A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes

Journal of Molecular and Cellular Cardiology

Volumn 114, Issue , 2018, Pages 72-82

  Bayoumi, Ahmed S ^a   Park, Kyoung mi ^a,c   Wang, Yongchao ^a,d   Teoh, Jian peng ^a   Aonuma, Tatsuya ^a   Tang, Yaoliang ^a,b   Su, Huabo ^a,b   Weintraub, Neal L ^a,b   Kim, Il man ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b Department of Medicine ^*  (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Apoptotic genes; Biased G protein coupled receptor signaling; Cardioprotection; MicroRNAs; arrestin

Indexed keywords

CARVEDILOL; MICRORNA 125B; MICRORNA 125B 5P; PROTEIN KINASE B; UNCLASSIFIED DRUG; CARDIOTONIC AGENT; CELL CYCLE PROTEIN; KLF13 PROTEIN, MOUSE; KLF13 PROTEIN, RAT; KRUPPEL LIKE FACTOR; MICRORNA; MIRN125 MICRORNA, MOUSE; MIRN125 MICRORNA, RAT; PROTEIN BAK; REPRESSOR PROTEIN;

ACUTE HEART INFARCTION; ADULT; AKT SIGNALING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAK1 GENE; CARDIAC MUSCLE CELL; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; GENE; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; HEART FUNCTION; HEART PROTECTION; IN VIVO STUDY; KLF13 GENE; LOSS OF FUNCTION MUTATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL LINE; DRUG EFFECT; GENE KNOCKDOWN; GENETICS; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CARDIOTONIC AGENTS; CARVEDILOL; CELL CYCLE PROTEINS; CELL LINE; GENE KNOCKDOWN TECHNIQUES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE, INBRED C57BL; MICRORNAS; MODELS, BIOLOGICAL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 85033405069     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2017.11.003     Document Type: Article

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