-
1
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H, (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
Kujala, P.4
Van Den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
2
-
-
0019476039
-
The stem-cell zone of the small intestinal epithelium. V. Evidence for controls over orientation of boundaries between the stem-cell zone, proliferative zone, and the maturation zone
-
Bjerknes M, Cheng H, (1981) The stem-cell zone of the small intestinal epithelium. V. Evidence for controls over orientation of boundaries between the stem-cell zone, proliferative zone, and the maturation zone. Am J Anat 160: 105-112
-
(1981)
Am J Anat
, vol.160
, pp. 105-112
-
-
Bjerknes, M.1
Cheng, H.2
-
3
-
-
84874730918
-
Intestinal label-retaining cells are secretory precursors expressing Lgr5
-
Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ, (2013) Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495: 65-69
-
(2013)
Nature
, vol.495
, pp. 65-69
-
-
Buczacki, S.J.1
Zecchini, H.I.2
Nicholson, A.M.3
Russell, R.4
Vermeulen, L.5
Kemp, R.6
Winton, D.J.7
-
4
-
-
84880548336
-
The intestinal crypt, a prototype stem cell compartment
-
Clevers H, (2013) The intestinal crypt, a prototype stem cell compartment. Cell 154: 274-284
-
(2013)
Cell
, vol.154
, pp. 274-284
-
-
Clevers, H.1
-
5
-
-
37349015334
-
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine
-
Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L, (2008) Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol 313: 58-66
-
(2008)
Dev Biol
, vol.313
, pp. 58-66
-
-
Desai, S.1
Loomis, Z.2
Pugh-Bernard, A.3
Schrunk, J.4
Doyle, M.J.5
Minic, A.6
McCoy, E.7
Sussel, L.8
-
6
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H, (2005) Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
Van Es, J.H.1
Van Gijn, M.E.2
Riccio, O.3
Van Den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
7
-
-
84867097416
-
+ secretory progenitor cells revert to stem cells upon crypt damage
-
+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol 14: 1099-1104
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1099-1104
-
-
Van Es, J.H.1
Sato, T.2
Van De Wetering, M.3
Lyubimova, A.4
Nee, A.N.5
Gregorieff, A.6
Sasaki, N.7
Zeinstra, L.8
Van Den Born, M.9
Korving, J.10
Martens, A.C.11
Barker, N.12
Van Oudenaarden, A.13
Clevers, H.14
-
8
-
-
84881524604
-
Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells
-
Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, et al, (2013) Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology 144: 381-391
-
(2013)
Gastroenterology
, vol.144
, pp. 381-391
-
-
Fafilek, B.1
Krausova, M.2
Vojtechova, M.3
Pospichalova, V.4
Tumova, L.5
Sloncova, E.6
Huranova, M.7
Stancikova, J.8
Hlavata, A.9
Svec, J.10
Sedlacek, R.11
Luksan, O.12
Oliverius, M.13
Voska, L.14
Jirsa, M.15
Paces, J.16
Kolar, M.17
Krivjanska, M.18
Klimesova, K.19
Tlaskalova-Hogenova, H.20
more..
-
9
-
-
84869864069
-
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
-
e1517
-
Farin HF, Van Es JH, Clevers H, (2012) Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 143: 1518-1529 e1517
-
(2012)
Gastroenterology
, vol.143
, pp. 1518-1529
-
-
Farin, H.F.1
Van Es, J.H.2
Clevers, H.3
-
10
-
-
61349150537
-
Transcription factor achaete scute-like 2 controls intestinal stem cell fate
-
van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H, (2009) Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136: 903-912
-
(2009)
Cell
, vol.136
, pp. 903-912
-
-
Van Der Flier, L.G.1
Van Gijn, M.E.2
Hatzis, P.3
Kujala, P.4
Haegebarth, A.5
Stange, D.E.6
Begthel, H.7
Van Den Born, M.8
Guryev, V.9
Oving, I.10
Van Es, J.H.11
Barker, N.12
Peters, P.J.13
Van De Wetering, M.14
Clevers, H.15
-
11
-
-
70349435300
-
The ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium
-
e1331-1333
-
Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H, (2009) The ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium. Gastroenterology 137: 1333-1345 e1331-1333
-
(2009)
Gastroenterology
, vol.137
, pp. 1333-1345
-
-
Gregorieff, A.1
Stange, D.E.2
Kujala, P.3
Begthel, H.4
Van Den Born, M.5
Korving, J.6
Peters, P.J.7
Clevers, H.8
-
12
-
-
1542618115
-
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
-
Haramis AP, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJ, Clevers H, (2004) De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303: 1684-1686
-
(2004)
Science
, vol.303
, pp. 1684-1686
-
-
Haramis, A.P.1
Begthel, H.2
Van Den Born, M.3
Van Es, J.4
Jonkheer, S.5
Offerhaus, G.J.6
Clevers, H.7
-
13
-
-
84876998128
-
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
-
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V, van den Brink GR, (2013) ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep 3: 1128-1139
-
(2013)
Cell Rep
, vol.3
, pp. 1128-1139
-
-
Heijmans, J.1
Van Lidth De Jeude, J.F.2
Koo, B.K.3
Rosekrans, S.L.4
Wielenga, M.C.5
Van De Wetering, M.6
Ferrante, M.7
Lee, A.S.8
Onderwater, J.J.9
Paton, J.C.10
Paton, A.W.11
Mommaas, A.M.12
Kodach, L.L.13
Hardwick, J.C.14
Hommes, D.W.15
Clevers, H.16
Muncan, V.17
Van Den Brink, G.R.18
-
14
-
-
77951819088
-
Systematic analysis of human protein complexes identifies chromosome segregation proteins
-
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, et al, (2010) Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328: 593-599
-
(2010)
Science
, vol.328
, pp. 593-599
-
-
Hutchins, J.R.1
Toyoda, Y.2
Hegemann, B.3
Poser, I.4
Heriche, J.K.5
Sykora, M.M.6
Augsburg, M.7
Hudecz, O.8
Buschhorn, B.A.9
Bulkescher, J.10
Conrad, C.11
Comartin, D.12
Schleiffer, A.13
Sarov, M.14
Pozniakovsky, A.15
Slabicki, M.M.16
Schloissnig, S.17
Steinmacher, I.18
Leuschner, M.19
Ssykor, A.20
more..
-
15
-
-
2142709556
-
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin
-
Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, Sansom OJ, Winton DJ, (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 126: 1236-1246
-
(2004)
Gastroenterology
, vol.126
, pp. 1236-1246
-
-
Ireland, H.1
Kemp, R.2
Houghton, C.3
Howard, L.4
Clarke, A.R.5
Sansom, O.J.6
Winton, D.J.7
-
16
-
-
84355162740
-
Single-molecule transcript counting of stem-cell markers in the mouse intestine
-
Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A, (2012) Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol 14: 106-114
-
(2012)
Nat Cell Biol
, vol.14
, pp. 106-114
-
-
Itzkovitz, S.1
Lyubimova, A.2
Blat, I.C.3
Maynard, M.4
Van Es, J.5
Lees, J.6
Jacks, T.7
Clevers, H.8
Van Oudenaarden, A.9
-
17
-
-
0037011171
-
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
-
Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, Jensen J, Kedinger M, Gradwohl G, (2002) Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J 21: 6338-6347
-
(2002)
EMBO J
, vol.21
, pp. 6338-6347
-
-
Jenny, M.1
Uhl, C.2
Roche, C.3
Duluc, I.4
Guillermin, V.5
Guillemot, F.6
Jensen, J.7
Kedinger, M.8
Gradwohl, G.9
-
18
-
-
84864147310
-
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells
-
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, et al, (2012) The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol 13: 729-736
-
(2012)
Nat Immunol
, vol.13
, pp. 729-736
-
-
Kanaya, T.1
Hase, K.2
Takahashi, D.3
Fukuda, S.4
Hoshino, K.5
Sasaki, I.6
Hemmi, H.7
Knoop, K.A.8
Kumar, N.9
Sato, M.10
Katsuno, T.11
Yokosuka, O.12
Toyooka, K.13
Nakai, K.14
Sakamoto, A.15
Kitahara, Y.16
Jinnohara, T.17
McSorley, S.J.18
Kaisho, T.19
Williams, I.R.20
more..
-
19
-
-
0032415359
-
Pax 4 and 6 regulate gastrointestinal endocrine cell development
-
Larsson LI, St-Onge L, Hougaard DM, Sosa-Pineda B, Gruss P, (1998) Pax 4 and 6 regulate gastrointestinal endocrine cell development. Mech Dev 79: 153-159
-
(1998)
Mech Dev
, vol.79
, pp. 153-159
-
-
Larsson, L.I.1
St-Onge, L.2
Hougaard, D.M.3
Sosa-Pineda, B.4
Gruss, P.5
-
20
-
-
84866465328
-
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"
-
de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, Nieuwenhuis E, Clevers H, (2012) Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol 32: 3639-3647
-
(2012)
Mol Cell Biol
, vol.32
, pp. 3639-3647
-
-
De Lau, W.1
Kujala, P.2
Schneeberger, K.3
Middendorp, S.4
Li, V.S.5
Barker, N.6
Martens, A.7
Hofhuis, F.8
Dekoter, R.P.9
Peters, P.J.10
Nieuwenhuis, E.11
Clevers, H.12
-
21
-
-
75749146169
-
Coexistence of quiescent and active adult stem cells in mammals
-
Li L, Clevers H, (2010) Coexistence of quiescent and active adult stem cells in mammals. Science 327: 542-545
-
(2010)
Science
, vol.327
, pp. 542-545
-
-
Li, L.1
Clevers, H.2
-
22
-
-
34547659144
-
Bright monomeric red fluorescent protein with an extended fluorescence lifetime
-
Merzlyak EM, Goedhart J, Shcherbo D, Bulina ME, Shcheglov AS, Fradkov AF, Gaintzeva A, Lukyanov KA, Lukyanov S, Gadella TW, Chudakov DM, (2007) Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat Methods 4: 555-557
-
(2007)
Nat Methods
, vol.4
, pp. 555-557
-
-
Merzlyak, E.M.1
Goedhart, J.2
Shcherbo, D.3
Bulina, M.E.4
Shcheglov, A.S.5
Fradkov, A.F.6
Gaintzeva, A.7
Lukyanov, K.A.8
Lukyanov, S.9
Gadella, T.W.10
Chudakov, D.M.11
-
23
-
-
78651067425
-
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
-
Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT, (2011) Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci USA 108: 179-184
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 179-184
-
-
Montgomery, R.K.1
Carlone, D.L.2
Richmond, C.A.3
Farilla, L.4
Kranendonk, M.E.5
Henderson, D.E.6
Baffour-Awuah, N.Y.7
Ambruzs, D.M.8
Fogli, L.K.9
Algra, S.10
Breault, D.T.11
-
24
-
-
33751018274
-
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc
-
Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR, (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol 26: 8418-8426
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8418-8426
-
-
Muncan, V.1
Sansom, O.J.2
Tertoolen, L.3
Phesse, T.J.4
Begthel, H.5
Sancho, E.6
Cole, A.M.7
Gregorieff, A.8
De Alboran, I.M.9
Clevers, H.10
Clarke, A.R.11
-
25
-
-
84864131103
-
The Lgr5 intestinal stem cell signature: Robust expression of proposed quiescent "+4" cell markers
-
Munoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H, (2012) The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent "+4" cell markers. EMBO J 31: 3079-3091
-
(2012)
EMBO J
, vol.31
, pp. 3079-3091
-
-
Munoz, J.1
Stange, D.E.2
Schepers, A.G.3
Van De Wetering, M.4
Koo, B.K.5
Itzkovitz, S.6
Volckmann, R.7
Kung, K.S.8
Koster, J.9
Radulescu, S.10
Myant, K.11
Versteeg, R.12
Sansom, O.J.13
Van Es, J.H.14
Barker, N.15
Van Oudenaarden, A.16
Mohammed, S.17
Heck, A.J.18
Clevers, H.19
-
26
-
-
0030886674
-
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
-
Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ, (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11: 2323-2334
-
(1997)
Genes Dev
, vol.11
, pp. 2323-2334
-
-
Naya, F.J.1
Huang, H.P.2
Qiu, Y.3
Mutoh, H.4
Demayo, F.J.5
Leiter, A.B.6
Tsai, M.J.7
-
27
-
-
84884844190
-
The cell-cycle state of stem cells determines cell fate propensity
-
Pauklin S, Vallier L, (2013) The cell-cycle state of stem cells determines cell fate propensity. Cell 155: 135-147
-
(2013)
Cell
, vol.155
, pp. 135-147
-
-
Pauklin, S.1
Vallier, L.2
-
28
-
-
0018034237
-
The segregation of DNA in epithelial stem cells
-
Potten CS, Hume WJ, Reid P, Cairns J, (1978) The segregation of DNA in epithelial stem cells. Cell 15: 899-906
-
(1978)
Cell
, vol.15
, pp. 899-906
-
-
Potten, C.S.1
Hume, W.J.2
Reid, P.3
Cairns, J.4
-
29
-
-
0036591968
-
Intestinal stem cells protect their genome by selective segregation of template DNA strands
-
Potten CS, Owen G, Booth D, (2002) Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 115: 2381-2388
-
(2002)
J Cell Sci
, vol.115
, pp. 2381-2388
-
-
Potten, C.S.1
Owen, G.2
Booth, D.3
-
30
-
-
84859196824
-
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
-
Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ, (2012) The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149: 146-158
-
(2012)
Cell
, vol.149
, pp. 146-158
-
-
Powell, A.E.1
Wang, Y.2
Li, Y.3
Poulin, E.J.4
Means, A.L.5
Washington, M.K.6
Higginbotham, J.N.7
Juchheim, A.8
Prasad, N.9
Levy, S.E.10
Guo, Y.11
Shyr, Y.12
Aronow, B.J.13
Haigis, K.M.14
Franklin, J.L.15
Coffey, R.J.16
-
31
-
-
46249128798
-
Bmi1 is expressed in vivo in intestinal stem cells
-
Sangiorgi E, Capecchi MR, (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-920
-
(2008)
Nat Genet
, vol.40
, pp. 915-920
-
-
Sangiorgi, E.1
Capecchi, M.R.2
-
32
-
-
2942668475
-
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
-
Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ, (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18: 1385-1390
-
(2004)
Genes Dev
, vol.18
, pp. 1385-1390
-
-
Sansom, O.J.1
Reed, K.R.2
Hayes, A.J.3
Ireland, H.4
Brinkmann, H.5
Newton, I.P.6
Batlle, E.7
Simon-Assmann, P.8
Clevers, H.9
Nathke, I.S.10
Clarke, A.R.11
Winton, D.J.12
-
33
-
-
34247187543
-
Myc deletion rescues Apc deficiency in the small intestine
-
Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR, (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446: 676-679
-
(2007)
Nature
, vol.446
, pp. 676-679
-
-
Sansom, O.J.1
Meniel, V.S.2
Muncan, V.3
Phesse, T.J.4
Wilkins, J.A.5
Reed, K.R.6
Vass, J.K.7
Athineos, D.8
Clevers, H.9
Clarke, A.R.10
-
34
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H, (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262-265
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
Van De Wetering, M.4
Barker, N.5
Stange, D.E.6
Van Es, J.H.7
Abo, A.8
Kujala, P.9
Peters, P.J.10
Clevers, H.11
-
35
-
-
78751644734
-
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
-
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H, (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418
-
(2011)
Nature
, vol.469
, pp. 415-418
-
-
Sato, T.1
Van Es, J.H.2
Snippert, H.J.3
Stange, D.E.4
Vries, R.G.5
Van Den Born, M.6
Barker, N.7
Shroyer, N.F.8
Van De Wetering, M.9
Clevers, H.10
-
36
-
-
84872600554
-
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
-
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, et al, (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152: 25-38
-
(2013)
Cell
, vol.152
, pp. 25-38
-
-
Schwitalla, S.1
Fingerle, A.A.2
Cammareri, P.3
Nebelsiek, T.4
Goktuna, S.I.5
Ziegler, P.K.6
Canli, O.7
Heijmans, J.8
Huels, D.J.9
Moreaux, G.10
Rupec, R.A.11
Gerhard, M.12
Schmid, R.13
Barker, N.14
Clevers, H.15
Lang, R.16
Neumann, J.17
Kirchner, T.18
Taketo, M.M.19
Van Den Brink, G.R.20
more..
-
37
-
-
79251564398
-
A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine
-
Sei Y, Lu X, Liou A, Zhao X, Wank SA, (2011) A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine. Am J Physiol Gastrointest Liver Physiol 300: G345-G356
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.300
, pp. G345-G356
-
-
Sei, Y.1
Lu, X.2
Liou, A.3
Zhao, X.4
Wank, S.A.5
-
38
-
-
34249987090
-
Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis
-
Shroyer NF, Helmrath MA, Wang VY, Antalffy B, Henning SJ, Zoghbi HY, (2007) Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132: 2478-2488
-
(2007)
Gastroenterology
, vol.132
, pp. 2478-2488
-
-
Shroyer, N.F.1
Helmrath, M.A.2
Wang, V.Y.3
Antalffy, B.4
Henning, S.J.5
Zoghbi, H.Y.6
-
39
-
-
84894541975
-
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion
-
Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H, (2014) Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO Rep 15: 62-69
-
(2014)
EMBO Rep
, vol.15
, pp. 62-69
-
-
Snippert, H.J.1
Schepers, A.G.2
Van Es, J.H.3
Simons, B.D.4
Clevers, H.5
-
40
-
-
80052526022
-
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system
-
Stamataki D, Holder M, Hodgetts C, Jeffery R, Nye E, Spencer-Dene B, Winton DJ, Lewis J, (2011) Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS ONE 6: e24484
-
(2011)
PLoS ONE
, vol.6
, pp. e24484
-
-
Stamataki, D.1
Holder, M.2
Hodgetts, C.3
Jeffery, R.4
Nye, E.5
Spencer-Dene, B.6
Winton, D.J.7
Lewis, J.8
-
41
-
-
84885672388
-
Differentiated troy(+) chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
-
Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H, (2013) Differentiated troy(+) chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155: 357-368
-
(2013)
Cell
, vol.155
, pp. 357-368
-
-
Stange, D.E.1
Koo, B.K.2
Huch, M.3
Sibbel, G.4
Basak, O.5
Lyubimova, A.6
Kujala, P.7
Bartfeld, S.8
Koster, J.9
Geahlen, J.H.10
Peters, P.J.11
Van Es, J.H.12
Van De Wetering, M.13
Mills, J.C.14
Clevers, H.15
-
42
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP, (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-15550
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
43
-
-
83255193921
-
Interconversion between intestinal stem cell populations in distinct niches
-
Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, Epstein JA, (2011) Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420-1424
-
(2011)
Science
, vol.334
, pp. 1420-1424
-
-
Takeda, N.1
Jain, R.2
Leboeuf, M.R.3
Wang, Q.4
Lu, M.M.5
Epstein, J.A.6
-
44
-
-
80054041585
-
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
-
Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ, (2011) A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478: 255-259
-
(2011)
Nature
, vol.478
, pp. 255-259
-
-
Tian, H.1
Biehs, B.2
Warming, S.3
Leong, K.G.4
Rangell, L.5
Klein, O.D.6
De Sauvage, F.J.7
-
45
-
-
35748956880
-
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse
-
Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G, (2007) Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev 124: 898-910
-
(2007)
Mech Dev
, vol.124
, pp. 898-910
-
-
Wang, S.1
Zhang, J.2
Zhao, A.3
Hipkens, S.4
Magnuson, M.A.5
Gu, G.6
-
46
-
-
84880558928
-
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
-
e381-321
-
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, et al, (2013) Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology 145: 383-395 e381-321
-
(2013)
Gastroenterology
, vol.145
, pp. 383-395
-
-
Wang, F.1
Scoville, D.2
He, X.C.3
Mahe, M.M.4
Box, A.5
Perry, J.M.6
Smith, N.R.7
Lei, N.Y.8
Davies, P.S.9
Fuller, M.K.10
Haug, J.S.11
McClain, M.12
Gracz, A.D.13
Ding, S.14
Stelzner, M.15
Dunn, J.C.16
Magness, S.T.17
Wong, M.H.18
Martin, M.G.19
Helmrath, M.20
more..
-
47
-
-
84859430024
-
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
-
Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB, (2012) Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 14: 401-408
-
(2012)
Nat Cell Biol
, vol.14
, pp. 401-408
-
-
Wong, V.W.1
Stange, D.E.2
Page, M.E.3
Buczacki, S.4
Wabik, A.5
Itami, S.6
Van De Wetering, M.7
Poulsom, R.8
Wright, N.A.9
Trotter, M.W.10
Watt, F.M.11
Winton, D.J.12
Clevers, H.13
Jensen, K.B.14
-
48
-
-
84862946094
-
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
-
Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ, (2012) The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci USA 109: 466-471
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 466-471
-
-
Yan, K.S.1
Chia, L.A.2
Li, X.3
Ootani, A.4
Su, J.5
Lee, J.Y.6
Su, N.7
Luo, Y.8
Heilshorn, S.C.9
Amieva, M.R.10
Sangiorgi, E.11
Capecchi, M.R.12
Kuo, C.J.13
-
49
-
-
0035824487
-
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
-
Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY, (2001) Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294: 2155-2158
-
(2001)
Science
, vol.294
, pp. 2155-2158
-
-
Yang, Q.1
Bermingham, N.A.2
Finegold, M.J.3
Zoghbi, H.Y.4
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