Transcranial amelioration of inflammation and cell death after brain injury

Nature

Volumn 505, Issue 7482, 2014, Pages 223-228

  Roth, Theodore L ^a   Nayak, Debasis ^a   Atanasijevic, Tatjana ^a   Koretsky, Alan P ^a   Latour, Lawrence L ^a   McGavern, Dorian B ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; PURINERGIC RECEPTOR; REACTIVE OXYGEN METABOLITE;

BRAIN; CELL ORGANELLE; CRANIUM; INJURY; NEUROLOGY; PATHOGENICITY; PATHOLOGY; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; BRAIN INJURY; CELL DEATH; CONTROLLED STUDY; HUMAN; INFLAMMATION; INNATE IMMUNITY; MICROGLIA; MICROSCOPY; MOUSE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIOXIDANTS; ASTROCYTES; BRAIN; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; ENCEPHALITIS; GLASGOW COMA SCALE; GLUTATHIONE; HUMANS; INTRACRANIAL HEMORRHAGES; MALE; MENINGES; MICE; MICROGLIA; NEUROPROTECTIVE AGENTS; NEUTROPHILS; PURINERGIC P2 RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; SKULL;

MURINAE;

EID: 84892369064     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12808     Document Type: Article

References (26)

1. DeKosky, S. T., Blennow, K., Ikonomovic, M. D. & Gandy, S. Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nature Rev. Neurol. 9, 192-200 (2013).
2. Roozenbeek, B., Maas, A. I. & Menon, D. K. Changing patterns in the epidemiology of traumatic brain injury. Nature Rev. Neurol. 9, 231-236 (2013).
3. Zetterberg, H.,Smith, D. H.&Blennow, K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nature Rev. Neurol. 9, 201-210 (2013).
4. McConeghy, K. W., Hatton, J., Hughes, L. & Cook, A. M. A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury. CNS Drugs 26, 613-636 (2012).
5. Xiong, Y., Mahmood, A. & Chopp, M. Animal models of traumatic brain injury. Nature Rev. Neurosci. 14, 128-142 (2013).
6. Finnie, J. W.Neuroinflammation: beneficial and detrimental effects after traumatic brain injury. Inflammopharmacology 21, 309-320 (2013).
7. Hall, E. D., Andrus, P. K. & Yonkers, P. A. Brain hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60, 588-594 (1993).
8. Lewén, A., Matz, P. & Chan, P. H. Free radical pathways in CNS injury. J. Neurotrauma 17, 871-890 (2000).
9. Young, W. Role of calcium in central nervous system injuries. J. Neurotrauma 9 (suppl. 1), S9-S25 (1992).
10. Bullock, R. et al. Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events. Ann. NY Acad. Sci. 765, 290-297 (1995).
11. Bullock, R. et al. Factors affecting excitatory amino acid release following severe human head injury. J. Neurosurg. 89, 507-518 (1998).
12. Mazzeo, A. T.,Beat, A., Singh, A.&Bullock, M. R. The role of mitochondrial transition pore, and itsmodulation, in traumatic brain injuryanddelayed neurodegeneration after TBI. Exp. Neurol. 218, 363-370 (2009).
13. Janowitz, T. & Menon, D. K. Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci. Transl. Med. 2, 27rv1 (2010).
14. Mamourian, A. C., Hoopes, P. J. & Lewis, L. D. Visualization of intravenously administered contrast material in the CSF on fluid-attenuated inversion-recovery MR images: an in vitro and animal-model investigation. AJNR Am. J. Neuroradiol. 21, 105-111 (2000).
15. Xu, H. T., Pan, F., Yang, G. & Gan, W. B. Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nature Neurosci. 10, 549-551 (2007).
16. Eltzschig, H. K., Sitkovsky, M. V. & Robson, S. C. Purinergic signaling during inflammation. N. Engl. J. Med. 367, 2322-2333 (2012).
17. Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neurosci. 8, 752-758 (2005).
18. Chen, G. Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nature Rev. Immunol. 10, 826-837 (2010).
19. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
20. Haynes, S. E. et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nature Neurosci. 9, 1512-1519 (2006).
21. McDonald, B. et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362-366 (2010).
22. Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106-4114 (2000).
23. Zhuo, L. et al. Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev. Biol. 187, 36-42 (1997).
24. Faust, N., Varas, F., Kelly, L. M., Heck, S. & Graf, T. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96, 719-726 (2000).
25. Yang, G., Pan, F., Parkhurst, C. N., Grutzendler, J. & Gan, W. B. Thinned-skull cranial window technique for long-termimaging of the cortex in live mice. Nature Protocols 5, 201-208 (2010).
26. Chuang, K. H., Koretsky, A. P. & Sotak, C. H. Temporal changes in the T1 and T2 relaxation rates (DR1 and DR2) in the rat brain are consistent with the tissueclearance rates of elemental manganese. Magn. Reson. Med. 61, 1528-1532 (2009).