Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 95, Issue , 2015, Pages 77-87

  Maschmeyer, Ilka ^a,b   Hasenberg, Tobias ^b   Jaenicke, Annika ^b   Lindner, Marcus ^b   Lorenz, Alexandra Katharina ^b   Zech, Julie ^b,e   Garbe, Leif Alexander ^b   Sonntag, Frank ^c   Hayden, Patrick ^d   Ayehunie, Seyoum ^d   Lauster, Roland ^b   Marx, Uwe ^a,b   Materne, Eva Maria ^b  

^a TISSUSE GMBH   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c FRAUNHOFER INSTITUTE FOR MATERIAL AND BEAM TECHNOLOGY IWS   (Germany)

^d MATTEK CORPORATION   (United States)

^e Research and Teaching Institute for Brewing in Berlin (VLB) Research Institute for Special Analyses (FIS)   (Germany)

Author keywords

3D tissue culture; Alternatives to animal testing; Human barrier models; Human on a chip; Intestine model; Microphysiological system; Organ on a chip; Skin equivalent; Systemic drug testing; Vasculature

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALBUMIN; CARBAMOYL PHOSPHATE SYNTHASE; CYTOCHROME P450 3A4; CYTOKERATIN 10; CYTOKERATIN 15; CYTOKERATIN 18; CYTOKERATIN 8; GLUCOSE; LACTIC ACID; MESSENGER RNA; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CHROMAN DERIVATIVE;

ARTICLE; CELL CONTACT; CELL COUNT; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; FLOW RATE; FLUID FLOW; GLUCOSE INTAKE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LIVER CELL CULTURE; LIVER NECROSIS; MICROFLUIDICS; PROTEIN EXPRESSION; PUNCH BIOPSY; REPEATED DRUG DOSE; RISK ASSESSMENT; SHEAR STRESS; SKIN BIOPSY; SKIN CULTURE; SUPERNATANT; TUNEL ASSAY; DRUG EFFECTS; FEMALE; ILEUM; LAB ON A CHIP; LIVER; METABOLISM; PROCEDURES; SKIN; TUMOR CELL LINE; VASCULAR ENDOTHELIUM; YOUNG ADULT;

CELL LINE, TUMOR; CHROMANS; COCULTURE TECHNIQUES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; ILEUM; LAB-ON-A-CHIP DEVICES; LIVER; SKIN; THIAZOLIDINEDIONES; YOUNG ADULT;

EID: 84944093438     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.002     Document Type: Article

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