메뉴 건너뛰기




Volumn 3, Issue 2, 2017, Pages

The ascendance of microphysiological systems to solve the drug testing dilemma

Author keywords

Body on a chip; Drug testing; Human on a chip; Microphysiological system; Multi organ chip

Indexed keywords

BIOCHIP; BODY ON A CHIP; CELL COMMUNICATION; CELL VIABILITY; COCULTURE; DRUG SCREENING; ELECTROPHYSIOLOGICAL PROCEDURES; FLOW RATE; FLUID RETENTION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MULTI ORGAN CHIP; PHYSICAL STIMULATION; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TISSUE INTERACTION;

EID: 85032810398     PISSN: None     EISSN: 20565623     Source Type: Journal    
DOI: 10.4155/fsoa-2017-0002     Document Type: Review
Times cited : (55)

References (89)
  • 1
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: The pharmaceutical industry's grand challenge
    • Paul SM, Mytelka DS, Dunwiddie CT et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 9(3), 203-214 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.3 , pp. 203-214
    • Paul, S.M.1    Mytelka, D.S.2    Dunwiddie, C.T.3
  • 2
    • 84959128138 scopus 로고    scopus 로고
    • Innovation in the pharmaceutical industry: New estimates of R&D costs
    • DiMasi JA, Grabowski HG, Hansen RW. Innovation in the pharmaceutical industry: new estimates of R&D costs. J. Health Econ. 47, 20-33 (2016).
    • (2016) J. Health Econ. , vol.47 , pp. 20-33
    • DiMasi, J.A.1    Grabowski, H.G.2    Hansen, R.W.3
  • 4
    • 84934439985 scopus 로고    scopus 로고
    • An analysis of the attrition of drug candidates from four major pharmaceutical companies
    • Waring MJ, Arrowsmith J, Leach AR et al. An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14(7), 475-486 (2015).
    • (2015) Nat. Rev. Drug Discov. , vol.14 , Issue.7 , pp. 475-486
    • Waring, M.J.1    Arrowsmith, J.2    Leach, A.R.3
  • 5
    • 84901946024 scopus 로고    scopus 로고
    • Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework
    • Cook D, Brown D, Alexander R et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat. Rev. Drug Discov. 13(6), 419-431 (2014).
    • (2014) Nat. Rev. Drug Discov. , vol.13 , Issue.6 , pp. 419-431
    • Cook, D.1    Brown, D.2    Alexander, R.3
  • 6
    • 84994106724 scopus 로고    scopus 로고
    • Acute neurologic disorder from an inhibitor of fatty acid amide hydrolase
    • Kerbrat A, Ferré J-C, Fillatre P et al. Acute neurologic disorder from an inhibitor of fatty acid amide hydrolase. N. Engl. J. Med. 375(18), 1717-1725 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , Issue.18 , pp. 1717-1725
    • Kerbrat, A.1    Ferré, J.-C.2    Fillatre, P.3
  • 7
    • 85069008364 scopus 로고    scopus 로고
    • ANSM: Agence Nationale de Sécurité du Médicament. Report by the Temporary Specialist Scientific Committee (TSSC), “FAAH (Fatty Acid Amide Hydrolase)”, on the causes of the accident during a Phase 1 clinical trial in Rennes in January 2016 (2016)
    • ANSM: Agence Nationale de Sécurité du Médicament. Report by the Temporary Specialist Scientific Committee (TSSC), “FAAH (Fatty Acid Amide Hydrolase)”, on the causes of the accident during a Phase 1 clinical trial in Rennes in January 2016 (2016). http://ansm.sante.fr/var/ansm_site/storage/original/
  • 8
    • 69349104947 scopus 로고    scopus 로고
    • Chemical regulators have overreached
    • Hartung T, Rovida C. Chemical regulators have overreached. Nature. 460(7259), 1080-1081 (2009).
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1080-1081
    • Hartung, T.1    Rovida, C.2
  • 10
    • 84994002972 scopus 로고    scopus 로고
    • Safety assessment strategies and predictive safety of biopharmaceuticals and antibody drug conjugates
    • Will Y McDuffie JE Olaharski AJ Jeffy BD John Wiley & Sons Inc
    • Horner MJ, Hinrichs MJ, Buss N. Safety assessment strategies and predictive safety of biopharmaceuticals and antibody drug conjugates. In: Drug discovery toxicology: From target assessment to translational biomarkers. Will Y, McDuffie JE, Olaharski AJ, Jeffy BD (Eds.). John Wiley & Sons Inc, 27-38 (2016).
    • (2016) Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers , pp. 27-38
    • Horner, M.J.1    Hinrichs, M.J.2    Buss, N.3
  • 11
    • 84864565222 scopus 로고    scopus 로고
    • A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro
    • Coleman MD, O'Neil JD, Woehrling EK et al. A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro. PLoS ONE 7(8), e42768 (2012).
    • (2012) Plos ONE , vol.7 , Issue.8 , pp. e42768
    • Coleman, M.D.1    O'Neil, J.D.2    Woehrling, E.K.3
  • 12
    • 84988920366 scopus 로고    scopus 로고
    • Validation of alternative in vitro methods to animal testing: Concepts, challenges, processes and tools
    • Springer International Publishing Eskes C Whelan M
    • Griesinger C, Desprez B, Coecke S, Casey W, Zuang V. Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools. In: Advances In Experimental Medicine And Biology. Springer International Publishing, Eskes C, Whelan M (Eds.), 65-132 (2016).
    • (2016) Advances In Experimental Medicine And Biology , pp. 65-132
    • Griesinger, C.1    Desprez, B.2    Coecke, S.3    Casey, W.4    Zuang, V.5
  • 13
    • 33749615999 scopus 로고    scopus 로고
    • Translation of research evidence from animals to humans
    • Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA 296(14), 1727-1732 (2006).
    • (2006) JAMA , vol.296 , Issue.14 , pp. 1727-1732
    • Hackam, D.G.1    Redelmeier, D.A.2
  • 14
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok J, Warren HS, Cuenca AG et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl Acad. Sci. USA 110(9), 3507-3512 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.9 , pp. 3507-3512
    • Seok, J.1    Warren, H.S.2    Cuenca, A.G.3
  • 15
    • 77950679333 scopus 로고    scopus 로고
    • Can animal models of disease reliably inform human studies?
    • van der Worp HB, Howells DW, Sena ES et al. Can animal models of disease reliably inform human studies? PLoS Med. 7(3), e1000245 (2010).
    • (2010) Plos Med. , vol.7 , Issue.3 , pp. e1000245
    • Van Der Worp, H.B.1    Howells, D.W.2    Sena, E.S.3
  • 16
    • 84876685425 scopus 로고    scopus 로고
    • Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice
    • Leist M, Hartung T. Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch. Toxicol. 87(4), 563-567 (2013).
    • (2013) Arch. Toxicol. , vol.87 , Issue.4 , pp. 563-567
    • Leist, M.1    Hartung, T.2
  • 17
    • 84873355257 scopus 로고    scopus 로고
    • Systematic reviews of animal models: Methodology versus epistemology
    • Greek R, Menache A. Systematic reviews of animal models: methodology versus epistemology. Int. J. Med. Sci. 10(3), 206-221 (2013).
    • (2013) Int. J. Med. Sci. , vol.10 , Issue.3 , pp. 206-221
    • Greek, R.1    Menache, A.2
  • 18
    • 77749314440 scopus 로고    scopus 로고
    • Per aspirin ad astra
    • Hartung T. Per aspirin ad astra. Altern. Lab. Anim. 37(Suppl. 2), 45-47 (2009).
    • (2009) Altern. Lab. Anim. , vol.37 , pp. 45-47
    • Hartung, T.1
  • 19
    • 0027474601 scopus 로고
    • Mechanism of the cardiotoxic actions of terfenadine
    • Woosley RL. Mechanism of the cardiotoxic actions of terfenadine. JAMA 269(12), 1532 (1993).
    • (1993) JAMA , vol.269 , Issue.12 , pp. 1532
    • Woosley, R.L.1
  • 23
    • 84930959624 scopus 로고    scopus 로고
    • A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
    • Maschmeyer I, Lorenz AK, Schimek K et al. A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents. Lab. Chip. 15(12), 2688-2699 (2015).
    • (2015) Lab. Chip. , vol.15 , Issue.12 , pp. 2688-2699
    • Maschmeyer, I.1    Lorenz, A.K.2    Schimek, K.3
  • 25
    • 84868204184 scopus 로고    scopus 로고
    • Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue
    • Maidhof R, Tandon N, Lee EJ et al. Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue. J. Tissue Eng. Regen. Med. 6(10), e12-e23 (2012).
    • (2012) J. Tissue Eng. Regen. Med. , vol.6 , Issue.10 , pp. e12-e23
    • Maidhof, R.1    Tandon, N.2    Lee, E.J.3
  • 26
    • 84882267983 scopus 로고    scopus 로고
    • Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine
    • Harink B, Le Gac S, Truckenmüller R, van Blitterswijk C, Habibovic P. Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine. Lab. Chip. 13(18), 3512-3528 (2013).
    • (2013) Lab. Chip. , vol.13 , Issue.18 , pp. 3512-3528
    • Harink, B.1    Le Gac, S.2    Truckenmüller, R.3    Van Blitterswijk, C.4    Habibovic, P.5
  • 27
    • 84889303621 scopus 로고    scopus 로고
    • An overview on bioreactor design, prototyping and process control for reproducible three-dimensional tissue culture
    • Marx U Sandig V Wiley-VCH
    • Pörtner R, Giese C. An overview on bioreactor design, prototyping and process control for reproducible three-dimensional tissue culture. In: Drug Testing In Vitro: Breakthroughs and Trends in Cell Culture Technology. Marx U, Sandig V (Eds). Wiley-VCH. (3), 53-78 (2006).
    • (2006) Drug Testing In Vitro: Breakthroughs and Trends in Cell Culture Technology , vol.3 , pp. 53-78
    • Pörtner, R.1    Giese, C.2
  • 28
    • 84873579795 scopus 로고    scopus 로고
    • “Human-on-a-chip” developments: A translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
    • Marx U, Walles H, Hoffmann S et al. “Human-on-a-chip” developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? Altern. Lab. Anim. 40(5), 235-257 (2012).
    • (2012) Altern. Lab. Anim. , vol.40 , Issue.5 , pp. 235-257
    • Marx, U.1    Walles, H.2    Hoffmann, S.3
  • 29
    • 84939228022 scopus 로고    scopus 로고
    • Designing a microfluidic device with integrated ratiometric oxygen sensors for the long-term control and monitoring of chronic and cyclic hypoxia
    • Grist SM, Schmok JC, Liu MC, Chrostowski L, Cheung KC. Designing a microfluidic device with integrated ratiometric oxygen sensors for the long-term control and monitoring of chronic and cyclic hypoxia. Sensors (Basel) 15(8), 20030-20052 (2015).
    • (2015) Sensors (basel) , vol.15 , Issue.8 , pp. 20030-20052
    • Grist, S.M.1    Schmok, J.C.2    Liu, M.C.3    Chrostowski, L.4    Cheung, K.C.5
  • 30
    • 84919882329 scopus 로고    scopus 로고
    • Au2D-Visualisierung des zellulären Sauerstoff verbrauchs in Mikrofluidiksystemen
    • Ochs CJ, Kasuya J, Liebsch G. au2D-Visualisierung des zellulären Sauerstoff verbrauchs in Mikrofluidiksystemen. BIOspektrum 20(7), 773-775 (2014).
    • (2014) Biospektrum , vol.20 , Issue.7 , pp. 773-775
    • Ochs, C.J.1    Kasuya, J.2    Liebsch, G.3
  • 31
    • 84882252041 scopus 로고    scopus 로고
    • A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
    • Wagner I, Materne E-M, Marx U et al. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip 13(18), 3538-3547 (2013).
    • (2013) Lab Chip , vol.13 , Issue.18 , pp. 3538-3547
    • Wagner, I.1    Materne, E.-M.2    Marx, U.3
  • 32
    • 18444370256 scopus 로고    scopus 로고
    • A microfabricated array bioreactor for perfused 3D liver culture
    • Powers MJ, Domansky K, Kaazempur-mofrad MR et al. A microfabricated array bioreactor for perfused 3D liver culture. Biotechnol. Bioeng. 78(3), 257-269 (2002).
    • (2002) Biotechnol. Bioeng. , vol.78 , Issue.3 , pp. 257-269
    • Powers, M.J.1    Domansky, K.2    Kaazempur-Mofrad, M.R.3
  • 33
    • 0035768206 scopus 로고    scopus 로고
    • Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles
    • Sin A, Baxter GT, Shuler ML. Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles. Microfluid. BioMEMS 4560, 98-101 (2001).
    • (2001) Microfluid. Biomems , vol.4560 , pp. 98-101
    • Sin, A.1    Baxter, G.T.2    Shuler, M.L.3
  • 34
    • 84979255712 scopus 로고    scopus 로고
    • Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
    • Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX 33(3), 272-321 (2016).
    • (2016) ALTEX , vol.33 , Issue.3 , pp. 272-321
    • Marx, U.1    Andersson, T.B.2    Bahinski, A.3    Beilmann, M.4    Beken, S.5    Cassee, F.R.6
  • 35
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • Hung PJ, Lee PJ, Sabounchi P, Lin R, Lee LP. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol. Bioeng. 89(1), 1-8 (2005).
    • (2005) Biotechnol. Bioeng. , vol.89 , Issue.1 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4    Lee, L.P.5
  • 37
    • 27944442381 scopus 로고    scopus 로고
    • A microscale in vitro physiological model of the liver: Predictive screens for drug metabolism and enzyme induction
    • Sivaraman A, Leach JK, Townsend S et al. A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr. Drug Metab. 6(6), 569-591 (2005).
    • (2005) Curr. Drug Metab. , vol.6 , Issue.6 , pp. 569-591
    • Sivaraman, A.1    Leach, J.K.2    Townsend, S.3
  • 38
    • 84976907426 scopus 로고    scopus 로고
    • Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
    • Gordon S, Daneshian M, Bouwstra J et al. Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology. ALTEX 32(4), 327-378 (2015).
    • (2015) ALTEX , vol.32 , Issue.4 , pp. 327-378
    • Gordon, S.1    Daneshian, M.2    Bouwstra, J.3
  • 39
    • 84956654664 scopus 로고    scopus 로고
    • Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
    • Benam KH, Villenave R, Lucchesi C et al. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat. Methods 13(2), 151-157 (2016).
    • (2016) Nat. Methods , vol.13 , Issue.2 , pp. 151-157
    • Benam, K.H.1    Villenave, R.2    Lucchesi, C.3
  • 40
    • 84882590738 scopus 로고    scopus 로고
    • Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
    • Jan K-J, Mehr AP, Hamilton GA et al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr. Biol. 5(9), 1119-1129 (2013).
    • (2013) Integr. Biol. , vol.5 , Issue.9 , pp. 1119-1129
    • Jan, K.-J.1    Mehr, A.P.2    Hamilton, G.A.3
  • 41
    • 84864832183 scopus 로고    scopus 로고
    • Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels
    • Korin N, Kanapathipillai M, Matthews BD et al. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science 337(6095), 738-742 (2012).
    • (2012) Science , vol.337 , Issue.6095 , pp. 738-742
    • Korin, N.1    Kanapathipillai, M.2    Matthews, B.D.3
  • 42
    • 84979666308 scopus 로고    scopus 로고
    • Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium
    • Jain A, van der Meer AD, Papa A-L et al. Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium. Biomed. Microdevices 18(4), 73 (2016).
    • (2016) Biomed. Microdevices , vol.18 , Issue.4 , pp. 73
    • Jain, A.1    Van Der Meer, A.D.2    Papa, A.-L.3
  • 43
    • 84901823942 scopus 로고    scopus 로고
    • Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro
    • Torisawa Y, Spina CS, Mammoto T et al. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nat. Methods 11(6), 663-669 (2014).
    • (2014) Nat. Methods , vol.11 , Issue.6 , pp. 663-669
    • Torisawa, Y.1    Spina, C.S.2    Mammoto, T.3
  • 44
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim HJ, Huh D, Hamilton G, Ingber DE. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip. 12, 2165-2174 (2012).
    • (2012) Lab Chip. , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 46
    • 85006085663 scopus 로고    scopus 로고
    • High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform
    • Wevers NR, Van Vught R, Wilschut KJ et al. High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform. Sci. Rep. 6, 1-10 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 1-10
    • Wevers, N.R.1    Van Vught, R.2    Wilschut, K.J.3
  • 47
    • 84930249306 scopus 로고    scopus 로고
    • 96-well format-based microfluidic platform for parallel interconnection of multiple multicellular spheroids
    • Kim J, Fluri DA, Kelm JM, Hierlemann A, Frey O. 96-well format-based microfluidic platform for parallel interconnection of multiple multicellular spheroids. J. Lab. Autom. 20(3), 274-282 (2015).
    • (2015) J. Lab. Autom. , vol.20 , Issue.3 , pp. 274-282
    • Kim, J.1    Fluri, D.A.2    Kelm, J.M.3    Hierlemann, A.4    Frey, O.5
  • 48
    • 84930940367 scopus 로고    scopus 로고
    • 3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis
    • Kim J-Y, Fluri DA, Marchan R et al. 3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis. J. Biotechnol. 205, 24-35 (2015).
    • (2015) J. Biotechnol. , vol.205 , pp. 24-35
    • Kim, J.-Y.1    Fluri, D.A.2    Marchan, R.3
  • 49
    • 1642385430 scopus 로고    scopus 로고
    • Microscale tissue engineering using gravity-enforced cell assembly
    • Kelm JM, Fussenegger M. Microscale tissue engineering using gravity-enforced cell assembly. Trends Biotechnol. 22(4), 195-202 (2004).
    • (2004) Trends Biotechnol. , vol.22 , Issue.4 , pp. 195-202
    • Kelm, J.M.1    Fussenegger, M.2
  • 50
    • 84872301011 scopus 로고    scopus 로고
    • Multi-cell type human liver microtissues for hepatotoxicity testing
    • Messner S, Agarkova I, Moritz W, Kelm JM. Multi-cell type human liver microtissues for hepatotoxicity testing. Arch. Toxicol. 87(1), 209-213 (2013).
    • (2013) Arch. Toxicol. , vol.87 , Issue.1 , pp. 209-213
    • Messner, S.1    Agarkova, I.2    Moritz, W.3    Kelm, J.M.4
  • 51
    • 84903650325 scopus 로고    scopus 로고
    • Reconfigurable microfluidic hanging drop network for multitissue interaction and analysis
    • Frey O, Misun PM, Fluri DA, Hengstler JG, Hierlemann A. Reconfigurable microfluidic hanging drop network for multitissue interaction and analysis. Nat. Commun. 5, 1-11 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 1-11
    • Frey, O.1    Misun, P.M.2    Fluri, D.A.3    Hengstler, J.G.4    Hierlemann, A.5
  • 52
    • 1842814047 scopus 로고    scopus 로고
    • Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies
    • Viravaidya K, Shuler ML. Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies. Biotechnol. Prog. 20(2), 590-597 (2004).
    • (2004) Biotechnol. Prog. , vol.20 , Issue.2 , pp. 590-597
    • Viravaidya, K.1    Shuler, M.L.2
  • 53
    • 84957586265 scopus 로고    scopus 로고
    • Multi-organ toxicity demonstration in a functional human in vitro system composed of four organs
    • Oleaga C, Bernabini C, Smith AST et al. Multi-organ toxicity demonstration in a functional human in vitro system composed of four organs. Sci. Rep. 6, 1-17 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 1-17
    • Oleaga, C.1    Bernabini, C.2    Smith, A.S.T.3
  • 54
    • 1142305959 scopus 로고    scopus 로고
    • Development of a microscale cell culture analog to probe naphthalene toxicity
    • Viravaidya K, Sin A, Shuler ML. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol. Prog. 20(1), 316-323 (2004).
    • (2004) Biotechnol. Prog. , vol.20 , Issue.1 , pp. 316-323
    • Viravaidya, K.1    Sin, A.2    Shuler, M.L.3
  • 55
    • 64749086511 scopus 로고    scopus 로고
    • A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers
    • Tatosian D a, Shuler ML. A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnol. Bioeng. 103(1), 187-198 (2009).
    • (2009) Biotechnol. Bioeng. , vol.103 , Issue.1 , pp. 187-198
    • Tatosian, D.1    Shuler, M.L.2
  • 56
    • 84983741937 scopus 로고    scopus 로고
    • Design and demonstration of a pumpless 14 compartment microphysiological system
    • Miller PG, Shuler ML. Design and demonstration of a pumpless 14 compartment microphysiological system. Biotechnol. Bioeng. 113(10), 2213-2227 (2016).
    • (2016) Biotechnol. Bioeng. , vol.113 , Issue.10 , pp. 2213-2227
    • Miller, P.G.1    Shuler, M.L.2
  • 57
    • 78149285919 scopus 로고    scopus 로고
    • Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    • 7321
    • Ding B-S, Nolan DJ, Butler JM et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468(7321), 310-315 (2010).
    • (2010) Nature , vol.468 , pp. 310-315
    • Ding, B.-S.1    Nolan, D.J.2    Butler, J.M.3
  • 58
    • 84882253484 scopus 로고    scopus 로고
    • Integrating biological vasculature into a multi-organ-chip microsystem
    • Schimek K, Busek M, Brincker S et al. Integrating biological vasculature into a multi-organ-chip microsystem. Lab Chip. 13(18), 3588-3598 (2013).
    • (2013) Lab Chip. , vol.13 , Issue.18 , pp. 3588-3598
    • Schimek, K.1    Busek, M.2    Brincker, S.3
  • 59
    • 84944068105 scopus 로고    scopus 로고
    • Emulating human microcapillaries in a multi-organ-chip platform
    • Hasenberg T, Mühleder S, Dotzler A et al. Emulating human microcapillaries in a multi-organ-chip platform. J. Biotechnol. 216, 1-10 (2015).
    • (2015) J. Biotechnol. , vol.216 , pp. 1-10
    • Hasenberg, T.1    Mühleder, S.2    Dotzler, A.3
  • 60
    • 36448955695 scopus 로고    scopus 로고
    • The costs of using unauthenticated, over-passaged cell lines: How much more data do we need?
    • 577-578 581-582 passim
    • Hughes P, Marshall D, Reid Y, Parkes H, Gelber C. The costs of using unauthenticated, over-passaged cell lines: how much more data do we need? Biotechniques 43(5), 575, 577-578, 581-582 passim (2007).
    • (2007) Biotechniques , vol.43 , Issue.5 , pp. 575
    • Hughes, P.1    Marshall, D.2    Reid, Y.3    Parkes, H.4    Gelber, C.5
  • 61
    • 84979515493 scopus 로고    scopus 로고
    • Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function
    • Kleensang A, Vantangoli MM, Odwin-DaCosta S et al. Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function. Sci. Rep. 6, 28994 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 28994
    • Kleensang, A.1    Vantangoli, M.M.2    Odwin-DaCosta, S.3
  • 62
    • 84930155232 scopus 로고    scopus 로고
    • Assessing the prevalence of mycoplasma contamination in cell culture via a survey of NCBI's RNA-seq archive
    • Olarerin-George AO, Hogenesch JB. Assessing the prevalence of mycoplasma contamination in cell culture via a survey of NCBI's RNA-seq archive. Nucleic Acids Res. 43(5), 2535-2542 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , Issue.5 , pp. 2535-2542
    • Olarerin-George, A.O.1    Hogenesch, J.B.2
  • 63
    • 84991396724 scopus 로고    scopus 로고
    • Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing
    • Tolosa L, Gómez-Lechón MJ, López S et al. Human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicol. Sci. 152(1), 214-229 (2016).
    • (2016) Toxicol. Sci. , vol.152 , Issue.1 , pp. 214-229
    • Tolosa, L.1    Gómez-Lechón, M.J.2    López, S.3
  • 64
    • 84959018459 scopus 로고    scopus 로고
    • Upcyte human hepatocytes: A potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds
    • Schaefer M, Schänzle G, Bischoff D, Süssmuth RD. Upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds. Drug Metab. Dispos. 44(3), 435-444 (2016).
    • (2016) Drug Metab. Dispos. , vol.44 , Issue.3 , pp. 435-444
    • Schaefer, M.1    Schänzle, G.2    Bischoff, D.3    Süssmuth, R.D.4
  • 65
    • 84888094038 scopus 로고    scopus 로고
    • Eternity and functionality - Rational access to physiologically relevant cell lines
    • Lipps C, May T, Hauser H, Wirth D. Eternity and functionality - rational access to physiologically relevant cell lines. Biol. Chem. 394(12), 1637-1648 (2013).
    • (2013) Biol. Chem. , vol.394 , Issue.12 , pp. 1637-1648
    • Lipps, C.1    May, T.2    Hauser, H.3    Wirth, D.4
  • 66
    • 84949466262 scopus 로고    scopus 로고
    • In vitro generation of functional liver organoid-like structures using adult human cells
    • Ramachandran SD, Schirmer K, Münst B et al. In vitro generation of functional liver organoid-like structures using adult human cells. PLoS ONE 10(10), e0139345 (2015).
    • (2015) Plos ONE , vol.10 , Issue.10 , pp. e0139345
    • Ramachandran, S.D.1    Schirmer, K.2    Münst, B.3
  • 68
    • 84944093438 scopus 로고    scopus 로고
    • Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro
    • Maschmeyer I, Hasenberg T, Jaenicke A et al. Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro. Eur. J. Pharm. Biopharm. 95, 77-87 (2015).
    • (2015) Eur. J. Pharm. Biopharm. , vol.95 , pp. 77-87
    • Maschmeyer, I.1    Hasenberg, T.2    Jaenicke, A.3
  • 69
    • 84860439214 scopus 로고    scopus 로고
    • Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models
    • van Midwoud PM, Janse A, Merema MT, Groothuis GMM, Verpoorte E. Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Anal. Chem. 84(9), 3938-3944 (2012).
    • (2012) Anal. Chem. , vol.84 , Issue.9 , pp. 3938-3944
    • Van Midwoud, P.M.1    Janse, A.2    Merema, M.T.3    Groothuis, G.M.M.4    Verpoorte, E.5
  • 74
    • 85012027021 scopus 로고    scopus 로고
    • Good cell culture practice for stem cells and stem-cell-derived models
    • Epub ahead of print
    • Pamies D, Bal-Price A, Simeonov A et al. Good cell culture practice for stem cells and stem-cell-derived models. ALTEX. doi:10.14573/altex.1607121 (2016) (Epub ahead of print).
    • (2016) ALTEX
    • Pamies, D.1    Bal-Price, A.2    Simeonov, A.3
  • 75
    • 84994235704 scopus 로고    scopus 로고
    • Screening out irrelevant cell-based models of disease
    • Horvath P, Aulner N, Bickle M et al. Screening out irrelevant cell-based models of disease. Nat. Rev. Drug Discov. 15(11), 751-769 (2016).
    • (2016) Nat. Rev. Drug Discov. , vol.15 , Issue.11 , pp. 751-769
    • Horvath, P.1    Aulner, N.2    Bickle, M.3
  • 78
    • 84937034325 scopus 로고    scopus 로고
    • Concordance of noncarcinogenic endpoints in rodent chemical bioassays
    • Wang B, Gray G. Concordance of noncarcinogenic endpoints in rodent chemical bioassays. Risk Anal. 35(6), 1154-1166 (2015).
    • (2015) Risk Anal , vol.35 , Issue.6 , pp. 1154-1166
    • Wang, B.1    Gray, G.2
  • 79
    • 84962821185 scopus 로고    scopus 로고
    • Analysis of publically available skin sensitization data from REACH registrations 2008-2014
    • Luechtefeld T, Maertens A, Russo DP, Rovida C, Zhu H, Hartung T. Analysis of publically available skin sensitization data from REACH registrations 2008-2014. ALTEX 33(2), 135-148 (2016).
    • (2016) ALTEX , vol.33 , Issue.2 , pp. 135-148
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3    Rovida, C.4    Zhu, H.5    Hartung, T.6
  • 80
    • 84962900969 scopus 로고    scopus 로고
    • Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data
    • Luechtefeld T, Maertens A, Russo DP, Rovida C, Zhu H, Hartung T. Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data. ALTEX 33(2), 123-134 (2016).
    • (2016) ALTEX , vol.33 , Issue.2 , pp. 123-134
    • Luechtefeld, T.1    Maertens, A.2    Russo, D.P.3    Rovida, C.4    Zhu, H.5    Hartung, T.6
  • 81
    • 85069006222 scopus 로고    scopus 로고
    • OECD: Organisation for Economic Co-operation Development
    • OECD: Organisation for Economic Co-operation and Development. Test No. 429: Skin Sensitisation (2016). www.oecd-ilibrary.org/content/book/
    • (2016) Test No. 429: Skin Sensitisation
  • 83
    • 84905725612 scopus 로고    scopus 로고
    • 3D bioprinting of tissues and organs
    • Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat. Biotechnol. 32(8), 773-785 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , Issue.8 , pp. 773-785
    • Murphy, S.V.1    Atala, A.2
  • 84
    • 84865223605 scopus 로고    scopus 로고
    • Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue
    • Ahadian S, Ramón-Azcón J, Ostrovidov S et al. Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue. Lab Chip. 12(18), 3491-3503 (2012).
    • (2012) Lab Chip. , vol.12 , Issue.18 , pp. 3491-3503
    • Ahadian, S.1    Ramón-Azcón, J.2    Ostrovidov, S.3
  • 86
    • 78149338941 scopus 로고    scopus 로고
    • A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells
    • Ferrell N, Desai RR, Fleischman AJ, Roy S, Humes HD, Fissell WH. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells. Biotechnol. Bioeng. 107(4), 707-716 (2010).
    • (2010) Biotechnol. Bioeng. , vol.107 , Issue.4 , pp. 707-716
    • Ferrell, N.1    Desai, R.R.2    Fleischman, A.J.3    Roy, S.4    Humes, H.D.5    Fissell, W.H.6
  • 87
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim HJ, Huh D, Hamilton G, Ingber DE, Links DA. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 12(12), 2165-2174 (2012).
    • (2012) Lab Chip , vol.12 , Issue.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4    Links, D.A.5
  • 88
    • 84864295451 scopus 로고    scopus 로고
    • In vitro 3D human small intestinal villous model for drug permeability determination
    • Yu J, Peng S, Luo D, March JC. In vitro 3D human small intestinal villous model for drug permeability determination. Biotechnol. Bioeng. 109(9), 2173-2178 (2012).
    • (2012) Biotechnol. Bioeng. , vol.109 , Issue.9 , pp. 2173-2178
    • Yu, J.1    Peng, S.2    Luo, D.3    March, J.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.