Disruption of K2P6.1 produces vascular dysfunction and hypertension in mice

Hypertension

Volumn 58, Issue 4, 2011, Pages 672-678

  Lloyd, Eric E ^a   Crossland, Randy F ^b   Phillips, Sharon C ^a   Marrelli, Sean P ^a,b   Reddy, Anilkumar K ^a   Taffet, George E ^a   Hartley, Craig J ^a   Bryan Jr , Robert M ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Biophysics Graduate Program in Cardiovascular Sciences   (United States)

Author keywords

2 pore domain potassium channels (K2P); hypertension; K2P6.1; Kcnk6; resting membrane potential; Rho kinase; TWIK 2

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM CHANNEL L TYPE; POTASSIUM CHANNEL; POTASSIUM CHANNEL K2P6.1; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VOLUME; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE STEADY POTENTIAL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EXON; GENE DELETION; HYPERTENSION; ISOLATED ARTERY; KNOCKOUT MOUSE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; WILD TYPE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; 3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; AORTA; BLOOD PRESSURE; CALCIUM CHANNEL AGONISTS; DISEASE MODELS, ANIMAL; HYPERTENSION; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; POTASSIUM CHLORIDE; RHO-ASSOCIATED KINASES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 80053564958     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.175349     Document Type: Article

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