Microglia processes block the spread of damage in the brain and require functional chloride channels

GLIA

Volumn 57, Issue 15, 2009, Pages 1610-1618

  Hines, Dustin J ^a   Hines, Rochelle M ^a   Mulligan, Sean J ^b   Macvicar, Brian A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Actin polymerization; Acute damage; Endfeet; Filopodia; Immune cell; Ion channels; Microglia

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CHLORIDE CHANNEL; POTASSIUM CHANNEL; TAMOXIFEN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN SLICE; CONTROLLED STUDY; FILOPODIUM; LASER MICROSCOPY; MICROGLIA; MOUSE; NERVE FIBER GROWTH; NERVE FUNCTION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACTINS; ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; CHLORIDE CHANNELS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; LASERS; MICE; MICE, TRANSGENIC; MICROGLIA; NITROBENZOATES; PSEUDOPODIA; RECEPTORS, CHEMOKINE; TAMOXIFEN; TIME FACTORS;

EID: 70449650338     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20874     Document Type: Article

References (41)

1. Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. 2002. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 109:509-521. (Pubitemid 34564477)
2. Chu S, Blaisdell CJ, Bamford P, Ferro TJ. 2004. Interferon-gamma regulates ClC-2 chloride channel in lung epithelial cells. Biochem Biophys Res Commun 324:31-39. (Pubitemid 39311455)
3. Darby M, Kuzmiski JB, Panenka W, Feighan D, MacVicar BA. 2003. ATP released from astrocytes during swelling activates chloride channels. J Neurophysiol 89:1870-1877. (Pubitemid 36444243)
4. Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. 2005. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8:752-758. (Pubitemid 43085841)
5. De Paola V, Holtmaat A, Knott G, Song S, Wilbrecht L, Caroni P, Svoboda K. 2006. Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex. Neuron 49:861-875. (Pubitemid 43376083)
6. Dent EW, Gertler FB. 2003. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 40:209-227. (Pubitemid 37244093)
7. Ducharme G, Newell EW, Pinto C, Schlichter LC. 2007. Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia. Eur J Neurosci 26:2119-2130. (Pubitemid 47620476)
8. Eder C. 2005. Regulation of microglial behavior by ion channel activity. J Neurosci Res 81:314-321. (Pubitemid 41359285)
9. Eder C, Klee R, Heinemann U. 1998. Involvement of stretch-activated Cl- channels in ramification of murine microglia. J Neurosci 18:7127-7137. (Pubitemid 28425800)
10. Eichhoff G, Busche MA, Garaschuk O. 2008. In vivo calcium imaging of the aging and diseased brain. Eur J Nucl Med Mol Imaging 35Suppl 1:S99-S106.
11. Fordyce CB, Jagasia R, Zhu X, Schlichter LC. 2005. Microglia Kv1.3 channels contribute to their ability to kill neurons. J Neurosci 25:7139-7149. (Pubitemid 41113930)
12. Fraser DD, Duffy S, Angelides KJ, Perez-Velazquez JL, Kettenmann H, MacVicar BA. 1995. GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes. J Neurosci 15:2720-2732.
13. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. 2003. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837-845. (Pubitemid 36929705)
14. Hanisch UK, Kettenmann H. 2007. Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10:1387-1394. (Pubitemid 350014685)
15. Harman D. 1989. Lipofuscin and ceroid formation: The cellular recycling system. Adv Exp Med Biol 266:3-15. (Pubitemid 20307305)
16. Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D. 2006. The P2Y(12) receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9:1512-1519. (Pubitemid 44862659)
17. Heidemann SR, Buxbaum RE. 1998. Cell crawling: First the motor, now the transmission. J Cell Biol 141:1-4.
18. Hirrlinger J, Hulsmann S, Kirchhoff F. 2004. Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235-2239. (Pubitemid 39331144)
19. Imai Y, Kohsaka S. 2002. Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1. Glia 40:164-174. (Pubitemid 35337374)
20. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20:4106-4114.
21. Kimelberg HK, Macvicar BA, Sontheimer H. 2006. Anion channels in astrocytes: Biophysics, pharmacology, and function. Glia 54:747-757. (Pubitemid 44629637)
22. Klee R, Heinemann U, Eder C. 1998. Changes in proton currents in murine microglia induced by cytoskeletal disruptive agents. Neurosci Lett 247:191-194. (Pubitemid 28240129)
23. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y. 2000. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci 20:6898-6906. (Pubitemid 30708016)
24. Lambrechts A, Van Troys M, Ampe C. 2004. The actin cytoskeleton in normal and pathological cell motility. Int J Biochem Cell Biol 36:1890-1909.
25. Lascola CD, Kraig RP. 1996. Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. J Neurosci 16:2532-2545.
26. Lascola CD, Nelson DJ, Kraig RP. 1998. Cytoskeletal actin gates a Clchannel in neocortical astrocytes. J Neurosci 18:1679-1692.
27. Macdonald RL, Olsen RW. 1994. GABAA receptor channels. Annu Rev Neurosci 17:569-602.
28. Minghetti L. 2005. Role of inflammation in neurodegenerative diseases. Curr Opin Neurol 18:315-321.
29. Mulligan SJ, MacVicar BA. 2004. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 431:195-199.
30. Newell EW, Schlichter LC. 2005. Integration of K1 and Cl- currents regulate steady-state and dynamic membrane potentials in cultured rat microglia. J Physiol 567:869-890.
31. Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318. (Pubitemid 40746128)
32. Nishiyama M, von Schimmelmann MJ, Togashi K, Findley WM, Hong K. 2008. Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning. Nat Neurosci 11:762-771.
33. Palmer DN, Fearnley IM, Walker JE, Hall NA, Lake BD, Wolfe LS, Haltia M, Martinus RD, Jolly RD. 1992. Mitochondrial ATP synthase subunit c storage in the ceroid-lipofuscinoses (Batten disease). Am J Med Genet 42:561-567.
34. Ransom CB, O'Neal JT, Sontheimer H. 2001. Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells. J Neurosci 21:7674-7683.
35. Rappert A, Biber K, Nolte C, Lipp M, Schubel A, Lu B, Gerard NP, Gerard C, Boddeke HW, Kettenmann H. 2002. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J Immunol 168:3221-3226. (Pubitemid 34250381)
36. Rebenko-Moll NM, Liu L, Cardona A, Ransohoff RM. 2006. Chemokines, mononuclear cells and the nervous system: Heaven (or hell) is in the details. Curr Opin Immunol 18:683-689. (Pubitemid 44635175)
37. Seehafer SS, Pearce DA. 2006. You say lipofuscin, we say ceroid: Defining autofluorescent storage material. Neurobiol Aging 27:576-588.
38. Starita C, Hussain AA, Marshall J. 1995. Decreasing hydraulic conductivity of Bruch's membrane: Relevance to photoreceptor survival and lipofuscinoses. Am J Med Genet 57:235-237.
39. Witteck A, Yao Y, Fechir M, Forstermann U, Kleinert H. 2003. Rho protein- mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression. Exp Cell Res 287:106-115. (Pubitemid 36683206)
40. Wu LJ, Vadakkan KI, Zhuo M. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55:810-821. (Pubitemid 46787192)
41. Zierler S, Kerschbaum HH. 2005. Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2. Brain Res 1039:162-170.