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Volumn 179, Issue 9, 2007, Pages 6169-6175

Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CD8ALPHA ANTIGEN; CELL MARKER; FLAGELLIN; INTERLEUKIN 12P70; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL DNA; CD8 ANTIGEN; CD8ALPHAALPHA ANTIGEN; UNCLASSIFIED DRUG;

EID: 38449101982     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.9.6169     Document Type: Article
Times cited : (56)

References (57)
  • 1
    • 0029965794 scopus 로고    scopus 로고
    • Salmonellosis: Host immune responses and bacterial virulence determinants
    • Jones, B. D., and S. Falkow. 1996. Salmonellosis: host immune responses and bacterial virulence determinants. Annu. Rev. Immunol. 14: 533-561.
    • (1996) Annu. Rev. Immunol , vol.14 , pp. 533-561
    • Jones, B.D.1    Falkow, S.2
  • 2
    • 2642571836 scopus 로고    scopus 로고
    • The global burden of typhoid fever
    • Crump, J. A., S. P. Luby, and E. D. Mintz. 2004. The global burden of typhoid fever. Bull. W. H. O. 82: 346-353.
    • (2004) Bull. W. H. O , vol.82 , pp. 346-353
    • Crump, J.A.1    Luby, S.P.2    Mintz, E.D.3
  • 5
    • 0017238362 scopus 로고
    • Genetics of resistance to infection with Salmonella typhimurium in mice
    • Plant, J., and A. A. Glynn. 1976. Genetics of resistance to infection with Salmonella typhimurium in mice. J. Infect. Dis. 133: 72-78.
    • (1976) J. Infect. Dis , vol.133 , pp. 72-78
    • Plant, J.1    Glynn, A.A.2
  • 6
    • 0026354288 scopus 로고
    • Role of γ interferon and tumor necrosis factor α in resistance to Salmonella typhimurium infection
    • Nauciel, C., and F. Espinasse-Maes. 1992. Role of γ interferon and tumor necrosis factor α in resistance to Salmonella typhimurium infection. Infect. Immun. 60: 450-454.
    • (1992) Infect. Immun , vol.60 , pp. 450-454
    • Nauciel, C.1    Espinasse-Maes, F.2
  • 7
    • 0029886029 scopus 로고    scopus 로고
    • + TCR-αβ cells and IFN-γ in bacterial clearance independent of intracellular location
    • + TCR-αβ cells and IFN-γ in bacterial clearance independent of intracellular location. J. Immunol. 156: 3321-3326.
    • (1996) J. Immunol , vol.156 , pp. 3321-3326
    • Hess, J.1    Ladel, C.2    Miko, D.3    Kaufmann, S.H.4
  • 8
    • 25444439804 scopus 로고    scopus 로고
    • Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection
    • Ravindran, R., J. Foley, T. Stoklasek, L. H. Glimcher, and S. J. McSorley. 2005. Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J. Immunol. 175: 4603-4610.
    • (2005) J. Immunol , vol.175 , pp. 4603-4610
    • Ravindran, R.1    Foley, J.2    Stoklasek, T.3    Glimcher, L.H.4    McSorley, S.J.5
  • 9
    • 33846136089 scopus 로고    scopus 로고
    • Innate recognition of intracellular bacteria
    • Delbridge, L. M., and M. X. O'Riordan. 2007. Innate recognition of intracellular bacteria. Curr. Opin. Immunol. 19: 10-16.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 10-16
    • Delbridge, L.M.1    O'Riordan, M.X.2
  • 10
    • 1642317049 scopus 로고    scopus 로고
    • Toll-like receptors are temporally involved in host defense
    • Weiss, D. S., B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky. 2004. Toll-like receptors are temporally involved in host defense. J. Immunol. 172: 4463-4469.
    • (2004) J. Immunol , vol.172 , pp. 4463-4469
    • Weiss, D.S.1    Raupach, B.2    Takeda, K.3    Akira, S.4    Zychlinsky, A.5
  • 12
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752.
    • (1999) J. Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 14
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz, A. T., T. A. Nava, S. Lyons, P. J. Godowski, and J. L. Madera. 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167: 1882-1885.
    • (2001) J. Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Nava, T.A.2    Lyons, S.3    Godowski, P.J.4    Madera, J.L.5
  • 17
    • 25444453726 scopus 로고    scopus 로고
    • Salmonella flagellin, a microbial target of the innate and adaptive immune system
    • Salazar-Gonzalez, R. M., and S. J. McSorley. 2005. Salmonella flagellin, a microbial target of the innate and adaptive immune system. Immunol. Lett. 101: 117-122.
    • (2005) Immunol. Lett , vol.101 , pp. 117-122
    • Salazar-Gonzalez, R.M.1    McSorley, S.J.2
  • 18
    • 24644442139 scopus 로고    scopus 로고
    • Effects of flagellin on innate and adaptive immunity
    • Honko, A. N., and S. B. Mizel. 2005. Effects of flagellin on innate and adaptive immunity. Immunol. Res. 33: 83-101.
    • (2005) Immunol. Res , vol.33 , pp. 83-101
    • Honko, A.N.1    Mizel, S.B.2
  • 19
    • 33644830557 scopus 로고    scopus 로고
    • Flag in the crossroads: Flagellin modulates innate and adaptive immunity
    • Gewirtz, A. T. 2006. Flag in the crossroads: flagellin modulates innate and adaptive immunity. Curr. Opin. Gastroenterol. 22: 8-12.
    • (2006) Curr. Opin. Gastroenterol , vol.22 , pp. 8-12
    • Gewirtz, A.T.1
  • 20
    • 0031913034 scopus 로고    scopus 로고
    • Salmonella flagellin induces tumor necrosis factor α in a human promonocytic cell line
    • Ciacci-Woolwine, F., I. C. Blomfield, S. H. Richardson, and S. B. Mizel. 1998. Salmonella flagellin induces tumor necrosis factor α in a human promonocytic cell line. Infect. Immun. 66: 1127-1134.
    • (1998) Infect. Immun , vol.66 , pp. 1127-1134
    • Ciacci-Woolwine, F.1    Blomfield, I.C.2    Richardson, S.H.3    Mizel, S.B.4
  • 21
    • 0032833747 scopus 로고    scopus 로고
    • Induction of cytokine synthesis by flagella from Gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes
    • Ciacci-Woolwine, F., P. F. McDermott, and S. B. Mizel. 1999. Induction of cytokine synthesis by flagella from Gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes. Infect. Immun. 67: 5176-5185.
    • (1999) Infect. Immun , vol.67 , pp. 5176-5185
    • Ciacci-Woolwine, F.1    McDermott, P.F.2    Mizel, S.B.3
  • 22
    • 0033007233 scopus 로고    scopus 로고
    • Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes
    • Wyant, T. L., M. K. Tanner, and M. B. Sztein. 1999. Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes. Infect. Immun. 67: 3619-3624.
    • (1999) Infect. Immun , vol.67 , pp. 3619-3624
    • Wyant, T.L.1    Tanner, M.K.2    Sztein, M.B.3
  • 23
    • 0035863730 scopus 로고    scopus 로고
    • Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: IκBα degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction
    • Eaves-Pyles, T., K. Murthy, L. Liaudet, L. Virag, G. Ross, F. G. Soriano, C. Szabo, and A. L. Salzman. 2001. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: IκBα degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J. Immunol. 166: 1248-1260.
    • (2001) J. Immunol , vol.166 , pp. 1248-1260
    • Eaves-Pyles, T.1    Murthy, K.2    Liaudet, L.3    Virag, L.4    Ross, G.5    Soriano, F.G.6    Szabo, C.7    Salzman, A.L.8
  • 25
    • 0036139175 scopus 로고    scopus 로고
    • Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide
    • Liaudet, L., K. G. Murthy, J. G. Mabley, P. Pacher, F. G. Soriano, A. L. Salzman, and C. Szabo. 2002. Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect. Immun. 70: 192-198.
    • (2002) Infect. Immun , vol.70 , pp. 192-198
    • Liaudet, L.1    Murthy, K.G.2    Mabley, J.G.3    Pacher, P.4    Soriano, F.G.5    Salzman, A.L.6    Szabo, C.7
  • 26
    • 7044220508 scopus 로고    scopus 로고
    • Mucosal administration of flagellin induces innate immunity in the mouse lung
    • Honko, A. N., and S. B. Mizel. 2004. Mucosal administration of flagellin induces innate immunity in the mouse lung. Infect. Immun. 72: 6676-6679.
    • (2004) Infect. Immun , vol.72 , pp. 6676-6679
    • Honko, A.N.1    Mizel, S.B.2
  • 29
    • 0035892911 scopus 로고    scopus 로고
    • Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein
    • Eaves-Pyles, T. D., H. R. Wong, K. Odoms, and R. B. Pyles. 2001. Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J. Immunol. 167: 7009-7016.
    • (2001) J. Immunol , vol.167 , pp. 7009-7016
    • Eaves-Pyles, T.D.1    Wong, H.R.2    Odoms, K.3    Pyles, R.B.4
  • 30
  • 31
    • 0036784636 scopus 로고    scopus 로고
    • Bacterial flagellin is an effective adjuvant for CD4 T cells in vivo
    • McSorley, S. J., B. D. Ehst, Y. Yu, and A. T. Gewirtz. 2002. Bacterial flagellin is an effective adjuvant for CD4 T cells in vivo. J. Immunol. 169: 3914.
    • (2002) J. Immunol , vol.169 , pp. 3914
    • McSorley, S.J.1    Ehst, B.D.2    Yu, Y.3    Gewirtz, A.T.4
  • 33
    • 33747791726 scopus 로고    scopus 로고
    • Humoral immune response to flagellin requires T cells and activation of innate immunity
    • Sanders, C. J., Y. Yu, D. A. Moore III, I. R. Williams, and A. T. Gewirtz. 2006. Humoral immune response to flagellin requires T cells and activation of innate immunity. J. Immunol. 177: 2810-2818.
    • (2006) J. Immunol , vol.177 , pp. 2810-2818
    • Sanders, C.J.1    Yu, Y.2    Moore III, D.A.3    Williams, I.R.4    Gewirtz, A.T.5
  • 34
    • 33845224163 scopus 로고    scopus 로고
    • Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
    • Huleatt, J. W., A. R. Jacobs, J. Tang, P. Desai, E. B. Kopp, Y. Huang, L. Song, V. Nakaar, and T. J. Powell. 2007. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 25: 763-775.
    • (2007) Vaccine , vol.25 , pp. 763-775
    • Huleatt, J.W.1    Jacobs, A.R.2    Tang, J.3    Desai, P.4    Kopp, E.B.5    Huang, Y.6    Song, L.7    Nakaar, V.8    Powell, T.J.9
  • 36
    • 0038222345 scopus 로고    scopus 로고
    • The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    • Means, T. K., F. Hayashi, K. D. Smith, A. Aderem, and A. D. Luster. 2003. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170: 5165-5175.
    • (2003) J. Immunol , vol.170 , pp. 5165-5175
    • Means, T.K.1    Hayashi, F.2    Smith, K.D.3    Aderem, A.4    Luster, A.D.5
  • 38
    • 0000060327 scopus 로고    scopus 로고
    • Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186: 1819-1829.
    • Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186: 1819-1829.
  • 39
    • 0033151915 scopus 로고    scopus 로고
    • Reis e Sousa, C., and R. N. Germain. 1999. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue. J. Immunol. 162: 6552-6561.
    • Reis e Sousa, C., and R. N. Germain. 1999. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue. J. Immunol. 162: 6552-6561.
  • 41
    • 12244253722 scopus 로고    scopus 로고
    • Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
    • Eriksson, S., S. Lucchini, A. Thompson, M. Rhen, and J. C. Hinton. 2003. Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica. Mol. Microbiol. 47: 103-118.
    • (2003) Mol. Microbiol , vol.47 , pp. 103-118
    • Eriksson, S.1    Lucchini, S.2    Thompson, A.3    Rhen, M.4    Hinton, J.C.5
  • 42
    • 33748329474 scopus 로고    scopus 로고
    • In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted
    • Cummings, L. A., W. D. Wilkerson, T. Bergsbaken, and B. T. Cookson. 2006. In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted. Mol. Microbiol. 61: 795-809.
    • (2006) Mol. Microbiol , vol.61 , pp. 795-809
    • Cummings, L.A.1    Wilkerson, W.D.2    Bergsbaken, T.3    Cookson, B.T.4
  • 43
    • 0021683649 scopus 로고
    • Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice
    • Carsiotis, M., D. L. Weinstein, H. Karch, I. A. Holder, and A. D. O'Brien. 1984. Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice. Infect. Immun. 46: 814-818.
    • (1984) Infect. Immun , vol.46 , pp. 814-818
    • Carsiotis, M.1    Weinstein, D.L.2    Karch, H.3    Holder, I.A.4    O'Brien, A.D.5
  • 44
    • 0021716765 scopus 로고
    • Flagella help Salmonella typhimurium survive within murine macrophages
    • Weinstein, D. L., M. Carsiotis, C. R. Lissner, and A. D. O'Brien. 1984. Flagella help Salmonella typhimurium survive within murine macrophages. Infect. Immun. 46: 819-825.
    • (1984) Infect. Immun , vol.46 , pp. 819-825
    • Weinstein, D.L.1    Carsiotis, M.2    Lissner, C.R.3    O'Brien, A.D.4
  • 46
    • 0025157622 scopus 로고
    • Salmonella typhimurium mutants lacking flagella or motility remain virulent in BALB/c mice
    • Lockman, H. A., and R. Curtiss III. 1990. Salmonella typhimurium mutants lacking flagella or motility remain virulent in BALB/c mice. Infect. Immun. 58: 137-143.
    • (1990) Infect. Immun , vol.58 , pp. 137-143
    • Lockman, H.A.1    Curtiss III, R.2
  • 47
    • 0034874499 scopus 로고    scopus 로고
    • Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis
    • Schmitt, C. K., J. S. Ikeda, S. C. Darnell, P. R. Watson, J. Bispham, T. S. Wallis, D. L. Weinstein, E. S. Metcalf, and A. D. O'Brien. 2001. Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis. Infect. Immun. 69: 5619-5625.
    • (2001) Infect. Immun , vol.69 , pp. 5619-5625
    • Schmitt, C.K.1    Ikeda, J.S.2    Darnell, S.C.3    Watson, P.R.4    Bispham, J.5    Wallis, T.S.6    Weinstein, D.L.7    Metcalf, E.S.8    O'Brien, A.D.9
  • 48
    • 0037238314 scopus 로고    scopus 로고
    • Lack of flagella disadvantages Salmonella enterica serovar Enteritidis during the early stages of infection in the rat
    • Robertson, J. M., N. H. McKenzie, M. Duncan, E. Allen-Vercoe, M. J. Woodward, H. J. Flint, and G. Grant. 2003. Lack of flagella disadvantages Salmonella enterica serovar Enteritidis during the early stages of infection in the rat. J. Med. Microbiol. 52: 91-99.
    • (2003) J. Med. Microbiol , vol.52 , pp. 91-99
    • Robertson, J.M.1    McKenzie, N.H.2    Duncan, M.3    Allen-Vercoe, E.4    Woodward, M.J.5    Flint, H.J.6    Grant, G.7
  • 49
    • 0034650406 scopus 로고    scopus 로고
    • + T cell responses during natural infection with Salmonella typhimurium
    • + T cell responses during natural infection with Salmonella typhimurium. J. Immunol. 164: 986-993.
    • (2000) J. Immunol , vol.164 , pp. 986-993
    • McSorley, S.J.1    Cookson, B.T.2    Jenkins, M.K.3
  • 50
    • 14744302999 scopus 로고
    • Use of the nirB promoter to direct the stable expression of hetrologous antigens in Salmonella oral vaccine strains: Development of a single-dose oral tetanus vaccine
    • Chatfield, S. N., I. G. Charles, A. J. Makoff, M. D. Oxer, G. Dougan, D. Pickard, D. Slater, and N. F. Fairweather. 1992. Use of the nirB promoter to direct the stable expression of hetrologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology 10: 888-892.
    • (1992) Biotechnology , vol.10 , pp. 888-892
    • Chatfield, S.N.1    Charles, I.G.2    Makoff, A.J.3    Oxer, M.D.4    Dougan, G.5    Pickard, D.6    Slater, D.7    Fairweather, N.F.8
  • 51
    • 34547546723 scopus 로고    scopus 로고
    • CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection
    • Ravindran, R., L. Rusch, A. Itano, M. K. Jenkins, and S. J. McSorley. 2007. CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection. Proc. Natl. Acad. Sci. USA 104: 12075-12080.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12075-12080
    • Ravindran, R.1    Rusch, L.2    Itano, A.3    Jenkins, M.K.4    McSorley, S.J.5
  • 52
    • 0022342125 scopus 로고
    • Method for the isolation of highly purified Salmonella flagellins
    • Ibrahim, G. F., G. H. Fleet, M. J. Lyons, and R. A. Walker. 1985. Method for the isolation of highly purified Salmonella flagellins. J. Clin. Microbiol. 22: 1040-1044.
    • (1985) J. Clin. Microbiol , vol.22 , pp. 1040-1044
    • Ibrahim, G.F.1    Fleet, G.H.2    Lyons, M.J.3    Walker, R.A.4
  • 53
    • 9244237556 scopus 로고    scopus 로고
    • Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
    • Sato, A., and A. Iwasaki. 2004. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc. Natl. Acad. Sci. USA 101: 16274-16279.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16274-16279
    • Sato, A.1    Iwasaki, A.2
  • 54
    • 33845382579 scopus 로고    scopus 로고
    • Effects of LPS-mediated bystander activation in the innate immune system
    • Yadav, R., D. J. Zammit, L. Lefrancois, and A. T. Vella. 2006. Effects of LPS-mediated bystander activation in the innate immune system. J. Leukocyte Biol. 80: 1251-1261.
    • (2006) J. Leukocyte Biol , vol.80 , pp. 1251-1261
    • Yadav, R.1    Zammit, D.J.2    Lefrancois, L.3    Vella, A.T.4
  • 55
    • 0037738569 scopus 로고    scopus 로고
    • + DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33: 827-833.
    • + DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33: 827-833.
  • 56
    • 0025150320 scopus 로고
    • + T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection
    • + T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection. J. Immunol. 145: 1265-1269.
    • (1990) J. Immunol , vol.145 , pp. 1265-1269
    • Nauciel, C.1
  • 57
    • 0027185279 scopus 로고
    • Adoptive transfer of immunity to oral challenge with virulent Salmonella in innately susceptible BALB/c mice requires both immune serum and T cells
    • Mastroeni, P., B. Villarreal-Ramos, and C. E. Hormaeche. 1993. Adoptive transfer of immunity to oral challenge with virulent Salmonella in innately susceptible BALB/c mice requires both immune serum and T cells. Infect. Immun. 61: 3981-3984.
    • (1993) Infect. Immun , vol.61 , pp. 3981-3984
    • Mastroeni, P.1    Villarreal-Ramos, B.2    Hormaeche, C.E.3


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