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Volumn 71, Issue 3, 2002, Pages 538-544

Toll-like receptor 9 mediates CpG-DNA signaling

Author keywords

IFN ; Innate immunity; M D88; NF B

Indexed keywords

BACTERIAL DNA; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYNUCLEOTIDE; PROTEIN; PROTEIN IRAK; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 0036521725     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (172)

References (52)
  • 1
    • 0033592530 scopus 로고    scopus 로고
    • Toll gates for pathogen selection
    • Ulevitch, R. J. (1999) Toll gates for pathogen selection. Nature 401, 755-756.
    • (1999) Nature , vol.401 , pp. 755-756
    • Ulevitch, R.J.1
  • 2
    • 0033578917 scopus 로고    scopus 로고
    • Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
    • Levashina, E. A., Langley, E., Green, C., Gubb, D., Ashbumer, M., Hoffmann, J. A., Reichhart, J. M. (1999) Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 285, 1917-1919.
    • (1999) Science , vol.285 , pp. 1917-1919
    • Levashina, E.A.1    Langley, E.2    Green, C.3    Gubb, D.4    Ashbumer, M.5    Hoffmann, J.A.6    Reichhart, J.M.7
  • 3
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem, A., Ulevitch, R. J. (2000) Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 4
    • 0035911644 scopus 로고    scopus 로고
    • Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells
    • Chuang, T., Ulevitch, R. J. (2001) Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518, 157-161.
    • (2001) Biochim. Biophys. Acta , vol.1518 , pp. 157-161
    • Chuang, T.1    Ulevitch, R.J.2
  • 7
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 9
    • 0031774181 scopus 로고    scopus 로고
    • Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
    • Kirschning, C. J., Wesche, H., Merrill, A. T., Rothe, M. (1998) Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188, 2091-2097.
    • (1998) J. Exp. Med. , vol.188 , pp. 2091-2097
    • Kirschning, C.J.1    Wesche, H.2    Merrill, A.T.3    Rothe, M.4
  • 10
    • 0033168728 scopus 로고    scopus 로고
    • Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R., Golenbock, D. (1999) Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163, 1-5.
    • (1999) J. Immunol. , vol.163 , pp. 1-5
    • Yoshimura, A.1    Lien, E.2    Ingalls, R.R.3    Tuomanen, E.4    Dziarski, R.5    Golenbock, D.6
  • 11
    • 0033215123 scopus 로고    scopus 로고
    • Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
    • Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T., Fenton, M. J. (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163, 3920-3927.
    • (1999) J. Immunol. , vol.163 , pp. 3920-3927
    • Means, T.K.1    Wang, S.2    Lien, E.3    Yoshimura, A.4    Golenbock, D.T.5    Fenton, M.J.6
  • 13
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A., Wilson, C. B., Bassetti, M., Aderem, A. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811-815.
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5    Bassetti, M.6    Aderem, A.7
  • 15
    • 0033775796 scopus 로고    scopus 로고
    • Interleukin-1/Toll receptor family members: Receptor structure and signal transduction pathways
    • Daun, J. M., Fenton, M. J. (2000) Interleukin-1/Toll receptor family members: receptor structure and signal transduction pathways. J. Interferon Cytokine Res. 20, 843-855.
    • (2000) J. Interferon Cytokine Res. , vol.20 , pp. 843-855
    • Daun, J.M.1    Fenton, M.J.2
  • 16
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • Anderson, K. V. (2000) Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12, 13-19.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 13-19
    • Anderson, K.V.1
  • 19
    • 0033397574 scopus 로고    scopus 로고
    • Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons
    • Yamamoto, S., Yamamoto, T., Tokunaga, T. (2000) Oligodeoxyribonucleotides with 5′-ACGT-3′ or 5′-TCGA-3′ sequence induce production of interferons. Curr. Top. Microbiol. Immunol. 247, 23-39.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.247 , pp. 23-39
    • Yamamoto, S.1    Yamamoto, T.2    Tokunaga, T.3
  • 20
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG DNA activates immune cells to signal infectious danger
    • Wagner, H. (1999) Bacterial CpG DNA activates immune cells to signal infectious danger. Adv. Immunol. 73, 329-368.
    • (1999) Adv. Immunol. , vol.73 , pp. 329-368
    • Wagner, H.1
  • 21
    • 0033749217 scopus 로고    scopus 로고
    • Mechanisms of immune stimulation by bacterial DNA process
    • Pisetsky, D. S. (2000) Mechanisms of immune stimulation by bacterial DNA process. Springer Semin. Immunopathol. 22, 21-33.
    • (2000) Springer Semin. Immunopathol. , vol.22 , pp. 21-33
    • Pisetsky, D.S.1
  • 22
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina, J. P., Gilkeson, G. S., Pisetsky, D. S. (1991) Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147, 1759-1764.
    • (1991) J. Immunol. , vol.147 , pp. 1759-1764
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 24
    • 0031915373 scopus 로고    scopus 로고
    • CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel
    • Yi, A. K., Krieg, A. M. (1998) CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel. J. Immunol. 160, 1240-1245.
    • (1998) J. Immunol. , vol.160 , pp. 1240-1245
    • Yi, A.K.1    Krieg, A.M.2
  • 25
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey, K. J., Sweet, M. J., Hume, D. A. (1996) Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157, 2116-2122.
    • (1996) J. Immunol. , vol.157 , pp. 2116-2122
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 26
    • 0030816325 scopus 로고    scopus 로고
    • Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
    • Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K., Wagner, H. (1997) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur. J. Immunol. 27, 1671-1679.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1671-1679
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3    Erdmann, A.4    Hacker, H.5    Heeg, K.6    Wagner, H.7
  • 27
    • 0032531036 scopus 로고    scopus 로고
    • Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
    • Jakob, T., Walker, P. S., Krieg, A. M., Udey, M. C., Vogel, J. C. (1998) Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 161, 3042-3049.
    • (1998) J. Immunol. , vol.161 , pp. 3042-3049
    • Jakob, T.1    Walker, P.S.2    Krieg, A.M.3    Udey, M.C.4    Vogel, J.C.5
  • 28
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G. B., Wagner, H. (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17, 6230-6240.
    • (1998) EMBO J. , vol.17 , pp. 6230-6240
    • Hacker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 29
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser, T., Koch, E. S., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W., Wagner, H. (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28, 2045-2054.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6    Wagner, H.7
  • 30
    • 0033385269 scopus 로고    scopus 로고
    • CpG DNA in cancer immunotherapy
    • Weiner, G. J. (2000) CpG DNA in cancer immunotherapy. Curr. Top. Microbiol. Immunol. 247, 157-170.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.247 , pp. 157-170
    • Weiner, G.J.1
  • 31
    • 0035101984 scopus 로고    scopus 로고
    • DNA-based immunotherapeutics for the treatment of allergic disease
    • Horner, A. A., Van Uden, J. H., Zubeldia, J. M., Broide, D., Raz, E. (2001) DNA-based immunotherapeutics for the treatment of allergic disease. Immunol. Rev. 179, 102-118.
    • (2001) Immunol. Rev. , vol.179 , pp. 102-118
    • Horner, A.A.1    Van Uden, J.H.2    Zubeldia, J.M.3    Broide, D.4    Raz, E.5
  • 32
    • 0034704236 scopus 로고    scopus 로고
    • How do you see CG?
    • Aderem, A., Hume, D. A. (2000) How do you see CG? Cell 103, 993-996.
    • (2000) Cell , vol.103 , pp. 993-996
    • Aderem, A.1    Hume, D.A.2
  • 33
    • 0025348273 scopus 로고
    • Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages
    • Mathison, J. C., Virca, G. D., Wolfson, E., Tobias, P. S., Glaser, K., Ulevitch, R. J. (1990) Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J. Clin. Investig. 85, 1108-1118.
    • (1990) J. Clin. Investig. , vol.85 , pp. 1108-1118
    • Mathison, J.C.1    Virca, G.D.2    Wolfson, E.3    Tobias, P.S.4    Glaser, K.5    Ulevitch, R.J.6
  • 36
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    • Chuang, T. H., Ulevitch, R. J. (2000) Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11, 372-378.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 372-378
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 37
    • 0028168798 scopus 로고
    • Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
    • Schindler, U., Baichwal, V. R. (1994) Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol. Cell. Biol. 14, 5820-5831.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5820-5831
    • Schindler, U.1    Baichwal, V.R.2
  • 38
    • 0031936182 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
    • Macfarlane, D. E., Manzel, L. (1998) Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds. J. Immunol. 160, 1122-1131.
    • (1998) J. Immunol. , vol.160 , pp. 1122-1131
    • Macfarlane, D.E.1    Manzel, L.2
  • 39
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas, Z. K., Rasmussen, W. L., Krieg, A. M. (1996) Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157, 1840-1845.
    • (1996) J. Immunol. , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 42
    • 0034254713 scopus 로고    scopus 로고
    • The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides
    • Liang, H., Reich, C. F., Pisetsky, D. S., Lipsky, P. E. (2000) The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides. J. Immunol. 165, 1438-1445.
    • (2000) J. Immunol. , vol.165 , pp. 1438-1445
    • Liang, H.1    Reich, C.F.2    Pisetsky, D.S.3    Lipsky, P.E.4
  • 43
    • 0027325137 scopus 로고
    • Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleolides
    • Zhao, Q., Matson, S., Herrera, C. J., Fisher, E., Yu, H., Krieg, A. M. (1993) Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleolides. Antisense Res. Dev. 3, 53-66.
    • (1993) Antisense Res. Dev. , vol.3 , pp. 53-66
    • Zhao, Q.1    Matson, S.2    Herrera, C.J.3    Fisher, E.4    Yu, H.5    Krieg, A.M.6
  • 44
    • 0034667770 scopus 로고    scopus 로고
    • Phosphorothioate backbone modification modulates macrophage activation by CpG DNA
    • Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A., Stacey, K. J. (2000) Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J. Immunol. 165, 4165-4173.
    • (2000) J. Immunol. , vol.165 , pp. 4165-4173
    • Sester, D.P.1    Naik, S.2    Beasley, S.J.3    Hume, D.A.4    Stacey, K.J.5
  • 45
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker, H., Vabulas, R. M., Takeuchi. O., Hoshino, K., Akira, S., Wagner, H. (2000) Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192, 595-600.
    • (2000) J. Exp. Med. , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 46
    • 0034699340 scopus 로고    scopus 로고
    • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
    • Schnare, M., Holtdagger, A. C., Takeda, K., Akira, S., Medzhitov, R. (2000) Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 10, 1139-1142.
    • (2000) Curr. Biol. , vol.10 , pp. 1139-1142
    • Schnare, M.1    Holtdagger, A.C.2    Takeda, K.3    Akira, S.4    Medzhitov, R.5
  • 49
    • 0034007076 scopus 로고    scopus 로고
    • Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation
    • Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S., Beutler, B. (2000) Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc. Natl. Acad. Sci. USA 97, 2163-2167.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2163-2167
    • Poltorak, A.1    Ricciardi-Castagnoli, P.2    Citterio, S.3    Beutler, B.4
  • 51
    • 0033027749 scopus 로고    scopus 로고
    • CpG DNA and LPS induce distinct patterns of activation in human monocytes
    • Hartmann, G., Krieg, A. M. (1999) CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Ther. 6, 893-903.
    • (1999) Gene Ther. , vol.6 , pp. 893-903
    • Hartmann, G.1    Krieg, A.M.2
  • 52
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi, A. K., Tuetken, R., Redford, T., Waldschmidt, M., Kirsch, J., Krieg, A. M. (1998) CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160, 4755-4761.
    • (1998) J. Immunol. , vol.160 , pp. 4755-4761
    • Yi, A.K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6


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