SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Nature

Volumn 532, Issue 7598, 2016, Pages 250-254

  Kaur, Amanpreet ^a,b   Webster, Marie R ^a   Marchbank, Katie ^a   Behera, Reeti ^a   Ndoye, Abibatou ^a   Kugel, Curtis H ^a   Dang, Vanessa M ^a   Appleton, Jessica ^a   O'Connell, Michael P ^a   Cheng, Phil ^c   Valiga, Alexander A ^a   Morissette, Rachel ^d   McDonnell, Nazli B ^d   Ferrucci, Luigi ^d   Kossenkov, Andrew V ^a   Meeth, Katrina ^e   Tang, Hsin Yao ^a   Yin, Xiangfan ^d   Wood, William H ^d   Lehrmann, Elin ^d   Becker, Kevin G ^f   Flaherty, Keith T ^f   Frederick, Dennie T ^g   Wargo, Jennifer A ^g   Cooper, Zachary A ^g   Tetzlaff, Michael T ^g   Hudgens, Courtney ^a   Aird, Katherine M ^a   Zhang, Rugang ^h   Xu, Xiaowei ^a   Liu, Qin ^h   Bartlett, Edmund ^h   Karakousis, Giorgos ⁱ   Eroglu, Zeynep ^j   Lo, Roger S ^k   Chan, Matthew ^l   Menzies, Alexander M ^l   Long, Georgina V ^m   Johnson, Douglas B ^m   Sosman, Jeffrey ^m   Schilling, Bastian ^n,o   Schadendorf, Dirk ^n,o   Speicher, David W ^a   Bosenberg, Marcus ^e   Ribas, Antoni ^j   Weeraratna, Ashani T ^a   more..

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF THE SCIENCES   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e YALE UNIVERSITY   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k WESTMEAD HOSPITAL   (Australia)

^l UNIVERSITY OF SYDNEY   (Australia)

^m VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

ⁿ UNIVERSITY OF DUISBURG ESSEN   (Germany)

^o GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; SECRETED FRIZZLED RELATED PROTEIN 2; VEMURAFENIB; APEX1 PROTEIN, HUMAN; BETA CATENIN; CONDITIONED MEDIUM; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; INDOLE DERIVATIVE; MEMBRANE PROTEIN; SFRP2 PROTEIN, HUMAN; SULFONAMIDE; WNT1 PROTEIN;

CANCER; CELLS AND CELL COMPONENTS; DISEASE TREATMENT; DNA; GENE; IMMUNITY; OXYGEN; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN TISSUE; MELANOMA CELL; MELANOMA METASTASIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THERAPY RESISTANCE; TUMOR MICROENVIRONMENT; ADULT; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; CONDITIONED MEDIUM; DISEASE COURSE; DRUG RESISTANCE; GENETICS; MALE; MELANOMA; METABOLISM; METASTASIS; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); OXIDATIVE STRESS; PATHOLOGY; PHARMACOLOGY; PHENOTYPE; SECRETION (PROCESS); TUMOR CELL LINE; VASCULARIZATION; WNT SIGNALING PATHWAY;

ADULT; AGING; ANIMALS; BETA CATENIN; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; DISEASE PROGRESSION; DNA DAMAGE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; HUMANS; INDOLES; MALE; MELANOMA; MEMBRANE PROTEINS; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; OXIDATIVE STRESS; PHENOTYPE; REACTIVE OXYGEN SPECIES; SULFONAMIDES; TUMOR MICROENVIRONMENT; WNT SIGNALING PATHWAY; WNT1 PROTEIN;

EID: 84964329374     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17392     Document Type: Article

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