Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adenoassociated viruses

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Yoon, Yeonsoo ^a   Wang, Dan ^a   Tai, Phillip W L ^a   Riley, Joy ^a   Gao, Guangping ^a   Rivera Pérez, Jaime A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYO; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; HOMOLOGY; MUTATION; NUCLEIC ACID; RODENT; VIRUS;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA END JOINING REPAIR; EMBRYO; EX VIVO STUDY; FEMALE; GENE EDITING; GENETICALLY ENGINEERED MOUSE STRAIN; IMPLANTATION; IN VIVO STUDY; INDEL MUTATION; MOUSE; MOUSE EMBRYO; NONHUMAN; OBSTETRIC DELIVERY; OVIDUCT; PREGNANCY; RECOMBINATION REPAIR; ANIMAL; BLASTOCYST; CRISPR CAS SYSTEM; DEPENDOPARVOVIRUS; EMBRYO DEVELOPMENT; EMBRYOLOGY; FALLOPIAN TUBE; GENETIC ENGINEERING; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PROCEDURES; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE;

ADENO-ASSOCIATED VIRUS; MAMMALIA; MUS; RODENTIA;

BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; ENDONUCLEASE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMALS; BACTERIAL PROTEINS; BLASTOCYST; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DEPENDOVIRUS; DNA END-JOINING REPAIR; EMBRYONIC DEVELOPMENT; ENDONUCLEASES; FALLOPIAN TUBES; FEMALE; GENE EDITING; GENES, REPORTER; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; MICE; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; PREGNANCY; RECOMBINATIONAL DNA REPAIR;

EID: 85041322868     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02706-7     Document Type: Article

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