Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo

Journal of Surgical Research

Volumn 192, Issue 2, 2014, Pages 317-325

  Yang, Tao ^a   Gu, Haihua ^b   Chen, Xiaofan ^b   Fu, Shaozhi ^b   Wang, Cheng ^b   Xu, Hongfei ^b   Feng, Qiang ^b   Ni, Yiming ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cardiac hypertrophy; EZH2; MicroRNA; Therapeutic target; Transgenic mouse

Indexed keywords

ANTAGOMIR; MESSENGER RNA; MICRORNA 214; TRANSCRIPTION FACTOR EZH2; EZH2 PROTEIN, HUMAN; EZH2 PROTEIN, MOUSE; LUCIFERASE; MICRORNA; MIRN214 MICRORNA, HUMAN; MIRN214 MICRORNA, MOUSE; POLYCOMB REPRESSIVE COMPLEX 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE MODEL; GENE OVEREXPRESSION; GENE SILENCING; HEART; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE SIZE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LUCIFERASE ASSAY; M MODE ECHOCARDIOGRAPHY; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PREDICTION; WILD TYPE; ANIMAL; C57BL MOUSE; CARDIOMEGALY; ECHOGRAPHY; GENE EXPRESSION; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE FUNCTION; HEK293 CELL LINE; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CARDIOMEGALY; GENE EXPRESSION; HEART FAILURE; HEK293 CELLS; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; LUCIFERASES; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; MYOCYTES, CARDIAC; POLYCOMB REPRESSIVE COMPLEX 2; RNA, MESSENGER; VENTRICULAR DYSFUNCTION;

EID: 84912126939     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.06.044     Document Type: Article

References (37)

1. Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 2013;153:828.
2. Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7novelty and significance. Circ Res 2011;108:305.
3. Lorenz K, Schmitt JP, Vidal M, Lohse MJ. Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. Int J Biochem cell biology 2009;41:2351.
4. Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456:980.
5. Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res 2011;108:305.
6. Li Q, Song X-W, Zou J, et al. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. J Cell Sci 2010;123:2444.
7. Delgado-Olguín P, Huang Y, Li X, et al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 2012;44:343.
8. Ono K, Kuwabara Y, Han J. MicroRNAs and cardiovascular diseases. FEBS J 2011;278:1619.
9. Dorn GW 2nd. MicroRNAs in cardiac disease. Transl Res: Journal of Laboratory and Clinical Medicine 2011;157:226.
10. Huang ZP, Neppl RL, Wang DZ. MicroRNAs in cardiac remodeling and disease. J Cardiovasc Transl Res 2010;3:212.
11. Cai B, Pan Z, Lu Y. The roles of microRNAs in heart diseases: a novel important regulator. Curr Med Chem 2010;17:407.
12. da Costa Martins PA, Bourajjaj M, Gladka M, et al. Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 2008;118:1567.
13. Divakaran V, Adrogue J, Ishiyama M, et al. Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ Heart Fail 2009;2:633.
14. Li S, Zhu J, Zhang W, et al. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation 2011;124:175.
15. Reddy S, Zhao M, Hu DQ, et al. Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure. Physiol Genomics 2012;44:562.
16. Yang KC, Ku YC, Lovett M, Nerbonne JM. Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kalpha signaling in cardiac hypertrophy. J Mol Cell Cardiol 2012;53:101.
17. Tatsuguchi M, Seok HY, Callis TE, et al. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 2007;42:1137.
18. Chen J-F, Murchison EP, Tang R, et al. Targeted deletion of dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 2008;105:2111.
19. Rao PK, Toyama Y, Chiang HR, et al. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 2009;105:585.
20. Cheng Y, Ji R, Yue J, et al. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 2007;170:1831.
21. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007;100:416.
22. Wang J, Xu R, Lin F, et al. MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart. Cardiology 2009;113:81.
23. Yang T, Zhang GF, Chen XF, et al. MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2. Biochem Biophys Res Commun 2013;436:578.
24. van Rooij E, Quiat D, Johnson BA, et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell 2009;17:662.
25. Townley-Tilson WH, Callis TE, Wang D. MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int J Biochem Cell Biol 2010;42:1252.
26. van Rooij E, Sutherland LB, Liu N, et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006;103:18255.
27. Aurora AB, Mahmoud AI, Luo X, et al. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca(2)(+) overload and cell death. J Clin Invest 2012;122:1222.
28. Lv G, Shao S, Dong H, Bian X, Yang X, Dong S. MicroRNA-214 protects cardiac myocytes against H2O2-induced injury. J Cell Biochem 2014;115:93.
29. Juan AH, Kumar RM, Marx JG, Young RA, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell 2009;36:61.
30. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 2007;316:575.
31. Cheng Y, Zhang C. MicroRNA-21 in cardiovascular disease. J Cardiovasc Transl Res 2010;3:251.
32. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007;13:613.
33. Horie T, Ono K, Nishi H, et al. MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochem Biophys Res Commun 2009;389:315.
34. Feng B, Chen S, George B, Feng Q, Chakrabarti S. miR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res Rev 2010;26:40.
35. Lin Z, Murtaza I, Wang K, Jiao J, Gao J, Li PF. miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci U S A 2009;106:12103.
36. Duisters RF, Tijsen AJ, Schroen B, et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 2009;104:170. 176p following 178.
37. Wagner KD, Wagner N, Ghanbarian H, et al. RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse. Dev Cell 2008;14:962.