메뉴 건너뛰기




Volumn 8, Issue DEC, 2017, Pages

CpG oligodeoxinucleotides and flagellin modulate the immune response to antigens targeted to CD8α+ and CD8α- conventional dendritic cell subsets

Author keywords

Antigen targeting; CpG oligodeoxinucleotides 1826; Dendritic cells; Flagellin; Hybrid monoclonal antibodies

Indexed keywords

ANTIGEN; B7 ANTIGEN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD40 ANTIGEN; CD86 ANTIGEN; CD8ALPHA ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; DENDRITIC CELL VACCINE; EPITOPE; FLAGELLIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MEROZOITE SURFACE PROTEIN 1; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR;

EID: 85036665713     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.01727     Document Type: Article
Times cited : (19)

References (65)
  • 1
    • 36248965712 scopus 로고    scopus 로고
    • Dendritic cells: understanding immunogenicity
    • Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol (2007) 37(Suppl 1):S53-60. doi:10.1002/eji.200737400
    • (2007) Eur J Immunol , vol.37 , pp. S53-S60
    • Steinman, R.M.1
  • 2
    • 84925441813 scopus 로고    scopus 로고
    • Control of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. Control of adaptive immunity by the innate immune system. Nat Immunol (2015) 16(4):343-53. doi:10.1038/ni.3123
    • (2015) Nat Immunol , vol.16 , Issue.4 , pp. 343-353
    • Iwasaki, A.1    Medzhitov, R.2
  • 3
    • 0036753722 scopus 로고    scopus 로고
    • Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses
    • MacLennan I, Vinuesa C. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity (2002) 17(3):235-8. doi:10.1016/S1074-7613(02)00398-9
    • (2002) Immunity , vol.17 , Issue.3 , pp. 235-238
    • MacLennan, I.1    Vinuesa, C.2
  • 4
    • 32944478316 scopus 로고    scopus 로고
    • Translating innate immunity into immunological memory: implications for vaccine development
    • Pulendran B, Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell (2006) 124(4):849-63. doi:10.1016/j.cell.2006.02.019
    • (2006) Cell , vol.124 , Issue.4 , pp. 849-863
    • Pulendran, B.1    Ahmed, R.2
  • 5
    • 84857067828 scopus 로고    scopus 로고
    • Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity
    • Eberlein J, Davenport B, Nguyen TT, Victorino F, Sparwasser T, Homann D. Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol (2012) 86(4):1955-70. doi:10.1128/JVI.05949-11
    • (2012) J Virol , vol.86 , Issue.4 , pp. 1955-1970
    • Eberlein, J.1    Davenport, B.2    Nguyen, T.T.3    Victorino, F.4    Sparwasser, T.5    Homann, D.6
  • 6
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature (1998) 392(6673):245-52. doi:10.1038/32588
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 7
    • 35549000134 scopus 로고    scopus 로고
    • Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    • Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, Dakic A, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 8(11):1217-26. doi:10.1038/ni1522
    • (2007) Nat Immunol , vol.8 , Issue.11 , pp. 1217-1226
    • Naik, S.H.1    Sathe, P.2    Park, H.Y.3    Metcalf, D.4    Proietto, A.I.5    Dakic, A.6
  • 8
    • 77349124883 scopus 로고    scopus 로고
    • Origin and development of dendritic cells
    • Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev (2010) 234(1):45-54. doi:10.1111/j.0105-2896.2009.00879.x
    • (2010) Immunol Rev , vol.234 , Issue.1 , pp. 45-54
    • Liu, K.1    Nussenzweig, M.C.2
  • 9
    • 84964798647 scopus 로고    scopus 로고
    • Dendritic cells and their multiple roles during malaria infection
    • Amorim KN, Chagas DC, Sulczewski FB, Boscardin SB. Dendritic cells and their multiple roles during malaria infection. J Immunol Res (2016) 2016:2926436. doi:10.1155/2016/2926436
    • (2016) J Immunol Res , vol.2016
    • Amorim, K.N.1    Chagas, D.C.2    Sulczewski, F.B.3    Boscardin, S.B.4
  • 10
    • 0034684659 scopus 로고    scopus 로고
    • CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo
    • den Haan JM, Lehar SM, Bevan MJ. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med (2000) 192(12):1685-96. doi:10.1084/jem.192.12.1685
    • (2000) J Exp Med , vol.192 , Issue.12 , pp. 1685-1696
    • den Haan, J.M.1    Lehar, S.M.2    Bevan, M.J.3
  • 11
    • 0037141105 scopus 로고    scopus 로고
    • The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
    • Iyoda T, Shimoyama S, Liu K, Omatsu Y, Akiyama Y, Maeda Y, et al. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med (2002) 195(10):1289-302. doi:10.1084/jem.20020161
    • (2002) J Exp Med , vol.195 , Issue.10 , pp. 1289-1302
    • Iyoda, T.1    Shimoyama, S.2    Liu, K.3    Omatsu, Y.4    Akiyama, Y.5    Maeda, Y.6
  • 13
    • 84990961171 scopus 로고    scopus 로고
    • Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species
    • Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, et al. Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Immunity (2016) 45(3):669-84. doi:10.1016/j.immuni.2016.08.015
    • (2016) Immunity , vol.45 , Issue.3 , pp. 669-684
    • Guilliams, M.1    Dutertre, C.A.2    Scott, C.L.3    McGovern, N.4    Sichien, D.5    Chakarov, S.6
  • 14
    • 80555149924 scopus 로고    scopus 로고
    • Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8alpha+ type
    • Crozat K, Tamoutounour S, Vu Manh TP, Fossum E, Luche H, Ardouin L, et al. Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8alpha+ type. J Immunol (2011) 187(9):4411-5. doi:10.4049/jimmunol.1101717
    • (2011) J Immunol , vol.187 , Issue.9 , pp. 4411-4415
    • Crozat, K.1    Tamoutounour, S.2    Vu Manh, T.P.3    Fossum, E.4    Luche, H.5    Ardouin, L.6
  • 15
    • 84905107360 scopus 로고    scopus 로고
    • Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
    • Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol (2014) 14(8):571-8. doi:10.1038/nri3712
    • (2014) Nat Rev Immunol , vol.14 , Issue.8 , pp. 571-578
    • Guilliams, M.1    Ginhoux, F.2    Jakubzick, C.3    Naik, S.H.4    Onai, N.5    Schraml, B.U.6
  • 16
    • 33846900261 scopus 로고    scopus 로고
    • Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation
    • Butler M, Morel AS, Jordan WJ, Eren E, Hue S, Shrimpton RE, et al. Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation. Immunology (2007) 120(3):362-71. doi:10.1111/j.1365-2567.2006.02512.x
    • (2007) Immunology , vol.120 , Issue.3 , pp. 362-371
    • Butler, M.1    Morel, A.S.2    Jordan, W.J.3    Eren, E.4    Hue, S.5    Shrimpton, R.E.6
  • 18
    • 33645087653 scopus 로고    scopus 로고
    • Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
    • Boscardin SB, Hafalla JC, Masilamani RF, Kamphorst AO, Zebroski HA, Rai U, et al. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 203(3):599-606. doi:10.1084/jem.20051639
    • (2006) J Exp Med , vol.203 , Issue.3 , pp. 599-606
    • Boscardin, S.B.1    Hafalla, J.C.2    Masilamani, R.F.3    Kamphorst, A.O.4    Zebroski, H.A.5    Rai, U.6
  • 19
    • 84893500529 scopus 로고    scopus 로고
    • Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge
    • Henriques HR, Rampazo EV, Goncalves AJ, Vicentin EC, Amorim JH, Panatieri RH, et al. Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge. PLoS Negl Trop Dis (2013) 7(7):e2330. doi:10.1371/journal.pntd.0002330
    • (2013) PLoS Negl Trop Dis , vol.7 , Issue.7
    • Henriques, H.R.1    Rampazo, E.V.2    Goncalves, A.J.3    Vicentin, E.C.4    Amorim, J.H.5    Panatieri, R.H.6
  • 20
    • 84923013834 scopus 로고    scopus 로고
    • Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen
    • Rampazo EV, Amorim KN, Yamamoto MM, Panatieri RH, Rodrigues MM, Boscardin SB. Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen. PLoS One (2015) 10(2):e0117778. doi:10.1371/journal.pone.0117778
    • (2015) PLoS One , vol.10 , Issue.2
    • Rampazo, E.V.1    Amorim, K.N.2    Yamamoto, M.M.3    Panatieri, R.H.4    Rodrigues, M.M.5    Boscardin, S.B.6
  • 21
    • 63849151352 scopus 로고    scopus 로고
    • Improving vaccines by targeting antigens to dendritic cells
    • Shortman K, Lahoud MH, Caminschi I. Improving vaccines by targeting antigens to dendritic cells. Exp Mol Med (2009) 41(2):61-6. doi:10.3858/emm.2009.41.2.008
    • (2009) Exp Mol Med , vol.41 , Issue.2 , pp. 61-66
    • Shortman, K.1    Lahoud, M.H.2    Caminschi, I.3
  • 22
    • 0035903326 scopus 로고    scopus 로고
    • Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    • Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 194(6):769-79. doi:10.1084/jem.194.6.769
    • (2001) J Exp Med , vol.194 , Issue.6 , pp. 769-779
    • Hawiger, D.1    Inaba, K.2    Dorsett, Y.3    Guo, M.4    Mahnke, K.5    Rivera, M.6
  • 23
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 196(12):1627-38. doi:10.1084/jem.20021598
    • (2002) J Exp Med , vol.196 , Issue.12 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 24
    • 0037616135 scopus 로고    scopus 로고
    • A potent adjuvant effect of CD40 antibody attached to antigen
    • Barr TA, McCormick AL, Carlring J, Heath AW. A potent adjuvant effect of CD40 antibody attached to antigen. Immunology (2003) 109(1):87-92. doi:10.1046/j.1365-2567.2003.01634.x
    • (2003) Immunology , vol.109 , Issue.1 , pp. 87-92
    • Barr, T.A.1    McCormick, A.L.2    Carlring, J.3    Heath, A.W.4
  • 25
    • 12144286596 scopus 로고    scopus 로고
    • In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    • Bonifaz LC, Bonnyay DP, Charalambous A, Darguste DI, Fujii S, Soares H, et al. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med (2004) 199(6):815-24. doi:10.1084/jem.20032220
    • (2004) J Exp Med , vol.199 , Issue.6 , pp. 815-824
    • Bonifaz, L.C.1    Bonnyay, D.P.2    Charalambous, A.3    Darguste, D.I.4    Fujii, S.5    Soares, H.6
  • 26
    • 77957131592 scopus 로고    scopus 로고
    • Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
    • Do Y, Koh H, Park CG, Dudziak D, Seo P, Mehandru S, et al. Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Eur J Immunol (2010) 40(10):2791-6. doi:10.1002/eji.201040511
    • (2010) Eur J Immunol , vol.40 , Issue.10 , pp. 2791-2796
    • Do, Y.1    Koh, H.2    Park, C.G.3    Dudziak, D.4    Seo, P.5    Mehandru, S.6
  • 27
    • 40649097299 scopus 로고    scopus 로고
    • The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
    • Trumpfheller C, Caskey M, Nchinda G, Longhi MP, Mizenina O, Huang Y, et al. The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A (2008) 105(7):2574-9. doi:10.1073/pnas.0711976105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.7 , pp. 2574-2579
    • Trumpfheller, C.1    Caskey, M.2    Nchinda, G.3    Longhi, M.P.4    Mizenina, O.5    Huang, Y.6
  • 28
    • 85007010450 scopus 로고    scopus 로고
    • The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells
    • Amorim KN, Rampazo EV, Antonialli R, Yamamoto MM, Rodrigues MM, Soares IS, et al. The presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells. Sci Rep (2016) 6:39250. doi:10.1038/srep39250
    • (2016) Sci Rep , vol.6 , pp. 39250
    • Amorim, K.N.1    Rampazo, E.V.2    Antonialli, R.3    Yamamoto, M.M.4    Rodrigues, M.M.5    Soares, I.S.6
  • 29
    • 67650445798 scopus 로고    scopus 로고
    • Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    • Longhi MP, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, et al. Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 206(7):1589-602. doi:10.1084/jem.20090247
    • (2009) J Exp Med , vol.206 , Issue.7 , pp. 1589-1602
    • Longhi, M.P.1    Trumpfheller, C.2    Idoyaga, J.3    Caskey, M.4    Matos, I.5    Kluger, C.6
  • 32
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by toll-like receptor 5
    • Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature (2001) 410(6832):1099-103. doi:10.1038/35074106
    • (2001) Nature , vol.410 , Issue.6832 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3    Hawn, T.R.4    Yi, E.C.5    Goodlett, D.R.6
  • 33
    • 84857335818 scopus 로고    scopus 로고
    • Structural basis of TLR5-flagellin recognition and signaling
    • Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, et al. Structural basis of TLR5-flagellin recognition and signaling. Science (2012) 335(6070):859-64. doi:10.1126/science.1215584
    • (2012) Science , vol.335 , Issue.6070 , pp. 859-864
    • Yoon, S.I.1    Kurnasov, O.2    Natarajan, V.3    Hong, M.4    Gudkov, A.V.5    Osterman, A.L.6
  • 34
    • 52549099416 scopus 로고    scopus 로고
    • Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    • Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol (2008) 9(10):1171-8. doi:10.1038/ni.1646
    • (2008) Nat Immunol , vol.9 , Issue.10 , pp. 1171-1178
    • Lightfield, K.L.1    Persson, J.2    Brubaker, S.W.3    Witte, C.E.4    von Moltke, J.5    Dunipace, E.A.6
  • 35
    • 33744464740 scopus 로고    scopus 로고
    • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    • Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 7(6):576-82. doi:10.1038/ni1346
    • (2006) Nat Immunol , vol.7 , Issue.6 , pp. 576-582
    • Franchi, L.1    Amer, A.2    Body-Malapel, M.3    Kanneganti, T.D.4    Ozoren, N.5    Jagirdar, R.6
  • 36
    • 33645960706 scopus 로고    scopus 로고
    • TLR signaling
    • Kawai T, Akira S. TLR signaling. Cell Death Differ (2006) 13(5):816-25. doi:10.1038/sj.cdd.4401850
    • (2006) Cell Death Differ , vol.13 , Issue.5 , pp. 816-825
    • Kawai, T.1    Akira, S.2
  • 37
    • 84908592762 scopus 로고    scopus 로고
    • Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer
    • Scheiermann J, Klinman DM. Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer. Vaccine (2014) 32(48):6377-89. doi:10.1016/j.vaccine.2014.06.065
    • (2014) Vaccine , vol.32 , Issue.48 , pp. 6377-6389
    • Scheiermann, J.1    Klinman, D.M.2
  • 38
    • 78649741148 scopus 로고    scopus 로고
    • Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults
    • Treanor JJ, Taylor DN, Tussey L, Hay C, Nolan C, Fitzgerald T, et al. Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults. Vaccine (2010) 28(52):8268-74. doi:10.1016/j.vaccine.2010.10.009
    • (2010) Vaccine , vol.28 , Issue.52 , pp. 8268-8274
    • Treanor, J.J.1    Taylor, D.N.2    Tussey, L.3    Hay, C.4    Nolan, C.5    Fitzgerald, T.6
  • 39
    • 79960308363 scopus 로고    scopus 로고
    • Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults
    • Turley CB, Rupp RE, Johnson C, Taylor DN, Wolfson J, Tussey L, et al. Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults. Vaccine (2011) 29(32):5145-52. doi:10.1016/j.vaccine.2011.05.041
    • (2011) Vaccine , vol.29 , Issue.32 , pp. 5145-5152
    • Turley, C.B.1    Rupp, R.E.2    Johnson, C.3    Taylor, D.N.4    Wolfson, J.5    Tussey, L.6
  • 40
    • 84878191150 scopus 로고    scopus 로고
    • IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
    • Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, et al. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 38(5):970-83. doi:10.1016/j.immuni.2013.04.011
    • (2013) Immunity , vol.38 , Issue.5 , pp. 970-983
    • Schlitzer, A.1    McGovern, N.2    Teo, P.3    Zelante, T.4    Atarashi, K.5    Low, D.6
  • 41
    • 84933678575 scopus 로고    scopus 로고
    • CD8alpha(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses
    • Shin C, Han JA, Koh H, Choi B, Cho Y, Jeong H, et al. CD8alpha(-) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses. Cell Rep (2015) 11(12):1929-40. doi:10.1016/j.celrep.2015.05.042
    • (2015) Cell Rep , vol.11 , Issue.12 , pp. 1929-1940
    • Shin, C.1    Han, J.A.2    Koh, H.3    Choi, B.4    Cho, Y.5    Jeong, H.6
  • 42
    • 84971254846 scopus 로고    scopus 로고
    • EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
    • Li J, Lu E, Yi T, Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature (2016) 533(7601):110-4. doi:10.1038/nature17947
    • (2016) Nature , vol.533 , Issue.7601 , pp. 110-114
    • Li, J.1    Lu, E.2    Yi, T.3    Cyster, J.G.4
  • 43
    • 1842680774 scopus 로고    scopus 로고
    • The pan HLA DR-binding epitope improves adjuvant-assisted immunization with a recombinant protein containing a malaria vaccine candidate
    • Rosa DS, Tzelepis F, Cunha MG, Soares IS, Rodrigues MM. The pan HLA DR-binding epitope improves adjuvant-assisted immunization with a recombinant protein containing a malaria vaccine candidate. Immunol Lett (2004) 92(3):259-68. doi:10.1016/j.imlet.2004.01.006
    • (2004) Immunol Lett , vol.92 , Issue.3 , pp. 259-268
    • Rosa, D.S.1    Tzelepis, F.2    Cunha, M.G.3    Soares, I.S.4    Rodrigues, M.M.5
  • 44
    • 0028675323 scopus 로고
    • Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
    • Alexander J, Sidney J, Southwood S, Ruppert J, Oseroff C, Maewal A, et al. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity (1994) 1(9):751-61. doi:10.1016/S1074-7613(94)80017-0
    • (1994) Immunity , vol.1 , Issue.9 , pp. 751-761
    • Alexander, J.1    Sidney, J.2    Southwood, S.3    Ruppert, J.4    Oseroff, C.5    Maewal, A.6
  • 45
    • 0030955428 scopus 로고    scopus 로고
    • Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo
    • del Guercio MF, Alexander J, Kubo RT, Arrhenius T, Maewal A, Appella E, et al. Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo. Vaccine (1997) 15(4):441-8. doi:10.1016/S0264-410X(97)00186-2
    • (1997) Vaccine , vol.15 , Issue.4 , pp. 441-448
    • del Guercio, M.F.1    Alexander, J.2    Kubo, R.T.3    Arrhenius, T.4    Maewal, A.5    Appella, E.6
  • 46
    • 33746161021 scopus 로고    scopus 로고
    • Detection of pathogenic intestinal bacteria by toll-like receptor 5 on intestinal CD11c+ lamina propria cells
    • Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, et al. Detection of pathogenic intestinal bacteria by toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 7(8):868-74. doi:10.1038/ni1362
    • (2006) Nat Immunol , vol.7 , Issue.8 , pp. 868-874
    • Uematsu, S.1    Jang, M.H.2    Chevrier, N.3    Guo, Z.4    Kumagai, Y.5    Yamamoto, M.6
  • 47
    • 0034619794 scopus 로고    scopus 로고
    • A toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A toll-like receptor recognizes bacterial DNA. Nature (2000) 408(6813):740-5. doi:10.1038/35047123
    • (2000) Nature , vol.408 , Issue.6813 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3    Kaisho, T.4    Sato, S.5    Sanjo, H.6
  • 48
    • 0035851327 scopus 로고    scopus 로고
    • Comparison of the immunogenic properties of recombinant proteins representing the Plasmodium vivax vaccine candidate MSP1(19) expressed in distinct bacterial vectors
    • Cunha MG, Rodrigues MM, Soares IS. Comparison of the immunogenic properties of recombinant proteins representing the Plasmodium vivax vaccine candidate MSP1(19) expressed in distinct bacterial vectors. Vaccine (2001) 20(3-4):385-96. doi:10.1016/S0264-410X(01)00359-0
    • (2001) Vaccine , vol.20 , Issue.3-4 , pp. 385-396
    • Cunha, M.G.1    Rodrigues, M.M.2    Soares, I.S.3
  • 49
    • 74149087014 scopus 로고    scopus 로고
    • CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein
    • Braga CJ, Massis LM, Sbrogio-Almeida ME, Alencar BC, Bargieri DY, Boscardin SB, et al. CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein. Vaccine (2010) 28(5):1373-82. doi:10.1016/j.vaccine.2009.11.003
    • (2010) Vaccine , vol.28 , Issue.5 , pp. 1373-1382
    • Braga, C.J.1    Massis, L.M.2    Sbrogio-Almeida, M.E.3    Alencar, B.C.4    Bargieri, D.Y.5    Boscardin, S.B.6
  • 50
    • 0038142387 scopus 로고    scopus 로고
    • A role for toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood (2003) 101(11):4500-4. doi:10.1182/blood-2002-11-3569
    • (2003) Blood , vol.101 , Issue.11 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 51
    • 65449118056 scopus 로고    scopus 로고
    • BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation
    • Eckl-Dorna J, Batista FD. BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation. Blood (2009) 113(17):3969-77. doi:10.1182/blood-2008-10-185421
    • (2009) Blood , vol.113 , Issue.17 , pp. 3969-3977
    • Eckl-Dorna, J.1    Batista, F.D.2
  • 52
    • 85010288632 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
    • Hanagata N. CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies. Int J Nanomedicine (2017) 12:515-31. doi:10.2147/IJN.S114477
    • (2017) Int J Nanomedicine , vol.12 , pp. 515-531
    • Hanagata, N.1
  • 53
    • 84859712235 scopus 로고    scopus 로고
    • Contribution of toll-like receptor signaling to germinal center antibody responses
    • DeFranco AL, Rookhuizen DC, Hou B. Contribution of toll-like receptor signaling to germinal center antibody responses. Immunol Rev (2012) 247(1):64-72. doi:10.1111/j.1600-065X.2012.01115.x
    • (2012) Immunol Rev , vol.247 , Issue.1 , pp. 64-72
    • DeFranco, A.L.1    Rookhuizen, D.C.2    Hou, B.3
  • 54
    • 84958555012 scopus 로고    scopus 로고
    • Intrinsic features of the CD8alpha(-) dendritic cell subset in inducing functional T follicular helper cells
    • Shin C, Han JA, Choi B, Cho YK, Do Y, Ryu S. Intrinsic features of the CD8alpha(-) dendritic cell subset in inducing functional T follicular helper cells. Immunol Lett (2016) 172:21-8. doi:10.1016/j.imlet.2016.01.009
    • (2016) Immunol Lett , vol.172 , pp. 21-28
    • Shin, C.1    Han, J.A.2    Choi, B.3    Cho, Y.K.4    Do, Y.5    Ryu, S.6
  • 55
    • 2442652766 scopus 로고    scopus 로고
    • Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response
    • Didierlaurent A, Ferrero I, Otten LA, Dubois B, Reinhardt M, Carlsen H, et al. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol (2004) 172(11):6922-30. doi:10.4049/jimmunol.172.11.6922
    • (2004) J Immunol , vol.172 , Issue.11 , pp. 6922-6930
    • Didierlaurent, A.1    Ferrero, I.2    Otten, L.A.3    Dubois, B.4    Reinhardt, M.5    Carlsen, H.6
  • 56
    • 84896715502 scopus 로고    scopus 로고
    • Flagellin induces antibody responses through a TLR5-and inflammasome-independent pathway
    • Lopez-Yglesias AH, Zhao X, Quarles EK, Lai MA, VandenBos T, Strong RK, et al. Flagellin induces antibody responses through a TLR5-and inflammasome-independent pathway. J Immunol (2014) 192(4):1587-96. doi:10.4049/jimmunol.1301893
    • (2014) J Immunol , vol.192 , Issue.4 , pp. 1587-1596
    • Lopez-Yglesias, A.H.1    Zhao, X.2    Quarles, E.K.3    Lai, M.A.4    VandenBos, T.5    Strong, R.K.6
  • 57
    • 84869044838 scopus 로고    scopus 로고
    • Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N-and C-terminal regions of flagellin
    • Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG. Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N-and C-terminal regions of flagellin. J Biol Chem (2012) 287(46):38460-72. doi:10.1074/jbc.M112.393512
    • (2012) J Biol Chem , vol.287 , Issue.46 , pp. 38460-38472
    • Halff, E.F.1    Diebolder, C.A.2    Versteeg, M.3    Schouten, A.4    Brondijk, T.H.5    Huizinga, E.G.6
  • 58
    • 34248997138 scopus 로고    scopus 로고
    • A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo
    • Soares H, Waechter H, Glaichenhaus N, Mougneau E, Yagita H, Mizenina O, et al. A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 204(5):1095-106. doi:10.1084/jem.20070176
    • (2007) J Exp Med , vol.204 , Issue.5 , pp. 1095-1106
    • Soares, H.1    Waechter, H.2    Glaichenhaus, N.3    Mougneau, E.4    Yagita, H.5    Mizenina, O.6
  • 59
    • 85014363837 scopus 로고    scopus 로고
    • Dendritic cell targeting effectively boosts T cell responses elicited by an HIV multiepitope DNA vaccine
    • Apostolico JS, Lunardelli VA, Yamamoto MM, Souza HF, Cunha-Neto E, Boscardin SB, et al. Dendritic cell targeting effectively boosts T cell responses elicited by an HIV multiepitope DNA vaccine. Front Immunol (2017) 8:101. doi:10.3389/fimmu.2017.00101
    • (2017) Front Immunol , vol.8 , pp. 101
    • Apostolico, J.S.1    Lunardelli, V.A.2    Yamamoto, M.M.3    Souza, H.F.4    Cunha-Neto, E.5    Boscardin, S.B.6
  • 60
    • 0037738569 scopus 로고    scopus 로고
    • Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines
    • Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, et al. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol (2003) 33(4):827-33. doi:10.1002/eji.200323797
    • (2003) Eur J Immunol , vol.33 , Issue.4 , pp. 827-833
    • Edwards, A.D.1    Diebold, S.S.2    Slack, E.M.3    Tomizawa, H.4    Hemmi, H.5    Kaisho, T.6
  • 61
    • 0345447639 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
    • Spies B, Hochrein H, Vabulas M, Huster K, Busch DH, Schmitz F, et al. Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol (2003) 171(11):5908-12. doi:10.4049/jimmunol.171.11.5908
    • (2003) J Immunol , vol.171 , Issue.11 , pp. 5908-5912
    • Spies, B.1    Hochrein, H.2    Vabulas, M.3    Huster, K.4    Busch, D.H.5    Schmitz, F.6
  • 62
    • 25644451261 scopus 로고    scopus 로고
    • Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions
    • Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, Matsumoto T, et al. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol (2005) 78(4):888-97. doi:10.1189/jlb.0105051
    • (2005) J Leukoc Biol , vol.78 , Issue.4 , pp. 888-897
    • Tsujimoto, H.1    Uchida, T.2    Efron, P.A.3    Scumpia, P.O.4    Verma, A.5    Matsumoto, T.6
  • 63
    • 68149125524 scopus 로고    scopus 로고
    • TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses
    • Vicente-Suarez I, Brayer J, Villagra A, Cheng F, Sotomayor EM. TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses. Immunol Lett (2009) 125(2):114-8. doi:10.1016/j.imlet.2009.06.007
    • (2009) Immunol Lett , vol.125 , Issue.2 , pp. 114-118
    • Vicente-Suarez, I.1    Brayer, J.2    Villagra, A.3    Cheng, F.4    Sotomayor, E.M.5
  • 64
    • 0038222345 scopus 로고    scopus 로고
    • The toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    • Means TK, Hayashi F, Smith KD, Aderem A, Luster AD. The toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 170(10):5165-75. doi:10.4049/jimmunol.170.10.5165
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 5165-5175
    • Means, T.K.1    Hayashi, F.2    Smith, K.D.3    Aderem, A.4    Luster, A.D.5
  • 65
    • 38449101982 scopus 로고    scopus 로고
    • Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo
    • Salazar-Gonzalez RM, Srinivasan A, Griffin A, Muralimohan G, Ertelt JM, Ravindran R, et al. Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo. J Immunol (2007) 179(9):6169-75. doi:10.4049/jimmunol.179.9.6169
    • (2007) J Immunol , vol.179 , Issue.9 , pp. 6169-6175
    • Salazar-Gonzalez, R.M.1    Srinivasan, A.2    Griffin, A.3    Muralimohan, G.4    Ertelt, J.M.5    Ravindran, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.