β-arrestin1-biased β1-adrenergic receptor signaling regulates MicroRNA processing

Circulation Research

Volumn 114, Issue 5, 2014, Pages 833-844

  Kim, Il Man ^a   Wang, Yongchao ^a   Park, Kyoung Mi ^a   Tang, Yaoping ^a   Teoh, Jian Peng ^a   Vinson, Joseph ^a   Traynham, Christopher J ^b   Pironti, Gianluigi ^c   Mao, Lan ^c   Su, Huabo ^a   Johnson, John A ^a   Koch, Walter J ^b   Rockman, Howard A ^c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Carvedilol; heart diseases

Indexed keywords

ALPRENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA ARRESTIN 1; CARVEDILOL; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; METOPROLOL; MICRORNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MATURATION; CELL STRAIN HEK293; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENETIC TRANSDUCTION; HEART DISEASE; HEART STIMULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PROCESSING; TREATMENT DURATION; UPREGULATION;

CARVEDILOL; HEART DISEASES;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; ANIMALS; ARRESTINS; CARBAZOLES; G-PROTEIN-COUPLED RECEPTOR KINASE 5; G-PROTEIN-COUPLED RECEPTOR KINASES; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-1; RNA PROCESSING, POST-TRANSCRIPTIONAL; SIGNAL TRANSDUCTION;

EID: 84895930317     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.302766     Document Type: Article

References (36)

1. Quiat D, Olson EN. MicroRNAs in cardiovascular disease: From pathogenesis to prevention and treatment. J Clin Invest. 2013;123:11-18.
2. Zhu H, Fan GC. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc Res. 2012;94:284-292.
3. Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11:597-610.
4. Siomi H, Siomi MC. Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 2010;38:323-332.
5. Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454:56-61.
6. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, Minami Y, OMalley BW, Kato S. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009;36:340-347.
7. Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature. 2009;459:1010-1014.
8. Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR III, Lefkowitz RJ. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci USA. 2007;104:12011-12016.
9. Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci USA. 2008;105:14555-14560.
10. Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: Carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci USA. 2007;104:16657-16662.
11. Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and. Proc Natl Acad Sci USA. 2003;100:10782-10787.
12. Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging -arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. J Pharmacol Exp Ther. 2010;335:572-579.
13. Patel CB, Noor N, Rockman HA. Functional selectivity in adrenergic and angiotensin signaling systems. Mol Pharmacol. 2010;78:983-992.
14. Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Distinct phosphorylation sites on the (2)-adrenergic receptor establish a barcode that encodes differential functions of -arrestin. Sci Signal. 2011;4:ra51.
15. Reiter E, Ahn S, Shukla AK, Lefkowitz RJ. Molecular mechanism of -arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol. 2012;52:179-197.
16. Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crepieux P, Poupon A, Clement F, Fages F, Lefkowitz RJ, Reiter E. Competing g protein-coupled receptor kinases balance g protein and beta-arrestin signaling. Mol Syst Biol. 2012;8:590
17. Ruffolo RR Jr, Feuerstein GZ. Pharmacology of carvedilol: Rationale for use in hypertension, coronary artery disease, and congestive heart failure. Cardiovasc Drugs Ther. 1997;11(suppl 1):247-256.
18. Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol. 2007;49:1722-1732.
19. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol. 2007;69:483-510.
20. Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science. 2005;308:512-517.
21. Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L. A nuclear function of beta-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription. Cell. 2005;123:833-847.
22. Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. 2009;139:535-546.
23. Ma L, Pei G. Beta-arrestin signaling and regulation of transcription. J Cell Sci. 2007;120:213-218.
24. Lu Y, Zhang Y, Shan H, Pan Z, Li X, Li B, Xu C, Zhang B, Zhang F, Dong D, Song W, Qiao G, Yang B. MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: A new mechanism for ischaemic cardioprotection. Cardiovasc Res. 2009;84:434-441.
25. Carrillo ED, Escobar Y, Gonzlez G, Hernndez A, Galindo JM, Garca MC, Snchez JA. Posttranscriptional regulation of the 2-subunit of cardiac L-type Ca2+ channels by MicroRNAs during long-term exposure to isoproterenol in rats. J Cardiovasc Pharmacol. 2011;58:470-478.
26. Zheng H, Zeng Y, Zhang X, Chu J, Loh HH, Law PY. mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Mol Pharmacol. 2010;77:102-109.
27. Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest. 2007;117:2445-2458.
28. Guil S, Cceres JF. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol. 2007;14:591-596.
29. Allegra D, Mertens D. In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system. Biochem Biophys Res Commun. 2011;406:501-505.
30. Monk CE, Hutvagner G, Arthur JS. Regulation of miRNA transcription in macrophages in response to Candida albicans. PLoS One. 2010;5:e13669.
31. Luttrell LM, Gesty-Palmer D. Beyond desensitization: Physiological relevance of arrestin-dependent signaling. Pharmacol Rev. 2010;62:305-330.
32. Rajagopal S, Rajagopal K, Lefkowitz RJ. Teaching old receptors new tricks: Biasing seven-transmembrane receptors. Nat Rev Drug Discov. 2010;9:373-386.
33. Rosano L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio AM, Natali PG, Bagnato A. Beta-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced beta-catenin signaling. Oncogene. 2013; 32:5066-5077.
34. Dinicolantonio JJ, Lavie CJ, Fares H, Menezes AR, OKeefe JH. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013;111:765-769.
35. Mangmool S, Shukla AK, Rockman HA. beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol. 2010;189:573-587.
36. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through 2-adrenoreceptors and -arrestin-1. Nature. 2011;477:349-353.