Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer

International Journal of Radiation Oncology Biology Physics

Volumn 65, Issue 4, 2006, Pages 1087-1096

  Chang, Joe Y ^a   Zhang, Xiaodong ^a   Wang, Xiaochun ^a   Kang, Yixiu ^a   Riley, Beverly ^a   Bilton, Stephen ^a   Mohan, Radhe ^a   Komaki, Ritsuko ^a   Cox, James D ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

4D CT; Conformal radiotherapy; Dose escalation; Dose volume histogram; Intensity modulated radiation therapy; Non small cell lung cancer; Proton radiotherapy

Indexed keywords

CELLS; COBALT; ESCALATORS; PROTONS; REDUCTION; TISSUE; TUMORS;

4D-CT; CONFORMAL RADIOTHERAPY; DOSE ESCALATION; DOSE-VOLUME HISTOGRAM; DOSE-VOLUME HISTOGRAMS (DVH); INTENSITY-MODULATED RADIATION THERAPY; NON-SMALL-CELL LUNG CANCER; PROTON RADIOTHERAPY;

RADIOTHERAPY;

COBALT;

ARTICLE; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED STUDY; ESOPHAGUS; HEART; HISTOGRAM; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; PHOTON THERAPY; PRIORITY JOURNAL; PROTON THERAPY; RADIATION DOSE; SPINAL CORD;

CARCINOMA, NON-SMALL-CELL LUNG; ESOPHAGUS; HEART; HUMANS; LUNG; LUNG NEOPLASMS; PHOTONS; PROTONS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, CONFORMAL; RADIOTHERAPY, INTENSITY-MODULATED; SPINAL CORD;

EID: 33745192610     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.01.052     Document Type: Article

References (30)

1. Jemal A., Murray T., Ward E., et al. Cancer statistics, 2005. CA Cancer J Clin 55 (2005) 10-30
2. Shields T.W. Surgical therapy for carcinoma of the lung. Clin Chest Med 14 (1993) 121-147
3. Naruke T., Goya T., Tsuchiya K., et al. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thoracic Cardiovasc Surg 96 (1988) 440-447
4. Dosoretz D., Katin M.J., Blitzer P.H., et al. Radiation therapy in the management of medically inoperable carcinoma of the lung. Results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys 24 (1992) 3-9
5. Dosoretz D.E., Katin M.J., Blitzer P.H., et al. Medically inoperable lung carcinoma. The role of radiation therapy. Semin Radiat Oncol 6 (1996) 98-104
6. Sibley G.S., Jamieson T.A., Marks L.B., et al. Radiotherapy alone for medically inoperable stage I non-small cell lung cancer. The Duke experience. Int J Radiat Oncol Biol Phys 40 (1998) 149-154
7. Dosoretz D.E., Galmarini D., Rubenstein J.H., et al. Local control in medically inoperable lung cancer. An analysis of its importance in outcome and factors determining the probability of tumor eradication. Int J Radiat Oncol Biol Phys 27 (1993) 507-516
8. Kaskowitz L., Graham M.V., Emami B., et al. Radiation therapy alone for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 27 (1993) 517-523
9. Bradley J., Graham M.V., Winter K., et al. Toxicity and outcome results of RTOG 9311. A phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 61 (2005) 318-328
10. Komaki R., Lee J.S., Milas L., et al. Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer. Report of a randomized comparative trial. Int J Radiat Oncol Biol Phys 58 (2004) 1369-1377
11. Sulman E.P., Chang J.Y., Liao Z., et al. Exclusion of elective nodal irradiation doesn't decrease local regional control of non-small cell lung cancer. Int J Radiat Oncol Biol Phys 63 (2005) S226
12. Rosenman J.G., Halle J.S., Socinski M.A., et al. High-dose conformal radiotherapy for treatment of stage IIIA/IIIB NSCLC. Technical issues and results of a phase I/II trail. Int J Radiat Oncol Biol Phys 54 (2002) 348-356
13. Kong F.M., Ten H.R.K., Schipper M.J., et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer. Long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 63 (2005) 324-333
14. Grills I.S., Yan D., Martinez A.A., et al. Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer. A comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. Int J Radiat Oncol Biol Phys 57 (2003) 875-890
15. Liu H.H., Wang X., Dong L., et al. Feasibility of sparing the lung and other thoracic structures with IMRT for NSCLC. Int J Radiat Oncol Biol Phys 60 (2004) 1473-1483
16. Murshed H., Liu H.H., Liao Z., et al. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 58 (2004) 1258-1267
17. Chui C.S., Yorke E., and Hong L. The effects of intra-fraction organ motion on the delivery of intensity-modulated field with a multileaf collimator. Med Phys 30 (2003) 1736-1746
18. Chang J.Y., Liu H.H., and Komaki R. Intensity-modulated radiation therapy and proton radiotherapy for non-small cell lung cancer. Curr Oncol Rep 7 (2005) 255-259
19. Yom S.S., Liao Z., Hu S., et al. Preliminary report of radiation pneumonitis in patients with NSCLC treated with IMRT and concurrent chemotherapy. Int J Radiat Oncol Biol Phys 63 (2005) S407
20. Moyers M.F., Miller D.W., Bush D.A., et al. Methodologies and tools for proton beam design for lung tumors. Int J Radiat Oncol Biol Phys 49 (2001) 1429-1438
21. Urie M., Goitein M., Holley W.R., et al. Degradation of the Bragg peak due to inhomogeneities. Phys Med Biol 31 (1986) 1-15
22. Liao Z., Wang S.L., Wei X., et al. Analysis of clinical and dosimetric factors associated with radiation pneumonitis in patients with NSCLC treated with concurrent chemotherapy and 3DCRT. Int J Radiat Oncol Biol Phys 63 (2005) S41
23. Emami B., Lyman J., Brown A., et al. Tolerances of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21 (1991) 109-122
24. Graham M.V., Purdy J.A., Emami B., et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 45 (1999) 323-329
25. Yorke E.D., Jackson A., Rosenzweig K.E., et al. Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys 54 (2002) 329-339
26. Chang J.Y., Dong L., Mohan R., et al. Image-guided proton radiotherapy for medically inoperable stage I non-small cell lung cancer. Lung Cancer 49 (2005) S93
27. Liu H., Wei X., Jang S., et al. Impact of respiratory motion on dose distributions and DVHs of thoracic structures-evaluation using 4DCT. Med Phys 32 (2005) 1924
28. Kang Y., Zhang X., Wang H., et al. Proton treatment planning for mobile lung tumors. Med Phys 32 (2005) 2144
29. Shioyama Y., Tokuuye K., Okumura T., et al. Clinical evaluation of proton radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 56 (2003) 7-13
30. Bush D.A., Slater J.D., Shin B.B., et al. Hypofractionated proton beam radiotherapy for stage I lung cancer. Chest 126 (2004) 1198-1203