메뉴 건너뛰기




Volumn 312, Issue 3, 2017, Pages G219-G227

WNT-5A regulates TGF-β-related activities in liver fibrosis

Author keywords

fibrosis; Interferon ; Remodeling; Transforming growth factor ; WNT

Indexed keywords

COLLAGEN TYPE 1; DESMIN; FIBRONECTIN; FRIZZLED PROTEIN; FRIZZLED RECEPTOR 2; FRIZZLED RECEPTOR 8; GAMMA INTERFERON; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR BB; PROCOLLAGEN; PROCOLLAGEN 1A1; PROCOLLAGEN 3A1; RNA 18S; SCLEROPROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIMENTIN; WNT5A PROTEIN; COLLAGEN;

EID: 85014593379     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00160.2016     Document Type: Article
Times cited : (50)

References (35)
  • 2
    • 79960718862 scopus 로고    scopus 로고
    • Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice
    • Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K. Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice. Hepatology 54: 586–596, 2011. doi: 10.1002/hep.24395.
    • (2011) Hepatology , vol.54 , pp. 586-596
    • Bansal, R.1    Prakash, J.2    Post, E.3    Beljaars, L.4    Schuppan, D.5    Poelstra, K.6
  • 3
    • 0028959114 scopus 로고
    • Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers
    • Bedossa P, Peltier E, Terris B, Franco D, Poynard T. Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 21: 760–766, 1995.10. 1002/hep.1840210325.
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 6
    • 84958765390 scopus 로고    scopus 로고
    • Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells
    • Corbett L, Mann J, Mann DA. Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells. PLoS One 10: e0142794, 2015. doi: 10.1371/ journal.pone.0142794.
    • (2015) Plos One , vol.10
    • Corbett, L.1    Mann, J.2    Mann, D.A.3
  • 7
    • 84934291528 scopus 로고    scopus 로고
    • Wnt5a promotes cytokines production and cell proliferation in human hepatic stellate cells independent of canonical Wnt pathway
    • Dong S, Wu C, Hu J, Wang Q, Chen S, Wang Z, Xiong W. Wnt5a promotes cytokines production and cell proliferation in human hepatic stellate cells independent of canonical Wnt pathway. Clin Lab 61: 537–547, 2015.
    • (2015) Clin Lab , vol.61 , pp. 537-547
    • Dong, S.1    Wu, C.2    Hu, J.3    Wang, Q.4    Chen, S.5    Wang, Z.6    Xiong, W.7
  • 9
    • 73349119711 scopus 로고    scopus 로고
    • A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion
    • Jenei V, Sherwood V, Howlin J, Linnskog R, Säfholm A, Axelsson L, Andersson T. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci USA 106: 19473–19478, 2009. doi: 10.1073/ pnas.0909409106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19473-19478
    • Jenei, V.1    Sherwood, V.2    Howlin, J.3    Linnskog, R.4    Säfholm, A.5    Axelsson, L.6    Andersson, T.7
  • 10
    • 33746511526 scopus 로고    scopus 로고
    • Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    • Jiang F, Parsons CJ, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45: 401–409, 2006. doi: 10.1016/j.jhep.2006.03.016.
    • (2006) J Hepatol , vol.45 , pp. 401-409
    • Jiang, F.1    Parsons, C.J.2    Stefanovic, B.3
  • 11
    • 38049086246 scopus 로고    scopus 로고
    • Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
    • Kordes C, Sawitza I, Häussinger D. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun 367: 116–123, 2008. doi: 10.1016/j.bbrc.2007.12.085.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 116-123
    • Kordes, C.1    Sawitza, I.2    Häussinger, D.3
  • 12
    • 84954378646 scopus 로고    scopus 로고
    • WNT-5A: Signaling and functions in health and disease
    • Kumawat K, Gosens R. WNT-5A: signaling and functions in health and disease. Cell Mol Life Sci 73: 567–587, 2016. doi: 10.1007/s00018-015-2076-y.
    • (2016) Cell Mol Life Sci , vol.73 , pp. 567-587
    • Kumawat, K.1    Gosens, R.2
  • 14
    • 84899638995 scopus 로고    scopus 로고
    • TGF-beta-activated kinase 1 (TAK1) signaling regulates TGFbeta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin
    • Kumawat K, Menzen MH, Slegtenhorst RM, Halayko AJ, Schmidt M, Gosens R. TGF-beta-activated kinase 1 (TAK1) signaling regulates TGFbeta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS One 9: e94801, 2014. doi: 10.1371/journal.pone.0094801.
    • (2014) Plos One , vol.9
    • Kumawat, K.1    Menzen, M.H.2    Slegtenhorst, R.M.3    Halayko, A.J.4    Schmidt, M.5    Gosens, R.6
  • 15
    • 80054008597 scopus 로고    scopus 로고
    • Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction
    • Laeremans H, Hackeng TM, van Zandvoort MA, Thijssen VL, Janssen BJ, Ottenheijm HC, Smits JF, Blankesteijn WM. Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction. Circulation 124: 1626–1635, 2011. doi: 10. 1161/CIRCULATIONAHA.110.976969.
    • (2011) Circulation , vol.124 , pp. 1626-1635
    • Laeremans, H.1    Hackeng, T.M.2    Van Zandvoort, M.A.3    Thijssen, V.L.4    Janssen, B.J.5    Ottenheijm, H.C.6    Smits, J.F.7    Blankesteijn, W.M.8
  • 16
    • 84904301831 scopus 로고    scopus 로고
    • Expression of Wnt-5a and +-catenin in primary hepatocellular carcinoma
    • Li P, Cao Y, Li Y, Zhou L, Liu X, Geng M. Expression of Wnt-5a and +-catenin in primary hepatocellular carcinoma. Int J Clin Exp Pathol 7: 3190–3195, 2014.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 3190-3195
    • Li, P.1    Cao, Y.2    Li, Y.3    Zhou, L.4    Liu, X.5    Geng, M.6
  • 17
    • 84879415865 scopus 로고    scopus 로고
    • Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis
    • Li X, Yamagata K, Nishita M, Endo M, Arfian N, Rikitake Y, Emoto N, Hirata K, Tanaka Y, Minami Y. Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis. Genes Cells 18: 608–619, 2013. doi: 10.1111/gtc.12064.
    • (2013) Genes Cells , vol.18 , pp. 608-619
    • Li, X.1    Yamagata, K.2    Nishita, M.3    Endo, M.4    Arfian, N.5    Rikitake, Y.6    Emoto, N.7    Hirata, K.8    Tanaka, Y.9    Minami, Y.10
  • 18
    • 84880314303 scopus 로고    scopus 로고
    • The enhanced liver fibrosis (ELF) score: Normal values, influence factors and proposed cut-off values
    • Lichtinghagen R, Pietsch D, Bantel H, Manns MP, Brand K, Bahr MJ. The enhanced liver fibrosis (ELF) score: normal values, influence factors and proposed cut-off values. J Hepatol 59: 236–242, 2013. doi: 10.1016/ j.jhep.2013.03.016.
    • (2013) J Hepatol , vol.59 , pp. 236-242
    • Lichtinghagen, R.1    Pietsch, D.2    Bantel, H.3    Manns, M.P.4    Brand, K.5    Bahr, M.J.6
  • 19
    • 44949099389 scopus 로고    scopus 로고
    • Expression of Wnt-5a and its clinicopathological significance in hepatocellular carcinoma
    • Liu XH, Pan MH, Lu ZF, Wu B, Rao Q, Zhou ZY, Zhou XJ. Expression of Wnt-5a and its clinicopathological significance in hepatocellular carcinoma. Dig Liver Dis 40: 560–567, 2008. doi: 10.1016/j.dld. 2007.12.011.
    • (2008) Dig Liver Dis , vol.40 , pp. 560-567
    • Liu, X.H.1    Pan, M.H.2    Lu, Z.F.3    Wu, B.4    Rao, Q.5    Zhou, Z.Y.6    Zhou, X.J.7
  • 20
    • 84887818214 scopus 로고    scopus 로고
    • Wnt signaling in liver fibrosis: Progress, challenges and potential directions
    • Miao CG, Yang YY, He X, Huang C, Huang Y, Zhang L, Lv XW, Jin Y, Li J. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie 95: 2326–2335, 2013. doi: 10.1016/j.biochi.2013.09.003.
    • (2013) Biochimie , vol.95 , pp. 2326-2335
    • Miao, C.G.1    Yang, Y.Y.2    He, X.3    Huang, C.4    Huang, Y.5    Zhang, L.6    Lv, X.W.7    Jin, Y.8    Li, J.9
  • 21
    • 84930031124 scopus 로고    scopus 로고
    • +-Catenin signaling and roles in liver homeostasis, injury, and tumorigenesis
    • Monga SP. +-Catenin signaling and roles in liver homeostasis, injury, and tumorigenesis. Gastroenterology 148: 1294–1310, 2015. doi: 10.1053/j. gastro.2015.02.056.
    • (2015) Gastroenterology , vol.148 , pp. 1294-1310
    • Monga, S.P.1
  • 23
    • 84961321892 scopus 로고    scopus 로고
    • Expression of WNT5A in idiopathic pulmonary fibrosis and its control by TGF-+ and WNT7B in human lung fibroblasts
    • Newman DR, Sills WS, Hanrahan K, Ziegler A, Tidd KM, Cook E, Sannes PL. Expression of WNT5A in idiopathic pulmonary fibrosis and its control by TGF-+ and WNT7B in human lung fibroblasts. J Histochem Cytochem 64: 99–111, 2016. doi: 10.1369/0022155415617988.
    • (2016) J Histochem Cytochem , vol.64 , pp. 99-111
    • Newman, D.R.1    Sills, W.S.2    Hanrahan, K.3    Ziegler, A.4    Tidd, K.M.5    Cook, E.6    Sannes, P.L.7
  • 24
    • 84896806249 scopus 로고    scopus 로고
    • Liver fibrosis and repair: Immune regulation of wound healing in a solid organ
    • Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol 14: 181–194, 2014. doi: 10.1038/nri3623.
    • (2014) Nat Rev Immunol , vol.14 , pp. 181-194
    • Pellicoro, A.1    Ramachandran, P.2    Iredale, J.P.3    Fallowfield, J.A.4
  • 25
    • 84864591367 scopus 로고    scopus 로고
    • Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
    • Rashid ST, Humphries JD, Byron A, Dhar A, Askari JA, Selley JN, Knight D, Goldin RD, Thursz M, Humphries MJ. Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res 11: 4052–4064, 2012. doi: 10.1021/pr3000927.
    • (2012) J Proteome Res , vol.11 , pp. 4052-4064
    • Rashid, S.T.1    Humphries, J.D.2    Byron, A.3    Dhar, A.4    Askari, J.A.5    Selley, J.N.6    Knight, D.7    Goldin, R.D.8    Thursz, M.9    Humphries, M.J.10
  • 28
    • 84930654452 scopus 로고    scopus 로고
    • Hepatic fibrosis: Concept to treatment. J Hepatol 62
    • Trautwein C, Friedman SL, Schuppan D, Pinzani M. Hepatic fibrosis: concept to treatment. J Hepatol 62, Suppl: S15–S24, 2015. doi: 10.1016/ j.jhep.2015.02.039.
    • (2015) Suppl , pp. S15-S24
    • Trautwein, C.1    Friedman, S.L.2    Schuppan, D.3    Pinzani, M.4
  • 30
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway
    • Ulloa L, Doody J, Massagué J. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397: 710–713, 1999. doi: 10.1038/17826.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massagué, J.3
  • 31
    • 84908440134 scopus 로고    scopus 로고
    • Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-gamma production by CD4T cells
    • Valencia J, Martinez VG, Hidalgo L, Hernandez-Lopez C, Canseco NM, Vicente A, Varas A, Sacedon R. Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-gamma production by CD4T cells. Immunol Lett 162: 188–199, 2014. doi: 10.1016/j.imlet.2014.08.015.
    • (2014) Immunol Lett , vol.162 , pp. 188-199
    • Valencia, J.1    Martinez, V.G.2    Hidalgo, L.3    Hernandez-Lopez, C.4    Canseco, N.M.5    Vicente, A.6    Varas, A.7    Sacedon, R.8
  • 32
    • 84969410090 scopus 로고    scopus 로고
    • Targeted therapies in liver fibrosis: Combining the best parts of platelet-derived growth factor BB and interferon gamma
    • van Dijk F, Olinga P, Poelstra K, Beljaars L. Targeted therapies in liver fibrosis: combining the best parts of platelet-derived growth factor BB and interferon gamma. Front Med (Lausanne) 2: 72, 2015. doi: 10.3389/fmed. 2015.00072.
    • (2015) Front Med (Lausanne) , vol.2
    • Van Dijk, F.1    Olinga, P.2    Poelstra, K.3    Beljaars, L.4
  • 34
    • 84866158400 scopus 로고    scopus 로고
    • Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays
    • Xiong WJ, Hu LJ, Jian YC, Wang LJ, Jiang M, Li W, He Y. Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays. World J Gastroenterol 18: 1745–1752, 2012. doi: 10.3748/wjg.v18.i15.1745.
    • (2012) World J Gastroenterol , vol.18 , pp. 1745-1752
    • Xiong, W.J.1    Hu, L.J.2    Jian, Y.C.3    Wang, L.J.4    Jiang, M.5    Li, W.6    He, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.