MiR-125b regulates cell progression in chronic myeloid leukemia via targeting BAK1

American Journal of Translational Research

Volumn 8, Issue 2, 2016, Pages 447-459

  Li, Quan ^a   Wu, Yaohui ^b   Zhang, Yongkang ^a   Sun, Huapeng ^a   Lu, Zhaoli ^a   Du, Ke ^a   Fang, Shanshan ^a   Li, Weiming ^b  

^a HUBEI UNIVERSITY OF ARTS AND SCIENCE   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chronic myeloid leukemia; MiR 125b; Mitochondrial apoptosis signaling pathway

Indexed keywords

CASPASE 3; MICRORNA 125B; MIR 125B INHIBITOR; MYC PROTEIN; NUCLEOTIDYLTRANSFERASE INHIBITOR; PROTEIN BAK; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION ASSAY; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MALE; MITOCHONDRION; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VOLUME; WESTERN BLOTTING;

EID: 84962091393     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A and Eaves C. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007; 21: 926-935.
2. Deininger MW, Goldman JM and Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000; 96: 3343-3356.
3. Shukla S, Kouanda A, Silverton L, Talele TT and Ambudkar SV. Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure-Activity Relationship Approach. Molecular pharmaceutics 2014; 11: 2313-2322.
4. Paw I, Carpenter RC, Watabe K, Debinski W and Lo HW. Mechanisms regulating glioma invasion. Cancer Lett 2015; 362: 1-7.
5. Sinha M, Ghatak S, Roy S and Sen CK. micro- RNA-200b as a switch for inducible adult angiogenesis. Antioxid Redox Signal 2015; 22: 1257-1272.
6. Hayes J, Peruzzi PP and Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 2014; 20: 460-469.
7. Negrini M, Cutrona G, Bassi C, Fabris S, Zagatti B, Colombo M, Ferracin M, D’Abundo L, Saccenti E and Matis S. microRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters. Clin Cancer Res 2014; 20: 4141-4153.
8. Cattaneo M, Pelosi E, Castelli G, Cerio A, Porretti L, Rebulla P, Pavesi L, Russo G, Giordano A and Turri J. A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes. J Cell Physiol 2015; 230: 1770-1780.
9. Navarro A, Díaz T, Cordeiro A, Beyá MD, Ferrer G, Fuster D, Martinez A and Monzó M. Epigenetic regulation of microRNA expression in Hodgkin lymphoma. Leuk Lymphoma 2015; 56: 2683-9.
10. Chapiro E, Russell L, Struski S, Cave H, Radford-Weiss I, Valle V, Lachenaud J, Brousset P, Bernard O and Harrison C. A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia 2010; 24: 1362-1364.
11. Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, La Starza R, Bastard C, Lippert E, Talmant P, Lafage-Pochitaloff M and Leroux D. Myeloid cell differentiation arrest by miR- 125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008; 205: 2499-2506.
12. Kandi R, Gutti U, Saladi RG, Gutti RK. MiR- 125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. Hematol Oncol Stem Cell Ther 2015; 8: 95-7.
13. Ren J, Xu Y, Huang Q, Yang J, Yang M, Hu K and Wei K. Chabamide induces cell cycle arrest and apoptosis by the Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Anticancer Drugs 2015; 26: 498-507.
14. Siddiqui WA, Ahad A and Ahsan H. The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update. Arch Toxicol 2015; 89: 289-317.
15. Troadec S, Blairvacq M, Oumata N, Galons H, Meijer L and Berthou C. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. J Biomed Sci 2015; 22: 1-16.
16. Kong F, Sun C, Wang Z, Han L, Weng D, Lu Y and Chen G. miR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. J Huazhong Univ Sci Technolog Med Sci 2011; 31: 543-549.
17. Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI, Tan M. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem 2010; 285: 21496-21507.
18. Kim C, Lee JH, Kim SH, Sethi G and Ahn KS. Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model. Oncotarget 2015; 6: 4020.
19. Capaccioli S. Proceedings of the discoveries on post-transcriptional Bcl-2 deregulation in human leukemias/lymphomas. RNA &Disease 2015; 2: 10-14800/rd.14694.
20. Ambros V, Lee RC, Lavanway A, Williams PT and Jewell D. MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol 2003; 13: 807-818.
21. Bousquet M, Harris MH, Zhou B and Lodish HF. MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A 2010; 107: 21558-21563.
22. Wang H, Tan G, Dong L, Cheng L, Li K, Wang Z and Luo H. Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One 2012; 7: e34210.
23. Nakanishi H, Taccioli C, Palatini J, Fernandez- Cymering C, Cui R, Kim T, Volinia S and Croce C. Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene 2014; 33: 702-712.
24. Sun D, Layer R, Mueller AC, Cichewicz MA, Negishi M, Paschal BM and Dutta A. Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR- 125b-2 miRNA cluster in prostate cancer cells. Oncogene 2014; 33: 1448-1457.
25. Zhang H, Luo XQ, Feng DD, Zhang XJ, Wu J, Zheng YS, Chen X, Xu L and Chen YQ. Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. Mol Cancer 2011; 10: 293.
26. Wang F, Cho W, Chan LW, Wong S, Tsui NB, Siu PM, Yip S and Yung BY. Gene Network Exploration of Crosstalk between Apoptosis and Autophagy in Chronic Myelogenous Leukemia. Biomed Res Int 2015; 2015: 459840.
27. Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL and Bishop JM. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med 2001; 193: 531-544.
28. Xiang Z, Qu F, Wang F, Xiao S, Jun L, Zhang Y and Yu Z. ChBax/Bak as key regulators of the mitochondrial apoptotic pathway: Cloned and characterized in Crassostrea hongkongensis. Fish Shellfish Immunol 2015; 42: 225-232.
29. Reed JC. Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML. In: editors. Targeted Therapy of Acute Myeloid Leukemia. Springer; 2015. pp. 47-65.
30. Weiß L, Hugle M, Romero S and Fulda S. Synergistic induction of apoptosis by polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells. Int J Cancer 2016; 138: 497-506