TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Neuron

Volumn 97, Issue 5, 2018, Pages 1023-1031.e7

  Zhao, Yingjun ^a   Wu, Xilin ^a,b   Li, Xiaoguang ^a   Jiang, Lu Lin ^a   Gui, Xun ^c   Liu, Yan ^a,d   Sun, Yu ^a   Zhu, Bing ^a   Piña Crespo, Juan C ^a   Zhang, Muxian ^d   Zhang, Ningyan ^c   Chen, Xiaochun ^b   Bu, Guojun ^d,e   An, Zhiqiang ^c   Huang, Timothy Y ^a   Xu, Huaxi ^a,d  

^a BURNHAM INSTITUTE   (United States)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d XIAMEN UNIVERSITY   (China)

^e MAYO GRADUATE SCHOOL   (United States)

Author keywords

Alzheimer's disease; A ; microglia; neuroinflammation; R47H; TREM2

Indexed keywords

AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; OLIGOMER; PROTEIN KINASE SYK; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; PROTEIN BINDING; TREM2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DEPOLARIZATION; FEMALE; GENE MUTATION; GENETIC VARIATION; HUMAN; HUMAN TISSUE; MALE; MICROGLIA; MOUSE; NONHUMAN; PATHOGENESIS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TREM2 GENE; AGED; ANIMAL; BRAIN; C3H MOUSE; C57BL MOUSE; CELL CULTURE; DOUBLE BLIND PROCEDURE; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELLS, CULTURED; DOUBLE-BLIND METHOD; FEMALE; HEK293 CELLS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC;

EID: 85042755304     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2018.01.031     Document Type: Article

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