Bariatric Surgery Improves Histological Features of Nonalcoholic Fatty Liver Disease and Liver Fibrosis

Journal of Gastrointestinal Surgery

Volumn 19, Issue 3, 2015, Pages 429-437

  Taitano, Andrew A ^a,b   Markow, Michael ^b   Finan, Jon E ^b   Wheeler, Donald E ^b   Gonzalvo, John Paul ^a,b   Murr, Michel M ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cirrhosis; Lipotoxicity; Liver biopsy; Liver injury; Roux en Y gastric bypass

Indexed keywords

ADULT; AGED; BARIATRIC SURGERY; BIOPSY; COMPLICATION; FEMALE; HEPATITIS; HUMAN; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; OBESITY, MORBID; PATHOLOGY; PREVALENCE; SINGLE BLIND PROCEDURE; YOUNG ADULT;

ADULT; AGED; BARIATRIC SURGERY; BIOPSY; FEMALE; HEPATITIS; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; PREVALENCE; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84925495884     PISSN: 1091255X     EISSN: 18734626     Source Type: Journal    
DOI: 10.1007/s11605-014-2678-y     Document Type: Article

References (27)

1. Burk, A, and Lucey MR. “Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Orthotopic Liver Transplantation.” American Journal of Transplantation; 4: 686–693. Doi:10.1111/j.1600-6143.2004.00432.x.
2. Hui, J, Kench, JG, Chitturi S, Sud, A, Farrell, GC, Byth, K, Hall, P, Khan, M, George, J. “Long-Term Outcomes of Cirrhosis in Nonalcoholic Steatohepatitis Compared with Hepatitis C.” Hepatology; (2003) 38;2: 420–27. DOI: 10.1053/jhep.2003.50320.
3. Argo, CK, Northup, PG, Al-Osaimi, AMS, Caldwell, SH. “Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis.” Journal of Hepatology; 51 (2009) 371–379. Doi:10.1016/j.jhep.2009.03.019.
4. Lazo, M., R. Hernaez, M. S. Eberhardt, S. Bonekamp, I. Kamel, E. Guallar, A. Koteish, F. L. Brancati, and J. M. Clark. “Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994.” American Journal of Epidemiology 178, 1 (12, 2013): 38–45. doi:10.1093/aje/kws448.
5. Shalhub S, Parsee A, Gallagher SF, Haines KL, Willkomm C, Brantley SG, Pinkas H, Saff-Koche L, MM Murr. “The Importance of Routine Liver Biopsy in Diagnosing Nonalcoholic Steatohepatitis in Bariatric Patients.” Obesity Surgery 14, 1 (12, 2004): 54–59. doi:10.1381/096089204772787293.
6. Liu X, Lazenby AJ, Clements RH, Jhala N, Abrams GA. Resolution of nonalcoholic steatohepatits after gastric bypass surgery. Obes Surg. 2007 Apr;17(4):486–92.
7. Kral JG, Thung SN, Biron S, Hould FS, Lebel S, Marceau S, Simard S, Marceau P. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004 Jan;135(1):48–58
8. Silverman EM, Sapala JA, Allepman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol. 1995;104:23–31.
9. Frantzides CT, Carlson MA, Moore RE, et al. Effect of body mass index on non-alcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. J gastrointest surg. 2004;8:849–855.
10. Dixon JB, Bhathal PS, Hughes NR, et al. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology. 2004;39:1647–1654.
11. Mattar, Samer G., Laura M. Velcu, Mordechai Rabinovitz, A. J. Demetris, A. M. Krasinskas, Emma Barinas-Mitchell, George M. Eid, Ramesh Ramanathan, Debra S. Taylor, and Philip R. Schauer. “Surgically-Induced Weight Loss Significantly Improves Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome.” Transactions of the … Meeting of the American Surgical Association 123, no. &NA; (12 2005): 304–14. doi:10.1097/01.sla.0000179652.07502.3
12. Víctor Vargas, Helena Allende, Albert Lecube, Maria Teresa Salcedo, Juan A Baena-Fustegueras, José M Fort, Joaquín Rivero, Roser Ferrer, Roberto Catalán, Eva Pardina, Santiago Ramón y Cajal, Jaime Guardia, Julia Peinado-Onsurbe “Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients” World J Hepatol. 2012 December 27; 4(12): 382–388. Published online 2012 December 27. doi: 10.4254/wjh.v4.i12.382
13. Adams, LA, Lymp, JF, St. Sauver, J, Sanderson, SO, Lindor, KD, Feldstein A, Angulo P. “The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study.” Gastroenterology; 2005;129:113–121. Doi:10.1053/j.gastro.2005.04.014.
14. Mathurin, P, Hollerbecque, A, Arnalsteen, L, Buob, D, Leteurtre, Emmanuelle, Caiazzo, R, Pigeyre, M, Verkindt, H, Dharancy S, Louvet, A, Romon, M, Pattou, F. “Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease.” Gastroenterology; 2009; 137:532–540. Doi:10.1053/j.gastro.2009.04.052.
15. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions Am J Gastroenterol. 1999 Sep;94(9):2467–74.
16. Brunt, EM, Kleiner, DE, Wilson, LA, Belt, P, Neuschwander-Tetri, BA. “NASH Clinical Research Network (CRN): The NAS and The Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings.” Hepatology. 53(3):810–20. 2011
17. Brunt EM: Non-alcoholic fatty liver disease: what’s new under the microscope?. Gut 60:1152–8. 2011
18. Clark JM, The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006 Mar; 40 Suppl 1:S5-10.
19. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, Fava JL, Wing RR. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010 Jan;51(1):121–9. doi: 10.1002/hep.23276.
20. Huang MA1, Greenson JK, Chao C, Anderson L, Peterman D, Jacobson J, Emick D, Lok AS, Conjeevaram HS. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol. 2005 May;100(5):1072–81.
21. Wong VW1, Wong GL, Choi PC, Chan AW, Li MK, Chan HY, Chim AM, Yu J, Sung JJ, Chan HL. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut. 2010 Jul;59(7):969–74. doi: 10.1136/gut.2009.205088.
22. Adams, L. A., Sanderson, S., Lindor, K. D., & Angulo, P. (2005, 12). The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies. Journal of Hepatology, 42(1), 132–138. doi: 10.1016/j.jhep.2004.09.012
23. Duvnjak M, Lerotic I, Barsic N, Tomasic V, Virovic JL, Velagic V. Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol. 2007;13(34):4539–4550.
24. Mehta K, Van Thiel D, Shah N, Mobarhan S. Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutr Rev. 2002;60(9):289–293;
25. Peng Y, Rideout DA, Rakita SS, Gower WR Jr, You M, Murr MM. Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats? J Gastrointest Surg. 2010 Feb; 14(2):221–8. Doi:10.1007/s11605-009-1102-5.
26. Peng Y, Rideout D, Rakita S, Lee J, Murr M. Diet-induced obesity associated with steatosis, oxidative stress, and inflammation in liver. Surg Obes Relat Dis. 2012 Jan-Feb;8(1):73–81. doi: 10.1016/j.soard.2011.07.019. Epub 2011 Aug 27.
27. Peng Y, Murr MM. Roux-en-Y gastric bypass improves hepatic mitochondrial function in obese rats. Peng Y, Murr MM. Surg Obes Relat Dis. 2013 May-Jun;9(3):429–35.