Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Shoemaker, Charles J ^a   Schornberg, Kathryn L ^a   Delos, Sue E ^a   Scully, Corinne ^b   Pajouhesh, Hassan ^c   Olinger, Gene G ^b   Johansen, Lisa M ^c   White, Judith M ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c Zalicus Inc   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CELL PROTEIN; CHOLESTEROL; CLOMIFENE; NIEMANN PICK C1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONCENTRATION (PARAMETERS); DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; ENDOSOME; IC 50; IN VITRO STUDY; LIPID STORAGE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; UPREGULATION; VIRUS ENTRY; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BIOSYNTHETIC PATHWAYS; CARRIER PROTEINS; CATIONS; CELL LINE; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMANS; MEMBRANE GLYCOPROTEINS; PHENOTYPE; STEROIDS; SURFACE-ACTIVE AGENTS; VIRUS INTERNALIZATION;

EID: 84874138355     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056265     Document Type: Article

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