Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism

Journal of Biological Chemistry

Volumn 290, Issue 12, 2015, Pages 7980-7991

  Devaraneni, Prasanna K ^a,b   Olson, Erik M ^a   Zhou, Qing ^a   Shyng, Show Ling ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINO ACIDS; DEFECTS; DISEASE CONTROL; POTASSIUM COMPOUNDS; PROTEINS;

CHANNEL COMPLEX; CONSTITUENT PROTEINS; HETEROMERIC COMPLEXES; POTENTIAL THERAPIES; PROTEIN MISFOLDING; STRUCTURAL DIFFERENCES; SUBUNIT INTERFACES; SULFONYLUREA RECEPTORS;

BIOSYNTHESIS;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARBAMAZEPINE; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA RECEPTOR 1; ADENOSINE TRIPHOSPHATE; LIGAND;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; IC50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; ANIMAL; BIOSYNTHESIS; CELL LINE; HAMSTER; METABOLISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CRICETINAE; KATP CHANNELS; LIGANDS;

EID: 84925337325     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.634576     Document Type: Article

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