Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

eLife

Volumn 4, Issue December2015, 2015, Pages

  Lu, Feiran ^a   Liang, Qiren ^a   Abi Mosleh, Lina ^a   Das, Akash ^a   de Brabander, Jef K ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NIEMANN PICK C1 LIKE 1 PROTEIN; STEROL CARRIER PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; 3-BETA-(2-(DIETHYLAMINO)ETHOXY)ANDROST-5-EN-17-ONE; ANDROSTANE DERIVATIVE; ANTIVIRUS AGENT; CARRIER PROTEIN; CHOLESTEROL; ENZYME INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; EBOLA HEMORRHAGIC FEVER; GENE MUTATION; HOMOLOGOUS RECOMBINATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; EBOLAVIRUS; METABOLISM; VIRUS ENTRY;

ANDROSTENES; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIVIRAL AGENTS; CARRIER PROTEINS; CHO CELLS; CHOLESTEROL; CRICETULUS; EBOLAVIRUS; ENZYME INHIBITORS; MEMBRANE GLYCOPROTEINS; VIRUS INTERNALIZATION;

EID: 84955259695     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.12177     Document Type: Article

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