Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: The TRANSFUSION-2 study (Impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry)

Journal of the American College of Cardiology

Volumn 63, Issue 13, 2014, Pages 1289-1296

  Silvain, Johanne ^a   Abtan, Jérémie ^a   Kerneis, Mathieu ^a   Martin, Réjane ^a   Finzi, Jonathan ^a   Vignalou, Jean Baptiste ^a   Barthélémy, Olivier ^a   O'Connor, Stephen A ^a   Luyt, Charles Edouard ^a   Brechot, Nicolas ^a   Mercadier, Anne ^a   Brugier, Delphine ^a   Galier, Sophie ^a   Collet, Jean Philippe ^a   Chastre, Jean ^a   Montalescot, Gilles ^a  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

ACS; clopidogrel; platelet response; transfusion

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; C REACTIVE PROTEIN; CD40 LIGAND; COLLAGEN; INTERLEUKIN 6; PADGEM PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PURINERGIC P2Y12 RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TISSUE FACTOR PATHWAY INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASODILATOR STIMULATED PHOSPHOPROTEIN; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CLOPIDOGREL; D DIMER; FIBRINOGEN RECEPTOR ANTAGONIST; PRASUGREL; PURINERGIC P2Y RECEPTOR ANTAGONIST; VON WILLEBRAND FACTOR;

ACUTE CORONARY SYNDROME; ADULT; AGED; ANALYTIC METHOD; ANEMIA; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ERYTHROCYTE TRANSFUSION; FEMALE; FLOW CYTOMETRY; HUMAN; INFLAMMATION; LIGHT TRANSMISSION AGGREGOMETRY; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PLATELET REACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; CARDIAC PATIENT; CARDIOVASCULAR PARAMETERS; CLINICAL TRIAL; FOLLOW UP; HEART DISEASE; IN VIVO STUDY; LENGTH OF STAY; LOADING DRUG DOSE; MAXIMAL PLATELET AGGREGATION; RESIDUAL PLATELET AGGREGATION; VASODILATOR STIMULATED PHOSPHOPROTEIN PLATELET REACTIVITY INDEX;

ACS; CLOPIDOGREL; PLATELET RESPONSE; TRANSFUSION;

AGED; ANEMIA; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; ERYTHROCYTE TRANSFUSION; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; MALE; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84897470580     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.11.029     Document Type: Article

References (28)

1. L. Wallentin, R.C. Becker, and A. Budaj et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 2009 1045 1057
2. S.D. Wiviott, E. Braunwald, and C.H. McCabe et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015
3. J.L. Mega, E. Braunwald, and S.D. Wiviott et al. Rivaroxaban in patients with a recent acute coronary syndrome N Engl J Med 366 2012 9 19
4. J.W. Eikelboom, S.R. Mehta, S.S. Anand, C. Xie, K.A. Fox, and S. Yusuf Adverse impact of bleeding on prognosis in patients with acute coronary syndromes Circulation 114 2006 774 782
5. S.V. Rao, K. O'Grady, and K.S. Pieper et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes Am J Cardiol 96 2005 1200 1206
6. S.V. Rao, K. O'Grady, and K.S. Pieper et al. A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes J Am Coll Cardiol 47 2006 809 816
7. W.C. Wu, S.S. Rathore, Y. Wang, M.J. Radford, and H.M. Krumholz Blood transfusion in elderly patients with acute myocardial infarction N Engl J Med 345 2001 1230 1236
8. P.C. Hebert, G. Wells, M.A. Blajchman for the Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care N Engl J Med 340 1999 409 417
9. D. Aronson, E.J. Dann, and L. Bonstein et al. Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction Am J Cardiol 102 2008 115 119
10. S.V. Rao, J.G. Jollis, and R.A. Harrington et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA 292 2004 1555 1562
11. X. Yang, K.P. Alexander, and A.Y. Chen et al. The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative J Am Coll Cardiol 46 2005 1490 1495
12. S.V. Rao, J.A. Eikelboom, C.B. Granger, R.A. Harrington, R.M. Califf, and J.P. Bassand Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes Eur Heart J 28 2007 1193 1204
13. S. Chatterjee, J. Wetterslev, A. Sharma, E. Lichstein, and D. Mukherjee Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis JAMA Intern Med 173 2013 132 139
14. J.P. Collet, J. Silvain, and A. Landivier et al. Dose effect of clopidogrel reloading in patients already on 75-mg maintenance dose: the Reload with Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term With Dual Antiplatelet Therapy (RELOAD) study Circulation 118 2008 1225 1233
15. M. Dalby, G. Montalescot, and C. Bal dit Sollier et al. Eptifibatide provides additional platelet inhibition in non-ST-elevation myocardial infarction patients already treated with aspirin and clopidogrel. Results of the Platelet Activity Extinction in Non-Q-Wave Myocardial Infarction With Aspirin, Clopidogrel, and Eptifibatide (PEACE) study J Am Coll Cardiol 43 2004 162 168
16. G. Montalescot, G. Sideris, and C. Meuleman et al. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial J Am Coll Cardiol 48 2006 931 938
17. G. Montalescot, C. Bal-dit-Sollier, and D. Chibedi et al. Comparison of effects on markers of blood cell activation of enoxaparin, dalteparin, and unfractionated heparin in patients with unstable angina pectoris or non-ST-segment elevation acute myocardial infarction (the ARMADA study) Am J Cardiol 91 2003 925 930
18. R. Mehran, S.V. Rao, and D.L. Bhatt et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium Circulation 123 2011 2736 2747
19. J. Silvain, A. Pena, and G. Cayla et al. Impact of red blood cell transfusion on platelet activation and aggregation in healthy volunteers: results of the TRANSFUSION study Eur Heart J 31 2010 2816 2821
20. D.J. Kumbhani, and D.L. Bhatt Platelet activation: yet another strike against routine TRANSFUSION Eur Heart J 31 2010 2712 2714
21. Z.M. Ruggeri Platelets in atherothrombosis Nat Med 8 2002 1227 1234
22. A. Gaarder, J. Jonsen, S. Laland, A. Hellem, and P.A. Owren Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets Nature 192 1961 531 532
23. J.W. Eikelboom, R.J. Cook, Y. Liu, and N.M. Heddle Duration of red cell storage before transfusion and in-hospital mortality Am Heart J 159 2010 737 743
24. J.L. Mega, S.L. Close, and S.D. Wiviott et al. Cytochrome p-450 polymorphisms and response to clopidogrel N Engl J Med 360 2009 354 362
25. A.R. Shuldiner, J.R. O'Connell, and K.P. Bliden et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy JAMA 302 2009 849 857
26. J.P. Collet, J.S. Hulot, and A. Pena et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study Lancet 373 2009 309 317
27. J.L. Mega, T. Simon, and J.P. Collet et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis JAMA 304 2010 1821 1830
28. J.L. Carson, and P.C. Hebert Here we go again - blood transfusion kills patients? Comment on "Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis" JAMA Intern Med 173 2013 139 141