Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 9146-9156

  Lin, Yu Wen ^a   Bushman, Jeremy D ^a   Yan, Fei Fei ^a   Haidar, Sara ^a   MacMullen, Courtney ^b   Ganguly, Arupa ^c   Stanley, Charles A ^b   Shyng, Show Ling ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CELL CULTURE; CELL MEMBRANES; DEFECTS; DISTILLATION; FLOW INTERACTIONS; GLUCOSE; HORMONES; INSULIN; PHYSIOLOGY; POTASSIUM; PROBABILITY DENSITY FUNCTION;

CELL FUNCTIONS; CELL LINES; CELL SURFACES; CHANNEL EXPRESSIONS; CHANNEL FUNCTIONS; CHANNEL GATING; CURRENT DECAYS; GLUCOSE CONCENTRATIONS; GLUCOSE METABOLISMS; INACTIVATION GATING; INSULIN SECRETIONS; MEMBRANE POTENTIALS; POTASSIUM CHANNELS; REGULATORY SUBUNITS; SULFONYLUREA RECEPTORS; SURFACE EXPRESSIONS; WILD TYPES;

PATHOLOGY;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ARGININE DERIVATIVE; CYSTEINE; GLUCOSE; GLYCINE; HISTIDINE; INSULIN; PROLINE; ABC TRANSPORTER; ABCC8 PROTEIN, RAT; ADENOSINE TRIPHOSPHATE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MULTIDRUG RESISTANCE PROTEIN; PROTEIN SUBUNIT;

ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL LINE; CELL SURFACE; CHANNEL GATING; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; GENE; GENE MUTATION; HUMAN; HUMAN CELL; INSULIN RELEASE; KCNJ11 GENE; MEMBRANE POTENTIAL; PANCREAS ISLET BETA CELL; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; PRIORITY JOURNAL; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE POTENTIAL; GENETICS; METABOLISM; MISSENSE MUTATION; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; SECRETION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION, MISSENSE; PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS;

EID: 44049086392     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708798200     Document Type: Article

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