Ultraconserved Enhancers Are Required for Normal Development

Cell

Volumn 172, Issue 3, 2018, Pages 491-499.e15

  Dickel, Diane E ^a   Ypsilanti, Athena R ^b   Pla, Ramón ^b   Zhu, Yiwen ^a   Barozzi, Iros ^a   Mannion, Brandon J ^a   Khin, Yupar S ^b   Fukuda Yuzawa, Yoko ^a   Plajzer Frick, Ingrid ^a   Pickle, Catherine S ^a   Lee, Elizabeth A ^a   Harrington, Anne N ^a   Pham, Quan T ^a   Garvin, Tyler H ^a   Kato, Momoe ^a   Osterwalder, Marco ^a   Akiyama, Jennifer A ^a   Afzal, Veena ^a   Rubenstein, John L R ^b   Pennacchio, Len A ^a,c,d   Visel, Axel ^a,c,e   more..

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DOE JOINT GENOME INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Arx; brain development; enhancer; gene regulation; hippocampus; in vivo; knockout; neurons; noncoding; ultraconserved

Indexed keywords

RNA; ARX PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARX GENE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CELL VIABILITY; CONSERVED SEQUENCE; CONTROLLED STUDY; ENHANCER REGION; FERTILE PERIOD; FOREBRAIN; FVB MOUSE; GENE; GENE DELETION; GENE EDITING; GENE EXPRESSION; GENE LOCUS; GENETIC CONSERVATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; MALE; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA SEQUENCE; TELENCEPHALON; ULTRACONSERVED ENHANCER; VENTRAL TELENCEPHALON; ABNORMALITIES; ANIMAL; BRAIN; EMBRYO DEVELOPMENT; EMBRYOLOGY; FEMALE; GENETICS; METABOLISM;

ANIMALS; BRAIN; CONSERVED SEQUENCE; EMBRYONIC DEVELOPMENT; ENHANCER ELEMENTS, GENETIC; FEMALE; GENE DELETION; HOMEODOMAIN PROTEINS; MALE; MICE; TRANSCRIPTION FACTORS;

EID: 85041112536     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.12.017     Document Type: Article

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