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Volumn 107, Issue , 2018, Pages 27-36

Considerations for successful cancer immunotherapy in aged hosts

Author keywords

Aging; Cancer; Immunity; Immunotherapy

Indexed keywords

ALPHA INTERFERON; BCG VACCINE; CANCER VACCINE; CD134 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENILEUKIN DIFTITOX; INTERLEUKIN 6; IPILIMUMAB; LENTINULA EDODES EXTRACT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9;

EID: 85034577471     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2017.10.002     Document Type: Review
Times cited : (29)

References (125)
  • 2
    • 0036838556 scopus 로고    scopus 로고
    • Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137)
    • Bansal-Pakala, P., Croft, M., Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137). J. Immunol. 169 (2002), 5005–5009.
    • (2002) J. Immunol. , vol.169 , pp. 5005-5009
    • Bansal-Pakala, P.1    Croft, M.2
  • 3
    • 78149461997 scopus 로고    scopus 로고
    • TGF-beta1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse
    • Barron, D.A., Strand, D.W., Ressler, S.J., Dang, T.D., Hayward, S.W., Yang, F., Ayala, G.E., Ittmann, M., Rowley, D.R., TGF-beta1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse. PLoS One, 5, 2010, e13751.
    • (2010) PLoS One , vol.5
    • Barron, D.A.1    Strand, D.W.2    Ressler, S.J.3    Dang, T.D.4    Hayward, S.W.5    Yang, F.6    Ayala, G.E.7    Ittmann, M.8    Rowley, D.R.9
  • 4
    • 48049118330 scopus 로고    scopus 로고
    • The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy
    • Begley, L.A., Kasina, S., MacDonald, J., Macoska, J.A., The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine 43 (2008), 194–199.
    • (2008) Cytokine , vol.43 , pp. 194-199
    • Begley, L.A.1    Kasina, S.2    MacDonald, J.3    Macoska, J.A.4
  • 7
    • 84894569022 scopus 로고    scopus 로고
    • Impact of aging in cancer immunotherapy: the importance of using accurate preclinical models
    • Bouchlaka, M.N., Murphy, W.J., Impact of aging in cancer immunotherapy: the importance of using accurate preclinical models. Oncoimmunology, 2, 2013, e27186.
    • (2013) Oncoimmunology , vol.2
    • Bouchlaka, M.N.1    Murphy, W.J.2
  • 10
    • 84884779301 scopus 로고    scopus 로고
    • Age-dependent changes in the expression of regulatory cell surface ligands in activated human T-cells
    • Canaday, D.H., Parker, K.E., Aung, H., Chen, H.E., Nunez-Medina, D., Burant, C.J., Age-dependent changes in the expression of regulatory cell surface ligands in activated human T-cells. BMC Immunol., 14, 2013, 45.
    • (2013) BMC Immunol. , vol.14 , pp. 45
    • Canaday, D.H.1    Parker, K.E.2    Aung, H.3    Chen, H.E.4    Nunez-Medina, D.5    Burant, C.J.6
  • 11
    • 70349420800 scopus 로고    scopus 로고
    • Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells
    • Channappanavar, R., Twardy, B.S., Krishna, P., Suvas, S., Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mech. Ageing Dev. 130 (2009), 709–712.
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 709-712
    • Channappanavar, R.1    Twardy, B.S.2    Krishna, P.3    Suvas, S.4
  • 12
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta, F., Allavena, P., Sica, A., Garlanda, C., Mantovani, A., Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30 (2009), 1073–1081.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 13
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • Curiel, T.J., Tregs and rethinking cancer immunotherapy. J. Clin. Invest. 117 (2007), 1167–1174.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1167-1174
    • Curiel, T.J.1
  • 14
    • 44749092510 scopus 로고    scopus 로고
    • Regulatory T cells and treatment of cancer
    • Curiel, T.J., Regulatory T cells and treatment of cancer. Curr. Opin. Immunol. 20 (2008), 241–246.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 241-246
    • Curiel, T.J.1
  • 17
    • 84991795220 scopus 로고    scopus 로고
    • Immune-stimulatory effects of rapamycin are mediated by stimulation of antitumor gammadelta T cells
    • Dao, V., Liu, Y., Pandeswara, S., Svatek, R.S., Gelfond, J.A., Liu, A., Hurez, V., Curiel, T.J., Immune-stimulatory effects of rapamycin are mediated by stimulation of antitumor gammadelta T cells. Cancer Res. 76 (2016), 5970–5982.
    • (2016) Cancer Res. , vol.76 , pp. 5970-5982
    • Dao, V.1    Liu, Y.2    Pandeswara, S.3    Svatek, R.S.4    Gelfond, J.A.5    Liu, A.6    Hurez, V.7    Curiel, T.J.8
  • 18
    • 79551615157 scopus 로고    scopus 로고
    • Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications
    • De Bock, K., Cauwenberghs, S., Carmeliet, P., Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications. Curr. Opin. Genet. Dev. 21 (2010), 73–79.
    • (2010) Curr. Opin. Genet. Dev. , vol.21 , pp. 73-79
    • De Bock, K.1    Cauwenberghs, S.2    Carmeliet, P.3
  • 21
    • 48549089991 scopus 로고    scopus 로고
    • Implications of aging and self-tolerance on the generation of immune and antitumor immune responses
    • Dominguez, A.L., Lustgarten, J., Implications of aging and self-tolerance on the generation of immune and antitumor immune responses. Cancer Res. 68 (2008), 5423–5431.
    • (2008) Cancer Res. , vol.68 , pp. 5423-5431
    • Dominguez, A.L.1    Lustgarten, J.2
  • 24
    • 84857118418 scopus 로고    scopus 로고
    • Expression of tumour-specific antigens underlies cancer immunoediting
    • DuPage, M., Mazumdar, C., Schmidt, L.M., Cheung, A.F., Jacks, T., Expression of tumour-specific antigens underlies cancer immunoediting. Nature 482 (2012), 405–409.
    • (2012) Nature , vol.482 , pp. 405-409
    • DuPage, M.1    Mazumdar, C.2    Schmidt, L.M.3    Cheung, A.F.4    Jacks, T.5
  • 25
    • 79251550444 scopus 로고    scopus 로고
    • A role for immature myeloid cells in immune senescence
    • Enioutina, E.Y., Bareyan, D., Daynes, R.A., A role for immature myeloid cells in immune senescence. J. Immunol. 186 (2011), 697–707.
    • (2011) J. Immunol. , vol.186 , pp. 697-707
    • Enioutina, E.Y.1    Bareyan, D.2    Daynes, R.A.3
  • 28
    • 85006197538 scopus 로고    scopus 로고
    • Age and sex affect αCTLA-4 efficacy alone and combined with αB7-H1 or regulatory T cell depletion in a melanoma model
    • Figueiredo, A.S.P., Hurez, V., Liu, A., TJCJI, Age and sex affect αCTLA-4 efficacy alone and combined with αB7-H1 or regulatory T cell depletion in a melanoma model. J. Immunol., 196, 2016, 213.4.
    • (2016) J. Immunol. , vol.196
    • Figueiredo, A.S.P.1    Hurez, V.2    Liu, A.3    TJCJI4
  • 30
    • 84886033654 scopus 로고    scopus 로고
    • Human T cell aging and the impact of persistent viral infections
    • Fulop, T., Larbi, A., Pawelec, G., Human T cell aging and the impact of persistent viral infections. Front. Immunol., 4, 2013, 271.
    • (2013) Front. Immunol. , vol.4 , pp. 271
    • Fulop, T.1    Larbi, A.2    Pawelec, G.3
  • 33
    • 67649402297 scopus 로고    scopus 로고
    • Aging in the lympho-hematopoietic stem cell compartment
    • Geiger, H., Rudolph, K.L., Aging in the lympho-hematopoietic stem cell compartment. Trends Immunol. 30 (2009), 360–365.
    • (2009) Trends Immunol. , vol.30 , pp. 360-365
    • Geiger, H.1    Rudolph, K.L.2
  • 34
    • 0028201822 scopus 로고
    • + ) cells in aged and PUVA-treated skin
    • + ) cells in aged and PUVA-treated skin. Skin Pharmacol. 7 (1994), 118–120.
    • (1994) Skin Pharmacol. , vol.7 , pp. 118-120
    • Ghersetich, I.1    Lotti, T.2
  • 37
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I., Greten, F.R., Karin, M., Immunity, inflammation, and cancer. Cell 140 (2010), 883–899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 38
    • 37349003404 scopus 로고    scopus 로고
    • Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice
    • Grizzle, W.E., Xu, X., Zhang, S., Stockard, C.R., Liu, C., Yu, S., Wang, J., Mountz, J.D., Zhang, H.G., Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice. Mech. Ageing Dev. 128 (2007), 672–680.
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 672-680
    • Grizzle, W.E.1    Xu, X.2    Zhang, S.3    Stockard, C.R.4    Liu, C.5    Yu, S.6    Wang, J.7    Mountz, J.D.8    Zhang, H.G.9
  • 40
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., Weinberg, R.A., The hallmarks of cancer. Cell 100 (2000), 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 43
    • 2142644403 scopus 로고    scopus 로고
    • Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
    • Haynes, L., Eaton, S.M., Burns, E.M., Rincon, M., Swain, S.L., Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 172 (2004), 5194–5199.
    • (2004) J. Immunol. , vol.172 , pp. 5194-5199
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Rincon, M.4    Swain, S.L.5
  • 44
    • 34447501752 scopus 로고    scopus 로고
    • Age and outcome of superficial bladder cancer treated with bacille Calmette-Guerin therapy
    • Herr, H.W., Age and outcome of superficial bladder cancer treated with bacille Calmette-Guerin therapy. Urology 70 (2007), 65–68.
    • (2007) Urology , vol.70 , pp. 65-68
    • Herr, H.W.1
  • 46
    • 31544446571 scopus 로고    scopus 로고
    • + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 66 (2006), 1123–1131.
    • (2006) Cancer Res. , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.H.8
  • 49
    • 84999036725 scopus 로고    scopus 로고
    • Considerations for successful cancer immunotherapy in aged hosts
    • Hurez, V., Padron, A.S., Svatek, R.S., Curiel, T.J., Considerations for successful cancer immunotherapy in aged hosts. Clin. Exp. Immunol. 187 (2017), 53–63.
    • (2017) Clin. Exp. Immunol. , vol.187 , pp. 53-63
    • Hurez, V.1    Padron, A.S.2    Svatek, R.S.3    Curiel, T.J.4
  • 50
    • 67650705116 scopus 로고    scopus 로고
    • Aging and human CD4(+) regulatory T cells
    • Hwang, K.A., Kim, H.R., Kang, I., Aging and human CD4(+) regulatory T cells. Mech. Ageing Dev. 130 (2009), 509–517.
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 509-517
    • Hwang, K.A.1    Kim, H.R.2    Kang, I.3
  • 54
    • 84975119976 scopus 로고    scopus 로고
    • Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract
    • Ishikawa, S., Matsui, Y., Wachi, S., Yamaguchi, H., Harashima, N., Harada, M., Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract. Cancer Immunol. Immunother. 65 (2016), 961–972.
    • (2016) Cancer Immunol. Immunother. , vol.65 , pp. 961-972
    • Ishikawa, S.1    Matsui, Y.2    Wachi, S.3    Yamaguchi, H.4    Harashima, N.5    Harada, M.6
  • 55
    • 84898787733 scopus 로고    scopus 로고
    • Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
    • Jackaman, C., Nelson, D.J., Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?. Exp. Gerontol. 54 (2014), 53–57.
    • (2014) Exp. Gerontol. , vol.54 , pp. 53-57
    • Jackaman, C.1    Nelson, D.J.2
  • 57
    • 84905383255 scopus 로고    scopus 로고
    • IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
    • Jackaman, C., Dye, D.E., Nelson, D.J., IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. Age (Dordr.), 36, 2014, 9655.
    • (2014) Age (Dordr.) , vol.36 , pp. 9655
    • Jackaman, C.1    Dye, D.E.2    Nelson, D.J.3
  • 59
    • 33645971937 scopus 로고    scopus 로고
    • The impact of age on the response of patients with superficial bladder cancer to intravesical immunotherapy
    • (discussion 9-40)
    • Joudi, F.N., Smith, B.J., O'Donnell, M.A., Konety, B.R., The impact of age on the response of patients with superficial bladder cancer to intravesical immunotherapy. J. Urol. 175 (2006), 1634–1639 (discussion 9-40).
    • (2006) J. Urol. , vol.175 , pp. 1634-1639
    • Joudi, F.N.1    Smith, B.J.2    O'Donnell, M.A.3    Konety, B.R.4
  • 64
    • 35048863845 scopus 로고    scopus 로고
    • Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice
    • Kozlowska, E., Biernacka, M., Ciechomska, M., Drela, N., Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice. Immunology 122 (2007), 445–453.
    • (2007) Immunology , vol.122 , pp. 445-453
    • Kozlowska, E.1    Biernacka, M.2    Ciechomska, M.3    Drela, N.4
  • 66
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages, C.S., Suffia, I., Velilla, P.A., Huang, B., Warshaw, G., Hildeman, D.A., Belkaid, Y., Chougnet, C., Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 181 (2008), 1835–1848.
    • (2008) J. Immunol. , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5    Hildeman, D.A.6    Belkaid, Y.7    Chougnet, C.8
  • 67
    • 78349286392 scopus 로고    scopus 로고
    • Partial restoration of T cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway
    • Lages, C.S., Lewkowich, I., Sproles, A., Wills-Karp, M., Chougnet, C., Partial restoration of T cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway. Aging Cell, 2010.
    • (2010) Aging Cell
    • Lages, C.S.1    Lewkowich, I.2    Sproles, A.3    Wills-Karp, M.4    Chougnet, C.5
  • 68
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • Li, H., Han, Y., Guo, Q., Zhang, M., Cao, X., Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J. Immunol. 182 (2009), 240–249.
    • (2009) J. Immunol. , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 70
    • 4644285723 scopus 로고    scopus 로고
    • Aged mice develop protective antitumor immune responses with appropriate costimulation
    • Lustgarten, J., Dominguez, A.L., Thoman, M., Aged mice develop protective antitumor immune responses with appropriate costimulation. J. Immunol. 173 (2004), 4510–4515.
    • (2004) J. Immunol. , vol.173 , pp. 4510-4515
    • Lustgarten, J.1    Dominguez, A.L.2    Thoman, M.3
  • 74
    • 80053928698 scopus 로고    scopus 로고
    • Diminished efficacy of Bacille Calmette-Guerin among elderly patients with nonmuscle invasive bladder cancer
    • Margel, D., Alkhateeb, S.S., Finelli, A., Fleshner, N., Diminished efficacy of Bacille Calmette-Guerin among elderly patients with nonmuscle invasive bladder cancer. Urology 78 (2011), 848–854.
    • (2011) Urology , vol.78 , pp. 848-854
    • Margel, D.1    Alkhateeb, S.S.2    Finelli, A.3    Fleshner, N.4
  • 75
    • 41149119143 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    • Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P., Bronte, V., Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 222 (2008), 162–179.
    • (2008) Immunol. Rev. , vol.222 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafini, P.3    Zanovello, P.4    Bronte, V.5
  • 78
    • 84941695057 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected
    • Marvel, D., Gabrilovich, D.I., Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 125 (2015), 3356–3364.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3356-3364
    • Marvel, D.1    Gabrilovich, D.I.2
  • 81
    • 84894107349 scopus 로고    scopus 로고
    • New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape
    • Mittal, D., Gubin, M.M., Schreiber, R.D., Smyth, M.J., New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape. Curr. Opin. Immunol. 27 (2014), 16–25.
    • (2014) Curr. Opin. Immunol. , vol.27 , pp. 16-25
    • Mittal, D.1    Gubin, M.M.2    Schreiber, R.D.3    Smyth, M.J.4
  • 84
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • Ostrand-Rosenberg, S., Sinha, P., Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182 (2009), 4499–4506.
    • (2009) J. Immunol. , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 85
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka, K., Banchereau, J., Cancer immunotherapy via dendritic cells. Nat. Rev. Cancer 12 (2012), 265–277.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 86
    • 0035963326 scopus 로고    scopus 로고
    • T cells and tumours
    • Pardoll, D., T cells and tumours. Nature 411 (2001), 1010–1012.
    • (2001) Nature , vol.411 , pp. 1010-1012
    • Pardoll, D.1
  • 87
    • 0042470540 scopus 로고    scopus 로고
    • Does the immune system see tumors as foreign or self?
    • Pardoll, D., Does the immune system see tumors as foreign or self?. Annu. Rev. Immunol. 21 (2003), 807–839.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 807-839
    • Pardoll, D.1
  • 88
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12 (2012), 252–264.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 89
    • 84856867834 scopus 로고    scopus 로고
    • Immunotherapy earns its spot in the ranks of cancer therapy
    • Pardoll, D., Drake, C., Immunotherapy earns its spot in the ranks of cancer therapy. J. Exp. Med. 209 (2012), 201–209.
    • (2012) J. Exp. Med. , vol.209 , pp. 201-209
    • Pardoll, D.1    Drake, C.2
  • 93
    • 84927745449 scopus 로고    scopus 로고
    • In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells
    • Ratliff, M., Alter, S., McAvoy, K., Frasca, D., Wright, J.A., Zinkel, S.S., Khan, W.N., Blomberg, B.B., Riley, R.L., In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells. Aging Cell 14 (2015), 382–390.
    • (2015) Aging Cell , vol.14 , pp. 382-390
    • Ratliff, M.1    Alter, S.2    McAvoy, K.3    Frasca, D.4    Wright, J.A.5    Zinkel, S.S.6    Khan, W.N.7    Blomberg, B.B.8    Riley, R.L.9
  • 94
    • 34447629515 scopus 로고    scopus 로고
    • Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    • Rosenkranz, D., Weyer, S., Tolosa, E., Gaenslen, A., Berg, D., Leyhe, T., Gasser, T., Stoltze, L., Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J. Neuroimmunol. 188 (2007), 117–127.
    • (2007) J. Neuroimmunol. , vol.188 , pp. 117-127
    • Rosenkranz, D.1    Weyer, S.2    Tolosa, E.3    Gaenslen, A.4    Berg, D.5    Leyhe, T.6    Gasser, T.7    Stoltze, L.8
  • 96
    • 63149184826 scopus 로고    scopus 로고
    • OX40-enhanced tumor rejection and effector T cell differentiation decreases with age
    • Ruby, C.E., Weinberg, A.D., OX40-enhanced tumor rejection and effector T cell differentiation decreases with age. J. Immunol. 182 (2009), 1481–1489.
    • (2009) J. Immunol. , vol.182 , pp. 1481-1489
    • Ruby, C.E.1    Weinberg, A.D.2
  • 97
    • 79958125217 scopus 로고    scopus 로고
    • The effect of aging on OX40 agonist-mediated cancer immunotherapy
    • Ruby, C.E., Weinberg, A.D., The effect of aging on OX40 agonist-mediated cancer immunotherapy. Cancer Immunol. Immunother. 58 (2009), 1941–1947.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1941-1947
    • Ruby, C.E.1    Weinberg, A.D.2
  • 98
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber, R.D., Old, L.J., Smyth, M.J., Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331 (2011), 1565–1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 99
    • 33845408098 scopus 로고    scopus 로고
    • High accumulation of T regulatory cells prevents the activation of immune responses in aged animals
    • Sharma, S., Dominguez, A.L., Lustgarten, J., High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J. Immunol. 177 (2006), 8348–8355.
    • (2006) J. Immunol. , vol.177 , pp. 8348-8355
    • Sharma, S.1    Dominguez, A.L.2    Lustgarten, J.3
  • 103
    • 77955268790 scopus 로고    scopus 로고
    • Transmission of donor melanoma by organ transplantation
    • Strauss, D.C., Thomas, J.M., Transmission of donor melanoma by organ transplantation. Lancet Oncol. 11 (2010), 790–796.
    • (2010) Lancet Oncol. , vol.11 , pp. 790-796
    • Strauss, D.C.1    Thomas, J.M.2
  • 104
    • 84860887914 scopus 로고    scopus 로고
    • Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells
    • Sun, L., Hurez, V.J., Thibodeaux, S.R., Kious, M.J., Liu, A., Lin, P., Murthy, K., Pandeswara, S., Shin, T., Curiel, T.J., Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell 11 (2012), 509–519.
    • (2012) Aging Cell , vol.11 , pp. 509-519
    • Sun, L.1    Hurez, V.J.2    Thibodeaux, S.R.3    Kious, M.J.4    Liu, A.5    Lin, P.6    Murthy, K.7    Pandeswara, S.8    Shin, T.9    Curiel, T.J.10
  • 106
    • 79958172278 scopus 로고    scopus 로고
    • Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged
    • Tang, Y.C., Thoman, M., Linton, P.J., Deisseroth, A., Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged. Cancer Immunol. Immunother. 58 (2009), 1949–1957.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1949-1957
    • Tang, Y.C.1    Thoman, M.2    Linton, P.J.3    Deisseroth, A.4
  • 117
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
    • Ward, P.S., Thompson, C.B., Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21 (2012), 297–308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 118
    • 33846479526 scopus 로고    scopus 로고
    • IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
    • Watkins, S.K., Egilmez, N.K., Suttles, J., Stout, R.D., IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J. Immunol. 178 (2007), 1357–1362.
    • (2007) J. Immunol. , vol.178 , pp. 1357-1362
    • Watkins, S.K.1    Egilmez, N.K.2    Suttles, J.3    Stout, R.D.4
  • 120
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn, J.I., Nagaraj, S., Collazo, M., Gabrilovich, D.I., Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol. 181 (2008), 5791–5802.
    • (2008) J. Immunol. , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 121
    • 58149286586 scopus 로고    scopus 로고
    • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis
    • Zhang, H., Podojil, J.R., Luo, X., Miller, S.D., Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J. Immunol. 181 (2008), 4638–4647.
    • (2008) J. Immunol. , vol.181 , pp. 4638-4647
    • Zhang, H.1    Podojil, J.R.2    Luo, X.3    Miller, S.D.4
  • 123
    • 84962788254 scopus 로고    scopus 로고
    • Microbiome and anticancer immunosurveillance
    • Zitvogel, L., Ayyoub, M., Routy, B., Kroemer, G., Microbiome and anticancer immunosurveillance. Cell 165 (2016), 276–287.
    • (2016) Cell , vol.165 , pp. 276-287
    • Zitvogel, L.1    Ayyoub, M.2    Routy, B.3    Kroemer, G.4
  • 124
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou, W., Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6 (2006), 295–307.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 295-307
    • Zou, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.