메뉴 건너뛰기




Volumn 15, Issue 1, 2018, Pages 3-13

Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases

Author keywords

cardiovascular disease; diabetes; kidney disease; metabolic disease; non alcoholic fatty liver disease; Wnt signalling

Indexed keywords

CYCLOOXYGENASE 2; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; VASCULAR CELL ADHESION MOLECULE 1; WNT PROTEIN;

EID: 85038594854     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164117738442     Document Type: Review
Times cited : (106)

References (100)
  • 1
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse R, Varmus HE., Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982; 31: 99–109.
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 2
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C, Wieschaus E., Mutations affecting segment number and polarity in Drosophila. Nature 1980; 287: 795–801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 3
    • 0026060707 scopus 로고
    • A new nomenclature for int-1 and related genes: the Wnt gene family
    • Nusse R, Brown A, Papkoff J. A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 1991; 64: 231.
    • (1991) Cell , vol.64 , pp. 231
    • Nusse, R.1    Brown, A.2    Papkoff, J.3
  • 4
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R., The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781–810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 5
    • 45549087821 scopus 로고    scopus 로고
    • Chronic diseases in developing countries
    • Nugent R., Chronic diseases in developing countries. Ann N Y Acad Sci 2008; 1136: 70–79.
    • (2008) Ann N Y Acad Sci , vol.1136 , pp. 70-79
    • Nugent, R.1
  • 6
    • 81555237175 scopus 로고    scopus 로고
    • Mitigating preventable chronic disease: progress report of the Cleveland clinic’s lifestyle 180 program
    • Ricanati EH, Golubić M, Yang D. Mitigating preventable chronic disease: progress report of the Cleveland clinic’s lifestyle 180 program. Nutr Metab 2011; 8: 83.
    • (2011) Nutr Metab , vol.8 , pp. 83
    • Ricanati, E.H.1    Golubić, M.2    Yang, D.3
  • 7
    • 77249149901 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease
    • Hwang I, Seo E, Ha H., Wnt/β-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease. Arch Pharm Res 2010; 32: 1653–1662.
    • (2010) Arch Pharm Res , vol.32 , pp. 1653-1662
    • Hwang, I.1    Seo, E.2    Ha, H.3
  • 8
    • 84924090632 scopus 로고    scopus 로고
    • Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling
    • Zhou L, Li Y, Hao S. Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling. J Am Soc Nephrol 2015; 26: 107–120.
    • (2015) J Am Soc Nephrol , vol.26 , pp. 107-120
    • Zhou, L.1    Li, Y.2    Hao, S.3
  • 9
    • 84955576338 scopus 로고    scopus 로고
    • Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases
    • Reuter S, Beckert H, Taube C., Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases. Lab Invest 2016; 96: 177–185.
    • (2016) Lab Invest , vol.96 , pp. 177-185
    • Reuter, S.1    Beckert, H.2    Taube, C.3
  • 10
    • 84940108581 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a
    • Wang S, Song K, Srivastava R. Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a. FASEB J 2015; 29: 3436–3445.
    • (2015) FASEB J , vol.29 , pp. 3436-3445
    • Wang, S.1    Song, K.2    Srivastava, R.3
  • 12
    • 33845927993 scopus 로고    scopus 로고
    • Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
    • Van Bezooijen RL, Svensson JP, Eefting D. Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J Bone Miner Res 2007; 22: 19–28.
    • (2007) J Bone Miner Res , vol.22 , pp. 19-28
    • Van Bezooijen, R.L.1    Svensson, J.P.2    Eefting, D.3
  • 13
    • 84959519253 scopus 로고    scopus 로고
    • Endothelial dysfunction in human diabetes is mediated by Wnt5a-JNK signaling
    • Bretón-Romero R, Feng B, Holbrook M. Endothelial dysfunction in human diabetes is mediated by Wnt5a-JNK signaling. Arterioscler Thromb Vasc Biol 2016; 36: 561–569.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 561-569
    • Bretón-Romero, R.1    Feng, B.2    Holbrook, M.3
  • 14
    • 0035049281 scopus 로고    scopus 로고
    • Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation
    • Sen M, Chamorro M, Reifert J. Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum 2001; 44: 772–781.
    • (2001) Arthritis Rheum , vol.44 , pp. 772-781
    • Sen, M.1    Chamorro, M.2    Reifert, J.3
  • 15
    • 84905823640 scopus 로고    scopus 로고
    • Activation of noncanonical Wnt signaling through Wnt5a in visceral adipose tissue of obese subjects is related to inflammation
    • Catalán V, Gómez-Ambrosi J, Rodríguez A. Activation of noncanonical Wnt signaling through Wnt5a in visceral adipose tissue of obese subjects is related to inflammation. J Clin Endocrinol Metab 2014; 99: E1407–E1417.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E1407-E1417
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3
  • 16
    • 84873181916 scopus 로고    scopus 로고
    • Increased Wnt5a mRNA expression in advanced atherosclerotic lesions, and oxidized LDL treated human monocyte-derived macrophages
    • Bhatt PM, Lewis CJ, House DL. Increased Wnt5a mRNA expression in advanced atherosclerotic lesions, and oxidized LDL treated human monocyte-derived macrophages. Open Circ Vasc J 2012; 5: 1–7.
    • (2012) Open Circ Vasc J , vol.5 , pp. 1-7
    • Bhatt, P.M.1    Lewis, C.J.2    House, D.L.3
  • 17
    • 33747339465 scopus 로고    scopus 로고
    • Wnt Signaling: multiple pathways, multiple receptors, and multiple transcription factors
    • Gordon MD, Nusse R., Wnt Signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006; 281: 22429–22433.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 18
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R., Wnt/β-catenin signaling and disease. Cell 2012; 149: 1192–1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 20
    • 83155181734 scopus 로고    scopus 로고
    • Wnt5a: its signalling, functions and implication in diseases
    • Kikuchi A, Yamamoto H, Sato A. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol 2012; 204: 17–33.
    • (2012) Acta Physiol , vol.204 , pp. 17-33
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3
  • 21
    • 46049083566 scopus 로고    scopus 로고
    • Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
    • Yamamoto S, Nishimura O, Misaki K. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 2008; 15: 23–36.
    • (2008) Dev Cell , vol.15 , pp. 23-36
    • Yamamoto, S.1    Nishimura, O.2    Misaki, K.3
  • 22
    • 84938100880 scopus 로고    scopus 로고
    • Alternative Wnt signaling activates YAP/TAZ
    • Park HW, Kim YC, Yu B. Alternative Wnt signaling activates YAP/TAZ. Cell 2015; 162: 780–794.
    • (2015) Cell , vol.162 , pp. 780-794
    • Park, H.W.1    Kim, Y.C.2    Yu, B.3
  • 23
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation
    • Topol L, Jiang X, Choi H. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J Cell Biol 2003; 162: 899–908.
    • (2003) J Cell Biol , vol.162 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3
  • 24
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • Van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development 2009; 136: 3205–3214.
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 25
    • 84958765390 scopus 로고    scopus 로고
    • Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells
    • Corbett L, Mann J, Mann DA., Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells. PLoS ONE 2015; 10: e0142794.
    • (2015) PLoS ONE , vol.10 , pp. e0142794
    • Corbett, L.1    Mann, J.2    Mann, D.A.3
  • 26
    • 58149277106 scopus 로고    scopus 로고
    • Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines
    • Anagnostou SH, Shepherd PR., Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines. Biochem J 2008; 416: 211–218.
    • (2008) Biochem J , vol.416 , pp. 211-218
    • Anagnostou, S.H.1    Shepherd, P.R.2
  • 27
    • 33947213491 scopus 로고    scopus 로고
    • Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
    • Kurayoshi M, Yamamoto H, Izumi S. Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J 2007; 402: 515–523.
    • (2007) Biochem J , vol.402 , pp. 515-523
    • Kurayoshi, M.1    Yamamoto, H.2    Izumi, S.3
  • 28
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and wingless signalling
    • Panáková D, Sprong H, Marois E. Lipoprotein particles are required for Hedgehog and wingless signalling. Nature 2005; 435: 58–65.
    • (2005) Nature , vol.435 , pp. 58-65
    • Panáková, D.1    Sprong, H.2    Marois, E.3
  • 30
    • 84961994260 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion
    • Fuster JJ, Zuriaga MA, Ngo DT-M. Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 2015; 64: 1235–1248.
    • (2015) Diabetes , vol.64 , pp. 1235-1248
    • Fuster, J.J.1    Zuriaga, M.A.2    Ngo, D.T.-M.3
  • 31
    • 84900388833 scopus 로고    scopus 로고
    • Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells
    • Carstensen M, Wiza C, Rohrig K. Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells. PLoS ONE 2014; 9: e0085906.
    • (2014) PLoS ONE , vol.9 , pp. e0085906
    • Carstensen, M.1    Wiza, C.2    Rohrig, K.3
  • 32
    • 84994666565 scopus 로고    scopus 로고
    • sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism and extracellular matrix remodeling
    • Lin H, Angeli M, Chung KJ. sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism and extracellular matrix remodeling. Am J Physiol: Cell Physiol 2016; 311: C710–C719.
    • (2016) Am J Physiol: Cell Physiol , vol.311 , pp. C710-C719
    • Lin, H.1    Angeli, M.2    Chung, K.J.3
  • 33
    • 77954844177 scopus 로고    scopus 로고
    • Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    • Ouchi N, Higuchi A, Ohashi K. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 2010; 329: 454–457.
    • (2010) Science , vol.329 , pp. 454-457
    • Ouchi, N.1    Higuchi, A.2    Ohashi, K.3
  • 34
    • 33847772075 scopus 로고    scopus 로고
    • STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (review)
    • Katoh M, Katoh M., STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (review). Int J Mol Med 2007; 19: 273–278.
    • (2007) Int J Mol Med , vol.19 , pp. 273-278
    • Katoh, M.1    Katoh, M.2
  • 35
    • 84897099207 scopus 로고    scopus 로고
    • Can we say what diet is best for health?
    • Katz DL, Meller S., Can we say what diet is best for health? Annu Rev Public Health 2014; 35: 83–103.
    • (2014) Annu Rev Public Health , vol.35 , pp. 83-103
    • Katz, D.L.1    Meller, S.2
  • 36
    • 84934877428 scopus 로고    scopus 로고
    • Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders
    • Bhatt PM, Malgor R., Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders. Atherosclerosis 2014; 237: 155–162.
    • (2014) Atherosclerosis , vol.237 , pp. 155-162
    • Bhatt, P.M.1    Malgor, R.2
  • 37
    • 84901499042 scopus 로고    scopus 로고
    • Wnt5a: a potential factor linking psoriasis to metabolic complications
    • Gerdes S, Laudes M, Neumann K. Wnt5a: a potential factor linking psoriasis to metabolic complications. Exp Dermatol 2014; 23: 439–440.
    • (2014) Exp Dermatol , vol.23 , pp. 439-440
    • Gerdes, S.1    Laudes, M.2    Neumann, K.3
  • 38
    • 84923599828 scopus 로고    scopus 로고
    • Psoriasis: in between the skin and the fat
    • Ståhle M., Psoriasis: in between the skin and the fat. Exp Dermatol 2015; 24: 181–182.
    • (2015) Exp Dermatol , vol.24 , pp. 181-182
    • Ståhle, M.1
  • 39
    • 33746660207 scopus 로고    scopus 로고
    • The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    • Blumenthal A, Ehlers S, Lauber J. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 2006; 108: 965–973.
    • (2006) Blood , vol.108 , pp. 965-973
    • Blumenthal, A.1    Ehlers, S.2    Lauber, J.3
  • 40
    • 67649515610 scopus 로고    scopus 로고
    • Transcriptional mechanisms of WNT5A based on NF-κB, Hedgehog, TGFβ, and notch signaling cascades
    • Katoh. Transcriptional mechanisms of WNT5A based on NF-κB, Hedgehog, TGFβ, and notch signaling cascades. Int J Mol Med 2009; 23: 763–769.
    • (2009) Int J Mol Med , vol.23 , pp. 763-769
    • Katoh1
  • 41
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise DR, DeBerardinis RJ, Mancuso A. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci 2008; 105: 18782–18787.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 18782-18787
    • Wise, D.R.1    DeBerardinis, R.J.2    Mancuso, A.3
  • 42
    • 65249128611 scopus 로고    scopus 로고
    • Identification of targets of the Wnt pathway destruction complex in addition to β-catenin
    • Kim N-G, Xu C, Gumbiner BM., Identification of targets of the Wnt pathway destruction complex in addition to β-catenin. Proc Natl Acad Sci 2009; 106: 5165–5170.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 5165-5170
    • Kim, N.-G.1    Xu, C.2    Gumbiner, B.M.3
  • 43
    • 69249206717 scopus 로고    scopus 로고
    • mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
    • Castilho RM, Squarize CH, Chodosh LA. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009; 5: 279–289.
    • (2009) Cell Stem Cell , vol.5 , pp. 279-289
    • Castilho, R.M.1    Squarize, C.H.2    Chodosh, L.A.3
  • 44
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM., mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21–35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 45
    • 0037905677 scopus 로고    scopus 로고
    • Novel candidate targets of β-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    • Schwartz DR, Wu R, Kardia SLR. Novel candidate targets of β-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res 2003; 63: 2913–2922.
    • (2003) Cancer Res , vol.63 , pp. 2913-2922
    • Schwartz, D.R.1    Wu, R.2    Kardia, S.L.R.3
  • 46
    • 77950877526 scopus 로고    scopus 로고
    • Wnt signalling and the control of cellular metabolism
    • Sethi JK, Vidal-Puig A., Wnt signalling and the control of cellular metabolism. Biochem J 2010; 427: 1–17.
    • (2010) Biochem J , vol.427 , pp. 1-17
    • Sethi, J.K.1    Vidal-Puig, A.2
  • 47
    • 79960058242 scopus 로고    scopus 로고
    • Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity
    • Farb MG, Bigornia S, Mott M. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol 2011; 58: 232–237.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 232-237
    • Farb, M.G.1    Bigornia, S.2    Mott, M.3
  • 48
    • 84999106880 scopus 로고    scopus 로고
    • WNT5A-JNK regulation of vascular insulin resistance in human obesity
    • Farb MG, Karki S, Park S-Y. WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med 2016; 21: 489–496.
    • (2016) Vasc Med , vol.21 , pp. 489-496
    • Farb, M.G.1    Karki, S.2    Park, S.-Y.3
  • 49
    • 84896547994 scopus 로고    scopus 로고
    • Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions
    • Malgor R, Bhatt PM, Connolly BA. Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions. Inflamm Res 2014; 63: 277–285.
    • (2014) Inflamm Res , vol.63 , pp. 277-285
    • Malgor, R.1    Bhatt, P.M.2    Connolly, B.A.3
  • 50
    • 85016005974 scopus 로고    scopus 로고
    • Dickkopf-3 ablation attenuates the development of atherosclerosis in ApoE-deficient mice
    • Cheng W-L, Yang Y, Zhang X-J. Dickkopf-3 ablation attenuates the development of atherosclerosis in ApoE-deficient mice. J Am Heart Assoc 2017; 6: e004690.
    • (2017) J Am Heart Assoc , vol.6 , pp. e004690
    • Cheng, W.-L.1    Yang, Y.2    Zhang, X.-J.3
  • 51
    • 79251520008 scopus 로고    scopus 로고
    • The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists
    • Hurt RT, Kulisek C, Buchanan LA. The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists. Gastroenterol Hepatol 2010; 6: 780–792.
    • (2010) Gastroenterol Hepatol , vol.6 , pp. 780-792
    • Hurt, R.T.1    Kulisek, C.2    Buchanan, L.A.3
  • 52
    • 14844282050 scopus 로고    scopus 로고
    • Regulation of PPARγ activity during adipogenesis
    • Farmer SR., Regulation of PPARγ activity during adipogenesis. Int J Obes 2005; 29: S13–S16.
    • (2005) Int J Obes , vol.29 , pp. S13-S16
    • Farmer, S.R.1
  • 53
    • 67651067535 scopus 로고    scopus 로고
    • Wnt5b stimulates adipogenesis by activating PPARγ, and inhibiting the β-catenin dependent Wnt signaling pathway together with Wnt5a
    • van Tienen FHJ, Laeremans H, van der, Kallen CJH. Wnt5b stimulates adipogenesis by activating PPARγ, and inhibiting the β-catenin dependent Wnt signaling pathway together with Wnt5a. Biochem Biophys Res Commun 2009; 387: 207–211.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 207-211
    • van Tienen, F.H.J.1    Laeremans, H.2    van der, D.3    Kallen, C.J.H.4
  • 54
    • 84855210399 scopus 로고    scopus 로고
    • Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor
    • Sánchez-Solana B, Laborda J, Baladrón V., Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor. Mol Endocrinol 2012; 26: 110–127.
    • (2012) Mol Endocrinol , vol.26 , pp. 110-127
    • Sánchez-Solana, B.1    Laborda, J.2    Baladrón, V.3
  • 55
    • 0034637103 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by Wnt signaling
    • Ross SE, Hemati N, Longo KA. Inhibition of adipogenesis by Wnt signaling. Science 2000; 289: 950–953.
    • (2000) Science , vol.289 , pp. 950-953
    • Ross, S.E.1    Hemati, N.2    Longo, K.A.3
  • 56
    • 84941687288 scopus 로고    scopus 로고
    • Dickkopf-1 promotes the differentiation and adipocytokines secretion via canonical Wnt signaling pathway in primary cultured human preadipocytes
    • Lu H, Li X, Mu P. Dickkopf-1 promotes the differentiation and adipocytokines secretion via canonical Wnt signaling pathway in primary cultured human preadipocytes. Obes Res Clin Pract 2016; 10: 454–464.
    • (2016) Obes Res Clin Pract , vol.10 , pp. 454-464
    • Lu, H.1    Li, X.2    Mu, P.3
  • 57
    • 77949909802 scopus 로고    scopus 로고
    • Role of Wnt-5a in the determination of human mesenchymal stem cells into preadipocytes
    • Bilkovski R, Schulte DM, Oberhauser F. Role of Wnt-5a in the determination of human mesenchymal stem cells into preadipocytes. J Biol Chem 2010; 285: 6170–6178.
    • (2010) J Biol Chem , vol.285 , pp. 6170-6178
    • Bilkovski, R.1    Schulte, D.M.2    Oberhauser, F.3
  • 58
    • 81155139119 scopus 로고    scopus 로고
    • Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans
    • Bilkovski R, Schulte DM, Oberhauser F. Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans. Int J Obes 2011; 35: 1450–1454.
    • (2011) Int J Obes , vol.35 , pp. 1450-1454
    • Bilkovski, R.1    Schulte, D.M.2    Oberhauser, F.3
  • 59
    • 0041374029 scopus 로고    scopus 로고
    • Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α
    • Ruan H, Lodish HF., Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α. Cytokine Growth Factor Rev 2003; 14: 447–455.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 447-455
    • Ruan, H.1    Lodish, H.F.2
  • 60
    • 84863935919 scopus 로고    scopus 로고
    • Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism
    • Li X, Shan J, Chang W. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proc Natl Acad Sci U S A 2012; 109: 11402–11407.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11402-11407
    • Li, X.1    Shan, J.2    Chang, W.3
  • 61
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel VT, Liu Z-X, Qu X. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279: 32345–32353.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.-X.2    Qu, X.3
  • 62
    • 84925495884 scopus 로고    scopus 로고
    • Bariatric surgery improves histological features of nonalcoholic fatty liver disease and liver fibrosis
    • Taitano AA, Markow M, Finan JE. Bariatric surgery improves histological features of nonalcoholic fatty liver disease and liver fibrosis. J Gastrointest Surg 2015; 19: 429–437.
    • (2015) J Gastrointest Surg , vol.19 , pp. 429-437
    • Taitano, A.A.1    Markow, M.2    Finan, J.E.3
  • 63
    • 84896747760 scopus 로고    scopus 로고
    • Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression
    • Tian F, Zhang YJ, Li Y. Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression. PLoS ONE 2014; 9: e83819.
    • (2014) PLoS ONE , vol.9 , pp. e83819
    • Tian, F.1    Zhang, Y.J.2    Li, Y.3
  • 64
    • 84893455140 scopus 로고    scopus 로고
    • The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue
    • Go G, Srivastava R, Hernandez-Ono A. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab 2014; 19: 209–220.
    • (2014) Cell Metab , vol.19 , pp. 209-220
    • Go, G.1    Srivastava, R.2    Hernandez-Ono, A.3
  • 65
    • 76149088123 scopus 로고    scopus 로고
    • Liver-specific β-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis
    • Behari J, Yeh T-H, Krauland L. Liver-specific β-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis. Am J Pathol 2010; 176: 744–753.
    • (2010) Am J Pathol , vol.176 , pp. 744-753
    • Behari, J.1    Yeh, T.-H.2    Krauland, L.3
  • 66
    • 84993142506 scopus 로고    scopus 로고
    • RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
    • Yin X, Yi H, Wang L. RSPOs facilitated HSC activation and promoted hepatic fibrogenesis. Oncotarget 2016; 7: 63767–63778.
    • (2016) Oncotarget , vol.7 , pp. 63767-63778
    • Yin, X.1    Yi, H.2    Wang, L.3
  • 68
    • 84920703518 scopus 로고    scopus 로고
    • Global regional national age–sex specific all-cause cause-specific mortality for 240 and causes of death, 1990–2013: a systematic analysis for the global burden of disease study 2013
    • GBD 2013 Mortality and Causes of Death Collaborators. Global regional national age–sex specific all-cause cause-specific mortality for 240 and causes of death, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet 2015; 385: 117–171.
    • (2015) Lancet , vol.385 , pp. 117-171
  • 70
    • 65249134946 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling promotes renal interstitial fibrosis
    • He W, Dai C, Li Y. Wnt/β-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009; 20: 765–776.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 765-776
    • He, W.1    Dai, C.2    Li, Y.3
  • 71
    • 77957968233 scopus 로고    scopus 로고
    • Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis
    • Yeh T-H, Krauland L, Singh V. Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis. Hepatology 2010; 52: 1410–1419.
    • (2010) Hepatology , vol.52 , pp. 1410-1419
    • Yeh, T.-H.1    Krauland, L.2    Singh, V.3
  • 72
    • 69849089270 scopus 로고    scopus 로고
    • Wnt/β-Catenin signaling promotes podocyte dysfunction and albuminuria
    • Dai C, Stolz DB, Kiss LP. Wnt/β-Catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 2009; 20: 1997–2008.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1997-2008
    • Dai, C.1    Stolz, D.B.2    Kiss, L.P.3
  • 74
    • 84899815905 scopus 로고    scopus 로고
    • Development of a chronic kidney disease model in C57BL/6 mice with relevance to human pathology
    • Huang L, Scarpellini A, Funck M. Development of a chronic kidney disease model in C57BL/6 mice with relevance to human pathology. Nephron Extra 2013; 3: 12–29.
    • (2013) Nephron Extra , vol.3 , pp. 12-29
    • Huang, L.1    Scarpellini, A.2    Funck, M.3
  • 75
    • 28444468088 scopus 로고    scopus 로고
    • Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    • Surendran K, Schiavi S, Hruska KA., Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16: 2373–2384.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2373-2384
    • Surendran, K.1    Schiavi, S.2    Hruska, K.A.3
  • 76
    • 0036690114 scopus 로고    scopus 로고
    • Drugs targeting the renin-angiotensin-aldosterone system
    • Zaman MA, Oparil S, Calhoun DA., Drugs targeting the renin-angiotensin-aldosterone system. Nat Rev Drug Discov 2002; 1: 621–636.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 621-636
    • Zaman, M.A.1    Oparil, S.2    Calhoun, D.A.3
  • 78
    • 84950104119 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2016 update
    • Mozaffarian D, Benjamin EJ, Go AS. Heart disease and stroke statistics-2016 update. Circulation 2015; 133: e38–e360.
    • (2015) Circulation , vol.133 , pp. e38-e360
    • Mozaffarian, D.1    Benjamin, E.J.2    Go, A.S.3
  • 79
    • 0035095435 scopus 로고    scopus 로고
    • Second nation-wide study of atherosclerosis in infants, children and young adults in Japan
    • Imakita M, Yutani C, Strong JP. Second nation-wide study of atherosclerosis in infants, children and young adults in Japan. Atherosclerosis 2001; 155: 487–497.
    • (2001) Atherosclerosis , vol.155 , pp. 487-497
    • Imakita, M.1    Yutani, C.2    Strong, J.P.3
  • 81
    • 85009961849 scopus 로고    scopus 로고
    • Loss of macrophage Wnt secretion improves remodeling and function after myocardial infarction in mice
    • Palevski D, Levin Kotler L-P, Kain D. Loss of macrophage Wnt secretion improves remodeling and function after myocardial infarction in mice. J Am Heart Assoc 2017; 6: e004387.
    • (2017) J Am Heart Assoc , vol.6 , pp. e004387
    • Palevski, D.1    Levin Kotler, L.-P.2    Kain, D.3
  • 82
    • 0141885294 scopus 로고    scopus 로고
    • From vulnerable plaque to vulnerable patient a call for new definitions and risk assessment strategies: Part I
    • Naghavi M, Libby P, Falk E. From vulnerable plaque to vulnerable patient a call for new definitions and risk assessment strategies: Part I. Circulation 2003; 108: 1664–1672.
    • (2003) Circulation , vol.108 , pp. 1664-1672
    • Naghavi, M.1    Libby, P.2    Falk, E.3
  • 83
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • Libby P, Ridker PM, Maseri A., Inflammation and atherosclerosis. Circulation 2002; 105: 1135–1143.
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1    Ridker, P.M.2    Maseri, A.3
  • 84
    • 84922464175 scopus 로고    scopus 로고
    • Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133+CD34+-hematopoietic progenitor cells
    • Herr F, Horndasch M, Howe D. Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133+CD34+-hematopoietic progenitor cells. Reprod Biol 2014; 14: 262–275.
    • (2014) Reprod Biol , vol.14 , pp. 262-275
    • Herr, F.1    Horndasch, M.2    Howe, D.3
  • 85
    • 57549105699 scopus 로고    scopus 로고
    • Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells
    • Malhotra S, Kincade PW., Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells. Exp Hematol 2009; 37: 19–30.
    • (2009) Exp Hematol , vol.37 , pp. 19-30
    • Malhotra, S.1    Kincade, P.W.2
  • 86
    • 24644518476 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-α
    • Eto M, Kouroedov A, Cosentino F. Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-α. Circulation 2005; 112: 1316–1322.
    • (2005) Circulation , vol.112 , pp. 1316-1322
    • Eto, M.1    Kouroedov, A.2    Cosentino, F.3
  • 87
    • 84925799247 scopus 로고    scopus 로고
    • Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation?
    • Derlindati E, Dei Cas A, Montanini B. Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation? PLoS ONE 2015; 10: e0119751.
    • (2015) PLoS ONE , vol.10 , pp. e0119751
    • Derlindati, E.1    Dei Cas, A.2    Montanini, B.3
  • 88
    • 84899548231 scopus 로고    scopus 로고
    • Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages
    • Naskar D, Maiti G, Chakraborty A. Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages. J Immunol 2014; 192: 4386–4397.
    • (2014) J Immunol , vol.192 , pp. 4386-4397
    • Naskar, D.1    Maiti, G.2    Chakraborty, A.3
  • 89
    • 65449123456 scopus 로고    scopus 로고
    • The wnt pathway: a macrophage effector molecule that triggers inflammation
    • Pereira CP, Bachli EB, Schoedon G., The wnt pathway: a macrophage effector molecule that triggers inflammation. Curr Atheroscler Rep 2009; 11: 236–242.
    • (2009) Curr Atheroscler Rep , vol.11 , pp. 236-242
    • Pereira, C.P.1    Bachli, E.B.2    Schoedon, G.3
  • 90
    • 40749112792 scopus 로고    scopus 로고
    • Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
    • Pereira C, Schaer DJ, Bachli EB. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol 2008; 28: 504–510.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 504-510
    • Pereira, C.1    Schaer, D.J.2    Bachli, E.B.3
  • 91
    • 84907472612 scopus 로고    scopus 로고
    • siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways
    • Yang L, Chu Y, Wang Y. siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways. Int J Mol Med 2014; 34: 1147–1152.
    • (2014) Int J Mol Med , vol.34 , pp. 1147-1152
    • Yang, L.1    Chu, Y.2    Wang, Y.3
  • 92
    • 84945496884 scopus 로고    scopus 로고
    • Inflammation and plaque vulnerability
    • Hansson GK, Libby P, Tabas I., Inflammation and plaque vulnerability. J Intern Med 2015; 278: 483–493.
    • (2015) J Intern Med , vol.278 , pp. 483-493
    • Hansson, G.K.1    Libby, P.2    Tabas, I.3
  • 93
    • 34748827997 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes
    • Kirton JP, Crofts NJ, George SJ. Wnt/β-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes. Circ Res 2007; 101: 581–589.
    • (2007) Circ Res , vol.101 , pp. 581-589
    • Kirton, J.P.1    Crofts, N.J.2    George, S.J.3
  • 94
    • 84969638940 scopus 로고    scopus 로고
    • Wnt2 and WISP-1/CCN4 induce intimal thickening via promotion of smooth muscle cell migration
    • Williams H, Mill CAE, Monk BA. Wnt2 and WISP-1/CCN4 induce intimal thickening via promotion of smooth muscle cell migration. Arterioscler Thromb Vasc Biol 2016; 36: 1417–1424.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 1417-1424
    • Williams, H.1    Mill, C.A.E.2    Monk, B.A.3
  • 95
    • 79952068996 scopus 로고    scopus 로고
    • Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening
    • Tsaousi A, Williams H, Lyon CA. Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening. Circ Res 2011; 108: 427–436.
    • (2011) Circ Res , vol.108 , pp. 427-436
    • Tsaousi, A.1    Williams, H.2    Lyon, C.A.3
  • 96
    • 84921517643 scopus 로고    scopus 로고
    • Wnt4/β-catenin signaling pathway modulates balloon-injured carotid artery restenosis via disheveled-1
    • Hua J, Xu Y, He Y. Wnt4/β-catenin signaling pathway modulates balloon-injured carotid artery restenosis via disheveled-1. Int J Clin Exp Pathol 2014; 7: 8421.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 8421
    • Hua, J.1    Xu, Y.2    He, Y.3
  • 97
    • 84875705913 scopus 로고    scopus 로고
    • Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells
    • Kumawat K, Menzen MH, Bos IST. Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells. FASEB J 2013; 27: 1631–1643.
    • (2013) FASEB J , vol.27 , pp. 1631-1643
    • Kumawat, K.1    Menzen, M.H.2    Bos, I.S.T.3
  • 98
    • 84896517331 scopus 로고    scopus 로고
    • Wnt3a activates β1-integrin and regulates migration and adhesion of vascular smooth muscle cells
    • Wu X, Wang J, Jiang H. Wnt3a activates β1-integrin and regulates migration and adhesion of vascular smooth muscle cells. Mol Med Rep 2014; 9: 1159–1164.
    • (2014) Mol Med Rep , vol.9 , pp. 1159-1164
    • Wu, X.1    Wang, J.2    Jiang, H.3
  • 99
    • 84911934768 scopus 로고    scopus 로고
    • Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress
    • Mill C, Monk BA, Williams H. Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress. Arterioscler Thromb Vasc Biol 2014; 34: 2449–2456.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 2449-2456
    • Mill, C.1    Monk, B.A.2    Williams, H.3
  • 100
    • 84903376328 scopus 로고    scopus 로고
    • Wnt signaling cascade in restenosis: a potential therapeutic target of public health relevance in a North American cohort of Nebraska State
    • Pandey S, Chandravati. Wnt signaling cascade in restenosis: a potential therapeutic target of public health relevance in a North American cohort of Nebraska State. Mol Biol Rep 2014; 41: 4549–4554.
    • (2014) Mol Biol Rep , vol.41 , pp. 4549-4554
    • Pandey, S.1    Chandravati2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.