Differential inhibition of human atherosclerotic plaque-induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: Functional and imaging studies

Journal of the American College of Cardiology

Volumn 65, Issue 22, 2015, Pages 2404-2415

  Jamasbi, Janina ^a   Megens, Remco T A ^a,b   Bianchini, Mariaelvy ^a   Münch, Götz ^c   Ungerer, Martin ^c   Faussner, Alexander ^a   Sherman, Shachar ^d   Walker, Adam ^e   Goyal, Pankaj ^f   Jung, Stephanie ^g   Brandl, Richard ^h   Weber, Christian ^a,b,i   Lorenz, Reinhard ^a   Farndale, Richard ^g   Elia, Natalie ^d   Siess, Wolfgang ^a,i  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ADVANCECOR GMBH   (Germany)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e GLAXOSMITHKLINE   (United Kingdom)

^f CENTRAL UNIVERSITY OF RAJASTHAN   (India)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h St Mary's Square Institute for Vascular Surgery and Phlebology   (Germany)

ⁱ DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

antithrombotic; atherothrombosis; glycoprotein VI; plaque rupture

Indexed keywords

5C4 ANTIBODY; ADENOSINE DIPHOSPHATE; BLO8 1 ANTIBODY; COLLAGEN; GLYCOPROTEIN VI; IMMUNOGLOBULIN F(AB) FRAGMENT ANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; PROTEIN ANTIBODY; THROMBOXANE A2; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOLOGIC FACTOR; PLATELET MEMBRANE GLYCOPROTEIN VI;

ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROTIC PLAQUE; BINDING SITE; BLEEDING; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE IMAGING; HUMAN; PRIORITY JOURNAL; SHEAR FLOW; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ANIMAL; BLOOD FLOW VELOCITY; CAROTID ARTERY; CAROTID STENOSIS; COMPLICATION; DRUG EFFECTS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLAQUE, ATHEROSCLEROTIC; RAT;

ANIMALS; BLOOD FLOW VELOCITY; CAROTID ARTERIES; CAROTID STENOSIS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOLOGIC FACTORS; PLAQUE, ATHEROSCLEROTIC; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; RATS;

EID: 84930885500     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.03.573     Document Type: Article

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