Anti-thrombotic effects and bleeding risk of AJvW-2, a monoclonal antibody against human von Willebrand factor

British Journal of Pharmacology

Volumn 122, Issue 1, 1997, Pages 165-171

  Kageyama, Shunsuke ^a   Yamamoto, Hiroshi ^a   Nagano, Mitsuyo ^a   Arisaka, Harumi ^a   Kayahara, Takashi ^a   Yoshimoto, Ryota ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

AJvW 2; Bleeding risk; GPIb; GPIIb IIIa; Shear stress; Thrombosis; Von Willebrand factor

Indexed keywords

ANTICOAGULANT AGENT; BOTROCETIN; COLLAGEN TYPE 1; GLYCOPROTEIN IB; LAMIFIBAN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AJVW 2; RISTOCETIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; BLEEDING; BLEEDING TIME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; GUINEA PIG; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RABBIT; RAT; RISK; SHEAR STRESS; SWINE; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, MONOCLONAL; BLEEDING TIME; BLOOD COAGULATION; COLLAGEN; CROTALID VENOMS; DOGS; FIBRINOLYTIC AGENTS; GUINEA PIGS; HEMORRHAGE; HUMANS; MICE; MICE, INBRED BALB C; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; RABBITS; RATS; RISTOCETIN; THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 0030800626     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701354     Document Type: Article

References (27)

1. AGUIRRE, F.V., TOPOL, E.J., FERGUSON, J.J., ANDERSON, K., BLANKENSHIP, J.C., HEUSER, R.R., SIGMON, K., TAYLOR, M., GOTTLEIB, B., HANOVICH, G., ROSENBERG, M., DONOHUE, T.J., WEISMAN, H.F., CALIFF, R.M. & THE EPIC INVESTIGATORS. (1995). Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa imegrin in patients undergoing percutaneous coronary intervention. Circulation, 91, 2882-2890.
2. ASHBY, B., DANIEL, J.L. & SMITH, J.B. (1990). Mechanisms of platelet activation and inhibition. Platelets Health Dis., 4, 1-26.
3. AZZAM, K., CISSE-THIAM, M. & DROUET, L. (1996). The antithrombotic effect of aurin tricarboxylic acid in the guinea pig is not solely due to its interaction with the von Willebrand factor-GPIb axis. Thromb. Haemost., 75, 203-210.
4. AZZAM, K., GARFINKEL, J.I., BAL DIT SOLLIER, C., CISSE THIAM, N. & DROUET, L. (1995). Antithrombotic effect of a recombinant von Willebrand factor, VCL, on nitrogen laser-induced thrombus formation in guinea pig mesentcric arteries. Thromb. Haemost., 73, 318-323.
5. BALSANIO, F., RIZZON, P., VIOLI, F., SCRUTINIO, D., CIMMINIELLO, C., AGUGLIA, F., PASOTTI, C. & RUDELLI, G. (1990). Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. Circulation, 82, 17-26.
6. BAUMGARTNER, H.R., TSCHOPP, T.B. & MEYER, D. (1980). Shear rate dependent inhibition of platelet adhesion and aggregation on collagenous surfaces by antibodies to human factor VIII/von Willebrand factor. Br. J. Haematol., 44, 100-139.
7. BECKER, B.H. & MILLER, J.L. (1989). Effects of an antiplatelet glycoprolein Ib antibody on hemostatic function in the guinea pig. Blood, 74, 690-694.
8. COLLER, B.S., FOLTS, J.D., SCUDDER, L.E. & SMITH, S.R. (1986). Antithrombotic effect of a monoclonal antibody to the platelet glycoproptein IIb/IIIa receptor in an experimental animal model. Blood, 68, 783-786.
9. COOK, N.S., BRUTTGER, O., PALLY, C. & HAGENBACH, A. (1993). The effects of two synthetic glycoprotein IIb/IIIa antagonists, Ro43-8857 and L-700,462, on platelet aggregation and bleeding in guinea-pigs and dogs: evidence that Ro43-8857 is orally active. Thromb. Haemost., 70, 838-847.
10. FUJIMURA, Y., TITANI, K., USAMI, Y., SUZUKI, M., OYAMI, R., MATSUI, T., FUKUI, H., SUGIMOTO, M. & RUGGERI, Z.M. (1991). Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca. Biochemistry, 30, 1957-1964.
11. FUKUYAMA, M., SAKAI, K., ITAGAKI, I., KAWANO, K., MURATA, M., KAWAI, Y., WATANABE, K., HANDA, M. & IKEDA, Y. (1989). Continuous measurement of shear-induced platelet aggregation. Thromh. Res., 54, 253-260.
12. GOLD, H.K., COLLER, B.S., YASUDA, T., SAITO, T., FALLON, J.T., GUERREO, J.L. LEINBACH, R.C., ZISKIND, A.A. & COLLEN. D. (1988). Rapid and sustained coronary artery recunalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation. Circulation. 77, 670-677.
13. IKEDA, Y., HANDA, M., KAWANO, K., KAMATA, T., MURATA, M., ARAKI, Y., ANDO, H., KAWAI, Y., WATANABE, K., ITAGAKI, I., SAKAI, K. & RUGGERI, Z.M. (1991). The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J. Clin. Invest., 87, 1234-1240.
14. JOHNSON, P.C., SHEPPECK, R.A., HRIBAR, S.R., BENTZ, M.L., JANOSKY, J. & DICKSON, C.S. (1991). Inhibition of platelet retention on artificial microvascular grafts with monoclonal antibodies and a high-affinity peptide directed against platelet membrane glycoproteins. Arterioscler. Thromb., 11, 552-560.
15. KAWASAKI, T., KAKU, S., KOHINATA, T., SAKAI, Y., TANIUCHI, Y., KAWAMURA, K., YANO, S., TAKENAKA, T. & FUJIMURA, Y. (1494). Inhibition by aurintricarboxylic acid of von Willebrand Factor binding to platelet GPIb, platelet retention, and thrombus formation in vivo. Am. J. Hematol., 47, 6-15.
16. KOEHLER, G. & MILSTEIN, C. (1975). Continuous cultures of fused cells secreting antibody of predetermined specificity. Nature, 256, 495-497.
17. MCGHIE, A.I., MCNATT, J., EZOV, N., CUI, K., MOWER, L.K., HAGAY, Y., BUJA, L.M., GARFINKEL, L.I., GORECKI, M. & WILLERSON, J.T. (1994). Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries in nonhuman primates with a peptide fragment (VCL) derived from human plasma von Willebrand factor-glycoprotein 1b binding domain. Circulation, 90, 2976-2981.
18. PENG, M., LU, W., BEVIGLIA, L., NIEWIAROWSKI, S. & KIRBY, E.P. (1993). Echicetin: A snake venom protein that inhibits binding of von Willebran factor and alboaggregins to platelet glycoprotein Ib. Blood, 81, 2321-2328.
19. PETO, R., GRAY, R., COLLINS, R., WHEATLEY, K., HENNEKENS, C., JANROZIK, K, WARLOW, C., HAFNER, B., THOMPSON, E., NORTON, S., GILLILAND, J. & DOLL, R. (1988). Randomised trial of prophylactic daily aspirin in British male doctors. Br. Med. J., 296, 313-316.
20. PHILIPS, D.R. CHARO, I.F. & SCARBOROUGH, R.M. (1991). GPIIb/ IIIa: the responsive integrin. Cell, 65, 359-362.
21. ROTE, W.E., NEDELMAN, M.A., MU, D.X., MANLEY, P.J., WEISMAN, H., CUNNINGHAM, M.R. & LUCCHESI, B.R. (1994). Chimeric 7E3 prevents carotid artery thrombosis in cynomolgus monkeys. Stroke, 25, 1223-1232.
22. ROTH, G. (1991). Developing relationships: arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins. Blood, 77, 5-19.
23. SAKARIASSEN, K.S., BOLHUIS, P.A. & SIXMA, J.J. (1979). Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-von Willebrand factor bound to the subendotherium. Nature, 279, 635-638.
24. STRONY, J., PHILLIPS, M., BRANDS, D., MOAKE, J. & ADELMAN, B. (1990). Aurincarboxylic acid in a canine model of coronary artery thrombosis. Circulation, 81, 1106-1114.
25. TAKIGUCHI, Y., HIRATA, Y., WADA, K. & NAKASHIMA, M. (1992). Arterial thrombosis model with photochemical reaction in guinea-pig and its property. Thromb. Res., 67, 435-445.
26. TOPOL, E.J., CALIFF, R.M., WEISMAN, H.F., ELLIS, S.G., TCHENG, J.E., WORLEY, S., IVANHOE, R., GEORGE, B.S., FINTEL, D., WESTON, M., SIGMON, K., ANDERSON, K.M., LEE, K.L. & WILLERSON, J.T. (1994). Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results in six months. Lancet, 343, 881-886.
27. YAO, S.K., OBER, J.C., GARFINKEL, L.I., HAGAY, Y., EZOV, N., FERGUSON, J.J., ANDERSON, H.V., PANET, A., GORECKI, M., BUJA, L.M. & WILLERSON, J.T. (1994). Blockade of platelet membrane glycoprotein Ib receptors delays intracoronary thrombogenesis, enhances thrombylosis, and delays coronary artery reocclusion in dogs. Circulation, 89, 2822-2828.