-
1
-
-
79959517565
-
Human fatty liver disease: Old questions and new insights
-
Cohen, J. C., Horton, J. D., and Hobbs, H. H. (2011) Human fatty liver disease: old questions and new insights. Science 332, 1519-1523
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
2
-
-
84902672359
-
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
-
Yki-Järvinen, H. (2014) Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2, 901-910
-
(2014)
Lancet Diabetes Endocrinol.
, vol.2
, pp. 901-910
-
-
Yki-Järvinen, H.1
-
4
-
-
84888065527
-
Relation of nonalcoholic fatty liver disease to the metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis
-
Zeb, I., Katz, R., Nasir, K., Ding, J., Rezaeian, P., and Budoff, M. J. (2013) Relation of nonalcoholic fatty liver disease to the metabolic syndrome: the Multi-Ethnic Study of Atherosclerosis. J. Cardiovasc. Comput. Tomogr. 7, 311-318
-
(2013)
J. Cardiovasc. Comput. Tomogr.
, vol.7
, pp. 311-318
-
-
Zeb, I.1
Katz, R.2
Nasir, K.3
Ding, J.4
Rezaeian, P.5
Budoff, M.J.6
-
5
-
-
84901485469
-
Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population
-
Kim, N. H., Park, J., Kim, S. H., Kim, Y. H., Kim, D. H., Cho, G. Y., Baik, I., Lim, H. E., Kim, E. J., Na, J. O., Lee, J. B., Lee, S. K., and Shin, C. (2014) Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population. Heart 100, 938-943
-
(2014)
Heart
, vol.100
, pp. 938-943
-
-
Kim, N.H.1
Park, J.2
Kim, S.H.3
Kim, Y.H.4
Kim, D.H.5
Cho, G.Y.6
Baik, I.7
Lim, H.E.8
Kim, E.J.9
Na, J.O.10
Lee, J.B.11
Lee, S.K.12
Shin, C.13
-
6
-
-
84924099832
-
Nonalcoholic fatty liver disease is associated with significant coronary artery disease in type 2 diabetic patients: A computed tomography angiography study
-
Idilman, I. S., Akata, D., Hazirolan, T., Doganay Erdogan, B., Aytemir, K., and Karcaaltincaba, M. (2015) Nonalcoholic fatty liver disease is associated with significant coronary artery disease in type 2 diabetic patients: a computed tomography angiography study. J. Diabetes 7, 279-286
-
(2015)
J. Diabetes
, vol.7
, pp. 279-286
-
-
Idilman, I.S.1
Akata, D.2
Hazirolan, T.3
Doganay Erdogan, B.4
Aytemir, K.5
Karcaaltincaba, M.6
-
7
-
-
33847656105
-
LRP6 mutation in a family with early coronary disease and metabolic risk factors
-
Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M. A., Nelson-Williams, C., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., and Lifton, R. P. (2007) LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315, 1278-1282
-
(2007)
Science
, vol.315
, pp. 1278-1282
-
-
Mani, A.1
Radhakrishnan, J.2
Wang, H.3
Mani, A.4
Mani, M.A.5
Nelson-Williams, C.6
Carew, K.S.7
Mane, S.8
Najmabadi, H.9
Wu, D.10
Lifton, R.P.11
-
8
-
-
84881616727
-
Rare nonconservative LRP6 mutations are associated with metabolic syndrome
-
Singh, R., Smith, E., Fathzadeh, M., Liu, W., Go, G. W., Subrahmanyan, L., Faramarzi, S., McKenna, W., and Mani, A. (2013) Rare nonconservative LRP6 mutations are associated with metabolic syndrome. Hum. Mutat. 34, 1221-1225
-
(2013)
Hum. Mutat.
, vol.34
, pp. 1221-1225
-
-
Singh, R.1
Smith, E.2
Fathzadeh, M.3
Liu, W.4
Go, G.W.5
Subrahmanyan, L.6
Faramarzi, S.7
McKenna, W.8
Mani, A.9
-
9
-
-
84893455140
-
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue
-
Go, G. W., Srivastava, R., Hernandez-Ono, A., Gang, G., Smith, S. B., Booth, C. J., Ginsberg, H. N., and Mani, A. (2014) The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab. 19, 209-220
-
(2014)
Cell Metab.
, vol.19
, pp. 209-220
-
-
Go, G.W.1
Srivastava, R.2
Hernandez-Ono, A.3
Gang, G.4
Smith, S.B.5
Booth, C.J.6
Ginsberg, H.N.7
Mani, A.8
-
10
-
-
80054806707
-
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease
-
Huang, Y., Cohen, J. C., and Hobbs, H. H. (2011) Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. J. Biol. Chem. 286, 37085-37093
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 37085-37093
-
-
Huang, Y.1
Cohen, J.C.2
Hobbs, H.H.3
-
11
-
-
77956636268
-
The association of genetic variability in patatinlike phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
-
Rotman, Y., Koh, C., Zmuda, J. M., Kleiner, D. E., and Liang, T. J.; NASH CRN. (2010) The association of genetic variability in patatinlike phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 52, 894-903
-
(2010)
Hepatology
, vol.52
, pp. 894-903
-
-
NASH CRN1
Rotman, Y.2
Koh, C.3
Zmuda, J.M.4
Kleiner, D.E.5
Liang, T.J.6
-
12
-
-
64049118574
-
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo
-
Bryja, V., Andersson, E. R., Schambony, A., Esner, M., Bryjová, L., Biris, K. K., Hall, A. C., Kraft, B., Cajanek, L., Yamaguchi, T. P., Buckingham, M., and Arenas, E. (2009) The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol. Biol. Cell 20, 924-936
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 924-936
-
-
Bryja, V.1
Andersson, E.R.2
Schambony, A.3
Esner, M.4
Bryjová, L.5
Biris, K.K.6
Hall, A.C.7
Kraft, B.8
Cajanek, L.9
Yamaguchi, T.P.10
Buckingham, M.11
Arenas, E.12
-
13
-
-
84857545934
-
Proinflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulatedby nutritional factorsin obese human subjects
-
Schulte, D. M., Müller, N., Neumann, K., Oberhäuser, F., Faust, M., Güdelhöfer, H., Brandt, B., Krone, W., and Laudes, M. (2012) Proinflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulatedby nutritional factorsin obese human subjects. PLoS One 7, e32437
-
(2012)
PLoS One
, vol.7
, pp. e32437
-
-
Schulte, D.M.1
Müller, N.2
Neumann, K.3
Oberhäuser, F.4
Faust, M.5
Güdelhöfer, H.6
Brandt, B.7
Krone, W.8
Laudes, M.9
-
14
-
-
26244445594
-
Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori
-
Lu, H., Wu, J. Y., Kudo, T., Ohno, T., Graham, D. Y., and Yamaoka, Y. (2005) Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori. Mol. Biol. Cell 16, 4954-4966
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4954-4966
-
-
Lu, H.1
Wu, J.Y.2
Kudo, T.3
Ohno, T.4
Graham, D.Y.5
Yamaoka, Y.6
-
15
-
-
70350125752
-
Rho kinase (ROCK) inhibitors and their application to inflammatory disorders
-
Lo Grasso, P. V., and Feng, Y. (2009) Rho kinase (ROCK) inhibitors and their application to inflammatory disorders. Curr. Top. Med. Chem. 9, 704-723
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 704-723
-
-
Lo Grasso, P.V.1
Feng, Y.2
-
16
-
-
77954844177
-
Sfrp5 is an antiinflammatory adipokine that modulates metabolic dysfunction in obesity
-
Ouchi, N., Higuchi, A., Ohashi, K., Oshima, Y., Gokce, N., Shibata, R., Akasaki, Y., Shimono, A., and Walsh, K. (2010) Sfrp5 is an antiinflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329, 454-457
-
(2010)
Science
, vol.329
, pp. 454-457
-
-
Ouchi, N.1
Higuchi, A.2
Ohashi, K.3
Oshima, Y.4
Gokce, N.5
Shibata, R.6
Akasaki, Y.7
Shimono, A.8
Walsh, K.9
-
17
-
-
84873395406
-
LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans
-
Singh, R., De Aguiar, R. B., Naik, S., Mani, S., Ostadsharif, K., Wencker, D., Sotoudeh, M., Malekzadeh, R., Sherwin, R. S., and Mani, A. (2013) LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. Cell Metab. 17, 197-209
-
(2013)
Cell Metab.
, vol.17
, pp. 197-209
-
-
Singh, R.1
De Aguiar, R.B.2
Naik, S.3
Mani, S.4
Ostadsharif, K.5
Wencker, D.6
Sotoudeh, M.7
Malekzadeh, R.8
Sherwin, R.S.9
Mani, A.10
-
18
-
-
77955480360
-
Wnt5a induces endothelial inflammation via betacatenin-independent signaling
-
Kim, J., Kim, J., Kim, D. W., Ha, Y., Ihm, M. H., Kim, H., Song, K., and Lee, I. (2010) Wnt5a induces endothelial inflammation via betacatenin-independent signaling. J. Immunol. 185, 1274-1282
-
(2010)
J. Immunol.
, vol.185
, pp. 1274-1282
-
-
Kim, J.1
Kim, J.2
Kim, D.W.3
Ha, Y.4
Ihm, M.H.5
Kim, H.6
Song, K.7
Lee, I.8
-
19
-
-
77957913899
-
New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies
-
Watsky, M. A., Weber, K. T., Sun, Y., and Postlethwaite, A. (2010) New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies. Int. Rev. Cell Mol. Biol. 282, 165-192
-
(2010)
Int. Rev. Cell Mol. Biol.
, vol.282
, pp. 165-192
-
-
Watsky, M.A.1
Weber, K.T.2
Sun, Y.3
Postlethwaite, A.4
-
20
-
-
41149107510
-
The myofibroblast: Phenotypic characterization as a prerequisite to understanding its functions in translational medicine
-
Eyden, B. (2008) The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J. Cell. Mol. Med. 12, 22-37
-
(2008)
J. Cell. Mol. Med.
, vol.12
, pp. 22-37
-
-
Eyden, B.1
-
21
-
-
0035143413
-
Triggering theinductionof myofibroblast and fibrogenesis by airway epithelial shedding
-
Morishima, Y., Nomura, A., Uchida, Y., Noguchi, Y., Sakamoto, T., Ishii, Y., Goto, Y., Masuyama, K., Zhang, M. J., Hirano, K., Mochizuki, M., Ohtsuka, M., and Sekizawa, K. (2001) Triggering theinductionof myofibroblast and fibrogenesis by airway epithelial shedding. Am. J. Respir. Cell Mol. Biol. 24, 1-11
-
(2001)
Am. J. Respir. Cell Mol. Biol.
, vol.24
, pp. 1-11
-
-
Morishima, Y.1
Nomura, A.2
Uchida, Y.3
Noguchi, Y.4
Sakamoto, T.5
Ishii, Y.6
Goto, Y.7
Masuyama, K.8
Zhang, M.J.9
Hirano, K.10
Mochizuki, M.11
Ohtsuka, M.12
Sekizawa, K.13
-
22
-
-
84877045248
-
Origins and functions of liver myofibroblasts
-
Lemoinne, S., Cadoret, A., El Mourabit, H., Thabut, D., and Housset, C. (2013) Origins and functions of liver myofibroblasts. Biochim. Biophys. Acta 1832, 948-954
-
(2013)
Biochim. Biophys. Acta
, vol.1832
, pp. 948-954
-
-
Lemoinne, S.1
Cadoret, A.2
El Mourabit, H.3
Thabut, D.4
Housset, C.5
-
23
-
-
0035135641
-
High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells
-
Ha, H., Yu, M. R., and Lee, H. B. (2001) High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells. Kidney Int. 59, 463-470
-
(2001)
Kidney Int.
, vol.59
, pp. 463-470
-
-
Ha, H.1
Yu, M.R.2
Lee, H.B.3
-
24
-
-
4243844292
-
Roles of TGF-beta in hepatic fibrosis
-
Gressner, A. M., Weiskirchen, R., Breitkopf, K., and Dooley, S. (2002) Roles of TGF-beta in hepatic fibrosis. Front. Biosci. 7, d793-d807
-
(2002)
Front. Biosci.
, vol.7
, pp. d793-d807
-
-
Gressner, A.M.1
Weiskirchen, R.2
Breitkopf, K.3
Dooley, S.4
-
25
-
-
77950597707
-
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
-
Taura, K., Miura, K., Iwaisako, K., Osterreicher, C. H., Kodama, Y., Penz-Osterreicher, M., and Brenner, D. A. (2010) Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51, 1027-1036
-
(2010)
Hepatology
, vol.51
, pp. 1027-1036
-
-
Taura, K.1
Miura, K.2
Iwaisako, K.3
Osterreicher, C.H.4
Kodama, Y.5
Penz-Osterreicher, M.6
Brenner, D.A.7
-
26
-
-
38549143883
-
Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
-
Rygiel, K. A., Robertson, H., Marshall, H. L., Pekalski, M., Zhao, L., Booth, T. A., Jones, D. E., Burt, A. D., and Kirby, J. A. (2008) Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab. Invest. 88, 112-123
-
(2008)
Lab. Invest.
, vol.88
, pp. 112-123
-
-
Rygiel, K.A.1
Robertson, H.2
Marshall, H.L.3
Pekalski, M.4
Zhao, L.5
Booth, T.A.6
Jones, D.E.7
Burt, A.D.8
Kirby, J.A.9
-
27
-
-
79955479506
-
Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses
-
Schaale, K., Neumann, J., Schneider, D., Ehlers, S., and Reiling, N. (2011) Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses. Eur. J. Cell Biol. 90, 553-559
-
(2011)
Eur. J. Cell Biol.
, vol.90
, pp. 553-559
-
-
Schaale, K.1
Neumann, J.2
Schneider, D.3
Ehlers, S.4
Reiling, N.5
-
28
-
-
33746915710
-
Wnt signaling regulates transendothelial migration of monocytes
-
Tickenbrock, L., Schwäble, J., Strey, A., Sargin, B., Hehn, S., Baas, M., Choudhary, C., Gerke, V., Berdel, W. E., Müller-Tidow, C., and Serve, H. (2006) Wnt signaling regulates transendothelial migration of monocytes. J. Leukoc. Biol. 79, 1306-1313
-
(2006)
J. Leukoc. Biol.
, vol.79
, pp. 1306-1313
-
-
Tickenbrock, L.1
Schwäble, J.2
Strey, A.3
Sargin, B.4
Hehn, S.5
Baas, M.6
Choudhary, C.7
Gerke, V.8
Berdel, W.E.9
Müller-Tidow, C.10
Serve, H.11
-
29
-
-
67649306197
-
Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
-
Argo, C. K., Northup, P. G., Al-Osaimi, A. M., and Caldwell, S. H. (2009) Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J. Hepatol. 51, 371-379
-
(2009)
J. Hepatol.
, vol.51
, pp. 371-379
-
-
Argo, C.K.1
Northup, P.G.2
Al-Osaimi, A.M.3
Caldwell, S.H.4
-
30
-
-
0034637103
-
Inhibition of adipogenesis by Wnt signaling
-
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., and MacDougald, O. A. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289, 950-953
-
(2000)
Science
, vol.289
, pp. 950-953
-
-
Ross, S.E.1
Hemati, N.2
Longo, K.A.3
Bennett, C.N.4
Lucas, P.C.5
Erickson, R.L.6
MacDougald, O.A.7
-
31
-
-
84891381427
-
Mechanisms of palmitate-induced lipotoxicity in human osteoblasts
-
Gunaratnam, K., Vidal, C., Gimble, J. M., and Duque, G. (2014) Mechanisms of palmitate-induced lipotoxicity in human osteoblasts. Endocrinology 155, 108-116
-
(2014)
Endocrinology
, vol.155
, pp. 108-116
-
-
Gunaratnam, K.1
Vidal, C.2
Gimble, J.M.3
Duque, G.4
-
32
-
-
77955690182
-
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
-
Neuschwander-Tetri, B. A. (2010) Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 52, 774-788
-
(2010)
Hepatology
, vol.52
, pp. 774-788
-
-
Neuschwander-Tetri, B.A.1
-
33
-
-
84875705913
-
Noncanonical WNT-5A signaling regulates TGF-%beta;-induced extracellular matrix production by airway smooth muscle cells
-
Kumawat, K., Menzen, M. H., Bos, I. S., Baarsma, H. A., Borger, P., Roth, M., Tamm, M., Halayko, A. J., Simoons, M., Prins, A., Postma, D. S., Schmidt, M., and Gosens, R. (2013) Noncanonical WNT-5A signaling regulates TGF-%beta;-induced extracellular matrix production by airway smooth muscle cells. FASEB J. 27, 1631-1643
-
(2013)
FASEB J.
, vol.27
, pp. 1631-1643
-
-
Kumawat, K.1
Menzen, M.H.2
Bos, I.S.3
Baarsma, H.A.4
Borger, P.5
Roth, M.6
Tamm, M.7
Halayko, A.J.8
Simoons, M.9
Prins, A.10
Postma, D.S.11
Schmidt, M.12
Gosens, R.13
-
34
-
-
79955123951
-
Lineage tracing demonstrates no evidence of cholangiocyte epithelial-tomesenchymal transition in murine models of hepatic fibrosis
-
Chu, A. S., Diaz, R., Hui, J. J., Yanger, K., Zong, Y., Alpini, G., Stanger, B. Z., and Wells, R. G. (2011) Lineage tracing demonstrates no evidence of cholangiocyte epithelial-tomesenchymal transition in murine models of hepatic fibrosis. Hepatology 53, 1685-1695
-
(2011)
Hepatology
, vol.53
, pp. 1685-1695
-
-
Chu, A.S.1
Diaz, R.2
Hui, J.J.3
Yanger, K.4
Zong, Y.5
Alpini, G.6
Stanger, B.Z.7
Wells, R.G.8
-
35
-
-
78651083174
-
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
-
Österreicher, C. H., Penz-Österreicher, M., Grivennikov, S. I., Guma, M., Koltsova, E. K., Datz, C., Sasik, R., Hardiman, G., Karin, M., and Brenner, D. A. (2011) Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc. Natl. Acad. Sci. USA 108, 308-313
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 308-313
-
-
Österreicher, C.H.1
Penz-Österreicher, M.2
Grivennikov, S.I.3
Guma, M.4
Koltsova, E.K.5
Datz, C.6
Sasik, R.7
Hardiman, G.8
Karin, M.9
Brenner, D.A.10
-
36
-
-
77951722845
-
Signals from dying hepatocytes trigger growth of liver progenitors
-
Jung, Y., Witek, R. P., Syn, W. K., Choi, S. S., Omenetti, A., Premont, R., Guy, C. D., and Diehl, A. M. (2010) Signals from dying hepatocytes trigger growth of liver progenitors. Gut 59, 655-665
-
(2010)
Gut
, vol.59
, pp. 655-665
-
-
Jung, Y.1
Witek, R.P.2
Syn, W.K.3
Choi, S.S.4
Omenetti, A.5
Premont, R.6
Guy, C.D.7
Diehl, A.M.8
-
37
-
-
48549103201
-
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
-
Patsenker, E., Popov, Y., Stickel, F., Jonczyk, A., Goodman, S. L., and Schuppan, D. (2008) Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology 135, 660-670
-
(2008)
Gastroenterology
, vol.135
, pp. 660-670
-
-
Patsenker, E.1
Popov, Y.2
Stickel, F.3
Jonczyk, A.4
Goodman, S.L.5
Schuppan, D.6
|