Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

eLife

Volumn 6, Issue , 2017, Pages

  Martin, Gregory M ^a   Kandasamy, Balamurugan ^a   Dimaio, Frank ^b   Yoshioka, Craig ^c   Shyng, Show Ling ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Oregon Health and Science University Department of Biomedical Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTIDIABETIC AGENT; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; LEUKOTRIENE A4; SULFONYLUREA; SULFONYLUREA RECEPTOR 1; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PROTEIN BINDING; SULFONYLUREA RECEPTOR;

ANTIDIABETIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; DRUG BINDING SITE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; HAMSTER; HUMAN; HUMAN CELL; IMAGE PROCESSING; LIPID BILAYER; MOLECULAR INTERACTION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VESTIBULE; WESTERN BLOTTING; ANIMAL; BINDING SITE; CHEMISTRY; CRYOELECTRON MICROSCOPY; METABOLISM; MOLECULAR MODEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CRICETINAE; CRYOELECTRON MICROSCOPY; GLYBURIDE; HYPOGLYCEMIC AGENTS; MODELS, MOLECULAR; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; SULFONYLUREA RECEPTORS;

EID: 85032942597     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.31054.001     Document Type: Article

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