Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting

PLoS Computational Biology

Volumn 14, Issue 1, 2018, Pages

  Abdel Haleem, Alyaa M ^a   Hefzi, Hooman ^b,c   Mineta, Katsuhiko ^a   Gao, Xin ^a   Gojobori, Takashi ^a   Palsson, Bernhard O ^b,c,d   Lewis, Nathan E ^c,d   Jamshidi, Neema ^d,e  

^a KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL DRUG; CENTRAL CARBON METABOLISMS; DRUG-TARGETING; EFFECTIVE THERAPY; EXPERIMENTAL ANIMALS; GENOME-SCALE METABOLIC MODELING; LIFE CYCLE STAGES; PLASMODIUM FALCIPARUM; POTENTIAL TARGETS; SPECIES SPECIFICS;

METABOLISM;

CARBON; CHOLINE; PANTOTHENIC ACID; THIAMINE;

ARTICLE; CARBON METABOLISM; CONTROLLED STUDY; MALARIA; MEASUREMENT ACCURACY; MICROBIAL METABOLISM; NONHUMAN; PLASMODIUM; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM BERGHEI; PLASMODIUM CYNOMOLGI; PLASMODIUM FALCIPARUM; PLASMODIUM KNOWLESI; PLASMODIUM VIVAX; PREDICTION; SPECIES DIFFERENCE; VITAMIN METABOLISM; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; FOOD; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GENOME; GLYCOLYSIS; HUMAN; LIFE CYCLE STAGE; METABOLISM; MOSQUITO; PARASITOLOGY; SYSTEMS BIOLOGY; TRANSMISSION;

ANIMALS; CHOLINE; CULICIDAE; DISEASE MODELS, ANIMAL; FOOD; GENE DELETION; GENE EXPRESSION REGULATION; GENOME; GLYCOLYSIS; HUMANS; LIFE CYCLE STAGES; MALARIA; MODELS, BIOLOGICAL; PANTOTHENIC ACID; PLASMODIUM FALCIPARUM; SPECIES SPECIFICITY; SYSTEMS BIOLOGY; THIAMINE;

EID: 85041426461     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1005895     Document Type: Article

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