메뉴 건너뛰기




Volumn 14, Issue 5, 2003, Pages 447-455

Insulin resistance in adipose tissue: Direct and indirect effects of tumor necrosis factor-α

Author keywords

Adipocyte secreted factors; Adipose tissue; Free fatty acid; Insulin resistance; NF B; Obesity; Tumor necrosis factor

Indexed keywords

ADIPOCYTE COMPLEMENT RELATED PROTEIN OF 30KDA; ADIPOCYTE SECRETED PROTEIN; ADIPONECTIN; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PROTEIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0041374029     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(03)00052-2     Document Type: Review
Times cited : (443)

References (112)
  • 1
    • 0022369781 scopus 로고
    • Mechanisms of insulin resistance in noninsulin-dependent (type II) diabetes
    • Olefsky JM, Ciaraldi TP, Kolterman OG. Mechanisms of insulin resistance in noninsulin-dependent (type II) diabetes. Am J Med 1985;79:12-22.
    • (1985) Am J Med , vol.79 , pp. 12-22
    • Olefsky, J.M.1    Ciaraldi, T.P.2    Kolterman, O.G.3
  • 2
    • 0028918346 scopus 로고
    • Insulin resistance and non-insulin-dependent diabetes mellitus: Cellular and molecular mechanisms
    • Olefsky JM, Nolan JJ. Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms. Am J Clin Nutr 1995;61:980S-6S.
    • (1995) Am J Clin Nutr , vol.61
    • Olefsky, J.M.1    Nolan, J.J.2
  • 3
    • 0036254607 scopus 로고    scopus 로고
    • Insulin resistance in type 2 diabetes: Role of fatty acids
    • Arner P. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab Res Rev 2002;18(Suppl 2):S5-9.
    • (2002) Diabetes Metab Res Rev , vol.18 , Issue.SUPPL. 2
    • Arner, P.1
  • 4
    • 0034973768 scopus 로고    scopus 로고
    • Insulin resistance: Definition and consequences
    • Lebovitz HE. Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes 2001;109:S135-48.
    • (2001) Exp Clin Endocrinol Diabetes , vol.109
    • Lebovitz, H.E.1
  • 5
    • 0027512732 scopus 로고
    • Role of insulin resistance in human disease (syndrome X): An expanded definition
    • Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993;44:121-31.
    • (1993) Annu Rev Med , vol.44 , pp. 121-131
    • Reaven, G.M.1
  • 6
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75:473-86.
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 7
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 1996;45:1661-9.
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 8
    • 0035786908 scopus 로고    scopus 로고
    • Insulin resistance and its treatment by thiazolidinediones
    • Lebovitz HE, Banerji MA. Insulin resistance and its treatment by thiazolidinediones. Recent Prog Horm Res 2001;56:265-94.
    • (2001) Recent Prog Horm Res , vol.56 , pp. 265-294
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 10
    • 0035992811 scopus 로고    scopus 로고
    • Glitazones: Clinical effects and molecular mechanisms
    • Stumvoll M, Haring HU. Glitazones: clinical effects and molecular mechanisms. Ann Med 2002;34:217-24.
    • (2002) Ann Med , vol.34 , pp. 217-224
    • Stumvoll, M.1    Haring, H.U.2
  • 11
    • 0035743452 scopus 로고    scopus 로고
    • Insulin resistance and insulin sensitizers
    • Stumvoll M, Haring H. Insulin resistance and insulin sensitizers. Horm Res 2001;55(Suppl 2):3-13.
    • (2001) Horm Res , vol.55 , Issue.SUPPL. 2 , pp. 3-13
    • Stumvoll, M.1    Haring, H.2
  • 14
    • 0036066970 scopus 로고    scopus 로고
    • Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
    • Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 2002;57:1-9.
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 1-9
    • Mauvais-Jarvis, F.1    Kulkarni, R.N.2    Kahn, C.R.3
  • 15
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002;3:25-38.
    • (2002) Dev Cell , vol.3 , pp. 25-38
    • Bluher, M.1    Michael, M.D.2    Peroni, O.D.3    Ueki, K.4    Carter, N.5    Kahn, B.B.6
  • 16
    • 0034783580 scopus 로고    scopus 로고
    • Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance
    • Guerra C, Navarro P, Valverde AM, Arribas M, Bruning J, Kozak LP, et al. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J Clin Invest 2001;108:1205-13.
    • (2001) J Clin Invest , vol.108 , pp. 1205-1213
    • Guerra, C.1    Navarro, P.2    Valverde, A.M.3    Arribas, M.4    Bruning, J.5    Kozak, L.P.6
  • 17
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000;6:87-97.
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6
  • 18
    • 0033524937 scopus 로고    scopus 로고
    • Tissuespecific knockout of the insulin receptor in pancreatic-β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissuespecific knockout of the insulin receptor in pancreatic-β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999;96:329-39.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 19
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 1998;2:559-69.
    • (1998) Mol Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, J.N.3    Hayashi, T.4    Horsch, D.5    Accili, D.6
  • 21
    • 0034308201 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase-1B in diabetes
    • Kennedy BP, Ramachandran C. Protein tyrosine phosphatase-1B in diabetes. Biochem Pharmacol 2000;60:877-83.
    • (2000) Biochem Pharmacol , vol.60 , pp. 877-883
    • Kennedy, B.P.1    Ramachandran, C.2
  • 22
    • 17944402626 scopus 로고    scopus 로고
    • Pi 3-kinase and its up- and down-stream modulators as potential targets for the treatment of type II diabetes
    • Jiang G, Zhang BB. Pi 3-kinase and its up- and down-stream modulators as potential targets for the treatment of type II diabetes. Front Biosci 2002;7:d903-7.
    • (2002) Front Biosci , vol.7
    • Jiang, G.1    Zhang, B.B.2
  • 23
    • 0030292743 scopus 로고    scopus 로고
    • Lilly lecture 1995. Glucose transport: Pivotal step in insulin action
    • Kahn BB. Lilly lecture 1995. Glucose transport: pivotal step in insulin action. Diabetes 1996;45:1644-54.
    • (1996) Diabetes , vol.45 , pp. 1644-1654
    • Kahn, B.B.1
  • 24
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002;283:E413-22.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1
  • 25
    • 0037026739 scopus 로고    scopus 로고
    • Insulin resistance as the core defect in type 2 diabetes mellitus
    • Goldstein BJ. Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 2002;90:3G-10G.
    • (2002) Am J Cardiol , vol.90
    • Goldstein, B.J.1
  • 26
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ
    • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001;60:329-39.
    • (2001) Proc Nutr Soc , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 27
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 1985;76:149-55.
    • (1985) J Clin Invest , vol.76 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3    Olsson, M.4    Wahren, J.5
  • 28
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992;340:925-59.
    • (1992) Lancet , vol.340 , pp. 925-959
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.S.5    Kahn, C.R.6
  • 29
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as 24 precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, et al. Insulin resistance and insulin secretory dysfunction as 24 precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993;329:1988-92.
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6
  • 30
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002;277:50230-6.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 32
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994;93:2438-46.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 34
    • 0030017591 scopus 로고    scopus 로고
    • Free fatty acids, insulin resistance and lipoprotein metabolism
    • Laws A. Free fatty acids, insulin resistance and lipoprotein metabolism. Curr Opin Lipidol 1996;7:172-7.
    • (1996) Curr Opin Lipidol , vol.7 , pp. 172-177
    • Laws, A.1
  • 35
    • 0024593478 scopus 로고
    • Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids
    • Saxena U, Witte LD, Goldberg IJ. Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids. J Biol Chem 1989;264:4349-55.
    • (1989) J Biol Chem , vol.264 , pp. 4349-4355
    • Saxena, U.1    Witte, L.D.2    Goldberg, I.J.3
  • 36
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced-β cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced-β cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95:2498-502.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 37
    • 0036828912 scopus 로고    scopus 로고
    • Profiling gene transcription in vivo reveals adipose tissue as an immediate target of TNF-α: Implications for insulin resistance
    • Ruan H, Miles PDG, Ladd CM, Ross K, Golub TR, Olefsky JM, et al. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of TNF-α: implications for insulin resistance. Diabetes 2002;51:3176-88.
    • (2002) Diabetes , vol.51 , pp. 3176-3188
    • Ruan, H.1    Miles, P.D.G.2    Ladd, C.M.3    Ross, K.4    Golub, T.R.5    Olefsky, J.M.6
  • 39
    • 0022371461 scopus 로고
    • Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
    • Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YC, Mathison J, et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 1985;316:552-4.
    • (1985) Nature , vol.316 , pp. 552-554
    • Beutler, B.1    Greenwald, D.2    Hulmes, J.D.3    Chang, M.4    Pan, Y.C.5    Mathison, J.6
  • 40
    • 0000072070 scopus 로고
    • Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells
    • Kawakami M, Pekala PH, Lane MD, Cerami A. Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. Proc Natl Acad Sci USA 1982;79:912-6.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 912-916
    • Kawakami, M.1    Pekala, P.H.2    Lane, M.D.3    Cerami, A.4
  • 41
    • 0019447659 scopus 로고
    • Studies of endotoxin-induced decrease in lipoprotein lipase activity
    • Kawakami M, Cerami A. Studies of endotoxin-induced decrease in lipoprotein lipase activity. J Exp Med 1981;154:631-9.
    • (1981) J Exp Med , vol.154 , pp. 631-639
    • Kawakami, M.1    Cerami, A.2
  • 43
    • 0023916786 scopus 로고
    • Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation
    • Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med 1988;167:1211-27.
    • (1988) J Exp Med , vol.167 , pp. 1211-1227
    • Tracey, K.J.1    Wei, H.2    Manogue, K.R.3    Fong, Y.4    Hesse, D.G.5    Nguyen, H.T.6
  • 44
    • 0024281428 scopus 로고
    • A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF
    • Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 1988;53:45-53.
    • (1988) Cell , vol.53 , pp. 45-53
    • Kriegler, M.1    Perez, C.2    DeFay, K.3    Albert, I.4    Lu, S.D.5
  • 48
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 49
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995;95:2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 50
  • 51
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111-9.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 53
    • 0026549669 scopus 로고
    • Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
    • Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992;130:43-52.
    • (1992) Endocrinology , vol.130 , pp. 43-52
    • Lang, C.H.1    Dobrescu, C.2    Bagby, G.J.3
  • 54
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α. J Clin Invest 1994;94:1543-9.
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 55
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesityinduced insulin resistance in mice lacking TNF-α function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesityinduced insulin resistance in mice lacking TNF-α function. Nature 1997;389:610-4.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 56
    • 0031757099 scopus 로고    scopus 로고
    • Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity
    • Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity. Endocrinology 1998;139:4832-8.
    • (1998) Endocrinology , vol.139 , pp. 4832-4838
    • Uysal, K.T.1    Wiesbrock, S.M.2    Hotamisligil, G.S.3
  • 57
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996;45:881-5.
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 58
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle P, Garland C, Hales C, Newsholme E. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-9.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.1    Garland, C.2    Hales, C.3    Newsholme, E.4
  • 59
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle PJ, Garland PB, Newsholme EA, Hales CN. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann N Y Acad Sci 1965;131:324-33.
    • (1965) Ann N Y Acad Sci , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 60
    • 0026002683 scopus 로고
    • Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
    • Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 1991;88:960-6.
    • (1991) J Clin Invest , vol.88 , pp. 960-966
    • Boden, G.1    Jadali, F.2    White, J.3    Liang, Y.4    Mozzoli, M.5    Chen, X.6
  • 61
    • 0021258643 scopus 로고
    • Correlation between muscle glycogen synthase activity and in vivo insulin action in man
    • Bogardus C, Lillioja S, Stone K, Mott D. Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 1984;73:1185-90.
    • (1984) J Clin Invest , vol.73 , pp. 1185-1190
    • Bogardus, C.1    Lillioja, S.2    Stone, K.3    Mott, D.4
  • 62
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990;322:223-8.
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 63
    • 0025764186 scopus 로고
    • Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulindependent) diabetes mellitus
    • Saloranta C, Franssila-Kallunki A, Ekstrand A, Taskinen MR, Groop L. Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulindependent) diabetes mellitus. Diabetologia 1991;34:409-15.
    • (1991) Diabetologia , vol.34 , pp. 409-415
    • Saloranta, C.1    Franssila-Kallunki, A.2    Ekstrand, A.3    Taskinen, M.R.4    Groop, L.5
  • 64
    • 0014480810 scopus 로고
    • Role of free fatty acids in glucose homeostasis
    • Ruderman NB, Toews CJ, Shafrir E. Role of free fatty acids in glucose homeostasis. Arch Intern Med 1969;123:299-313.
    • (1969) Arch Intern Med , vol.123 , pp. 299-313
    • Ruderman, N.B.1    Toews, C.J.2    Shafrir, E.3
  • 65
    • 0025946231 scopus 로고
    • Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells
    • Byrne CD, Brindle NP, Wang TW, Hales CN. Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells. Biochem J 1991;280:99-104.
    • (1991) Biochem J , vol.280 , pp. 99-104
    • Byrne, C.D.1    Brindle, N.P.2    Wang, T.W.3    Hales, C.N.4
  • 66
    • 0026485386 scopus 로고
    • Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin
    • Byrne CD, Wang TW, Hales CN. Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin. Biochem J 1992;288:101-7.
    • (1992) Biochem J , vol.288 , pp. 101-107
    • Byrne, C.D.1    Wang, T.W.2    Hales, C.N.3
  • 67
    • 0027531667 scopus 로고
    • Regulation of hepatic secretion of apolipoprotein Bcontaining lipoproteins: Information obtained from cultured liver cells
    • Dixon JL, Ginsberg HN. Regulation of hepatic secretion of apolipoprotein Bcontaining lipoproteins: information obtained from cultured liver cells. J Lipid Res 1993;34:167-79.
    • (1993) J Lipid Res , vol.34 , pp. 167-179
    • Dixon, J.L.1    Ginsberg, H.N.2
  • 68
    • 0030008060 scopus 로고    scopus 로고
    • Fatty acids and insulin resistance
    • Boden G. Fatty acids and insulin resistance. Diabetes Care 1996;19:394-5.
    • (1996) Diabetes Care , vol.19 , pp. 394-395
    • Boden, G.1
  • 72
    • 0023845559 scopus 로고
    • Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocininduced diabetes
    • Reaven GM, Chang H, Hoffman BB. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocininduced diabetes. Diabetes 1988;37:28-32.
    • (1988) Diabetes , vol.37 , pp. 28-32
    • Reaven, G.M.1    Chang, H.2    Hoffman, B.B.3
  • 73
    • 0015857066 scopus 로고
    • Influence of nicotinic acid on the rates of turnover and oxidation of plasma glucose in man
    • Balasse EO, Neef MA. Influence of nicotinic acid on the rates of turnover and oxidation of plasma glucose in man. Metabolism 1973;22:1193-204.
    • (1973) Metabolism , vol.22 , pp. 1193-1204
    • Balasse, E.O.1    Neef, M.A.2
  • 74
    • 0031716376 scopus 로고    scopus 로고
    • Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
    • Boden G, Chen X, Iqbal N. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes 1998;47:1609-12.
    • (1998) Diabetes , vol.47 , pp. 1609-1612
    • Boden, G.1    Chen, X.2    Iqbal, N.3
  • 75
    • 0025007289 scopus 로고
    • Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans
    • Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA. Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol 1990;259:E736-50.
    • (1990) Am J Physiol , vol.259
    • Bonadonna, R.C.1    Groop, L.C.2    Zych, K.3    Shank, M.4    DeFronzo, R.A.5
  • 76
    • 0023226232 scopus 로고
    • Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with type 2 (noninsulin-dependent) diabetes
    • Swislocki AL, Chen YD, Golay A, Chang MO, Reaven GM. Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with type 2 (noninsulin-dependent) diabetes. Diabetologia 1987;30:622-6.
    • (1987) Diabetologia , vol.30 , pp. 622-626
    • Swislocki, A.L.1    Chen, Y.D.2    Golay, A.3    Chang, M.O.4    Reaven, G.M.5
  • 77
    • 0025827712 scopus 로고
    • Regulation of non-esterified fatty acid and glycerol concentration by insulin in normal individuals and patients with type 2 diabetes
    • Skowronski R, Hollenbeck CB, Varasteh BB, Chen YD, Reaven GM. Regulation of non-esterified fatty acid and glycerol concentration by insulin in normal individuals and patients with type 2 diabetes. Diabet Med 1991;8:330-3.
    • (1991) Diabet Med , vol.8 , pp. 330-333
    • Skowronski, R.1    Hollenbeck, C.B.2    Varasteh, B.B.3    Chen, Y.D.4    Reaven, G.M.5
  • 78
    • 0031034428 scopus 로고    scopus 로고
    • Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Relation to plasma triglyceride and apolipoprotein B concentrations
    • Insulin Resistance Atherosclerosis Study (IRAS) Investigators
    • Laws A, Hoen HM, Selby JV, Saad MF, Haffner SM, Howard BV. Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Relation to plasma triglyceride and apolipoprotein B concentrations. Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Arterioscler Thromb Vasc Biol 1997;17:64-71.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 64-71
    • Laws, A.1    Hoen, H.M.2    Selby, J.V.3    Saad, M.F.4    Haffner, S.M.5    Howard, B.V.6
  • 80
    • 0023153344 scopus 로고
    • Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus
    • Chen YD, Golay A, Swislocki AL, Reaven GM. Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987;64:17-21.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 17-21
    • Chen, Y.D.1    Golay, A.2    Swislocki, A.L.3    Reaven, G.M.4
  • 81
    • 0011682519 scopus 로고
    • Hormonal regulation of hormone-sensitive lipase in intact adipocytes: Identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin
    • Stralfors P, Bjorgell P, Belfrage P. Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin. Proc Natl Acad Sci USA 1984;81:3317-21.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3317-3321
    • Stralfors, P.1    Bjorgell, P.2    Belfrage, P.3
  • 82
    • 0024307638 scopus 로고
    • Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity
    • Stralfors P, Honnor RC. Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity. Eur J Biochem 1989;182:379-85.
    • (1989) Eur J Biochem , vol.182 , pp. 379-385
    • Stralfors, P.1    Honnor, R.C.2
  • 83
    • 0024341125 scopus 로고
    • Insulin regulation of lipolysis in nondiabetic and IDDM subjects
    • Jensen MD, Caruso M, Heiling V, Miles JM. Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes 1989;38:1595-601.
    • (1989) Diabetes , vol.38 , pp. 1595-1601
    • Jensen, M.D.1    Caruso, M.2    Heiling, V.3    Miles, J.M.4
  • 84
    • 0027085687 scopus 로고
    • Regulation of free fatty acid metabolism by insulin in humans: Role of lipolysis and reesterification
    • Campbell PJ, Carlson MG, Hill JO, Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 1992;263:E1063-9.
    • (1992) Am J Physiol , vol.263
    • Campbell, P.J.1    Carlson, M.G.2    Hill, J.O.3    Nurjhan, N.4
  • 85
    • 0021822478 scopus 로고
    • Antilipolytic action of insulin: Role of cAMP phosphodiesterase activation
    • Elks ML, Manganiello VC. Antilipolytic action of insulin: role of cAMP phosphodiesterase activation. Endocrinology 1985;116:2119-21.
    • (1985) Endocrinology , vol.116 , pp. 2119-2121
    • Elks, M.L.1    Manganiello, V.C.2
  • 86
    • 0022377539 scopus 로고
    • Molecular mechanisms for hormonal control of adipose tissue lipolysis
    • Belfrage P, Fredrikson G, Olsson H, Stralfors P. Molecular mechanisms for hormonal control of adipose tissue lipolysis. Int J Obes 1985;9(Suppl 1):129-35.
    • (1985) Int J Obes , vol.9 , Issue.SUPPL. 1 , pp. 129-135
    • Belfrage, P.1    Fredrikson, G.2    Olsson, H.3    Stralfors, P.4
  • 87
    • 0019847943 scopus 로고
    • Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase
    • Belfrage P, Fredrikson G, Nilsson NO, Stralfors P. Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase. Int J Obes 1981;5:635-41.
    • (1981) Int J Obes , vol.5 , pp. 635-641
    • Belfrage, P.1    Fredrikson, G.2    Nilsson, N.O.3    Stralfors, P.4
  • 88
    • 0035834709 scopus 로고    scopus 로고
    • Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol
    • Igal RA, Wang S, Gonzalez-Baro M, Coleman RA. Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol. J Biol Chem 2001;276:42205-12.
    • (2001) J Biol Chem , vol.276 , pp. 42205-42212
    • Igal, R.A.1    Wang, S.2    Gonzalez-Baro, M.3    Coleman, R.A.4
  • 89
    • 0035145685 scopus 로고    scopus 로고
    • Overexpression of 1-acyl-glycerol-3-phosphate acyltransferase-α enhances lipid storage in cellular models of adipose tissue and skeletal muscle
    • Ruan H, Pownall HJ. Overexpression of 1-acyl-glycerol-3-phosphate acyltransferase-α enhances lipid storage in cellular models of adipose tissue and skeletal muscle. Diabetes 2001;50:233-40.
    • (2001) Diabetes , vol.50 , pp. 233-240
    • Ruan, H.1    Pownall, H.J.2
  • 90
  • 91
    • 0029836585 scopus 로고    scopus 로고
    • Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
    • Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996;120:803-12.
    • (1996) J Biochem (Tokyo) , vol.120 , pp. 803-812
    • Nakano, Y.1    Tobe, T.2    Choi-Miura, N.H.3    Mazda, T.4    Tomita, M.5
  • 92
    • 0029980285 scopus 로고    scopus 로고
    • cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1)
    • Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-9.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 93
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-703.
    • (1996) J Biol Chem , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 94
    • 0036511213 scopus 로고    scopus 로고
    • ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism
    • Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84-9.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 84-89
    • Berg, A.H.1    Combs, T.P.2    Scherer, P.E.3
  • 95
    • 0032510463 scopus 로고    scopus 로고
    • The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
    • Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998;8:335-8.
    • (1998) Curr Biol , vol.8 , pp. 335-338
    • Shapiro, L.1    Scherer, P.E.2
  • 96
    • 0034961514 scopus 로고    scopus 로고
    • Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: Regulation by amino acid concentrations
    • Bogan JS, McKee AE, Lodish HF. Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations. Mol Cell Biol 2001;21:4785-806.
    • (2001) Mol Cell Biol , vol.21 , pp. 4785-4806
    • Bogan, J.S.1    McKee, A.E.2    Lodish, H.F.3
  • 97
    • 0036313033 scopus 로고    scopus 로고
    • Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-κB activation by TNF-α is obligatory
    • Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF. Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-κB activation by TNF-α is obligatory. Diabetes 2002;51:1319-36.
    • (2002) Diabetes , vol.51 , pp. 1319-1336
    • Ruan, H.1    Hacohen, N.2    Golub, T.R.3    Van Parijs, L.4    Lodish, H.F.5
  • 99
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kDa by PPARγ agonists: A potential mechanism of insulin sensitization
    • Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, et al. Induction of adipocyte complement-related protein of 30 kDa by PPARγ agonists: a potential mechanism of insulin sensitization. Endocrinology 2002;143:998-1007.
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3    Doebber, T.4    Wang, W.J.5    Zhang, B.B.6
  • 100
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30 kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, et al. Proteolytic cleavage product of 30 kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001;98:2005-10.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.5    Yen, F.T.6
  • 101
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5    Uchida, S.6
  • 102
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang CcC, Itani SI, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002;99:16309-13.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang, C.C.C.5    Itani, S.I.6
  • 103
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
    • Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001;108:1875-81.
    • (2001) J Clin Invest , vol.108 , pp. 1875-1881
    • Combs, T.P.1    Berg, A.H.2    Obici, S.3    Scherer, P.E.4    Rossetti, L.5
  • 104
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-53.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 105
    • 0037135523 scopus 로고    scopus 로고
    • Disruption of adiponectin causes insulin resistance and neointimal formation
    • Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002;277:25863-6.
    • (2002) J Biol Chem , vol.277 , pp. 25863-25866
    • Kubota, N.1    Terauchi, Y.2    Yamauchi, T.3    Kubota, T.4    Moroi, M.5    Matsui, J.6
  • 107
    • 0037144394 scopus 로고    scopus 로고
    • Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin
    • Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, et al. Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 2002;277:34658-61.
    • (2002) J Biol Chem , vol.277 , pp. 34658-34661
    • Ma, K.1    Cabrero, A.2    Saha, P.K.3    Kojima, H.4    Li, L.5    Chang, B.H.6
  • 108
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity
    • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 2003;278:9073-85.
    • (2003) J Biol Chem , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6
  • 109
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 1996;271:665-8.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 110
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 2001;293:1673-7.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6
  • 111
    • 0036307845 scopus 로고    scopus 로고
    • Role of peroxisome proliferatoractivated receptor-γ in maintenance of the characteristics of mature 3T3-L1 adipocytes
    • Tamori Y, Masugi J, Nishino N, Kasuga M. Role of peroxisome proliferatoractivated receptor-γ in maintenance of the characteristics of mature 3T3-L1 adipocytes. Diabetes 2002;51:2045-55.
    • (2002) Diabetes , vol.51 , pp. 2045-2055
    • Tamori, Y.1    Masugi, J.2    Nishino, N.3    Kasuga, M.4
  • 112
    • 0042867242 scopus 로고    scopus 로고
    • Troglitazone antagonizes TNF-α-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kB
    • Ruan H, Pownall HJ, Lodish HF. Troglitazone antagonizes TNF-α-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kB. J Biol Chem 2003;278:28181-92.
    • (2003) J Biol Chem , vol.278 , pp. 28181-28192
    • Ruan, H.1    Pownall, H.J.2    Lodish, H.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.