-
1
-
-
76649123607
-
Osteoporosis: Impact on health and economics
-
Harvey, N., Dennison, E. & Cooper, C. Osteoporosis: impact on health and economics. Nat. Rev. Rheumatol. 6, 99-105 (2010).
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 99-105
-
-
Harvey, N.1
Dennison, E.2
Cooper, C.3
-
3
-
-
80053938104
-
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
-
Nakashima, T. et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat. Med. 17, 1231-1234 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 1231-1234
-
-
Nakashima, T.1
-
4
-
-
80053978532
-
Matrix-embedded cells control osteoclast formation
-
Xiong, J. et al. Matrix-embedded cells control osteoclast formation. Nat. Med. 17, 1235-1241 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 1235-1241
-
-
Xiong, J.1
-
5
-
-
84873558051
-
WNT signaling in bone homeostasis and disease: From human mutations to treatments
-
Baron, R. & Kneissel, M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat. Med. 19, 179-192 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 179-192
-
-
Baron, R.1
Kneissel, M.2
-
6
-
-
84893044528
-
Romosozumab in postmenopausal women with low bone mineral density
-
McClung, M. R. et al. Romosozumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 370, 412-20 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 412-420
-
-
McClung, M.R.1
-
7
-
-
84947615517
-
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects
-
Cheloha, R. W., Gellman, S. H., Vilardaga, J. P. & Gardella, T. J. PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat. Rev. Endocrinol. 11, 712-724 (2015).
-
(2015)
Nat. Rev. Endocrinol.
, vol.11
, pp. 712-724
-
-
Cheloha, R.W.1
Gellman, S.H.2
Vilardaga, J.P.3
Gardella, T.J.4
-
8
-
-
21844467220
-
SOST is a target gene for PTH in bone
-
Keller, H. & Kneissel, M. SOST is a target gene for PTH in bone. Bone 37, 148-158 (2005).
-
(2005)
Bone
, vol.37
, pp. 148-158
-
-
Keller, H.1
Kneissel, M.2
-
9
-
-
79955578020
-
PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
-
Rhee, Y. et al. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 26, 1035-1046 (2011).
-
(2011)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.26
, pp. 1035-1046
-
-
Rhee, Y.1
-
10
-
-
77952992328
-
Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice
-
Kramer, I., Loots, G. G., Studer, A., Keller, H. & Kneissel, M. Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 25, 178-189 (2010).
-
(2010)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.25
, pp. 178-189
-
-
Kramer, I.1
Loots, G.G.2
Studer, A.3
Keller, H.4
Kneissel, M.5
-
11
-
-
84880072246
-
Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH
-
Saini, V. et al. Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. J. Biol. Chem. 288, 20122-20134 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 20122-20134
-
-
Saini, V.1
-
12
-
-
0037073707
-
Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein
-
Fu, Q., Jilka, R. L., Manolagas, S. C. & O'Brien, C. A. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J. Biol. Chem. 277, 48868-48875 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48868-48875
-
-
Fu, Q.1
Jilka, R.L.2
Manolagas, S.C.3
O'Brien, C.A.4
-
13
-
-
33747792713
-
Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer
-
Fu, Q., Manolagas, S. C. & O'Brien, C. A. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol. Cell Biol. 26, 6453-6468 (2006).
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 6453-6468
-
-
Fu, Q.1
Manolagas, S.C.2
O'Brien, C.A.3
-
14
-
-
33846029473
-
Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers
-
Kim, S., Yamazaki, M., Shevde, N. K. & Pike, J. W. Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers. Mol. Endocrinol. 21, 197-214 (2007).
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 197-214
-
-
Kim, S.1
Yamazaki, M.2
Shevde, N.K.3
Pike, J.W.4
-
15
-
-
84936803678
-
The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro
-
Spatz, J. M. et al. The Wnt inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in vitro. J. Biol. Chem. 290, 16744-16758 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 16744-16758
-
-
Spatz, J.M.1
-
16
-
-
84964694097
-
HDAC5 controls MEF2C-driven sclerostin expression in osteocytes
-
Wein, M. N. et al. HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 30, 400-411 (2015).
-
(2015)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.30
, pp. 400-411
-
-
Wein, M.N.1
-
17
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland, M., Montgomery, R. L. & Olson, E. N. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat. Rev. Genet. 10, 32-42 (2009).
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
18
-
-
77955686258
-
Regulatory signal transduction pathways for class IIa histone deacetylases
-
Parra, M. & Verdin, E. Regulatory signal transduction pathways for class IIa histone deacetylases. Curr. Opin. Pharmacol. 10, 454-460 (2010).
-
(2010)
Curr. Opin. Pharmacol.
, vol.10
, pp. 454-460
-
-
Parra, M.1
Verdin, E.2
-
19
-
-
79951962147
-
CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals
-
Altarejos, J. Y. & Montminy, M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat. Rev. Mol. Cell Biol. 12, 141-151 (2011).
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 141-151
-
-
Altarejos, J.Y.1
Montminy, M.2
-
20
-
-
34249664888
-
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
-
Berdeaux, R. et al. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13, 597-603 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 597-603
-
-
Berdeaux, R.1
-
21
-
-
84857254443
-
SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
-
Sasagawa, S. et al. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development 139, 1153-1163 (2012).
-
(2012)
Development
, vol.139
, pp. 1153-1163
-
-
Sasagawa, S.1
-
22
-
-
84874334971
-
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
-
Walkinshaw, D. R. et al. The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases. J. Biol. Chem. 288, 9345-9362 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 9345-9362
-
-
Walkinshaw, D.R.1
-
23
-
-
84983246909
-
Development of chemical probes for investigation of salt-inducible kinase function in vivo
-
Sundberg, T. B. et al. Development of chemical probes for investigation of salt-inducible kinase function in vivo. ACS Chem. Biol. 11, 2105-2111 (2016).
-
(2016)
ACS Chem. Biol.
, vol.11
, pp. 2105-2111
-
-
Sundberg, T.B.1
-
24
-
-
84903162356
-
HDAC4 integrates PTH and sympathetic signaling in osteoblasts
-
Obri, A., Makinistoglu, M. P., Zhang, H. & Karsenty, G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J. Cell Biol. 205, 771-780 (2014).
-
(2014)
J. Cell Biol.
, vol.205
, pp. 771-780
-
-
Obri, A.1
Makinistoglu, M.P.2
Zhang, H.3
Karsenty, G.4
-
25
-
-
34247258572
-
DMP1-targeted Cre expression in odontoblasts and osteocytes
-
Lu, Y. et al. DMP1-targeted Cre expression in odontoblasts and osteocytes. J. Dent. Res. 86, 320-325 (2007).
-
(2007)
J. Dent. Res.
, vol.86
, pp. 320-325
-
-
Lu, Y.1
-
26
-
-
0034597816
-
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
-
McKinsey, T. A., Zhang, C. L., Lu, J. & Olson, E. N. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106-111 (2000).
-
(2000)
Nature
, vol.408
, pp. 106-111
-
-
McKinsey, T.A.1
Zhang, C.L.2
Lu, J.3
Olson, E.N.4
-
27
-
-
0034608955
-
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
-
Grozinger, C. M. & Schreiber, S. L. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl Acad. Sci. USA 97, 7835-7840 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7835-7840
-
-
Grozinger, C.M.1
Schreiber, S.L.2
-
28
-
-
84863393789
-
Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import
-
Taniguchi, M. et al. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron 73, 108-120 (2012).
-
(2012)
Neuron
, vol.73
, pp. 108-120
-
-
Taniguchi, M.1
-
29
-
-
84906968829
-
And IIa histone deacetylases have opposite effects on sclerostin gene regulation
-
Baertschi, S. et al. and IIa histone deacetylases have opposite effects on sclerostin gene regulation. J. Biol. Chem. 289, 24995-25009 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 24995-25009
-
-
Baertschi, S.1
-
30
-
-
80052364465
-
Gsalpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
-
Wu, J. Y. et al. Gsalpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. The J. Clin. Investig. 121, 3492-3504 (2011).
-
(2011)
The J. Clin. Investig.
, vol.121
, pp. 3492-3504
-
-
Wu, J.Y.1
-
31
-
-
84873575928
-
Myelopoiesis is regulated by osteocytes through Gsalpha-dependent signaling
-
Fulzele, K. et al. Myelopoiesis is regulated by osteocytes through Gsalpha-dependent signaling. Blood 121, 930-939 (2013).
-
(2013)
Blood
, vol.121
, pp. 930-939
-
-
Fulzele, K.1
-
32
-
-
84866265455
-
Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
-
Bonnet, N., Conway, S. J. & Ferrari, S. L. Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc. Natl Acad. Sci. USA 109, 15048-15053 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 15048-15053
-
-
Bonnet, N.1
Conway, S.J.2
Ferrari, S.L.3
-
33
-
-
84907863539
-
Increases osteoblast activity via decreased Mef2c/Sost in senescent osteopenic mice
-
Saidak, Z. et al. increases osteoblast activity via decreased Mef2c/Sost in senescent osteopenic mice. J. Endocrinol. 223, 25-33 (2014).
-
(2014)
J. Endocrinol.
, vol.223
, pp. 25-33
-
-
Saidak, Z.1
-
34
-
-
70350547780
-
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway
-
Kozhemyakina, E., Cohen, T., Yao, T. P. & Lassar, A. B. Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol. Cell Biol. 29, 5751-5762 (2009).
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 5751-5762
-
-
Kozhemyakina, E.1
Cohen, T.2
Yao, T.P.3
Lassar, A.B.4
-
35
-
-
79955802436
-
A hormone-dependent module regulating energy balance
-
Wang, B. et al. A hormone-dependent module regulating energy balance. Cell 145, 596-606 (2011).
-
(2011)
Cell
, vol.145
, pp. 596-606
-
-
Wang, B.1
-
36
-
-
84862237698
-
The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes
-
Henriksson, E. et al. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes. Biochem. J. 444, 503-514 (2012).
-
(2012)
Biochem. J.
, vol.444
, pp. 503-514
-
-
Henriksson, E.1
-
37
-
-
84922161593
-
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes
-
Henriksson, E. et al. SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes. J. Cell Sci. 128, 472-486 (2015).
-
(2015)
J. Cell Sci.
, vol.128
, pp. 472-486
-
-
Henriksson, E.1
-
38
-
-
84905457029
-
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
-
Patel, K. et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat. Commun. 5, 4535 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4535
-
-
Patel, K.1
-
39
-
-
41549090516
-
CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation
-
Yang, D., Guo, J., Divieti, P., Shioda, T. & Bringhurst, F. R. CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation. Endocrinology 149, 1728-1735 (2008).
-
(2008)
Endocrinology
, vol.149
, pp. 1728-1735
-
-
Yang, D.1
Guo, J.2
Divieti, P.3
Shioda, T.4
Bringhurst, F.R.5
-
40
-
-
37549006425
-
Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass
-
Galli, C. et al. Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology 149, 146-153 (2008).
-
(2008)
Endocrinology
, vol.149
, pp. 146-153
-
-
Galli, C.1
-
41
-
-
33747787316
-
Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers
-
Kim, S., Yamazaki, M., Zella, L. A., Shevde, N. K. & Pike, J. W. Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol. Cell Biol. 26, 6469-6486 (2006).
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 6469-6486
-
-
Kim, S.1
Yamazaki, M.2
Zella, L.A.3
Shevde, N.K.4
Pike, J.W.5
-
42
-
-
84959309485
-
Deletion of the distal Tnfsf11 RL-D2 enhancer that contributes to PTH-mediated RANKL expression in osteoblast lineage cells results in a high bone mass phenotype in mice
-
Onal, St M., John, H. C., Danielson, A. L. & Pike, J. W. Deletion of the distal Tnfsf11 RL-D2 enhancer that contributes to PTH-mediated RANKL expression in osteoblast lineage cells results in a high bone mass phenotype in mice. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 31, 416-429 (2015).
-
(2015)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.31
, pp. 416-429
-
-
Onal St, M.1
John, H.C.2
Danielson, A.L.3
Pike, J.W.4
-
43
-
-
84867650065
-
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
-
Clark, K. et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc. Natl Acad. Sci. USA 109, 16986-16991 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16986-16991
-
-
Clark, K.1
-
44
-
-
84906707276
-
Small-molecule screening identifies inhibition of saltinducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
-
Sundberg, T. B. et al. Small-molecule screening identifies inhibition of saltinducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc. Natl Acad. Sci. USA 111, 12468-12473 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 12468-12473
-
-
Sundberg, T.B.1
-
45
-
-
0038687536
-
Developmental regulation of the growth plate
-
Kronenberg, H. M. Developmental regulation of the growth plate. Nature 423, 332-336 (2003).
-
(2003)
Nature
, vol.423
, pp. 332-336
-
-
Kronenberg, H.M.1
-
46
-
-
77951920659
-
Regulation of phosphate homeostasis by PTH, Vitamin D, and FGF23
-
Bergwitz, C. & Juppner, H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Ann. Rev. Med. 61, 91-104 (2010).
-
(2010)
Ann. Rev. Med.
, vol.61
, pp. 91-104
-
-
Bergwitz, C.1
Juppner, H.2
-
47
-
-
84890786469
-
Role of T cells in the modulation of PTH action: Physiological and clinical significance
-
Pacifici, R. Role of T cells in the modulation of PTH action: physiological and clinical significance. Endocrine 44, 576-582 (2013).
-
(2013)
Endocrine
, vol.44
, pp. 576-582
-
-
Pacifici, R.1
-
48
-
-
84906934662
-
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
-
Kir, S. et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 513, 100-104 (2014).
-
(2014)
Nature
, vol.513
, pp. 100-104
-
-
Kir, S.1
-
49
-
-
38749151347
-
Control of the SOST bone enhancer by PTH using MEF2 transcription factors
-
Leupin, O. et al. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 22, 1957-1967 (2007).
-
(2007)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.22
, pp. 1957-1967
-
-
Leupin, O.1
-
50
-
-
85013728875
-
Analysis of SOST expression using large minigenes reveals the MEF2C binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D or TGFbeta responsiveness
-
S0960-0760
-
St John, H. C., Hansen, S. J. & Pike, J. W. Analysis of SOST expression using large minigenes reveals the MEF2C binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D or TGFbeta responsiveness. J. Steroid Biochem. Mol. Biol. S0960-0760, 30063-30067 (2015).
-
(2015)
J. Steroid Biochem. Mol. Biol.
, pp. 30063-30067
-
-
St John, H.C.1
Hansen, S.J.2
Pike, J.W.3
-
51
-
-
84926431501
-
Lipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression
-
Li, C. et al. Lipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression. Ann. N. Y. Acad. Sci. 1364, 62-73 (2015).
-
(2015)
Ann. N. Y. Acad. Sci.
, vol.1364
, pp. 62-73
-
-
Li, C.1
-
52
-
-
77951222926
-
HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression
-
Shimizu, E., Selvamurugan, N., Westendorf, J. J., Olson, E. N. & Partridge, N. C. HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. J. Biol. Chem. 285, 9616-9626 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 9616-9626
-
-
Shimizu, E.1
Selvamurugan, N.2
Westendorf, J.J.3
Olson, E.N.4
Partridge, N.C.5
-
53
-
-
33846139305
-
Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation
-
Haberland, M. et al. Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation. Mol. Cell Biol. 27, 518-525 (2007).
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 518-525
-
-
Haberland, M.1
-
54
-
-
84856154871
-
Mef2c deletion in osteocytes results in increased bone mass
-
Kramer, I., Baertschi, S., Halleux, C., Keller, H. & Kneissel, M. Mef2c deletion in osteocytes results in increased bone mass. J.Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 27, 360-373 (2012).
-
(2012)
J.Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.27
, pp. 360-373
-
-
Kramer, I.1
Baertschi, S.2
Halleux, C.3
Keller, H.4
Kneissel, M.5
-
55
-
-
81155148568
-
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
-
Tu, X. et al. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone 50, 209-217 (2012).
-
(2012)
Bone
, vol.50
, pp. 209-217
-
-
Tu, X.1
-
56
-
-
0029811142
-
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
-
Weir, E. C. et al. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc. Natl Acad. Sci. USA 93, 10240-10245 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 10240-10245
-
-
Weir, E.C.1
-
57
-
-
79960344540
-
The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers
-
Martowicz, M. L., Meyer, M. B. & Pike, J. W. The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers. J. Cell. Biochem. 112, 2030-2045 (2011).
-
(2011)
J. Cell. Biochem.
, vol.112
, pp. 2030-2045
-
-
Martowicz, M.L.1
Meyer, M.B.2
Pike, J.W.3
-
58
-
-
78049312858
-
Downregulation of SIK2 expression promotes the melanogenic program in mice
-
Horike, N. et al. Downregulation of SIK2 expression promotes the melanogenic program in mice. Pigm. Cell Melanoma Res. 23, 809-819 (2010).
-
(2010)
Pigm. Cell Melanoma Res.
, vol.23
, pp. 809-819
-
-
Horike, N.1
-
59
-
-
78650961108
-
SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB
-
Sasaki, T. et al. SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB. Neuron 69, 106-119 (2011).
-
(2011)
Neuron
, vol.69
, pp. 106-119
-
-
Sasaki, T.1
-
60
-
-
84899697539
-
Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake
-
Popov, S. et al. Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake. PLOS ONE 9, e95771 (2014).
-
(2014)
PLOS ONE
, vol.9
, pp. e95771
-
-
Popov, S.1
-
61
-
-
84908611789
-
SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo
-
Park, J. et al. SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo. Diabetes 63, 3659-3673 (2014).
-
(2014)
Diabetes
, vol.63
, pp. 3659-3673
-
-
Park, J.1
-
62
-
-
84895455224
-
Role of the SIK2-p35-PJA2 complex in pancreatic beta-cell functional compensation
-
Sakamaki, J. et al. Role of the SIK2-p35-PJA2 complex in pancreatic beta-cell functional compensation. Nat. Cell Biol. 16, 234-244 (2014).
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 234-244
-
-
Sakamaki, J.1
-
63
-
-
84961653939
-
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
-
Yahara, Y. et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat. Commun. 7, 10959 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 10959
-
-
Yahara, Y.1
-
64
-
-
0026023289
-
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
-
Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702 (1991).
-
(1991)
Cell
, vol.64
, pp. 693-702
-
-
Soriano, P.1
Montgomery, C.2
Geske, R.3
Bradley, A.4
-
65
-
-
0036092801
-
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
-
Dai, X. M. et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99, 111-120 (2002).
-
(2002)
Blood
, vol.99
, pp. 111-120
-
-
Dai, X.M.1
-
66
-
-
4544358659
-
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
-
Chang, S. et al. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol. Cell Biol. 24, 8467-8476 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 8467-8476
-
-
Chang, S.1
-
67
-
-
84864862726
-
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation
-
Kim, M. S. et al. An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J. Neurosci.: Off. J. Soc. Neurosci. 32, 10879-10886 (2012).
-
(2012)
J. Neurosci.: Off. J. Soc. Neurosci.
, vol.32
, pp. 10879-10886
-
-
Kim, M.S.1
-
68
-
-
84887010498
-
Genome engineering using the CRISPR-Cas9 system
-
Ran, F. A. et al. Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8, 2281-2308 (2013).
-
(2013)
Nat. Protoc.
, vol.8
, pp. 2281-2308
-
-
Ran, F.A.1
-
69
-
-
77954756294
-
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
-
Bouxsein, M. L. et al. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 25, 1468-1486 (2010).
-
(2010)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.25
, pp. 1468-1486
-
-
Bouxsein, M.L.1
-
70
-
-
84872866350
-
Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
-
Dempster, D. W. et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res. 28, 2-17 (2013).
-
(2013)
J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res.
, vol.28
, pp. 2-17
-
-
Dempster, D.W.1
|