A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth

Biochemical Journal

Volumn 435, Issue 2, 2011, Pages 529-537

  Fernandez Zapico, Martin E ^a,b   Lomberk, Gwen A ^a   Tsuji, Shoichiro ^a   DeMars, Cathrine J ^a   Bardsley, Michael R ^a   Lin, Yi Hui ^b   Almada, Luciana L ^b   Han, Jing Jing ^a   Mukhopadhyay, Debabrata ^c   Ordog, Tamas ^a   Buttar, Navtej S ^a   Urrutia, Raul ^a,c  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Cyclin A; Kr ppel like factor (KLF) protein; Kr ppel like factor 11 (KLF11); Pancreatic cancer; Tumour suppression; V Ki ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS)

Indexed keywords

AGAR; BROXURIDINE; CYCLIN A; K RAS PROTEIN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 11; KRUPPEL LIKE FACTOR 13; KRUPPEL LIKE FACTOR 14; KRUPPEL LIKE FACTOR 15; KRUPPEL LIKE FACTOR 16; KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 3; KRUPPEL LIKE FACTOR 4; TRANSCRIPTION FACTOR SP; TRANSCRIPTION FACTOR SP5; TRANSCRIPTION FACTOR SP8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONTROLLED STUDY; EMBRYO; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION;

ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GENES, TUMOR SUPPRESSOR; GENETIC ASSOCIATION STUDIES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C57BL; MICE, NUDE; MULTIGENE FAMILY; NIH 3T3 CELLS; SP TRANSCRIPTION FACTORS;

RATTUS;

EID: 79953172903     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100773     Document Type: Article

References (29)

1. Zhao, C. and Meng, A. (2005) Sp1-like transcription factors are regulators of embryonic development in vertebrates. Dev. Growth Differ. 47, 201-211
2. Black, A., Black, J. and Azizkhan-Clifford, J. (2001) Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell. Physiol. 188, 143-160
3. Kaczynski, J., Cook, T. and Urrutia, R. (2003) Sp1- and Kruppel-like transcription factors. GenomeBiology 4, 206
4. Safe, S. and Abdelrahim, M. (2005) Sp transcription factor family and its role in cancer. Eur. J. Cancer 41, 2438-2448 (Pubitemid 41540621)
5. Lomberk, G. and Urrutia, R. (2005) The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem. J. 392, 1-11 (Pubitemid 41689395)
6. Matsumura, T., Suzuki, T., Aizawa, K., Munemasa, Y., Muto, S., Horikoshi, M. and Nagai, R. (2005) The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction. J. Biol. Chem. 280, 12123-12129
7. Malumbres, M. and Barbacid, M. (2003) RAS oncogenes: the first 30 years. Nat. Rev. Cancer 3, 459-465
8. Cook, T., Gebelein, B., Belal, M., Mesa, K. and Urrutia, R. (1999) Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins. J. Biol. Chem. 274, 29500-29504
9. Ellenrieder, V., Buck, A., Harth, A., Jungert, K., Buchholz, M., Adler, G., Urrutia, R. and Gress, T. (2004) KLF11 mediates a critical mechanism in TGF-β signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. Gastroenterology 127, 607-620 (Pubitemid 39091908)
10. Ellenrieder, V., Zhang, J., Kaczynski, J. and Urrutia, R. (2002) Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor. EMBO J. 21, 2451-2460 (Pubitemid 34546717)
11. Zhang, J., Moncrieffe, M., Kaczynski, J., Ellenrieder, V., Prendergast, F. and Urrutia, R. (2001) A conserved α-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Mol. Cell. Biol. 21, 5041-5049
12. Huser, M., Luckett, J., Chiloeches, A., Mercer, K., Iwobi, M., Giblett, S., Sun, X.-M., Brown, J., Marais, R. and Pritchard, C. (2001) MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951 (Pubitemid 32397396)
13. Furukawa, T., Duguid, W. P., Rosenberg, L., Viallet, J., Galloway, D. A. and Tsao, M. S. (1996) Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am. J. Pathol. 148, 1763-1770
14. Lee, M. D., She, Y., Soskis, M. J., Borella, C. P., Gardner, J. R., Hayes, P. A., Dy, B. M., Heaney, M. L., Philips, M. R., Bornmann, W. G. et al. (2004) Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J. Clin. Invest. 114, 1107-1116
15. Gebelein, B., Fernandez-Zapico, M., Imoto, M. and Urrutia, R. (1998) KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. J. Clin. Invest. 102, 1911-1919
16. Cook, T., Gebelein, B., Mesa, K., Mladek, A. and Urrutia, R. (1998) Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor- β-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J. Biol. Chem. 273, 25929-25936
17. Fernandez-Zapico, M. E., Mladek, A., Ellenrieder, V., Folch-Puy, E., Miller, L. and Urrutia, R. (2003) An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J. 22, 4748-4758 (Pubitemid 37162911)
18. Neve, B., Fernandez-Zapico, M., Ashkenazi-Katalan, V., Dina, C., Hamid, Y., Joly, E., Vaillant, E., Benmezroua, Y., Durand, E., Bakaher, N. et al. (2005) Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc. Natl. Acad. Sci. U.S.A. 102, 4807-4812
19. Gebelein, B. and Urrutia, R. (2001) Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein. Mol. Cell. Biol. 21, 928-939
20. Fernandez-Zapico, M. E., van Velkinburgh, J. C., Gutierrez-Aguilar, R., Neve, B., Froguel, P., Urrutia, R. and Stein, R. (2009) MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J. Biol. Chem. 284, 36482-36490
21. Bureau, C., Hanoun, N., Torrisani, J., Vinel, J. P., Buscail, L. and Cordelier, P. (2009) Expression and function of Kruppel like-factors (KLF) in carcinogenesis. Curr. Genomics 10, 353-360
22. Wei, D., Kanai, M., Jia, Z., Le, X. and Xie, K. (2008) Kruppel-like factor 4 induces p27 Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res. 68, 4631-4639
23. Ghaleb, A. M., Nandan, M. O., Chanchevalap, S., Dalton, W. B., Hisamuddin, I. M. and Yang, V. W. (2005) Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 15, 92-96
24. Potapova, A., Hasemeier, B., Römermann, D., Metzig, K., Göhring, G., Schlegelberger, B., Länger, F., Kreipe, H. and Lehmann, U. (2010) Epigenetic inactivation of tumour suppressor gene KLF11 in myelodysplastic syndromes. Eur. J. Haematol. 84, 298-303
25. Wermann, H., Stoop, H., Gillis, A. J., Honecker, F., van Gurp, R. J., Ammerpohl, O., Richter, J., Oosterhuis, J. W., Bokemeyer, C. and Looijenga, L. H. (2010) Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J. Pathol. 221, 433-442
26. Gebhard, C., Schwarzfischer, L., Pham, T.-H., Schilling, E., Klug, M., Andreesen, R. and Rehli, M. (2006) Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res. 66, 6118-6128
27. Buttar, N S., DeMars, C. J., Lomberk, G., Rizvi, S., Bonilla-Velez, J., Achra, S., Rashtak, S., Wang, K. K., Fernandez-Zapico, M. E. and Urrutia, R. (2010) Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. J. Biol. Chem. 285, 11433-11444
28. Belbin, T. J., Singh, B., Barber, I., Socci, N., Wenig, B., Smith, R., Prystowsky, M. B. and Childs, G. (2002) Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays. Cancer Res. 62, 1184-1190 (Pubitemid 34160307)
29. Blanchard, J.-M. (2000) Cyclin A2 transcriptional regulation: modulation of cell cycle control at the G1/S transition by peripheral cues. Biochem. Pharmacol. 60, 1179-1184