An environment-dependent transcriptional network specifies human microglia identity

Science

Volumn 356, Issue 6344, 2017, Pages 1248-1259

  Gosselin, David ^a   Skola, Dylan ^a   Coufal, Nicole G ^b,c   Holtman, Inge R ^a,d   Schlachetzki, Johannes C M ^a   Sajti, Eniko ^c   Jaeger, Baptiste N ^b   O'Connor, Carolyn ^b   Fitzpatrick, Conor ^b   Pasillas, Martina P ^a   Pena, Monique ^b   Adair, Amy ^b   Gonda, David D ^e   Levy, Michael L ^e   Ransohoff, Richard M ^f   Gage, Fred H ^b   Glass, Christopher K ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e RADY CHILDREN'S HOSPITAL   (United States)

^f BIOGEN   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOC1 PROTEIN; APOLIPOPROTEIN E; CHEMOKINE RECEPTOR CX3CR1; CIITA PROTEIN; COMPLEMENTARY DNA; EARLY GROWTH RESPONSE FACTOR 3; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; NUCLEAR RECEPTOR RELATED FACTOR 1; OSTEONECTIN; P2RY12 PROTEIN; POLYADENYLATED RNA; SALL1 PROTEIN; SALL3 PROTEIN; SMAD1 PROTEIN; STAT3 PROTEIN; TMEM119 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR MAFB; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTOME; TRANSPOSASE; UNCLASSIFIED DRUG; VSIG4 PROTEIN;

BRAIN; CELLS AND CELL COMPONENTS; GENE EXPRESSION; HOMEOSTASIS; HOMINID; MOLECULAR ANALYSIS; NERVOUS SYSTEM; PHENOTYPE; RODENT;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BRAIN TISSUE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; ENHANCER REGION; ENVIRONMENTAL IMPACT; EPIGENETICS; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MENTAL DISEASE; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; RNA SEQUENCE; TISSUE CULTURE; TRANSCRIPTOMICS; ANIMAL; BRAIN TUMOR; C57BL MOUSE; CELL CULTURE; CYTOLOGY; ENVIRONMENT; EPILEPSY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN NEOPLASMS; CELLS, CULTURED; ENVIRONMENT; EPILEPSY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA;

EID: 85020163581     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aal3222     Document Type: Article

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