메뉴 건너뛰기




Volumn 15, Issue 3, 2018, Pages 181-191

Current and future antiplatelet therapies: Emphasis on preserving haemostasis

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; COLLAGEN; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCOPROTEIN VI; ISOMERASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN DISULFIDE ISOMERASE; PROTEINASE ACTIVATED RECEPTOR 1 ANTAGONIST; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; FIBRINOLYTIC AGENT;

EID: 85041950324     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2017.206     Document Type: Review
Times cited : (216)

References (116)
  • 1
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    • Naghavi, M. et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385, 117-171 (2015).
    • (2015) Lancet , vol.385 , pp. 117-171
    • Naghavi, M.1
  • 4
    • 0020639814 scopus 로고
    • Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi
    • Falk, E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br. Heart J. 50, 127-134 (1983).
    • (1983) Br. Heart J. , vol.50 , pp. 127-134
    • Falk, E.1
  • 5
    • 0032724684 scopus 로고    scopus 로고
    • Structure and function of von Willebrand factor
    • Ruggeri, Z. M. Structure and function of von Willebrand factor. Thromb. Haemost. 82, 576-584 (1999).
    • (1999) Thromb. Haemost. , vol.82 , pp. 576-584
    • Ruggeri, Z.M.1
  • 6
    • 64249090109 scopus 로고    scopus 로고
    • Platelet adhesion under flow
    • Ruggeri, Z. M. Platelet adhesion under flow. Microcirculation 16, 58-83 (2009).
    • (2009) Microcirculation , vol.16 , pp. 58-83
    • Ruggeri, Z.M.1
  • 7
    • 84887001106 scopus 로고    scopus 로고
    • Differentiating haemostasis from thrombosis for therapeutic benefit
    • McFadyen, J. D. & Jackson, S. P. Differentiating haemostasis from thrombosis for therapeutic benefit. Thromb. Haemost. 110, 859-867 (2013).
    • (2013) Thromb. Haemost. , vol.110 , pp. 859-867
    • McFadyen, J.D.1    Jackson, S.P.2
  • 8
    • 84867888747 scopus 로고    scopus 로고
    • Platelet GPVI: A target for antithrombotic therapy?!
    • Dütting, S., Bender, M. & Nieswandt, B. Platelet GPVI: a target for antithrombotic therapy?! Trends Pharmacol. Sci. 11, 583-590 (2012).
    • (2012) Trends Pharmacol. Sci. , vol.11 , pp. 583-590
    • Dütting, S.1    Bender, M.2    Nieswandt, B.3
  • 9
    • 0031916728 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
    • Jin, J., Daniel, J. L. & Kunapuli, S. P. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J. Biol. Chem. 273, 2030-2034 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 2030-2034
    • Jin, J.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 11
    • 0033613183 scopus 로고    scopus 로고
    • How the protease thrombin talks to cells
    • Coughlin, S. R. How the protease thrombin talks to cells. Proc. Natl Acad. Sci. USA 96, 11023-11027 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 11023-11027
    • Coughlin, S.R.1
  • 12
    • 31044441154 scopus 로고    scopus 로고
    • Structure and function of the platelet integrin αiIbβ3
    • Bennett, J. S. Structure and function of the platelet integrin αIIbβ3. J. Clin. Invest. 115, 3363-3369 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3363-3369
    • Bennett, J.S.1
  • 14
    • 50449098285 scopus 로고    scopus 로고
    • Mechanisms of thrombus formation
    • Furie, B. & Furie, B. C. Mechanisms of thrombus formation. N. Engl. J. Med. 359, 938-949 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 938-949
    • Furie, B.1    Furie, B.C.2
  • 15
    • 0027309290 scopus 로고
    • Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
    • Ishii, K., Hein, L., Kobilka, B. & Coughlin, S. R. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J. Biol. Chem. 268, 9780-9786 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 9780-9786
    • Ishii, K.1    Hein, L.2    Kobilka, B.3    Coughlin, S.R.4
  • 16
    • 0036213048 scopus 로고    scopus 로고
    • Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome
    • Covic, L., Singh, C., Smith, H. & Kuliopulos, A. Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome. Thromb. Haemost. 87, 722-727 (2002).
    • (2002) Thromb. Haemost. , vol.87 , pp. 722-727
    • Covic, L.1    Singh, C.2    Smith, H.3    Kuliopulos, A.4
  • 17
    • 67149093849 scopus 로고    scopus 로고
    • A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    • Nesbitt, W. S. et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat. Med. 15, 665-673 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 665-673
    • Nesbitt, W.S.1
  • 18
    • 84876542457 scopus 로고    scopus 로고
    • Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network
    • Stalker, T. J. et al. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood 121, 1875-1885 (2013).
    • (2013) Blood , vol.121 , pp. 1875-1885
    • Stalker, T.J.1
  • 19
    • 84906085931 scopus 로고    scopus 로고
    • A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
    • Welsh, J. D. et al. A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood 124, 1808-1815 (2014).
    • (2014) Blood , vol.124 , pp. 1808-1815
    • Welsh, J.D.1
  • 20
    • 84906097811 scopus 로고    scopus 로고
    • A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity
    • Stalker, T. J. et al. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood 124, 1824-1831 (2014).
    • (2014) Blood , vol.124 , pp. 1824-1831
    • Stalker, T.J.1
  • 21
    • 21044454703 scopus 로고    scopus 로고
    • PI 3-kinase p110β: A new target for antithrombotic therapy
    • Jackson, S. P. et al. PI 3-kinase p110β: a new target for antithrombotic therapy. Nat. Med. 11, 507-514 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 507-514
    • Jackson, S.P.1
  • 22
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. Inflammation in atherosclerosis. Nature 420, 868-874 (2002).
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 24
    • 4444264392 scopus 로고    scopus 로고
    • Integrins: Dynamic scaffolds for adhesion and signaling in platelets
    • Shattil, S. J. & Newman, P. J. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood 104, 1606-1615 (2004).
    • (2004) Blood , vol.104 , pp. 1606-1615
    • Shattil, S.J.1    Newman, P.J.2
  • 25
    • 84887408822 scopus 로고    scopus 로고
    • A directional switch of integrin signalling and a new anti-thrombotic strategy
    • Shen, B. et al. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature 503, 131-135 (2013).
    • (2013) Nature , vol.503 , pp. 131-135
    • Shen, B.1
  • 26
    • 84897518813 scopus 로고    scopus 로고
    • Thiol isomerases in thrombus formation
    • Furie, B. & Flaumenhaft, R. Thiol isomerases in thrombus formation. Circ. Res. 114, 1162-1173 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 1162-1173
    • Furie, B.1    Flaumenhaft, R.2
  • 27
    • 40549084318 scopus 로고    scopus 로고
    • A critical role for extracellular protein disulfide isomerase during thrombus formation in mice
    • Cho, J., Furie, B. C., Coughlin, S. R. & Furie, B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J. Clin. Invest. 118, 1123-1131 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1123-1131
    • Cho, J.1    Furie, B.C.2    Coughlin, S.R.3    Furie, B.4
  • 28
    • 84886930949 scopus 로고    scopus 로고
    • Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice
    • Kim, K. et al. Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood 122, 1052-1061 (2013).
    • (2013) Blood , vol.122 , pp. 1052-1061
    • Kim, K.1
  • 29
    • 80053289254 scopus 로고    scopus 로고
    • The evolution of antiplatelet therapy in cardiovascular disease
    • Yousuf, O. & Bhatt, D. L. The evolution of antiplatelet therapy in cardiovascular disease. Nat. Rev. Cardiol. 8, 547-559 (2011).
    • (2011) Nat. Rev. Cardiol. , vol.8 , pp. 547-559
    • Yousuf, O.1    Bhatt, D.L.2
  • 30
    • 84875124713 scopus 로고    scopus 로고
    • Dual anti-platelet therapy after coronary artery bypass grafting: Is there any benefit? A systematic review and meta-analysis
    • Deo, S. V. et al. Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis. J. Card. Surg. 28, 109-116 (2013).
    • (2013) J. Card. Surg. , vol.28 , pp. 109-116
    • Deo, S.V.1
  • 32
    • 0030773146 scopus 로고    scopus 로고
    • Aspirin as a therapeutic agent in cardiovascular disease: A statement for healthcare professionals from the American Heart Association
    • Hennekens, C. H., Dyken, M. L. & Fuster, V. Aspirin as a therapeutic agent in cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 96, 2751-2753 (1997).
    • (1997) Circulation , vol.96 , pp. 2751-2753
    • Hennekens, C.H.1    Dyken, M.L.2    Fuster, V.3
  • 33
    • 0020528647 scopus 로고
    • Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina-results of a Veterans Administration cooperative study
    • Lewis, H. D. Jr et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina-results of a Veterans Administration cooperative study. N. Engl. J. Med. 309, 396-403 (1983).
    • (1983) N. Engl. J. Med. , vol.309 , pp. 396-403
    • Lewis, H.D.1
  • 34
    • 0023805341 scopus 로고
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 2, 349-360 (1988).
    • (1988) Lancet , vol.2 , pp. 349-360
  • 35
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists Collaboration
    • Antithrombotic Trialists Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324, 71-86 (2002).
    • (2002) BMJ , vol.324 , pp. 71-86
  • 36
    • 68949130179 scopus 로고    scopus 로고
    • P2Y(12) inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use
    • Wallentin, L. P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. Eur. Heart J. 30, 1964-1977 (2009).
    • (2009) Eur. Heart J. , vol.30 , pp. 1964-1977
    • Wallentin, L.1
  • 37
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf, S. et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N. Engl. J. Med. 345, 494-502 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 494-502
    • Yusuf, S.1
  • 38
    • 56849130022 scopus 로고    scopus 로고
    • Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    • Erlinge, D. et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J. Am. Coll. Cardiol. 52, 1968-1977 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 1968-1977
    • Erlinge, D.1
  • 39
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin, L. et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur. Heart J. 29, 21-30 (2008).
    • (2008) Eur. Heart J. , vol.29 , pp. 21-30
    • Wallentin, L.1
  • 40
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin, L. et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1045-1057
    • Wallentin, L.1
  • 41
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted, S. et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur. Heart J. 27, 1038-1047 (2006).
    • (2006) Eur. Heart J. , vol.27 , pp. 1038-1047
    • Husted, S.1
  • 43
    • 84875779761 scopus 로고    scopus 로고
    • Effect of platelet inhibition with cangrelor during PCI on ischemic events
    • Bhatt, D. L. et al. Effect of platelet inhibition with cangrelor during PCI on ischemic events. N. Engl. J. Med. 368, 1303-1313 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1303-1313
    • Bhatt, D.L.1
  • 44
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin, S. R. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J. Thromb. Haemost. 3, 1800-1814 (2005).
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 46
    • 69249225639 scopus 로고    scopus 로고
    • Antithrombotics in acute coronary syndromes
    • Bonaca, M. P. et al. Antithrombotics in acute coronary syndromes. J. Am. Coll. Cardiol. 54, 969-984 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.54 , pp. 969-984
    • Bonaca, M.P.1
  • 47
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow, D. A. et al. Vorapaxar in the secondary prevention of atherothrombotic events. N. Engl. J. Med. 366, 1404-1413 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1404-1413
    • Morrow, D.A.1
  • 48
    • 84921578013 scopus 로고    scopus 로고
    • Novel antiplatelet agents in acute coronary syndrome
    • Franchi, F. & Angiolillo, D. J. Novel antiplatelet agents in acute coronary syndrome. Nat. Rev. Cardiol. 12, 30-47 (2015).
    • (2015) Nat. Rev. Cardiol. , vol.12 , pp. 30-47
    • Franchi, F.1    Angiolillo, D.J.2
  • 49
    • 83655177669 scopus 로고    scopus 로고
    • Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
    • Tricoci, P. et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N. Engl. J. Med. 366, 20-33 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 20-33
    • Tricoci, P.1
  • 50
    • 75949128633 scopus 로고    scopus 로고
    • Antiplatelet therapies for the treatment of cardiovascular disease
    • Michelson, A. D. Antiplatelet therapies for the treatment of cardiovascular disease. Nat. Rev. Drug Discov. 9, 154-169 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 154-169
    • Michelson, A.D.1
  • 51
    • 0034721399 scopus 로고    scopus 로고
    • Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
    • Bhatt, D. L. & Topol, E. J. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. JAMA 284, 1549-1558 (2000).
    • (2000) JAMA , vol.284 , pp. 1549-1558
    • Bhatt, D.L.1    Topol, E.J.2
  • 52
    • 33645507439 scopus 로고    scopus 로고
    • Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: The ISAR-REACT 2 randomized trial
    • Kastrati, A. et al. Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA 295, 1531-1538 (2006).
    • (2006) JAMA , vol.295 , pp. 1531-1538
    • Kastrati, A.1
  • 53
    • 84899468272 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes
    • Bosch, X., Marrugat, J. & Sanchis, J. Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes. Cochrane Database Syst. Rev. 11, CD002130 (2013).
    • (2013) Cochrane Database Syst. Rev. , vol.11 , pp. CD002130
    • Bosch, X.1    Marrugat, J.2    Sanchis, J.3
  • 54
    • 0347416911 scopus 로고    scopus 로고
    • Risk of bleeding complications with antiplatelet agents: Meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials
    • Serebruany, V. L., Malinin, A. I., Eisert, R. M. & Sane, D. C. Risk of bleeding complications with antiplatelet agents: meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials. Am. J. Hematol. 75, 40-47 (2004).
    • (2004) Am. J. Hematol. , vol.75 , pp. 40-47
    • Serebruany, V.L.1    Malinin, A.I.2    Eisert, R.M.3    Sane, D.C.4
  • 55
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott, S. D. et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1
  • 56
    • 84961910962 scopus 로고    scopus 로고
    • 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery
    • 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction
    • Levine, G. N. et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery. Circulation 134, e123-e155 (2016).
    • (2016) Circulation , vol.134 , pp. e123-e155
    • Levine, G.N.1
  • 57
    • 84913619061 scopus 로고    scopus 로고
    • 2014 ESC/EACTS guidelines on myocardial revascularization: The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS): Developed with the special contribution of the European association of percutaneous cardiovascular interventions (EAPCI)
    • Windecker, S. et al. 2014 ESC/EACTS guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS): developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur. Heart J. 35, 2541-2619 (2014).
    • (2014) Eur. Heart J. , vol.35 , pp. 2541-2619
    • Windecker, S.1
  • 58
    • 79959550517 scopus 로고    scopus 로고
    • Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium
    • Mehran, R. et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 123, 2736-2747 (2011).
    • (2011) Circulation , vol.123 , pp. 2736-2747
    • Mehran, R.1
  • 59
    • 77958005516 scopus 로고    scopus 로고
    • Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • Mehta, S. R. et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet 376, 1233-1243 (2010).
    • (2010) Lancet , vol.376 , pp. 1233-1243
    • Mehta, S.R.1
  • 60
    • 34547801673 scopus 로고    scopus 로고
    • Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes
    • Rao, S. V. et al. Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. Eur. Heart J. 28, 1193-1204 (2007).
    • (2007) Eur. Heart J. , vol.28 , pp. 1193-1204
    • Rao, S.V.1
  • 61
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom, J. W. et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 114, 774-782 (2006).
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1
  • 62
    • 33947575142 scopus 로고    scopus 로고
    • Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: An analysis from the ACUITY Trial
    • Manoukian, S. V. et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial. J. Am. Coll. Cardiol. 49, 1362-1368 (2007).
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 1362-1368
    • Manoukian, S.V.1
  • 63
    • 65649119646 scopus 로고    scopus 로고
    • Bleeding blood transfusion, and increased mortality after percutaneous coronary intervention: Implications for contemporary practice
    • Doyle, B. J., Rihal, C. S., Gastineau, D. A. & Holmes, D. R. Jr. Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: implications for contemporary practice. J. Am. Coll. Cardiol. 53, 2019-2027 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 2019-2027
    • Doyle, B.J.1    Rihal, C.S.2    Gastineau, D.A.3    Holmes, D.R.4
  • 64
    • 84947913255 scopus 로고    scopus 로고
    • Association of spontaneous and procedure-related bleeds with short-and long-term mortality after acute coronary syndromes: An analysis from the PLATO trial
    • Ducrocq, G. et al. Association of spontaneous and procedure-related bleeds with short-and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial. EuroIntervention 11, 737-745 (2015).
    • (2015) EuroIntervention , vol.11 , pp. 737-745
    • Ducrocq, G.1
  • 65
    • 84897470580 scopus 로고    scopus 로고
    • Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: The TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry)
    • Silvain, J. et al. Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: the TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry). J. Am. Coll. Cardiol. 63, 1289-1296 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 1289-1296
    • Silvain, J.1
  • 66
    • 85015653179 scopus 로고    scopus 로고
    • Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): A double-blind, multicentre, randomised trial
    • Ohman, E. M. et al. Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial. Lancet 389, 1799-1808 (2017).
    • (2017) Lancet , vol.389 , pp. 1799-1808
    • Ohman, E.M.1
  • 67
    • 85029804845 scopus 로고    scopus 로고
    • Rivaroxaban with or without aspirin in stable cardiovascular disease
    • Eikelboom, J. W. et al. Rivaroxaban with or without aspirin in stable cardiovascular disease. N. Engl. J. Med. 377, 1319-1330 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 1319-1330
    • Eikelboom, J.W.1
  • 68
    • 85002328350 scopus 로고    scopus 로고
    • Long-term ticagrelor monotherapy versus standard dual antiplatelet therapy followed by aspirin monotherapy in patients undergoing biolimus-eluting stent implantation: Rationale and design of the GLOBAL LEADERS trial
    • Vranckx, P. et al. Long-term ticagrelor monotherapy versus standard dual antiplatelet therapy followed by aspirin monotherapy in patients undergoing biolimus-eluting stent implantation: rationale and design of the GLOBAL LEADERS trial. EuroIntervention 12, 1239-1245 (2016).
    • (2016) EuroIntervention , vol.12 , pp. 1239-1245
    • Vranckx, P.1
  • 69
    • 84992736573 scopus 로고    scopus 로고
    • Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study
    • Baber, U. et al. Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: rationale and design of the TWILIGHT study. Am. Heart J. 182, 125-134 (2016).
    • (2016) Am. Heart J. , vol.182 , pp. 125-134
    • Baber, U.1
  • 70
    • 84872867886 scopus 로고    scopus 로고
    • Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
    • Westein, E. et al. Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner. Proc. Natl Acad. Sci. USA 110, 1357-1362 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1357-1362
    • Westein, E.1
  • 71
    • 0022852282 scopus 로고
    • Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation
    • Moake, J. L., Turner, N. A., Stathopoulos, N. A., Nolasco, L. H. & Hellums, J. D. Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation. J. Clin. Invest. 78, 1456-1461 (1986).
    • (1986) J. Clin. Invest. , vol.78 , pp. 1456-1461
    • Moake, J.L.1    Turner, N.A.2    Stathopoulos, N.A.3    Nolasco, L.H.4    Hellums, J.D.5
  • 72
    • 33748704252 scopus 로고    scopus 로고
    • Activation-independent platelet adhesion and aggregation under elevated shear stress
    • Ruggeri, Z. M., Orje, J. N., Habermann, R., Federici, A. B. & Reininger, A. J. Activation-independent platelet adhesion and aggregation under elevated shear stress. Blood 108, 1903-1910 (2006).
    • (2006) Blood , vol.108 , pp. 1903-1910
    • Ruggeri, Z.M.1    Orje, J.N.2    Habermann, R.3    Federici, A.B.4    Reininger, A.J.5
  • 73
    • 33747175371 scopus 로고    scopus 로고
    • Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis
    • Konstantinides, S. et al. Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis. J. Thromb. Haemost. 4, 2014-2021 (2006).
    • (2006) J. Thromb. Haemost. , vol.4 , pp. 2014-2021
    • Konstantinides, S.1
  • 74
    • 33750941414 scopus 로고    scopus 로고
    • The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand von Willebrand factor in arterial thrombosis
    • Bergmeier, W. et al. The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc. Natl Acad. Sci. USA 103, 16900-16905 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 16900-16905
    • Bergmeier, W.1
  • 75
    • 33847618245 scopus 로고    scopus 로고
    • Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome
    • Strassel, C. et al. Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arterioscler. Thromb. Vasc. Biol. 27, 241-247 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 241-247
    • Strassel, C.1
  • 76
    • 0036162199 scopus 로고    scopus 로고
    • Inhibition of platelet glycoprotein Ib, glycoprotein IIb/IIIa, or both by monoclonal antibodies prevents arterial thrombosis in baboons
    • Wu, D., Meiring, M., Kotze, H. F., Deckmyn, H. & Cauwenberghs, N. Inhibition of platelet glycoprotein Ib, glycoprotein IIb/IIIa, or both by monoclonal antibodies prevents arterial thrombosis in baboons. Arterioscler. Thromb. Vasc. Biol. 22, 323-328 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 323-328
    • Wu, D.1    Meiring, M.2    Kotze, H.F.3    Deckmyn, H.4    Cauwenberghs, N.5
  • 77
    • 0030800626 scopus 로고    scopus 로고
    • Anti-thrombotic effects and bleeding risk of AJvW-2 a monoclonal antibody against human von Willebrand factor
    • Kageyama, S. et al. Anti-thrombotic effects and bleeding risk of AJvW-2, a monoclonal antibody against human von Willebrand factor. Br. J. Pharmacol. 122, 165-171 (1997).
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 165-171
    • Kageyama, S.1
  • 78
    • 79960058122 scopus 로고    scopus 로고
    • Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs
    • Ulrichts, H. et al. Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs. Blood 118, 757-765 (2011).
    • (2011) Blood , vol.118 , pp. 757-765
    • Ulrichts, H.1
  • 79
    • 84893185728 scopus 로고    scopus 로고
    • Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis
    • Lei, X. et al. Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb. Haemost. 111, 279-289 (2014).
    • (2014) Thromb. Haemost. , vol.111 , pp. 279-289
    • Lei, X.1
  • 80
    • 67649518156 scopus 로고    scopus 로고
    • Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779
    • Diener, J. L. et al. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J. Thromb. Haemost. 7, 1155-1162 (2009).
    • (2009) J. Thromb. Haemost. , vol.7 , pp. 1155-1162
    • Diener, J.L.1
  • 81
    • 34547862097 scopus 로고    scopus 로고
    • The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time
    • Wadanoli, M. et al. The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time. Thromb. Haemost. 98, 397-405 (2007).
    • (2007) Thromb. Haemost. , vol.98 , pp. 397-405
    • Wadanoli, M.1
  • 82
    • 0028804347 scopus 로고
    • Antithrombotic effect of a recombinant von Willebrand factor VCL on nitrogen laser-induced thrombus formation in Guinea pig mesenteric arteries
    • Azzam, K., Garfinkel, L. I., Bal dit Sollier, C., Cisse Thiam, M. & Drouet, L. Antithrombotic effect of a recombinant von Willebrand factor, VCL, on nitrogen laser-induced thrombus formation in guinea pig mesenteric arteries. Thromb. Haemost. 73, 318-323 (1995).
    • (1995) Thromb. Haemost. , vol.73 , pp. 318-323
    • Azzam, K.1    Garfinkel, L.I.2    Dit Sollier Bal, C.3    Cisse Thiam, M.4    Drouet, L.5
  • 83
    • 79961210182 scopus 로고    scopus 로고
    • The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: A randomized trial
    • Markus, H. S. et al. The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: a randomized trial. Stroke 42, 2149-2153 (2011).
    • (2011) Stroke , vol.42 , pp. 2149-2153
    • Markus, H.S.1
  • 84
    • 84877750064 scopus 로고    scopus 로고
    • Novel antiplatelet agents: ALX-0081 a nanobody directed towards von Willebrand factor
    • Bartunek, J. et al. Novel antiplatelet agents: ALX-0081, a nanobody directed towards von Willebrand factor. J. Cardiovasc. Transl Res. 6, 355-363 (2013).
    • (2013) J. Cardiovasc. Transl Res. , vol.6 , pp. 355-363
    • Bartunek, J.1
  • 85
    • 79954545891 scopus 로고    scopus 로고
    • Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions
    • Gratacap, M. P. et al. Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions. Adv. Enzyme Regul. 51, 106-116 (2011).
    • (2011) Adv. Enzyme Regul. , vol.51 , pp. 106-116
    • Gratacap, M.P.1
  • 86
    • 77950423041 scopus 로고    scopus 로고
    • Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
    • Martin, V. et al. Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood 115, 2008-2013 (2010).
    • (2010) Blood , vol.115 , pp. 2008-2013
    • Martin, V.1
  • 87
    • 84866876711 scopus 로고    scopus 로고
    • Human target validation of phosphoinositide 3-kinase (PI3K)β: Effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor
    • Nylander, S. et al. Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J. Thromb. Haemost. 10, 2127-2136 (2012).
    • (2012) J. Thromb. Haemost. , vol.10 , pp. 2127-2136
    • Nylander, S.1
  • 88
    • 84937971229 scopus 로고    scopus 로고
    • Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase β inhibition and aspirin in man
    • Nylander, S., Wagberg, F., Andersson, M., Skarby, T. & Gustafsson, D. Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase β inhibition and aspirin in man. J. Thromb. Haemost. 13, 1494-1502 (2015).
    • (2015) J. Thromb. Haemost. , vol.13 , pp. 1494-1502
    • Nylander, S.1    Wagberg, F.2    Andersson, M.3    Skarby, T.4    Gustafsson, D.5
  • 89
    • 84921724552 scopus 로고    scopus 로고
    • Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate
    • Laurent, P. A. et al. Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate. Blood 125, 881-888 (2015).
    • (2015) Blood , vol.125 , pp. 881-888
    • Laurent, P.A.1
  • 90
    • 84905912638 scopus 로고    scopus 로고
    • Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents
    • Giordanetto, F. et al. Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents. Bioorg. Med. Chem. Lett. 24, 3936-3943 (2014).
    • (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 3936-3943
    • Giordanetto, F.1
  • 91
    • 0032212143 scopus 로고    scopus 로고
    • Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (αIIbβ3) inhibitors
    • Peter, K. et al. Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (αIIbβ3) inhibitors. Blood 92, 3240-3249 (1998).
    • (1998) Blood , vol.92 , pp. 3240-3249
    • Peter, K.1
  • 92
    • 33847032135 scopus 로고    scopus 로고
    • A mechanistic model for paradoxical platelet activation by ligand-mimetic αiIbβ3 (GPIIb/IIIa) antagonists
    • Bassler, N. et al. A mechanistic model for paradoxical platelet activation by ligand-mimetic αIIbβ3 (GPIIb/IIIa) antagonists. Arterioscler. Thromb. Vasc. Biol. 27, e9-e15 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. e9-e15
    • Bassler, N.1
  • 93
    • 0032873921 scopus 로고    scopus 로고
    • Platelet activation as a potential mechanism of GP IIb/IIIa inhibitor-induced thrombocytopenia
    • Peter, K. et al. Platelet activation as a potential mechanism of GP IIb/IIIa inhibitor-induced thrombocytopenia. Am. J. Cardiol. 84, 519-524 (1999).
    • (1999) Am. J. Cardiol. , vol.84 , pp. 519-524
    • Peter, K.1
  • 94
    • 84860531948 scopus 로고    scopus 로고
    • GPIIb/IIIa inhibitors: From bench to bedside and back to bench again
    • Armstrong, P. C. & Peter, K. GPIIb/IIIa inhibitors: from bench to bedside and back to bench again. Thromb. Haemost. 107, 808-814 (2012).
    • (2012) Thromb. Haemost. , vol.107 , pp. 808-814
    • Armstrong, P.C.1    Peter, K.2
  • 95
    • 84913554789 scopus 로고    scopus 로고
    • RUC-4: A novel αiIbβ3 antagonist for prehospital therapy of myocardial infarction
    • Li, J. et al. RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 34, 2321-2329 (2014).
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 2321-2329
    • Li, J.1
  • 96
    • 33746234764 scopus 로고    scopus 로고
    • Conformation-specific blockade of the integrin GPIIb/IIIa: A novel antiplatelet strategy that selectively targets activated platelets
    • Schwarz, M. et al. Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets. Circ. Res. 99, 25-33 (2006).
    • (2006) Circ. Res. , vol.99 , pp. 25-33
    • Schwarz, M.1
  • 97
    • 84879139563 scopus 로고    scopus 로고
    • Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: Breaking the link between antithrombotic potency and bleeding?
    • Hohmann, J. D. et al. Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding? Blood 121, 3067-3075 (2013).
    • (2013) Blood , vol.121 , pp. 3067-3075
    • Hohmann, J.D.1
  • 98
    • 34247402058 scopus 로고    scopus 로고
    • Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation
    • Stoll, P. et al. Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation. Arterioscler. Thromb. Vasc. Biol. 27, 1206-1212 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 1206-1212
    • Stoll, P.1
  • 99
    • 84897567751 scopus 로고    scopus 로고
    • Towards effective and safe thrombolysis and thromboprophylaxis: Preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets
    • Wang, X. et al. Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets. Circ. Res. 114, 1083-1093 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 1083-1093
    • Wang, X.1
  • 100
    • 84920285138 scopus 로고    scopus 로고
    • Targeting integrin and integrin signaling in treating thrombosis
    • Estevez, B., Shen, B. & Du, X. Targeting integrin and integrin signaling in treating thrombosis. Arterioscler. Thromb. Vasc. Biol. 35, 24-29 (2015).
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , pp. 24-29
    • Estevez, B.1    Shen, B.2    Du, X.3
  • 102
    • 84925359034 scopus 로고    scopus 로고
    • Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
    • Aisiku, O. et al. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood 125, 1976-1985 (2015).
    • (2015) Blood , vol.125 , pp. 1976-1985
    • Aisiku, O.1
  • 103
    • 85010661813 scopus 로고    scopus 로고
    • Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
    • Wong, P. C. et al. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding. Sci. Transl. Med. 9, eaaf5294 (2017).
    • (2017) Sci. Transl. Med. , vol.9 , pp. eaaf5294
    • Wong, P.C.1
  • 104
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT02208882 (2015).
    • (2015) ClinicalTrials.gov
  • 105
    • 84920283235 scopus 로고    scopus 로고
    • Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease
    • Flaumenhaft, R., Furie, B. & Zwicker, J. I. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler. Thromb. Vasc. Biol. 35, 16-23 (2015).
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , pp. 16-23
    • Flaumenhaft, R.1    Furie, B.2    Zwicker, J.I.3
  • 106
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT02195232 (2017).
    • (2017) ClinicalTrials.gov
  • 107
    • 84871094320 scopus 로고    scopus 로고
    • The future of glycoprotein VI as an antithrombotic target
    • Zahid, M. et al. The future of glycoprotein VI as an antithrombotic target. J. Thromb. Haemost. 10, 2418-2427 (2012).
    • (2012) J. Thromb. Haemost. , vol.10 , pp. 2418-2427
    • Zahid, M.1
  • 108
    • 33744455164 scopus 로고    scopus 로고
    • Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency
    • Mangin, P. et al. Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency. Blood 107, 4346-4353 (2006).
    • (2006) Blood , vol.107 , pp. 4346-4353
    • Mangin, P.1
  • 109
    • 79959841785 scopus 로고    scopus 로고
    • Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl3-induced thrombosis
    • Bender, M., Hagedorn, I. & Nieswandt, B. Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl3-induced thrombosis. J. Thromb. Haemost. 9, 1423-1426 (2011).
    • (2011) J. Thromb. Haemost. , vol.9 , pp. 1423-1426
    • Bender, M.1    Hagedorn, I.2    Nieswandt, B.3
  • 110
    • 43749099001 scopus 로고    scopus 로고
    • Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression
    • Ohlmann, P. et al. Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression. J. Thromb. Haemost. 6, 1003-1011 (2008).
    • (2008) J. Thromb. Haemost. , vol.6 , pp. 1003-1011
    • Ohlmann, P.1
  • 111
    • 68149163242 scopus 로고    scopus 로고
    • Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro
    • Muzard, J. et al. Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro. FEBS J. 276, 4207-4222 (2009).
    • (2009) FEBS J. , vol.276 , pp. 4207-4222
    • Muzard, J.1
  • 112
    • 85027958733 scopus 로고    scopus 로고
    • Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
    • Ungerer, M. et al. Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans. Circulation 123, 1891-1899 (2011).
    • (2011) Circulation , vol.123 , pp. 1891-1899
    • Ungerer, M.1
  • 113
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT01645306 (2017).
    • (2017) ClinicalTrials.gov
  • 114
    • 84930885500 scopus 로고    scopus 로고
    • Differential inhibition of human atherosclerotic plaque-induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: Functional and imaging studies
    • Jamasbi, J. et al. Differential inhibition of human atherosclerotic plaque-induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: functional and imaging studies. J. Am. Coll. Cardiol. 65, 2404-2415 (2015).
    • (2015) J. Am. Coll. Cardiol. , vol.65 , pp. 2404-2415
    • Jamasbi, J.1
  • 116
    • 77953558899 scopus 로고    scopus 로고
    • US national library of medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT00853450 (2009).
    • (2009) ClinicalTrials.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.