-
1
-
-
84903133961
-
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society
-
Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation 2014; 129: S102-138.
-
(2014)
Circulation
, vol.129
, pp. S102-138
-
-
Jensen, M.D.1
Ryan, D.H.2
Apovian, C.M.3
-
2
-
-
84906882822
-
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013
-
Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-781.
-
(2014)
Lancet
, vol.384
, pp. 766-781
-
-
Ng, M.1
Fleming, T.2
Robinson, M.3
-
4
-
-
62849107573
-
Body-mass index and cause-specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies
-
Prospective Studies Collaboration
-
Prospective Studies Collaboration, Whitlock G, Lewington S, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009; 373: 1083-1096.
-
(2009)
Lancet
, vol.373
, pp. 1083-1096
-
-
Whitlock, G.1
Lewington, S.2
-
5
-
-
84856230498
-
Arteriolar function in visceral adipose tissue is impaired in human obesity
-
Farb MG, Ganley-Leal L, Mott M, et al. Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol 2012; 32: 467-473.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 467-473
-
-
Farb, M.G.1
Ganley-Leal, L.2
Mott, M.3
-
6
-
-
84928648966
-
Visceral adiposopathy: A vascular perspective
-
Farb MG, Gokce N,. Visceral adiposopathy: A vascular perspective. Horm Mol Biol Clin Investig 2015; 21: 125-136.
-
(2015)
Horm Mol Biol Clin Investig
, vol.21
, pp. 125-136
-
-
Farb, M.G.1
Gokce, N.2
-
7
-
-
84895905811
-
Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity
-
Farb MG, Tiwari S, Karki S, et al. Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity. Obesity (Silver Spring) 2014; 22: 349-355.
-
(2014)
Obesity (Silver Spring)
, vol.22
, pp. 349-355
-
-
Farb, M.G.1
Tiwari, S.2
Karki, S.3
-
8
-
-
0031947613
-
The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation
-
Hashimoto M, Akishita M, Eto M, et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord 1998; 22: 477-484.
-
(1998)
Int J Obes Relat Metab Disord
, vol.22
, pp. 477-484
-
-
Hashimoto, M.1
Akishita, M.2
Eto, M.3
-
9
-
-
70350566626
-
Visceral and subcutaneous adiposity and brachial artery vasodilator function
-
Parikh NI, Keyes MJ, Larson MG, et al. Visceral and subcutaneous adiposity and brachial artery vasodilator function. Obesity (Silver Spring) 2009; 17: 2054-2059.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 2054-2059
-
-
Parikh, N.I.1
Keyes, M.J.2
Larson, M.G.3
-
10
-
-
34948902196
-
Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart Study
-
Pou KM, Massaro JM, Hoffmann U, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart Study. Circulation 2007; 116: 1234-1241.
-
(2007)
Circulation
, vol.116
, pp. 1234-1241
-
-
Pou, K.M.1
Massaro, J.M.2
Hoffmann, U.3
-
11
-
-
84959519253
-
Endothelial dysfunction in human diabetes is mediated by Wnt5a-JNK signaling
-
Breton-Romero R, Feng B, Holbrook M, et al. Endothelial dysfunction in human diabetes is mediated by Wnt5a-JNK signaling. Arterioscler Thromb Vasc Biol 2016; 36: 561-569.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, pp. 561-569
-
-
Breton-Romero, R.1
Feng, B.2
Holbrook, M.3
-
12
-
-
84961994260
-
Noncanonical wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion
-
Fuster JJ, Zuriaga MA, Ngo DT, et al. Noncanonical wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 2015; 64: 1235-1248.
-
(2015)
Diabetes
, vol.64
, pp. 1235-1248
-
-
Fuster, J.J.1
Zuriaga, M.A.2
Ngo, D.T.3
-
13
-
-
77954844177
-
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
-
Ouchi N, Higuchi A, Ohashi K, et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 2010; 329: 454-457.
-
(2010)
Science
, vol.329
, pp. 454-457
-
-
Ouchi, N.1
Higuchi, A.2
Ohashi, K.3
-
14
-
-
84953319726
-
Defective Wnt signaling: A potential contributor to cardiometabolic disease?
-
Arnold AC, Robertson D,. Defective Wnt signaling: A potential contributor to cardiometabolic disease? Diabetes 2015; 64: 3342-3344.
-
(2015)
Diabetes
, vol.64
, pp. 3342-3344
-
-
Arnold, A.C.1
Robertson, D.2
-
15
-
-
83155181734
-
Wnt5a: Its signalling, functions and implication in diseases
-
Kikuchi A, Yamamoto H, Sato A, et al. Wnt5a: Its signalling, functions and implication in diseases. Acta Physiol (Oxf) 2012; 204: 17-33.
-
(2012)
Acta Physiol (Oxf)
, vol.204
, pp. 17-33
-
-
Kikuchi, A.1
Yamamoto, H.2
Sato, A.3
-
16
-
-
84934877428
-
Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders
-
Bhatt PM, Malgor R,. Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders. Atherosclerosis 2014; 237: 155-162.
-
(2014)
Atherosclerosis
, vol.237
, pp. 155-162
-
-
Bhatt, P.M.1
Malgor, R.2
-
17
-
-
84905823640
-
Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation
-
Catalan V, Gomez-Ambrosi J, Rodriguez A, et al. Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation. J Clin Endocrinol Metab 2014; 99: E1407-1417.
-
(2014)
J Clin Endocrinol Metab
, vol.99
, pp. E1407-1417
-
-
Catalan, V.1
Gomez-Ambrosi, J.2
Rodriguez, A.3
-
19
-
-
84896282224
-
Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease
-
Miyoshi T, Doi M, Usui S, et al. Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease. Atherosclerosis 2014; 233: 454-459.
-
(2014)
Atherosclerosis
, vol.233
, pp. 454-459
-
-
Miyoshi, T.1
Doi, M.2
Usui, S.3
-
20
-
-
84857545934
-
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects
-
Schulte DM, Muller N, Neumann K, et al. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. PLoSOne 2012; 7: e32437.
-
(2012)
PLoSOne
, vol.7
, pp. e32437
-
-
Schulte, D.M.1
Muller, N.2
Neumann, K.3
-
21
-
-
84872081425
-
Protein kinase C-beta contributes to impaired endothelial insulin signaling in humans with diabetes mellitus
-
Tabit CE, Shenouda SM, Holbrook M, et al. Protein kinase C-beta contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation 2013; 127: 86-95.
-
(2013)
Circulation
, vol.127
, pp. 86-95
-
-
Tabit, C.E.1
Shenouda, S.M.2
Holbrook, M.3
-
22
-
-
84959158349
-
Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling
-
Fetterman JL, Holbrook M, Flint N, et al. Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis 2016; 247: 207-217.
-
(2016)
Atherosclerosis
, vol.247
, pp. 207-217
-
-
Fetterman, J.L.1
Holbrook, M.2
Flint, N.3
-
23
-
-
84933051523
-
Forkhead box o-1 modulation improves endothelial insulin resistance in human obesity
-
Karki S, Farb MG, Ngo DT, et al. Forkhead box o-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol 2015; 35: 1498-1506.
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 1498-1506
-
-
Karki, S.1
Farb, M.G.2
Ngo, D.T.3
-
24
-
-
77953393648
-
Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications
-
Tabit CE, Chung WB, Hamburg NM, et al. Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications. Rev Endocr Metab Disord 2010; 11: 61-74.
-
(2010)
Rev Endocr Metab Disord
, vol.11
, pp. 61-74
-
-
Tabit, C.E.1
Chung, W.B.2
Hamburg, N.M.3
-
25
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
Han MS, Jung DY, Morel C, et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 2013; 339: 218-222.
-
(2013)
Science
, vol.339
, pp. 218-222
-
-
Han, M.S.1
Jung, D.Y.2
Morel, C.3
-
26
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas G, Vilcu C, Neels JG, et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab 2007; 6: 386-397.
-
(2007)
Cell Metab
, vol.6
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
-
27
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597-601.
-
(1999)
Nature
, vol.399
, pp. 597-601
-
-
Fulton, D.1
Gratton, J.P.2
McCabe, T.J.3
-
28
-
-
0033857388
-
Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
-
Luo Z, Fujio Y, Kureishi Y, et al. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Investig 2000; 106: 493-499.
-
(2000)
J Clin Investig
, vol.106
, pp. 493-499
-
-
Luo, Z.1
Fujio, Y.2
Kureishi, Y.3
-
29
-
-
77951666491
-
The human visceral fat depot has a unique inflammatory profile
-
Alvehus M, Buren J, Sjostrom M, et al. The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring) 2010; 18: 879-883.
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 879-883
-
-
Alvehus, M.1
Buren, J.2
Sjostrom, M.3
-
30
-
-
84872144478
-
Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications
-
Lee MJ, Wu Y, Fried SK,. Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med 2013; 34: 1-11.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1-11
-
-
Lee, M.J.1
Wu, Y.2
Fried, S.K.3
-
31
-
-
84863592684
-
Body fat distribution and risk of cardiovascular disease: An update
-
Despres JP,. Body fat distribution and risk of cardiovascular disease: An update. Circulation 2012; 126: 1301-1313.
-
(2012)
Circulation
, vol.126
, pp. 1301-1313
-
-
Despres, J.P.1
-
32
-
-
84961290875
-
An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease
-
Kikuchi R, Nakamura K, MacLauchlan S, et al. An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nat Med 2014; 20: 1464-1471.
-
(2014)
Nat Med
, vol.20
, pp. 1464-1471
-
-
Kikuchi, R.1
Nakamura, K.2
MacLauchlan, S.3
-
33
-
-
79751515852
-
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
-
Gao B, Song H, Bishop K, et al. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell 2011; 20: 163-176.
-
(2011)
Dev Cell
, vol.20
, pp. 163-176
-
-
Gao, B.1
Song, H.2
Bishop, K.3
-
34
-
-
10744219743
-
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
-
Oishi I, Suzuki H, Onishi N, et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 2003; 8: 645-654.
-
(2003)
Genes Cells
, vol.8
, pp. 645-654
-
-
Oishi, I.1
Suzuki, H.2
Onishi, N.3
-
35
-
-
54249099723
-
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
-
Nomachi A, Nishita M, Inaba D, et al. Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem 2008; 283: 27,973-27,981.
-
(2008)
J Biol Chem
, vol.283
, pp. 27973-27981
-
-
Nomachi, A.1
Nishita, M.2
Inaba, D.3
-
36
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
-
37
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008; 322: 1539-1543.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
-
39
-
-
84926672252
-
Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: Role of perivascular adipose tissue
-
Virdis A, Duranti E, Rossi C, et al. Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: Role of perivascular adipose tissue. Eur Heart J 2015; 36: 784-794.
-
(2015)
Eur Heart J
, vol.36
, pp. 784-794
-
-
Virdis, A.1
Duranti, E.2
Rossi, C.3
-
40
-
-
34250863505
-
Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity
-
Bashan N, Dorfman K, Tarnovscki T, et al. Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity. Endocrinology 2007; 148: 2955-2962.
-
(2007)
Endocrinology
, vol.148
, pp. 2955-2962
-
-
Bashan, N.1
Dorfman, K.2
Tarnovscki, T.3
-
41
-
-
0034913442
-
Immunohistochemical study of the phosphorylated and activated form of c-Jun NH2-terminal kinase in human aorta
-
Nishio H, Matsui K, Tsuji H, et al. Immunohistochemical study of the phosphorylated and activated form of c-Jun NH2-terminal kinase in human aorta. Histochem J 2001; 33: 167-171.
-
(2001)
Histochem J
, vol.33
, pp. 167-171
-
-
Nishio, H.1
Matsui, K.2
Tsuji, H.3
-
42
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
Jiang ZY, Lin YW, Clemont A, et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999; 104: 447-457.
-
(1999)
J Clin Invest
, vol.104
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.W.2
Clemont, A.3
-
43
-
-
77955292064
-
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein e null mice
-
Rask-Madsen C, Li Q, Freund B, et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab 2010; 11: 379-389.
-
(2010)
Cell Metab
, vol.11
, pp. 379-389
-
-
Rask-Madsen, C.1
Li, Q.2
Freund, B.3
-
44
-
-
0028030813
-
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
-
Steinberg HO, Brechtel G, Johnson A, et al. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172-1179.
-
(1994)
J Clin Invest
, vol.94
, pp. 1172-1179
-
-
Steinberg, H.O.1
Brechtel, G.2
Johnson, A.3
-
45
-
-
0029977757
-
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
-
Steinberg HO, Chaker H, Leaming R, et al. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Investig 1996; 97: 2601-2610.
-
(1996)
J Clin Investig
, vol.97
, pp. 2601-2610
-
-
Steinberg, H.O.1
Chaker, H.2
Leaming, R.3
-
46
-
-
79960057777
-
Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients
-
Virdis A, Santini F, Colucci R, et al. Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients. J Am Coll Cardiol 2011; 58: 238-247.
-
(2011)
J Am Coll Cardiol
, vol.58
, pp. 238-247
-
-
Virdis, A.1
Santini, F.2
Colucci, R.3
-
47
-
-
84862791851
-
Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function
-
Dharmashankar K, Welsh A, Wang J, et al. Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function. Am J Hypertens 2012; 25: 528-534.
-
(2012)
Am J Hypertens
, vol.25
, pp. 528-534
-
-
Dharmashankar, K.1
Welsh, A.2
Wang, J.3
-
48
-
-
84904550355
-
Adipose and leptomeningeal arteriole endothelial dysfunction induced by beta-amyloid peptide: A practical human model to study Alzheimer's disease vasculopathy
-
Truran S, Franco DA, Roher AE, et al. Adipose and leptomeningeal arteriole endothelial dysfunction induced by beta-amyloid peptide: A practical human model to study Alzheimer's disease vasculopathy. J Neurosci Methods 2014; 235: 123-129.
-
(2014)
J Neurosci Methods
, vol.235
, pp. 123-129
-
-
Truran, S.1
Franco, D.A.2
Roher, A.E.3
-
49
-
-
68049123594
-
Perioperative safety in the longitudinal assessment of bariatric surgery
-
Longitudinal Assessment of Bariatric Surgery Consortium
-
Longitudinal Assessment of Bariatric Surgery Consortium, Flum DR, Belle SH, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med 2009; 361: 445-454.
-
(2009)
N Engl J Med
, vol.361
, pp. 445-454
-
-
Flum, D.R.1
Belle, S.H.2
-
50
-
-
84890060174
-
Insulin status and vascular responses to weight loss in obesity
-
Bigornia SJ, Farb MG, Tiwari S, et al. Insulin status and vascular responses to weight loss in obesity. J Am Coll Cardiol 2013; 62: 2297-2305.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 2297-2305
-
-
Bigornia, S.J.1
Farb, M.G.2
Tiwari, S.3
|