Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer

Cancer Science

Volumn 102, Issue 7, 2011, Pages 1257-1263

  Yasuda, Koji ^a   Nirei, Takako ^a   Tsuno, Nelson Hirokazu ^a   Nagawa, Hirokazu ^a   Kitayama, Joji ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RADIOTHERAPY; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION RESPONSE; RECTUM CANCER; REGULATORY T LYMPHOCYTE; SPLEEN CELL; SUPPRESSOR CELL; TUMOR IMMUNITY;

ANIMALS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; FEMALE; INJECTIONS, INTRALESIONAL; INTERLEUKIN-2; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED BALB C; RECTAL NEOPLASMS;

EID: 79959246500     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01940.x     Document Type: Article

References (40)

1. Sauer R, Becker H, Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351: 1731-40.
2. Bosset JF, Collette L, Calais G et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-23.
3. Ortholan C, Francois E, Thomas O et al. Role of radiotherapy with surgery for T3 and resectable T4 rectal cancer: evidence from randomized trials. Dis Colon Rectum 2006; 49: 302-10.
4. Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003; 3: 117-29.
5. Mothersill C, Seymour CB. Radiation-induced bystander effects - implications for cancer. Nat Rev Cancer 2004; 4: 158-64.
6. Prise KM, Schettino G, Folkard M, Held KD. New insights on cell death from radiation exposure. Lancet Oncol 2005; 6: 520-8.
7. Barcellos-Hoff MH, Park C, Wright EG. Radiation and the microenvironment - tumorigenesis and therapy. Nat Rev Cancer 2005; 5: 867-75.
8. Stone HB, Peters LJ, Milas L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J Natl Cancer Inst 1979; 63: 1229-35.
9. Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009; 10: 718-26.
10. Kitayama J, Yasuda K, Kawai K, Sunami E, Nagawa H. Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. Radiat Oncol 2010; 5: 47.
11. Nobler MP. The abscopal effect in malignant lymphoma and its relationship to lymphocyte circulation. Radiology 1969; 93: 410-2.
12. Kitakata H, Nemoto-Sasaki Y, Takahashi Y, Kondo T, Mai M, Mukaida N. Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. Cancer Res 2002; 62: 6682-7.
13. Japanese Classification of Colorectal Carcinoma. Tokyo: Kanehara, 2009.
14. Rodriguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol Rev 2008; 222: 180-91.
15. Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009; 182: 4499-506.
16. Demaria S, Formenti SC. Sensors of ionizing radiation effects on the immunological microenvironment of cancer. Int J Radiat Biol 2007; 83: 819-25.
17. Lorimore SA, Coates PJ, Scobie GE, Milne G, Wright EG. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene 2001; 20: 7085-95.
18. Apetoh L, Ghiringhelli F, Tesniere A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13: 1050-9.
19. Liao YP, Wang CC, Butterfield LH et al. Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells. J Immunol 2004; 173: 2462-9.
20. Dybal EJ, Haas GP, Maughan RL, Sud S, Pontes JE, Hillman GG. Synergy of radiation therapy and immunotherapy in murine renal cell carcinoma. J Urol 1992; 148: 1331-7.
21. Younes E, Haas GP, Dezso B et al. Local tumor irradiation augments the response to IL-2 therapy in a murine renal adenocarcinoma. Cell Immunol 1995; 165: 243-51.
22. Dezso B, Haas GP, Hamzavi F et al. The mechanism of local tumor irradiation combined with interleukin 2 therapy in murine renal carcinoma: histological evaluation of pulmonary metastases. Clin Cancer Res 1996; 2: 1543-52.
23. Jurgenliemk-Schulz IM, Renes IB, Rutgers DH et al. Anti-tumor effects of local irradiation in combination with peritumoral administration of low doses of recombinant interleukin-2 (rIL-2). Radiat Oncol Investig 1997; 5: 54-61.
24. Redman BG, Hillman GG, Flaherty L, Forman J, Dezso B, Haas GP. Phase II trial of sequential radiation and interleukin 2 in the treatment of patients with metastatic renal cell carcinoma. Clin Cancer Res 1998; 4: 283-6.
25. Timar J, Forster-Horvath C, Lukits J et al. The effect of leukocyte interleukin injection (Multikine) treatment on the peritumoral and intratumoral subpopulation of mononuclear cells and on tumor epithelia: a possible new approach to augmenting sensitivity to radiation therapy and chemotherapy in oral cancer - a multicenter phase I/II clinical Trial. Laryngoscope 2003; 113: 2206-17.
26. Lechleider RJ, Arlen PM, Tsang KY et al. Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clin Cancer Res 2008; 14: 5284-91.
27. Mole RH. Whole body irradiation; radiobiology or medicine? Br J Radiol 1953; 26: 234-41.
28. Antoniades J, Brady LW, Lightfoot DA. Lymphangiographic demonstration of the abscopal effect in patients with malignant lymphomas. Int J Radiat Oncol Biol Phys 1977; 2: 141-7.
29. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973; 46: 220-2.
30. Kingsley DP. An interesting case of possible abscopal effect in malignant melanoma. Br J Radiol 1975; 48: 863-6.
31. Rees GJ, Ross CM. Abscopal regression following radiotherapy for adenocarcinoma. Br J Radiol 1983; 56: 63-6.
32. Friedman EJ. Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr Pharm Des 2002; 8: 1765-80.
33. Chakrabarty A, Hillman GG, Maughan RL, Ali E, Pontes JE, Haas GP. Radiation therapy enhances the therapeutic effect of immunotherapy on pulmonary metastases in a murine renal adenocarcinoma model. In Vivo 1994; 8: 25-31.
34. Nesslinger NJ, Sahota RA, Stone B et al. Standard treatments induce antigen-specific immune responses in prostate cancer. Clin Cancer Res 2007; 13: 1493-502.
35. Heisel SM, Ketter R, Keller A et al. Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation. PLoS ONE 2008; 3: e2164.
36. Schaue D, Comin-Anduix B, Ribas A et al. T-cell responses to survivin in cancer patients undergoing radiation therapy. Clin Cancer Res 2008; 14: 4883-90.
37. Sutherland RM. Radiation-enhanced immune response to cancer: workshop, Anaheim, CA, April 17, 2005. Int J Radiat Oncol Biol Phys 2006; 64: 3-5.
38. Kudo-Saito C, Schlom J, Camphausen K, Coleman CN, Hodge JW. The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors. Clin Cancer Res 2005; 11: 4533-44.
39. Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol 2005; 174: 7516-23.
40. Lee Y, Auh SL, Wang Y et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 2009; 114: 589-95.