Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

Neuron

Volumn 97, Issue 2, 2018, Pages 299-312.e6

  Madry, Christian ^a,b   Kyrargyri, Vasiliki ^a   Arancibia Cárcamo, I Lorena ^a   Jolivet, Renaud ^a,c   Kohsaka, Shinichi ^d   Bryan, Robert M ^e   Attwell, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

ATP; inflammasome; interleukin 1 ; microglia; potassium channel; ramification; surveillance; THIK 1

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; INFLAMMASOME; INTERLEUKIN 1BETA; POTASSIUM; POTASSIUM CHANNEL; PURINERGIC P2Y12 RECEPTOR; THIK 1 POTASSIUM CHANNEL; UNCLASSIFIED DRUG; KCNK13 PROTEIN, MOUSE; KCNK13 PROTEIN, RAT; P2RY12 PROTEIN, MOUSE; TANDEM PORE DOMAIN POTASSIUM CHANNEL; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CELL ACTIVATION; CELL FUNCTION; CELL GROWTH; CELL MOTILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; FEMALE; IMMUNOSURVEILLANCE; MALE; MEMBRANE CURRENT; MICROGLIA; MICROGLIAL RAMIFICATION; MOUSE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; POTASSIUM CURRENT; POTASSIUM DEPLETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; CELL POLARITY; CELL SHAPE; CELL SURFACE; CHEMOTAXIS; DEFICIENCY; DRUG EFFECT; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL MOVEMENT; CELL POLARITY; CELL SHAPE; CELL SURFACE EXTENSIONS; CHEMOTAXIS; INFLAMMASOMES; INTERLEUKIN-1BETA; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MICROGLIA; POTASSIUM; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2Y12; TRANSCRIPTOME;

EID: 85042017303     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2017.12.002     Document Type: Article

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