Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: A preclinical study

Physics in Medicine and Biology

Volumn 61, Issue 24, 2016, Pages N697-N707

  Hao, Yao ^a   Yasmin Karim, Sayeda ^b   Moreau, Michele ^a   Sinha, Neeharika ^c   Sajo, Erno ^a   Ngwa, Wilfred ^a,b  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c WENTWORTH INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

abscopal effect; immunoadjuvants; multifunctional radiotherapy biomaterials; nanoparticles; SBRT

Indexed keywords

BIOLOGICAL ORGANS; CELL CULTURE; DISEASES; MAMMALS; NANOPARTICLES; PATHOLOGY; TOXICITY; TUMORS;

ABSCOPAL EFFECT; IMAGE GUIDED RADIOTHERAPY; IMMUNOADJUVANTS; LOADING CONCENTRATION; PRECLINICAL STUDIES; SBRT; STEREOTACTIC BODY RADIOTHERAPY; SYSTEMIC TOXICITIES;

RADIOTHERAPY;

BIOMATERIAL; CD40 ANTIGEN; IMMUNOLOGICAL ADJUVANT; MONOCLONAL ANTIBODY; NANOPARTICLE; RADIOSENSITIZING AGENT;

ANIMAL; BRACHYTHERAPY; C57BL MOUSE; CARCINOMA, LEWIS LUNG; CHEMISTRY; IMMUNOLOGY; MALE; MOUSE; PATHOLOGY; TUMOR VOLUME;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; BIOCOMPATIBLE MATERIALS; BRACHYTHERAPY; CARCINOMA, LEWIS LUNG; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; RADIATION-SENSITIZING AGENTS; TUMOR BURDEN;

EID: 85007189763     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/1361-6560/61/24/N697     Document Type: Article

References (43)

1. Armour M, Ford E, Iordachita I and Wong J 2010 CT guidance is needed to achieve reproducible positioning of the mouse head for repeat precision cranial irradiation Radiat. Res. 173 119-23
2. Balluffi R W, Allen S M, Carter W C and Kemper R A 2005 Kinetics of Materials (Hoboken, NJ: Wiley)
3. Cao-Milan R and Liz-Marzan L M 2014 Gold nanoparticle conjugates: recent advances toward clinical applications Expert Opin. Drug Deliv. 11 741-52
4. Cho S H, Jones B L and Krishnan S 2009 The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources Phys. Med. Biol. 54 4889-905
5. Collins B T et al 2007 Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors Radiat. Oncol. 2 39
6. Cormack R A, Sridhar S, Suh W W, D'Amico A V and Makrigiorgos G M 2010 Biological in situ dose painting for image-guided radiation therapy using drug-loaded implantable devices Int. J. Radiat. Oncol. Biol. Phys. 76 615-23
7. Demaria S, Kawashima N, Yang A M, Devitt M L, Babb J S, Allison J P and Formenti S C 2005 Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer Clin. Cancer Res. 11 728-34
8. Demaria S, Ng B, Devitt M L, Babb J S, Kawashima N, Liebes L and Formenti S C 2004 Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated Int. J. Radiat. Oncol. Biol. Phys. 58 862-70
9. Dewan M Z, Galloway A E, Kawashima N, Dewyngaert J K, Babb J S, Formenti S C and Demaria S 2009 Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody Clin. Cancer Res. 15 5379-88
10. Fan X et al 2012 CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with x-linked hyper IgM syndrome Clin. Immunol. 143 152-61
11. Formenti S C and Demaria S 2013 Combining radiotherapy and cancer immunotherapy: a paradigm shift J. Natl Cancer Inst. 105 256-65
12. Fransen M F, Cordfunke R A, Sluijter M, van Steenbergen M J, Drijfhout J W, Ossendorp F, Hennink W E and Melief C J 2014 Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer Vaccine 32 1654-60
13. Fransen M F, Sluijter M, Morreau H, Arens R and Melief C J 2011 Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody Clin. Cancer Res. 17 2270-80
14. Fransen M F, van der Sluis T C, Ossendorp F, Arens R and Melief C J 2013 Controlled local delivery of CTLA-4 blocking antibody induces CD8 + T-cell-dependent tumor eradication and decreases risk of toxic side effects Clin. Cancer Res. 19 5381-9
15. Golden E B, Demaria S, Schiff P B, Chachoua A and Formenti S C 2013 An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer Cancer Immunol. Res. 1 365-72
16. Hainfeld J F, Dilmanian F A, Slatkin D N and Smilowitz H M 2008 Radiotherapy enhancement with gold nanoparticles J. Pharm. Pharmacol. 60 977-85
17. Hainfeld J F, Slatkin D N, Focella T M and Smilowitz H M 2006 Gold nanoparticles: a new x-ray contrast agent Br. J. Radiol. 79 248-53
18. Hainfeld J F, Slatkin D N and Smilowitz H M 2004 The use of gold nanoparticles to enhance radiotherapy in mice Phys. Med. Biol. 49 N309-15
19. Hao Y, Altundal Y, Moreau M, Sajo E, Kumar R and Ngwa W 2015 Potential for enhancing external beam radiotherapy for lung cancer using high-Z nanoparticles administered via inhalation Phys. Med. Biol. 60 7035-43
20. Hiniker S M, Chen D S, Reddy S, Chang D T, Jones J C, Mollick J A, Swetter S M and Knox S J 2012 A systemic complete response of metastatic melanoma to local radiation and immunotherapy Transl. Oncol. 5 404-7
21. Jain R K and Stylianopoulos T 2010 Delivering nanomedicine to solid tumors Nat. Rev. Clin. Oncol. 7 653-64
22. Jain S, Hirst D G and O'Sullivan J M 2012 Gold nanoparticles as novel agents for cancer therapy Br. J. Radiol. 85 101-13
23. Khong A, Nelson D J, Nowak A K, Lake R A and Robinson B W 2012 The use of agonistic anti-CD40 therapy in treatments for cancer Int. Rev. Immunol. 31 246-66
24. Kodama K, Higashiyama M, Okami J, Tokunaga T, Inoue N, Akazawa T and Seya T 2013 A possible abscopal effect of post-irradiation immunotherapy in two patients with metastatic lung tumors Int. Cancer Conf. J. 3 122-27
25. Lee Y et al 2009 Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment Blood 114 589-95
26. Netti P A, Berk D A, Swartz M A, Grodzinsky A J and Jain R K 2000 Role of extracellular matrix assembly in interstitial transport in solid tumors Cancer Res. 60 2497-503
27. Ngwa W, Kumar R, Sridhar S, Korideck H, Zygmanski P, Cormack R A, Berbeco R and Makrigiorgos G M 2014 Targeted radiotherapy with gold nanoparticles: current status and future perspectives Nanomedicine 9 1063-82
28. Ngwa W, Makrigiorgos G M and Berbeco R I 2010 Applying gold nanoparticles as tumor-vascular disrupting agents during brachytherapy: estimation of endothelial dose enhancement Phys. Med. Biol. 55 6533-48
29. Ngwa W and Ngoma T 2016 Emerging Models for Global Health in Radiation Oncology (Bristol: IOP Publishing)
30. Ohta K, Shimohira M, Iwata H, Hashizume T, Ogino H, Miyakawa A, Murai T and Shibamoto Y 2013 Percutaneous fiducial marker placement under CT fluoroscopic guidance for stereotactic body radiotherapy of the lung: an initial experience J. Radiat. Res. 54 957-61
31. Pluen A et al 2001 Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial versus subcutaneous tumors Proc. Natl Acad. Sci. USA 98 4628-33
32. Postow M A et al 2012 Immunologic correlates of the abscopal effect in a patient with melanoma New Engl. J. Med. 366 925-31
33. Sandin L C, Orlova A, Gustafsson E, Ellmark P, Tolmachev V, Totterman T H and Mangsbo S M 2014a Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer Cancer Immunol. Res. 2 80-90
34. Sandin L C, Totterman T H and Mangsbo S M 2014b Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer Oncoimmunology 3 e27400
35. Schaue D, Ratikan J A, Iwamoto K S and McBride W H 2012 Maximizing tumor immunity with fractionated radiation Int. J. Radiat. Oncol. Biol. Phys. 83 1306-10
36. Sinha N, Cifter G, Sajo E, Kumar R, Sridhar S, Nguyen P L, Cormack R A, Makrigiorgos G M and Ngwa W 2015 Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters Int. J. Radiat. Oncol. Biol. Phys. 91 385-92
37. Slovin S F et al 2013 Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study Ann. Oncol. 24 1813-21
38. Small E J, Tchekmedyian N S, Rini B I, Fong L, Lowy I and Allison J P 2007 A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer Clin. Cancer Res. 13 1810-5
39. Tang C et al 2014 Combining radiation and immunotherapy: a new systemic therapy for solid tumors? Cancer Immunol. Res. 2 831-8
40. Thomas D G 1965 Transport characteristics of suspension: VIII. A note on the viscosity of Newtonian suspensions of uniform spherical particles J. Colloid Sci. 20 267-77
41. Vonderheide R H and Glennie M J 2013 Agonistic CD40 antibodies and cancer therapy Clin. Cancer Res. 19 1035-43
42. Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan V P, Jiang W, Popovic Z, Jain R K, Bawendi M G and Fukumura D 2011 Multistage nanoparticle delivery system for deep penetration into tumor tissue Proc. Natl Acad. Sci. USA 108 2426-31
43. Wong J et al 2008 High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities Int. J. Radiat. Oncol. Biol. Phys. 71 1591-9