Hepatitis C virus replication depends on endosomal cholesterol homeostasis

Journal of Virology

Volumn 92, Issue 1, 2018, Pages

  Stoeck, Ina Karen ^a   Lee, Ji Young ^a   Tabata, Keisuke ^a   Romero Brey, Inés ^a   Paul, David ^a   Schult, Philipp ^a   Lohmann, Volker ^a   Kaderali, Lars ^b   Bartenschlager, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

Author keywords

Cholesterol; DMV; HCV; Lipid transfer; NPC1; RNA replication

Indexed keywords

BINDING PROTEIN; LIPID TRANSFER PROTEIN; NIEMANN PICK TYPE C1; OXYSTEROL BINDING PROTEIN RELATED 1A; OXYSTEROL BINDING PROTEIN RELATED 1B; PROTEIN STARD3; SHORT HAIRPIN RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CHOLESTEROL; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN; NS-5 PROTEIN, HEPATITIS C VIRUS; OXYSTEROL BINDING PROTEIN; STARD3NL PROTEIN, HUMAN; STEROID RECEPTOR; VIRAL PROTEIN; VIRUS RNA;

ARTICLE; CELL MEMBRANE; CELL VIABILITY; CELLULAR DISTRIBUTION; CHOLESTEROL HOMEOSTASIS; CHOLESTEROL TRANSPORT; CYTOPLASM; DENGUE VIRUS; ENDOPLASMIC RETICULUM; ENDOSOME; GENE; GENOTYPE; HEPATITIS C VIRUS; HOMEOSTASIS; LYSOSOME MEMBRANE; NONHUMAN; NPC1 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPLICON; RNA INTERFERENCE; RNA REPLICATION; VIRUS ENTRY; VIRUS GENOME; VIRUS REPLICATION; VIRUS TITRATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; GENETICS; HEK293 CELL LINE; HEPACIVIRUS; HUMAN; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VIROLOGY;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; CHOLESTEROL; ENDOPLASMIC RETICULUM; ENDOSOMES; HEK293 CELLS; HEPACIVIRUS; HOMEOSTASIS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; RECEPTORS, STEROID; RNA INTERFERENCE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 85037987072     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01196-17     Document Type: Article

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