Wnt3a activates β1-integrin and regulates migration and adhesion of vascular smooth muscle cells

Molecular Medicine Reports

Volumn 9, Issue 4, 2014, Pages 1159-1164

  Wu, Xiaolin ^a,b   Wang, Jichun ^a   Jiang, Hong ^a   Hu, Qi ^a   Chen, Jing ^a   Zhang, Jing ^a   Zhu, Rui ^b   Liu, Wenwei ^b   Li, Bin ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY OF ARTS AND SCIENCE   (China)

Author keywords

Adhesion; Member 3a; Migration; Vascular smooth muscle cells; Wingless type MMTV integration site family; 1 integrin

Indexed keywords

BETA CATENIN; BETA1 INTEGRIN; COLLAGEN TYPE 1; GLYCOGEN SYNTHASE KINASE 3BETA; INTEGRIN LINKED KINASE; RECOMBINANT PROTEIN; RECOMBINANT WNT3A PROTEIN; SERINE; UNCLASSIFIED DRUG; WNT3A PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL ADHESION ASSAY; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; CULTURE MEDIUM; EXPERIMENTAL SURGICAL WOUND; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; TISSUE CULTURE; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; WNT SIGNALING PATHWAY; WOUND HEALING;

ANIMALS; ANTIGENS, CD29; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN TYPE I; FLOW CYTOMETRY; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, SPRAGUE-DAWLEY; WNT3A PROTEIN;

EID: 84896517331     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1937     Document Type: Article

References (34)

1. van de Schans VA, Smits JF and Blankesteijn WM: The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe? Eur J Pharmacol 585: 338-345, 2008.
2. Rao TP and Kühl M: An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 106: 1798-1806, 2010.
3. Tsaousi A, Mill C and George SJ: The Wnt pathways in vascular disease: lessons from vascular development. Curr Opin Lipidol 22: 350-357, 2011.
4. Montanez E, Ussar S, Schifferer M, et al: Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22: 1325-1330, 2008. (Pubitemid 351717522)
5. Kim C, Ye F and Ginsberg MH: Regulation of integrin activation. Annu Rev Cell Dev Biol 27: 321-345, 2011.
6. Schambony A, Kunz M and Gradl D: Cross-regulation of Wnt signaling and cell adhesion. Differentiation 72: 307-318, 2004. (Pubitemid 41702123)
7. Oloumi A, McPhee T and Dedhar S: Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta 1691: 1-15, 2004. (Pubitemid 38410945)
8. Hannigan G, Troussard AA and Dedhar S: Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5: 51- 63, 2005.
9. Rallis C, Pinchin SM and Ish-Horowicz D: Cell-autonomous integrin control of Wnt and Notch signalling during somito-genesis. Development 137: 3591-3601, 2010.
10. Oloumi A, Syam S and Dedhar S: Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25: 7747-7757, 2006. (Pubitemid 44967969)
11. Blaschke F, Stawowy P, Goetze S, et al: Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells. Biochem Biophys Res Commun 296: 890-896, 2002.
12. Stringa E, Knäuper V, Murphy G and Gavrilovic J: Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells. J Cell Sci 113: 2055-2064, 2000. (Pubitemid 30386509)
13. Bao XL, Song H, Chen Z and Tang X: Wnt3a promotes epithelial-mesenchymal transition, migration, and proliferation of lens epithelial cells. Mol Vis 18: 1983-1990, 2012.
14. Amin N and Vincan E: The Wnt signaling pathways and cell adhesion. Front Biosci (Landmark Ed) 17: 784-804, 2012.
15. Nelson WJ and Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303: 1483-1487, 2004. (Pubitemid 38314410)
16. Tan CW, Gardiner BS, Hirokawa Y, Layton MJ, Smith DW and Burgess AW: Wnt signalling pathway parameters for mammalian cells. PLoS One 7: e31882, 2012.
17. Parmalee NL and Kitajewski J: Wnt signaling in angiogenesis. Curr Drug Targets 9: 558-564, 2008.
18. Samarzija I, Sini P, Schlange T, Macdonald G and Hynes NE: Wnt3a regulates proliferation and migration of HUVEC via canonical and non- canonical Wnt signaling pathways. Biochem Biophys Res Commun 386: 449-454, 2009.
19. Nusse R: Wnt signaling in disease and in development. Cell Res 15: 28-32, 2005.
20. Brembeck FH, Rosário M and Birchmeier W: Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 16: 51-59, 2006. (Pubitemid 43089612)
21. Marchand A, Atassi F, Gaaya A, et al: The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans. Aging Cell 10: 220-232, 2011.
22. Taurin S, Sandbo N, Yau DM, Sethakorn N and Dulin NO: Phosphorylation of beta- catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells. Am J Physiol Cell Physiol 294: C1169- C1174, 2008.
23. Mill C and George SJ: Wnt signalling in smooth muscle cells and its role in cardiovascular disorders. Cardiovasc Res 95: 233-240, 2012.
24. Ho B, Hou G, Pickering JG, Hannigan G, Langille BL and Bendeck MP: Integrin-linked kinase in the vascular smooth muscle cell response to injury. Am J Pathol 173: 278-288, 2008. (Pubitemid 351947974)
25. Ho B and Bendeck MP: Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells. Cell Adh Migr 3: 174-176, 2009.
26. McDonald PC, Fielding AB and Dedhar S: Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 121: 3121-3132, 2008.
27. Hannigan GE, Coles JG and Dedhar S: Integrin-linked kinase at the heart of cardiac contractility, repair, and disease. Circ Res 100: 1408-1414, 2007. (Pubitemid 46834753)
28. Huttenlocher A and Horwitz AR: Integrins in cell migration. Cold Spring Harb Perspect Biol 3: a005074, 2011.
29. Wang HQ, Bai L, Shen BR, Yan ZQ and Jiang ZL: Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt. Eur J Cell Biol 86: 51-62, 2007. (Pubitemid 44910103)
30. Carlson TR, Hu H, Braren R, Kim YH and Wang RA: Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development 135: 2193-2202, 2008. (Pubitemid 352015153)
31. Parsons JT, Horwitz AR and Schwartz MA: Cell adhesion: inte grating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 11: 633- 643, 2010.
32. Kappert K, Schmidt G, Doerr G, Wollert-Wulf B, Fleck E and Graf K: Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs. Hypertension 35: 255-261, 2000. (Pubitemid 30054182)
33. Olivares-Navarrete R, Hyzy SL, Park JH, et al: Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop. Biomaterials 32: 6399-6411, 2011.
34. Régent M, Planus E, Bouin AP, et al: Specificities of β1 integrin signaling in the control of cell adhesion and adhesive strength. Eur J Cell Biol 90: 261-269, 2011.