of radiation. Semin Radiat Oncol. 2015;25:18–27.
    • (2015) Semin Radiat Oncol , vol.25 , pp. 18-27
    • Vatner, R.E.1    Formenti, S.C.2
  • 28
    • 0026757759 scopus 로고
    • Synergy of radiation therapy and immunotherapy in murine renal cell carcinoma
    • COI: 1:STN:280:DyaK3s%2FitFCkug%3D%3D, PID: 1404669
    • Dybal EJ, Haas GP, Maughan RL, Sud S, Pontes JE, Hillman GG. Synergy of radiation therapy and immunotherapy in murine renal cell carcinoma. J Urol. 1992;148:1331–7.
    • (1992) J Urol , vol.148 , pp. 1331-1337
    • Dybal, E.J.1    Haas, G.P.2    Maughan, R.L.3    Sud, S.4    Pontes, J.E.5    Hillman, G.G.6
  • 29
    • 79959246500 scopus 로고    scopus 로고
    • Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer
    • COI: 1:CAS:528:DC%2BC3MXptlSiuro%3D, PID: 21443690
    • Yasuda K, Nirei T, Tsuno NH, Nagawa H, Kitayama J. Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer. Cancer Sci. 2011;102:1257–63.
    • (2011) Cancer Sci , vol.102 , pp. 1257-1263
    • Yasuda, K.1    Nirei, T.2    Tsuno, N.H.3    Nagawa, H.4    Kitayama, J.5
  • 30
    • 0033572416 scopus 로고    scopus 로고
    • Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer
    • COI: 1:CAS:528:DC%2BD3cXktFyjtw%3D%3D, PID: 10626784
    • Chakravarty PK, Alfieri A, Thomas EK, et al. Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer. Cancer Res. 1999;59:6028–32.
    • (1999) Cancer Res , vol.59 , pp. 6028-6032
    • Chakravarty, P.K.1    Alfieri, A.2    Thomas, E.K.3
  • 31
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • PID: 14967443
    • Demaria S, Ng B, Devitt ML, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004;58:862–70.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 862-870
    • Demaria, S.1    Ng, B.2    Devitt, M.L.3
  • 32
    • 20344389060 scopus 로고    scopus 로고
    • Toll-like receptors: linking innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BD2MXhtlCjsLzE, PID: 15932016
    • Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol. 2005;560:11–8.
    • (2005) Adv Exp Med Biol , vol.560 , pp. 11-18
    • Pasare, C.1    Medzhitov, R.2
  • 33
    • 84871230007 scopus 로고    scopus 로고
    • Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
    • COI: 1:CAS:528:DC%2BC38XhvFSiurfJ, PID: 23048078
    • Dewan MZ, Vanpouille-Box C, Kawashima N, et al. Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer. Clin Cancer Res. 2012;18:6668–78.
    • (2012) Clin Cancer Res , vol.18 , pp. 6668-6678
    • Dewan, M.Z.1    Vanpouille-Box, C.2    Kawashima, N.3
  • 34
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • COI: 1:CAS:528:DC%2BD2MXislWgurw%3D, PID: 15701862
    • Demaria S, Kawashima N, Yang AM, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005;11:728–34.
    • (2005) Clin Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 35
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • COI: 1:CAS:528:DC%2BD1MXhtVOntrjP, PID: 19706802
    • Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15:5379–88.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 36
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • COI: 1:CAS:528:DC%2BC3sXivFyku7k%3D, PID: 23462419
    • Zeng J, See AP, Phallen J, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013;86:343–9.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3
  • 37
    • 84983353116 scopus 로고    scopus 로고
    • Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen
    • COI: 1:CAS:528:DC%2BC2MXlvFemtLg%3D, PID: 25527358
    • Sharabi AB, Nirschl CJ, Kochel CM, et al. Stereotactic radiation therapy augments antigen-specific PD-1-mediated antitumor immune responses via cross-presentation of tumor antigen. Cancer Immunol Res. 2015;3:345–55.
    • (2015) Cancer Immunol Res , vol.3 , pp. 345-355
    • Sharabi, A.B.1    Nirschl, C.J.2    Kochel, C.M.3
  • 38
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • COI: 1:CAS:528:DC%2BC2MXktVCnsbw%3D, PID: 25754329, The authors report that triple therapy using PD-L1 blockade, CTLA-4 blockade, and radiation work in nonredundant, complementary fashion to promote antitumor immunity. PDL-1 and CTLA-4 inhibition reverses T cell exhaustion and decreases regulatory T cells while radiation broadens the T cell receptor repertoire of TILs and shape the repertoire of the expanded peripheral clones
    • • Twyman-Saint Victor C, Rech AJ, Maity A, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373–7. The authors report that triple therapy using PD-L1 blockade, CTLA-4 blockade, and radiation work in nonredundant, complementary fashion to promote antitumor immunity. PDL-1 and CTLA-4 inhibition reverses T cell exhaustion and decreases regulatory T cells while radiation broadens the T cell receptor repertoire of TILs and shape the repertoire of the expanded peripheral clones.
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1    Rech, A.J.2    Maity, A.3
  • 39
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • COI: 1:CAS:528:DC%2BC38XktFOgurw%3D, PID: 22397654
    • Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366:925–31.
    • (2012) N Engl J Med , vol.366 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 40
    • 84871694504 scopus 로고    scopus 로고
    • A systemic complete response of metastatic melanoma to local radiation and immunotherapy
    • PID: 23323154
    • Hiniker SM, Chen DS, Reddy S, et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol. 2012;5:404–7.
    • (2012) Transl Oncol , vol.5 , pp. 404-407
    • Hiniker, S.M.1    Chen, D.S.2    Reddy, S.3
  • 41
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study
    • COI: 1:STN:280:DC%2BC3srgt1Cmtg%3D%3D, PID: 23535954
    • Slovin SF, Higano CS, Hamid O, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol. 2013;24:1813–21.
    • (2013) Ann Oncol , vol.24 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3
  • 42
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
    • COI: 1:CAS:528:DC%2BC2MXhtVKhtb3F, PID: 26095785, The study reported that the combination of GM-CSF with radiochemotherapy resulted in abscopal responses in five (36%) of 14 patients with breast cancer. They show for the first time that the abscopal response can be induced in solid metastatic tumors by combining radiochemotherapy with immunotherapy
    • • Golden EB, Chhabra A, Chachoua A, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 2015;16:795–803. The study reported that the combination of GM-CSF with radiochemotherapy resulted in abscopal responses in five (36%) of 14 patients with breast cancer. They show for the first time that the abscopal response can be induced in solid metastatic tumors by combining radiochemotherapy with immunotherapy.
    • (2015) Lancet Oncol , vol.16 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3
  • 43
    • 20444406500 scopus 로고    scopus 로고
    • Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    • COI: 1:CAS:528:DC%2BD2MXkvVOmt78%3D, PID: 15944250
    • Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol. 2005;174:7516–23.
    • (2005) J Immunol , vol.174 , pp. 7516-7523
    • Lugade, A.A.1    Moran, J.P.2    Gerber, S.A.3    Rose, R.C.4    Frelinger, J.G.5    Lord, E.M.6
  • 44
    • 84942915875 scopus 로고    scopus 로고
    • Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions
    • COI: 1:CAS:528:DC%2BC2MXhtlKltr3P, PID: 25869387
    • Filatenkov A, Baker J, Mueller AM, Kenkel J, Ahn GO, Dutt S, et al. Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions. Clin Cancer Res. 2015;21(16):3727–39.
    • (2015) Clin Cancer Res , vol.21 , Issue.16 , pp. 3727-3739
    • Filatenkov, A.1    Baker, J.2    Mueller, A.M.3    Kenkel, J.4    Ahn, G.O.5    Dutt, S.6
  • 45
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
    • COI: 1:CAS:528:DC%2BC2cXhs1GnsbnL, PID: 25274032
    • Dovedi SJ, Adlard AL, Lipowska-Bhalla G, McKenna C, Jones S, Cheadle EJ, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 2014;74(19):5458–68.
    • (2014) Cancer Res , vol.74 , Issue.19 , pp. 5458-5468
    • Dovedi, S.J.1    Adlard, A.L.2    Lipowska-Bhalla, G.3    McKenna, C.4    Jones, S.5    Cheadle, E.J.6
  • 46
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    • COI: 1:CAS:528:DC%2BD1MXpt1Wmsbc%3D, PID: 19349616
    • Lee Y, Auh SL, Wang Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood. 2009;114:589–95.
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3
  • 47
    • 84941784779 scopus 로고    scopus 로고
    • A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab
    • PID: 26451318
    • Chandra RA, Wilhite TJ, Balboni TA, et al. A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab. Oncoimmunology. 2015;4:e1046028.
    • (2015) Oncoimmunology , vol.4
    • Chandra, R.A.1    Wilhite, T.J.2    Balboni, T.A.3
  • 48
    • 84997497897 scopus 로고    scopus 로고
    • Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking?
    • PID: 27190630
    • Demaria S, Formenti SC. Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking? J Immunother Cancer. 2016;4:29.
    • (2016) J Immunother Cancer , vol.4 , pp. 29
    • Demaria, S.1    Formenti, S.C.2
  • 49
    • 85015094683 scopus 로고    scopus 로고
    • Study to assess the efficacy of pembrolizumab plus radiotherapy in metastatic triple negative breast cancer patients
    • Study to assess the efficacy of pembrolizumab plus radiotherapy in metastatic triple negative breast cancer patients. 2016. at (https://clinicaltrials.gov/ct2/show/NCT02730130.)
    • (2016)
  • 50
    • 85015043595 scopus 로고    scopus 로고
    • Trial of hypofractionated radiotherapy in combination with MEDI4736 and tremelimumab for patients with metastatic melanoma and lung, breast and pancreatic cancers
    • Trial of hypofractionated radiotherapy in combination with MEDI4736 and tremelimumab for patients with metastatic melanoma and lung, breast and pancreatic cancers. 2016. at (https://clinicaltrials.gov/ct2/show/NCT02639026.)
    • (2016)
  • 51
    • 85015025754 scopus 로고    scopus 로고
    • Nivolumab after induction treatment in triple-negative breast cancer (TNBC) patients (TONIC)
    • Nivolumab after induction treatment in triple-negative breast cancer (TNBC) patients (TONIC). 2016. at (https://clinicaltrials.gov/ct2/show/NCT02499367.)
    • (2016)
  • 52
    • 85015046898 scopus 로고    scopus 로고
    • Pilot study of stereotactic ablation for oligometastatic breast neoplasia in combination with the anti-PD-1 antibody MK-3475
    • Pilot study of stereotactic ablation for oligometastatic breast neoplasia in combination with the anti-PD-1 antibody MK-3475 (BOSTON II). 2016. at (https://clinicaltrials.gov/ct2/show/NCT02303366.)
    • (2016)
  • 53
    • 85015106425 scopus 로고    scopus 로고
    • LY2157299 monohydrate (LY2157299) and radiotherapy in metastatic breast cancer
    • LY2157299 monohydrate (LY2157299) and radiotherapy in metastatic breast cancer. 2016. at (https://clinicaltrials.gov/ct2/show/NCT02538471.)
    • (2016)
  • 54
    • 85015000086 scopus 로고    scopus 로고
    • Stereotactic body radiation and monoclonal antibody to OX40 (MEDI6469) in breast cancer patients with metastatic lesions (OX40 Breast)
    • Stereotactic body radiation and monoclonal antibody to OX40 (MEDI6469) in breast cancer patients with metastatic lesions (OX40 Breast).2016. at https://clinicaltrials.gov/ct2/show/NCT01862900
    • (2016)
  • 56
    • 85015095545 scopus 로고    scopus 로고
    • RADVAX: a stratified phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with advanced and metastatic cancers
    • RADVAX: a stratified phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with advanced and metastatic cancers. 2016. at https://clinicaltrials.gov/ct2/show/NCT02303990.
    • (2016)
  • 57
    • 84991715941 scopus 로고    scopus 로고
    • Study of PD1 blockade by pembrolizumab with stereotactic body radiotherapy in advanced solid tumors
    • Study of PD1 blockade by pembrolizumab with stereotactic body radiotherapy in advanced solid tumors. 2016. at(https://clinicaltrials.gov/ct2/show/NCT02608385.)
    • (2016)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.