메뉴 건너뛰기




Volumn 237, Issue 1, 2014, Pages 155-162

Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders

Author keywords

Atherosclerosis; Inflammation; Inflammatory disorders; Macrophages; Wnt5a

Indexed keywords

OXIDIZED LOW DENSITY LIPOPROTEIN; WNT5A PROTEIN; BIOLOGICAL MARKER; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LRP5 PROTEIN, HUMAN; LRP6 PROTEIN, HUMAN; ONCOPROTEIN; WNT PROTEIN; WNT5A PROTEIN, HUMAN;

EID: 84934877428     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.08.027     Document Type: Review
Times cited : (86)

References (71)
  • 1
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 2
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004, 20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 3
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers S., Moon R.T. Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 2009, 10:468-477.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 4
    • 39849091185 scopus 로고    scopus 로고
    • Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
    • Li C., Chen H., Hu L., Xing Y., Sasaki T., Villosis M.F., et al. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol 2008, 9:11.
    • (2008) BMC Mol Biol , vol.9 , pp. 11
    • Li, C.1    Chen, H.2    Hu, L.3    Xing, Y.4    Sasaki, T.5    Villosis, M.F.6
  • 5
    • 0025696476 scopus 로고
    • Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development
    • Gavin B.J., McMahon J.A., McMahon A.P. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev 1990, 4:2319-2332.
    • (1990) Genes Dev , vol.4 , pp. 2319-2332
    • Gavin, B.J.1    McMahon, J.A.2    McMahon, A.P.3
  • 6
    • 0026772731 scopus 로고
    • Wnt genes
    • Nusse R., Varmus H.E. Wnt genes. Cell 1992, 69:1073-1087.
    • (1992) Cell , vol.69 , pp. 1073-1087
    • Nusse, R.1    Varmus, H.E.2
  • 8
    • 33746660207 scopus 로고    scopus 로고
    • The wingless homolog WNT5A and its receptor frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    • Blumenthal A., Ehlers S., Lauber J., Buer J., Lange C., Goldmann T., et al. The wingless homolog WNT5A and its receptor frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 2006, 108:965-973.
    • (2006) Blood , vol.108 , pp. 965-973
    • Blumenthal, A.1    Ehlers, S.2    Lauber, J.3    Buer, J.4    Lange, C.5    Goldmann, T.6
  • 10
    • 65449123456 scopus 로고    scopus 로고
    • The Wnt pathway: a macrophage effector molecule that triggers inflammation
    • Pereira C.P., Bachli E.B., Schoedon G. The Wnt pathway: a macrophage effector molecule that triggers inflammation. Curr Atheroscler Rep 2009, 11:236-242.
    • (2009) Curr Atheroscler Rep , vol.11 , pp. 236-242
    • Pereira, C.P.1    Bachli, E.B.2    Schoedon, G.3
  • 11
    • 84873181916 scopus 로고    scopus 로고
    • Increased Wnt5a mRNA expression in advanced atherosclerotic lesions, and oxidized LDL treated human monocyte-derived macrophages
    • Bhatt P.M., Lewis C.J., House D.L., Keller C.M., Kohn L.D., Silver M.J., et al. Increased Wnt5a mRNA expression in advanced atherosclerotic lesions, and oxidized LDL treated human monocyte-derived macrophages. Open Circ Vasc J 2012, 5:1-7.
    • (2012) Open Circ Vasc J , vol.5 , pp. 1-7
    • Bhatt, P.M.1    Lewis, C.J.2    House, D.L.3    Keller, C.M.4    Kohn, L.D.5    Silver, M.J.6
  • 12
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: processing, secretion and reception
    • Mikels A.J., Nusse R. Wnts as ligands: processing, secretion and reception. Oncogene 2006, 25:7461-7468.
    • (2006) Oncogene , vol.25 , pp. 7461-7468
    • Mikels, A.J.1    Nusse, R.2
  • 14
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • Veeman M.T., Axelrod J.D., Moon R.T. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003, 5:367-377.
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 15
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald S.L., Silver A. The opposing roles of Wnt-5a in cancer. Br J Cancer 2009, 101:209-214.
    • (2009) Br J Cancer , vol.101 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 16
    • 34548064011 scopus 로고    scopus 로고
    • High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration
    • McCall K.D., Harii N., Lewis C.J., Malgor R., Kim W.B., Saji M., et al. High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration. Endocrinology 2007, 148:4226-4237.
    • (2007) Endocrinology , vol.148 , pp. 4226-4237
    • McCall, K.D.1    Harii, N.2    Lewis, C.J.3    Malgor, R.4    Kim, W.B.5    Saji, M.6
  • 17
    • 0037382333 scopus 로고    scopus 로고
    • The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
    • Kilian B., Mansukoski H., Barbosa F.C., Ulrich F., Tada M., Heisenberg C.P. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev 2003, 120:467-476.
    • (2003) Mech Dev , vol.120 , pp. 467-476
    • Kilian, B.1    Mansukoski, H.2    Barbosa, F.C.3    Ulrich, F.4    Tada, M.5    Heisenberg, C.P.6
  • 18
    • 0034214847 scopus 로고    scopus 로고
    • The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape
    • Kuhl M., Sheldahl L.C., Park M., Miller J.R., Moon R.T. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 2000, 16:279-283.
    • (2000) Trends Genet , vol.16 , pp. 279-283
    • Kuhl, M.1    Sheldahl, L.C.2    Park, M.3    Miller, J.R.4    Moon, R.T.5
  • 19
    • 24644499046 scopus 로고    scopus 로고
    • Wnt and calcium signaling: beta-catenin-independent pathways
    • Kohn A.D., Moon R.T. Wnt and calcium signaling: beta-catenin-independent pathways. Cell calcium 2005, 38:439-446.
    • (2005) Cell calcium , vol.38 , pp. 439-446
    • Kohn, A.D.1    Moon, R.T.2
  • 20
    • 0034920494 scopus 로고    scopus 로고
    • Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling
    • Kuhl M., Geis K., Sheldahl L.C., Pukrop T., Moon R.T., Wedlich D. Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling. Mech Dev 2001, 106:61-76.
    • (2001) Mech Dev , vol.106 , pp. 61-76
    • Kuhl, M.1    Geis, K.2    Sheldahl, L.C.3    Pukrop, T.4    Moon, R.T.5    Wedlich, D.6
  • 21
    • 33846396811 scopus 로고    scopus 로고
    • Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
    • Seifert J.R., Mlodzik M. Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet 2007, 8:126-138.
    • (2007) Nat Rev Genet , vol.8 , pp. 126-138
    • Seifert, J.R.1    Mlodzik, M.2
  • 22
    • 67649515610 scopus 로고    scopus 로고
    • Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and notch signaling cascades
    • Katoh M., Katoh M. Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and notch signaling cascades. Int J Mol Med 2009, 23:763-769.
    • (2009) Int J Mol Med , vol.23 , pp. 763-769
    • Katoh, M.1    Katoh, M.2
  • 23
    • 83155181734 scopus 로고    scopus 로고
    • Wnt5a: its signalling, functions and implication in diseases
    • Kikuchi A., Yamamoto H., Sato A., Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol 2012, 204:17-33.
    • (2012) Acta Physiol , vol.204 , pp. 17-33
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3    Matsumoto, S.4
  • 24
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: a common theme in animal development
    • Cadigan K.M., Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997, 11:3286-3305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 25
    • 0027752991 scopus 로고
    • Wnt family proteins are secreted and associated with the cell surface
    • Smolich B.D., McMahon J.A., McMahon A.P., Papkoff J. Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell 1993, 4:1267-1275.
    • (1993) Mol Biol Cell , vol.4 , pp. 1267-1275
    • Smolich, B.D.1    McMahon, J.A.2    McMahon, A.P.3    Papkoff, J.4
  • 26
    • 10744219743 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
    • Oishi I., Suzuki H., Onishi N., Takada R., Kani S., Ohkawara B., et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 2003, 8:645-654.
    • (2003) Genes Cells , vol.8 , pp. 645-654
    • Oishi, I.1    Suzuki, H.2    Onishi, N.3    Takada, R.4    Kani, S.5    Ohkawara, B.6
  • 27
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    • Mikels A.J., Nusse R. Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 2006, 4:570-582.
    • (2006) PLoS Biol , vol.4 , pp. 570-582
    • Mikels, A.J.1    Nusse, R.2
  • 28
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2012 update: a report from the American Heart Association
    • Roger V.L., Go A.S., Lloyd-Jones D.M., Benjamin E.J., Berry J.D., Borden W.B., et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 2012, 125:e2-e220.
    • (2012) Circulation , vol.125 , pp. e2-e220
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Benjamin, E.J.4    Berry, J.D.5    Borden, W.B.6
  • 29
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: a perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362:801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 30
    • 0032693599 scopus 로고    scopus 로고
    • Atherosclerosis is an inflammatory disease
    • Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999, 138:S419-S420.
    • (1999) Am Heart J , vol.138 , pp. S419-S420
    • Ross, R.1
  • 31
    • 0033600729 scopus 로고    scopus 로고
    • Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells
    • Wright M., Aikawa M., Szeto W., Papkoff J. Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. Biochem Biophys Res Co 1999, 263:384-388.
    • (1999) Biochem Biophys Res Co , vol.263 , pp. 384-388
    • Wright, M.1    Aikawa, M.2    Szeto, W.3    Papkoff, J.4
  • 32
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002, 868-874.
    • (2002) Nature , pp. 868-874
    • Libby, P.1
  • 33
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore K.J., Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 34
    • 33845398385 scopus 로고    scopus 로고
    • Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2
    • Masckauchan T.N., Agalliu D., Vorontchikhina M., Ahn A., Parmalee N.L., Li C.M., et al. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell 2006, 17:5163-5172.
    • (2006) Mol Biol Cell , vol.17 , pp. 5163-5172
    • Masckauchan, T.N.1    Agalliu, D.2    Vorontchikhina, M.3    Ahn, A.4    Parmalee, N.L.5    Li, C.M.6
  • 35
    • 36249004436 scopus 로고    scopus 로고
    • Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration
    • Cheng C.W., Yeh J.C., Fan T.P., Smith S.K., Charnock-Jones D.S. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Co 2008, 365:285-290.
    • (2008) Biochem Biophys Res Co , vol.365 , pp. 285-290
    • Cheng, C.W.1    Yeh, J.C.2    Fan, T.P.3    Smith, S.K.4    Charnock-Jones, D.S.5
  • 37
    • 84911119164 scopus 로고    scopus 로고
    • The novel role and underlying mechanism of Wnt5a in regulating cellular cholesterol accumulation
    • [Epub ahead of print]
    • Qin L., Hu R., Zhu N., Yao H.L., Lei X.Y., Li S.X., et al. The novel role and underlying mechanism of Wnt5a in regulating cellular cholesterol accumulation. Clin Exp Pharmacol Physiol 2014, [Epub ahead of print]. 10.1111/1440-1681.12258.
    • (2014) Clin Exp Pharmacol Physiol
    • Qin, L.1    Hu, R.2    Zhu, N.3    Yao, H.L.4    Lei, X.Y.5    Li, S.X.6
  • 39
    • 77955480360 scopus 로고    scopus 로고
    • Wnt5a induces endothelial inflammation via beta-catenin-independent signaling
    • Kim J., Kim J., Kim D.W., Ha Y., Ihm M.H., Kim H., et al. Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol 2010, 185:1274-1282.
    • (2010) J Immunol , vol.185 , pp. 1274-1282
    • Kim, J.1    Kim, J.2    Kim, D.W.3    Ha, Y.4    Ihm, M.H.5    Kim, H.6
  • 40
    • 84863644232 scopus 로고    scopus 로고
    • Wnt signalling in smooth muscle cells and its role in cardiovascular disorders
    • Mill C., George S.J. Wnt signalling in smooth muscle cells and its role in cardiovascular disorders. Cardiovasc Res 2012, 95:233-240.
    • (2012) Cardiovasc Res , vol.95 , pp. 233-240
    • Mill, C.1    George, S.J.2
  • 41
    • 0141817707 scopus 로고    scopus 로고
    • Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads
    • Doherty T.M., Asotra K., Fitzpatrick L.A., Qiao J.-H., Wilkin D.J., Detrano R.C., et al. Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A 2003, 100(20):11201-11206.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.20 , pp. 11201-11206
    • Doherty, T.M.1    Asotra, K.2    Fitzpatrick, L.A.3    Qiao, J.-H.4    Wilkin, D.J.5    Detrano, R.C.6
  • 42
    • 84873143404 scopus 로고    scopus 로고
    • The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification
    • Xin H., Xin F., Zhou S., Guan S. The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification. Int J Mol Med 2013, 31(3):583-588.
    • (2013) Int J Mol Med , vol.31 , Issue.3 , pp. 583-588
    • Xin, H.1    Xin, F.2    Zhou, S.3    Guan, S.4
  • 43
    • 84866975779 scopus 로고    scopus 로고
    • The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
    • Woldt E., Terrand J., Mlih M., Matz R.L., Bruban V., Coudane F., et al. The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nat Commun 2012, 3:1077.
    • (2012) Nat Commun , vol.3 , pp. 1077
    • Woldt, E.1    Terrand, J.2    Mlih, M.3    Matz, R.L.4    Bruban, V.5    Coudane, F.6
  • 45
    • 84861029037 scopus 로고    scopus 로고
    • Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery
    • Gui T., Shimokado A., Sun Y., Akasaka T., Muragaki Y. Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. Mediat Inflamm 2012, 2012:693083.
    • (2012) Mediat Inflamm , vol.2012 , pp. 693083
    • Gui, T.1    Shimokado, A.2    Sun, Y.3    Akasaka, T.4    Muragaki, Y.5
  • 46
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    • Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006, 177:7303-7311.
    • (2006) J Immunol , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 47
    • 76449107634 scopus 로고    scopus 로고
    • Monocytes in atherosclerosis: subsets and functions.
    • Woollard KJ, Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol;7:77-86.
    • Nat Rev Cardiol , vol.7 , pp. 77-86
    • Woollard, K.J.1    Geissmann, F.2
  • 48
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Immunol 2003, 3:23-35.
    • (2003) Nat Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 49
    • 84862066130 scopus 로고    scopus 로고
    • Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients
    • Bergenfelz C., Medrek C., Ekstrom E., Jirstrom K., Janols H., Wullt M., et al. Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients. J Immunol 2012, 188:5448-5458.
    • (2012) J Immunol , vol.188 , pp. 5448-5458
    • Bergenfelz, C.1    Medrek, C.2    Ekstrom, E.3    Jirstrom, K.4    Janols, H.5    Wullt, M.6
  • 50
    • 0035049281 scopus 로고    scopus 로고
    • Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation
    • Sen M., Chamorro M., Reifert J., Corr M., Carson D.A. Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum 2001, 44:772-781.
    • (2001) Arthritis Rheum , vol.44 , pp. 772-781
    • Sen, M.1    Chamorro, M.2    Reifert, J.3    Corr, M.4    Carson, D.A.5
  • 51
    • 70349310357 scopus 로고    scopus 로고
    • Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration
    • Ghosh M.C., Collins G.D., Vandanmagsar B., Patel K., Brill M., Carter A., et al. Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration. Blood 2009, 114:1366-1373.
    • (2009) Blood , vol.114 , pp. 1366-1373
    • Ghosh, M.C.1    Collins, G.D.2    Vandanmagsar, B.3    Patel, K.4    Brill, M.5    Carter, A.6
  • 52
    • 33847772075 scopus 로고    scopus 로고
    • STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer
    • Katoh M., Katoh M. STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer. Int J Mol Med 2007, 19:273-278.
    • (2007) Int J Mol Med , vol.19 , pp. 273-278
    • Katoh, M.1    Katoh, M.2
  • 53
    • 40749112792 scopus 로고    scopus 로고
    • Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
    • Pereira C., Schaer D.J., Bachli E.B., Kurrer M.O., Schoedon G. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol 2008, 28(3):504-510.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.3 , pp. 504-510
    • Pereira, C.1    Schaer, D.J.2    Bachli, E.B.3    Kurrer, M.O.4    Schoedon, G.5
  • 54
    • 4344708101 scopus 로고    scopus 로고
    • Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes
    • Fujio Y., Matsuda T., Oshima Y., Maeda M., Mohri T., Ito T., et al. Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. FEBS Lett 2004, 573:202-206.
    • (2004) FEBS Lett , vol.573 , pp. 202-206
    • Fujio, Y.1    Matsuda, T.2    Oshima, Y.3    Maeda, M.4    Mohri, T.5    Ito, T.6
  • 55
    • 79955479506 scopus 로고    scopus 로고
    • Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses
    • Schaale K., Neumann J., Schneider D., Ehlers S., Reiling N. Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses. Eur J Cell Biol 2011, 90:553-559.
    • (2011) Eur J Cell Biol , vol.90 , pp. 553-559
    • Schaale, K.1    Neumann, J.2    Schneider, D.3    Ehlers, S.4    Reiling, N.5
  • 56
    • 33645774667 scopus 로고    scopus 로고
    • Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines
    • Pukrop T., Klemm F., Hagemann T., Gradl D., Schulz M., Siemes S., et al. Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A 2006, 103:5454-5459.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5454-5459
    • Pukrop, T.1    Klemm, F.2    Hagemann, T.3    Gradl, D.4    Schulz, M.5    Siemes, S.6
  • 57
    • 84865417394 scopus 로고    scopus 로고
    • Wnt5a activates THP-1 monocytic cells via a beta-catenin-independent pathway involving JNK and NF-kappaB activation
    • Kim J., Chang W., Jung Y., Song K., Lee I. Wnt5a activates THP-1 monocytic cells via a beta-catenin-independent pathway involving JNK and NF-kappaB activation. Cytokine 2012, 60:242-248.
    • (2012) Cytokine , vol.60 , pp. 242-248
    • Kim, J.1    Chang, W.2    Jung, Y.3    Song, K.4    Lee, I.5
  • 58
    • 84907472612 scopus 로고    scopus 로고
    • SiRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-kappaB pathways
    • Yang L., Chu Y., Wang Y., Zhao X., Xu W., Zhang P., et al. siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-kappaB pathways. Int J Mol Med 2014 Jul 22, 10.3892/ijmm.2014.1890.
    • (2014) Int J Mol Med
    • Yang, L.1    Chu, Y.2    Wang, Y.3    Zhao, X.4    Xu, W.5    Zhang, P.6
  • 59
    • 33746225592 scopus 로고    scopus 로고
    • Molecular and cellular basis of rheumatoid joint destruction
    • Karouzakis E., Neidhart M., Gay R.E., Gay S. Molecular and cellular basis of rheumatoid joint destruction. Immunol Lett 2006, 106:8-13.
    • (2006) Immunol Lett , vol.106 , pp. 8-13
    • Karouzakis, E.1    Neidhart, M.2    Gay, R.E.3    Gay, S.4
  • 60
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes I.B., Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007, 7:429-442.
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 61
    • 0036233913 scopus 로고    scopus 로고
    • Wnt signaling in rheumatoid synoviocyte activation
    • Sen M., Carson D.A. Wnt signaling in rheumatoid synoviocyte activation. Mod Rheumatol 2002, 12:5-9.
    • (2002) Mod Rheumatol , vol.12 , pp. 5-9
    • Sen, M.1    Carson, D.A.2
  • 62
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes M.A., Bowcock A.M., Krueger J.G. Pathogenesis and therapy of psoriasis. Nature 2007, 445:866-873.
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 64
    • 65449136296 scopus 로고    scopus 로고
    • Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon
    • Romanowska M., Evans A., Kellock D., Bray S.E., McLean K., Donandt S., et al. Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PloS One 2009, 4:e5354.
    • (2009) PloS One , vol.4 , pp. e5354
    • Romanowska, M.1    Evans, A.2    Kellock, D.3    Bray, S.E.4    McLean, K.5    Donandt, S.6
  • 65
    • 81155139119 scopus 로고    scopus 로고
    • Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via Wnt-5a in humans
    • Bilkovski R., Schulte D.M., Oberhauser F., Mauer J., Hampel B., Gutschow C., et al. Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via Wnt-5a in humans. Int J Obes 2011, 35:1450-1454.
    • (2011) Int J Obes , vol.35 , pp. 1450-1454
    • Bilkovski, R.1    Schulte, D.M.2    Oberhauser, F.3    Mauer, J.4    Hampel, B.5    Gutschow, C.6
  • 66
    • 58649104220 scopus 로고    scopus 로고
    • LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
    • Terrand J., Bruban V., Zhou L., Gong W., El Asmar Z., May P., et al. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 2009, 284(1):381-388.
    • (2009) J Biol Chem , vol.284 , Issue.1 , pp. 381-388
    • Terrand, J.1    Bruban, V.2    Zhou, L.3    Gong, W.4    El Asmar, Z.5    May, P.6
  • 68
    • 77957260181 scopus 로고    scopus 로고
    • Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2
    • Kadl A., Meher A.K., Sharma P.R., Lee M.Y., Doran A.C., Johnstone S.R., et al. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res 2010, 107:737-746.
    • (2010) Circ Res , vol.107 , pp. 737-746
    • Kadl, A.1    Meher, A.K.2    Sharma, P.R.3    Lee, M.Y.4    Doran, A.C.5    Johnstone, S.R.6
  • 69
    • 79151484549 scopus 로고    scopus 로고
    • Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Kruppel-like factor 2
    • van Tits L.J., Stienstra R., van Lent P.L., Netea M.G., Joosten L.A., Stalenhoef A.F. Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Kruppel-like factor 2. Atherosclerosis 2011, 214:345-349.
    • (2011) Atherosclerosis , vol.214 , pp. 345-349
    • van Tits, L.J.1    Stienstra, R.2    van Lent, P.L.3    Netea, M.G.4    Joosten, L.A.5    Stalenhoef, A.F.6
  • 70
    • 70349581878 scopus 로고    scopus 로고
    • Macrophage diversity and polarization in atherosclerosis: a question of balance
    • Mantovani A., Garlanda C., Locati M. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler Thromb Vasc Biol 2009, 29:1419-1423.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1419-1423
    • Mantovani, A.1    Garlanda, C.2    Locati, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.