-
2
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009;460:392-5.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
3
-
-
84892421283
-
ERapa restores a normal life span in a FAP mouse model
-
Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, et al. eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res 2014;7:169-78.
-
(2014)
Cancer Prev Res
, vol.7
, pp. 169-178
-
-
Hasty, P.1
Livi, C.B.2
Dodds, S.G.3
Jones, D.4
Strong, R.5
Javors, M.6
-
4
-
-
84874987821
-
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
-
Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, et al. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging 2013;5:100-10.
-
(2013)
Aging
, vol.5
, pp. 100-110
-
-
Livi, C.B.1
Hardman, R.L.2
Christy, B.A.3
Dodds, S.G.4
Jones, D.5
Williams, C.6
-
5
-
-
79951794971
-
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
-
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011; 66:191-201.
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
Baur, J.A.4
Boyd, A.R.5
De Cabo, R.6
-
6
-
-
84942526120
-
Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage
-
Dao V, Pandeswara S, Liu Y, Hurez V, Dodds S, Callaway D, et al. Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage. Cancer Prev Res 2015;8:400-9.
-
(2015)
Cancer Prev Res
, vol.8
, pp. 400-409
-
-
Dao, V.1
Pandeswara, S.2
Liu, Y.3
Hurez, V.4
Dodds, S.5
Callaway, D.6
-
7
-
-
58149355295
-
Inhibition of mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions
-
Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind JS. Inhibition of mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res 2008;14:8094-101.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8094-8101
-
-
Amornphimoltham, P.1
Leelahavanichkul, K.2
Molinolo, A.3
Patel, V.4
Gutkind, J.S.5
-
8
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 2011;12:295-303.
-
(2011)
Nat Immunol
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
-
9
-
-
84881192927
-
MTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
-
Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 2013;499:485-90.
-
(2013)
Nature
, vol.499
, pp. 485-490
-
-
Zeng, H.1
Yang, K.2
Cloer, C.3
Neale, G.4
Vogel, P.5
Chi, H.6
-
10
-
-
84939890933
-
Activation of mTOR pathway in myeloid-derived suppressor cellsstimulates cancer cell proliferation and metastasis in lal mice
-
Zhao T, Du H, Ding X, Walls K, Yan C. Activation of mTOR pathway in myeloid-derived suppressor cellsstimulates cancer cell proliferation and metastasis in lal mice. Oncogene 2015;34:1938-48.
-
(2015)
Oncogene
, vol.34
, pp. 1938-1948
-
-
Zhao, T.1
Du, H.2
Ding, X.3
Walls, K.4
Yan, C.5
-
11
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009;460: 108-12.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
-
12
-
-
84978540809
-
Rapalogs efficacy relies on the modulation of antitumor T-cell immunity
-
May 17. [Epub ahead of print]
-
Beziaud L, Mansi L, Ravel P, Marie-Joseph EL, Laheurte C, Rangan L, et al. Rapalogs efficacy relies on the modulation of antitumor T-cell immunity. Cancer Res 2016 May 17. [Epub ahead of print].
-
(2016)
Cancer Res
-
-
Beziaud, L.1
Mansi, L.2
Ravel, P.3
Marie-Joseph, E.L.4
Laheurte, C.5
Rangan, L.6
-
13
-
-
84954361691
-
ChronicmTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice
-
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, et al. ChronicmTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell 2015;14:945-56.
-
(2015)
Aging Cell
, vol.14
, pp. 945-956
-
-
Hurez, V.1
Dao, V.2
Liu, A.3
Pandeswara, S.4
Gelfond, J.5
Sun, L.6
-
14
-
-
0041884744
-
The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer
-
Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, et al. The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer. J Exp Med 2003;198:747-55.
-
(2003)
J Exp Med
, vol.198
, pp. 747-755
-
-
Girardi, M.1
Glusac, E.2
Filler, R.B.3
Roberts, S.J.4
Propperova, I.5
Lewis, J.6
-
15
-
-
80052212385
-
CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis
-
Winkler AE, Brotman JJ, Pittman ME, Judd NP, Lewis JS Jr, Schreiber RD, et al. CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis. Cancer Res 2011;71: 5707-16.
-
(2011)
Cancer Res
, vol.71
, pp. 5707-5716
-
-
Winkler, A.E.1
Brotman, J.J.2
Pittman, M.E.3
Judd, N.P.4
Lewis, J.S.5
Schreiber, R.D.6
-
16
-
-
0035914134
-
Regulation of cutaneous malignancy by gammadelta T cells
-
Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science 2001;294:605-9.
-
(2001)
Science
, vol.294
, pp. 605-609
-
-
Girardi, M.1
Oppenheim, D.E.2
Steele, C.R.3
Lewis, J.M.4
Glusac, E.5
Filler, R.6
-
17
-
-
80052021730
-
Inhibitory effects of interferon-gamma plasmid DNA on DMBA-TPA induced mouse skin carcinogenesis
-
Ko JH, Jung BG, Park YS, Lee BJ. Inhibitory effects of interferon-gamma plasmid DNA on DMBA-TPA induced mouse skin carcinogenesis. Cancer Gene Ther 2011;18:646-54.
-
(2011)
Cancer Gene Ther
, vol.18
, pp. 646-654
-
-
Ko, J.H.1
Jung, B.G.2
Park, Y.S.3
Lee, B.J.4
-
18
-
-
84872187583
-
What lessons can be learned from γδ T cell-based cancer immunotherapy trials?
-
Fournie JJ, Sicard H, Poupot M, Bezombes C, Blanc A, Romagne F, et al. What lessons can be learned from γδ T cell-based cancer immunotherapy trials? Cell Mol Immunol 2013;10:35-41.
-
(2013)
Cell Mol Immunol
, vol.10
, pp. 35-41
-
-
Fournie, J.J.1
Sicard, H.2
Poupot, M.3
Bezombes, C.4
Blanc, A.5
Romagne, F.6
-
19
-
-
84865974140
-
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
-
Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J, Jung A, et al. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest 2012;122:3127-44.
-
(2012)
J Clin Invest
, vol.122
, pp. 3127-3144
-
-
Jamieson, T.1
Clarke, M.2
Steele, C.W.3
Samuel, M.S.4
Neumann, J.5
Jung, A.6
-
20
-
-
79953814668
-
Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
-
Li H, Pauza CD. Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro. Cancer Immunol Immunother 2011;60:361-70.
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 361-370
-
-
Li, H.1
Pauza, C.D.2
-
21
-
-
73049125323
-
Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts
-
Winn HJ. Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts. J Immunol 1961;86:228-39.
-
(1961)
J Immunol
, vol.86
, pp. 228-239
-
-
Winn, H.J.1
-
22
-
-
0035953308
-
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
-
Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001;410:1107-11.
-
(2001)
Nature
, vol.410
, pp. 1107-1111
-
-
Shankaran, V.1
Ikeda, H.2
Bruce, A.T.3
White, J.M.4
Swanson, P.E.5
Old, L.J.6
-
24
-
-
81455141962
-
Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
-
Mabuchi T, Takekoshi T, Hwang ST. Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis. J Immunol 2011;187:5026-31.
-
(2011)
J Immunol
, vol.187
, pp. 5026-5031
-
-
Mabuchi, T.1
Takekoshi, T.2
Hwang, S.T.3
-
25
-
-
79952716229
-
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy
-
Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med 2011;208:491-503.
-
(2011)
J Exp Med
, vol.208
, pp. 491-503
-
-
Ma, Y.1
Aymeric, L.2
Locher, C.3
Mattarollo, S.R.4
Delahaye, N.F.5
Pereira, P.6
-
26
-
-
0022475348
-
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
-
Heilig JS, Tonegawa S. Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature 1986;322:836-40.
-
(1986)
Nature
, vol.322
, pp. 836-840
-
-
Heilig, J.S.1
Tonegawa, S.2
-
27
-
-
79952725610
-
Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells
-
Sumaria N, Roediger B, Ng LG, Qin J, Pinto R, Cavanagh LL, et al. Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. J Exp Med 2011;208:505-18.
-
(2011)
J Exp Med
, vol.208
, pp. 505-518
-
-
Sumaria, N.1
Roediger, B.2
Ng, L.G.3
Qin, J.4
Pinto, R.5
Cavanagh, L.L.6
-
28
-
-
34548862559
-
IFN-gamma and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells
-
Barbi J, Oghumu S, Lezama-Davila CM, Satoskar AR. IFN-gamma and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells. Blood 2007;110: 2215-6.
-
(2007)
Blood
, vol.110
, pp. 2215-2216
-
-
Barbi, J.1
Oghumu, S.2
Lezama-Davila, C.M.3
Satoskar, A.R.4
-
29
-
-
77956224317
-
Naturally activated v gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin
-
He W, Hao J, Dong S, Gao Y, Tao J, Chi H, et al. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. J Immunol 2010;185:126-33.
-
(2010)
J Immunol
, vol.185
, pp. 126-133
-
-
He, W.1
Hao, J.2
Dong, S.3
Gao, Y.4
Tao, J.5
Chi, H.6
-
30
-
-
84891691365
-
Targeting gamma delta T cells for cancer immunotherapy: Bench to bedside
-
Gogoi D, Chiplunkar SV. Targeting gamma delta T cells for cancer immunotherapy: bench to bedside. Indian J Med Res 2013;138:755-61.
-
(2013)
Indian J Med Res
, vol.138
, pp. 755-761
-
-
Gogoi, D.1
Chiplunkar, S.V.2
-
31
-
-
48249107111
-
Isopentenyl pyrophosphate-activated CD56+ {gamma} {delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma
-
Alexander AA, Maniar A, Cummings JS, Hebbeler AM, Schulze DH, Gastman BR, et al. Isopentenyl pyrophosphate-activated CD56+ {gamma} {delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. Clin Cancer Res 2008;14:4232-40.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4232-4240
-
-
Alexander, A.A.1
Maniar, A.2
Cummings, J.S.3
Hebbeler, A.M.4
Schulze, D.H.5
Gastman, B.R.6
-
32
-
-
84872930787
-
Six-of-the-best: Unique contributions of γδ T cells to immunology
-
Vantourout P, Hayday A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol 2013;13:88-100.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 88-100
-
-
Vantourout, P.1
Hayday, A.2
-
33
-
-
84872564714
-
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice
-
Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging 2012;4:709-14.
-
(2012)
Aging
, vol.4
, pp. 709-714
-
-
Komarova, E.A.1
Antoch, M.P.2
Novototskaya, L.R.3
Chernova, O.B.4
Paszkiewicz, G.5
Leontieva, O.V.6
-
34
-
-
79960103054
-
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
-
Checkley LA, Rho O, Moore T, Hursting S, DiGiovanni J. Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Prev Res 2011;4:1011-20.
-
(2011)
Cancer Prev Res
, vol.4
, pp. 1011-1020
-
-
Checkley, L.A.1
Rho, O.2
Moore, T.3
Hursting, S.4
DiGiovanni, J.5
-
35
-
-
84937945349
-
Inflammation induces dermal Vγ4+ γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses
-
Ramirez-Valle F, Gray EE, Cyster JG. Inflammation induces dermal Vγ4+ γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A 2015;112:8046-51.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 8046-8051
-
-
Ramirez-Valle, F.1
Gray, E.E.2
Cyster, J.G.3
-
36
-
-
84932646690
-
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints
-
Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat Commun 2015;6:7458.
-
(2015)
Nat Commun
, vol.6
, pp. 7458
-
-
Mikucki, M.E.1
Fisher, D.T.2
Matsuzaki, J.3
Skitzki, J.J.4
Gaulin, N.B.5
Muhitch, J.B.6
-
38
-
-
0025062551
-
T-cell receptor gamma delta bearing cells in normal human skin
-
Bos JD, Teunissen MB, Cairo I, Krieg SR, Kapsenberg ML, Das PK, et al. T-cell receptor gamma delta bearing cells in normal human skin. J Invest Dermatol 1990;94:37-42.
-
(1990)
J Invest Dermatol
, vol.94
, pp. 37-42
-
-
Bos, J.D.1
Teunissen, M.B.2
Cairo, I.3
Krieg, S.R.4
Kapsenberg, M.L.5
Das, P.K.6
-
39
-
-
33750610317
-
Conversion from calcineurin inhibitors to everolimus in kidney transplant recipients with malignant neoplasia
-
Fernandez A, Marcen R, Pascual J, Galeano C, Ocana J, Arellano EM, et al. Conversion from calcineurin inhibitors to everolimus in kidney transplant recipients with malignant neoplasia. Transplant Proc 2006;38:2453-5.
-
(2006)
Transplant Proc
, vol.38
, pp. 2453-2455
-
-
Fernandez, A.1
Marcen, R.2
Pascual, J.3
Galeano, C.4
Ocana, J.5
Arellano, E.M.6
-
40
-
-
84887976550
-
The kinase mTOR modulates the antibody response to provide crossprotective immunity to lethal infection with influenza virus
-
Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, et al. The kinase mTOR modulates the antibody response to provide crossprotective immunity to lethal infection with influenza virus. Nat Immunol 2013;14:1266-76.
-
(2013)
Nat Immunol
, vol.14
, pp. 1266-1276
-
-
Keating, R.1
Hertz, T.2
Wehenkel, M.3
Harris, T.L.4
Edwards, B.A.5
McClaren, J.L.6
-
41
-
-
84919756169
-
MTOR inhibition improves immune function in the elderly
-
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, et al. mTOR inhibition improves immune function in the elderly. Sci Transl Med 2014;6:268ra179.
-
(2014)
Sci Transl Med
, vol.6
, pp. 268ra179
-
-
Mannick, J.B.1
Del Giudice, G.2
Lattanzi, M.3
Valiante, N.M.4
Praestgaard, J.5
Huang, B.6
-
42
-
-
84924366457
-
Friends not foes: CTLA-4 blockade andmTORinhibition cooperate during CD8+T cell priming to promote memory formation and metabolic readiness
-
Pedicord VA, Cross JR, Montalvo-Ortiz W, Miller ML, Allison JP. Friends not foes: CTLA-4 blockade andmTORinhibition cooperate during CD8+T cell priming to promote memory formation and metabolic readiness. J Immunol 2015;194:2089-98.
-
(2015)
J Immunol
, vol.194
, pp. 2089-2098
-
-
Pedicord, V.A.1
Cross, J.R.2
Montalvo-Ortiz, W.3
Miller, M.L.4
Allison, J.P.5
-
43
-
-
80053930031
-
Expansion of human peripheral blood γδT cells using zoledronate
-
Kondo M, Izumi T, Fujieda N, Kondo A, Morishita T, Matsushita H, et al. Expansion of human peripheral blood γδT cells using zoledronate. J Vis Exp 2011;(55):3182. doi: 10.3791/3182.
-
(2011)
J Vis Exp
, Issue.55
, pp. 3182
-
-
Kondo, M.1
Izumi, T.2
Fujieda, N.3
Kondo, A.4
Morishita, T.5
Matsushita, H.6
-
44
-
-
84946181488
-
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset
-
Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, et al. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci 2015; 70:577-88.
-
(2015)
J Gerontol A Biol Sci Med Sci
, vol.70
, pp. 577-588
-
-
Tardif, S.1
Ross, C.2
Bergman, P.3
Fernandez, E.4
Javors, M.5
Salmon, A.6
|