메뉴 건너뛰기




Volumn 1862, Issue 1, 2018, Pages 61-70

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

Author keywords

Autophagy; Geraniin; M1 polarization; Macrophages; mTOR; Urolithin A

Indexed keywords

ANTIINFLAMMATORY AGENT; GERANIIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MAMMALIAN TARGET OF RAPAMYCIN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UROLITHIN A; 3,8-DIHYDROXY-6H-DIBENZO(B,D)PYRAN-6-ONE; COUMARIN DERIVATIVE; LIPOPOLYSACCHARIDE; RAL PROTEIN; RALA PROTEIN, MOUSE; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

EID: 85032729685     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2017.10.006     Document Type: Article
Times cited : (62)

References (76)
  • 1
    • 69949091124 scopus 로고    scopus 로고
    • An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana
    • Agyare, C. et al., An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana. J. Ethnopharmacol. 125 (2009), 393–403, 10.1016/j.jep.2009.07.024.
    • (2009) J. Ethnopharmacol. , vol.125 , pp. 393-403
    • Agyare, C.1
  • 2
    • 84964556093 scopus 로고    scopus 로고
    • Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin
    • Boakye, Y.D., Agyare, C., Abotsi, W.K., Ayande, P.G., Ossei, P.P., Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin. J. Ethnopharmacol. 187 (2016), 17–27, 10.1016/j.jep.2016.04.020.
    • (2016) J. Ethnopharmacol. , vol.187 , pp. 17-27
    • Boakye, Y.D.1    Agyare, C.2    Abotsi, W.K.3    Ayande, P.G.4    Ossei, P.P.5
  • 3
    • 84964000462 scopus 로고    scopus 로고
    • Ellagitannin geraniin: a review of the natural sources, biosynthesis, pharmacokinetics and biological effects
    • Cheng, H.S., Ton, S.H., Kadir, K.A., Ellagitannin geraniin: a review of the natural sources, biosynthesis, pharmacokinetics and biological effects. Phytochem. Rev. 16 (2017), 159–193, 10.1007/s11101-016-9464-2.
    • (2017) Phytochem. Rev. , vol.16 , pp. 159-193
    • Cheng, H.S.1    Ton, S.H.2    Kadir, K.A.3
  • 4
    • 79960738872 scopus 로고    scopus 로고
    • Metabolites of the ellagitannin geraniin and their antioxidant activities
    • Ito, H., Metabolites of the ellagitannin geraniin and their antioxidant activities. Planta Med. 77 (2011), 1110–1115, 10.1055/s-0030-1270749.
    • (2011) Planta Med. , vol.77 , pp. 1110-1115
    • Ito, H.1
  • 5
    • 38949106503 scopus 로고    scopus 로고
    • Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats
    • Ito, H., Iguchi, A., Hatano, T., Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats. J. Agric. Food Chem. 56 (2008), 393–400, 10.1021/jf0726942.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 393-400
    • Ito, H.1    Iguchi, A.2    Hatano, T.3
  • 6
    • 79955692116 scopus 로고    scopus 로고
    • Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts
    • Agyare, C., Lechtenberg, M., Deters, A., Petereit, F., Hensel, A., Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts. Phytomedicine 18 (2011), 617–624, 10.1016/j.phymed.2010.08.020.
    • (2011) Phytomedicine , vol.18 , pp. 617-624
    • Agyare, C.1    Lechtenberg, M.2    Deters, A.3    Petereit, F.4    Hensel, A.5
  • 7
    • 33847775740 scopus 로고    scopus 로고
    • The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection
    • Yang, C.M., Cheng, H.Y., Lin, T.C., Chiang, L.C., Lin, C.C., The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. J. Ethnopharmacol. 110 (2007), 555–558, 10.1016/j.jep.2006.09.039.
    • (2007) J. Ethnopharmacol. , vol.110 , pp. 555-558
    • Yang, C.M.1    Cheng, H.Y.2    Lin, T.C.3    Chiang, L.C.4    Lin, C.C.5
  • 8
    • 84862822935 scopus 로고    scopus 로고
    • Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo
    • Yang, Y., Zhang, L., Fan, X., Qin, C., Liu, J., Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo. Bioorg. Med. Chem. Lett. 22 (2012), 2209–2211, 10.1016/j.bmcl.2012.01.102.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2209-2211
    • Yang, Y.1    Zhang, L.2    Fan, X.3    Qin, C.4    Liu, J.5
  • 9
    • 84987837934 scopus 로고    scopus 로고
    • Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA
    • Liu, C. et al., Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antivir. Res. 134 (2016), 97–107, 10.1016/j.antiviral.2016.08.026.
    • (2016) Antivir. Res. , vol.134 , pp. 97-107
    • Liu, C.1
  • 10
    • 84983587918 scopus 로고    scopus 로고
    • Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK
    • Zhai, J.W. et al., Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK. Toxicol. Mech. Methods 26 (2016), 311–318, 10.3109/15376516.2016.1139025.
    • (2016) Toxicol. Mech. Methods , vol.26 , pp. 311-318
    • Zhai, J.W.1
  • 11
    • 85020297919 scopus 로고    scopus 로고
    • Geraniin suppresses ovarian cancer growth through inhibition of NF-kappaB activation and downregulation of Mcl-1 expression
    • Wang, X. et al., Geraniin suppresses ovarian cancer growth through inhibition of NF-kappaB activation and downregulation of Mcl-1 expression. J. Biochem. Mol. Toxicol., 2017, 10.1002/jbt.21929.
    • (2017) J. Biochem. Mol. Toxicol.
    • Wang, X.1
  • 12
    • 85017210612 scopus 로고    scopus 로고
    • Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice
    • Aayadi, H., Mittal, S.P.K., Deshpande, A., Gore, M., Ghaskadbi, S.S., Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice. Biochem. Biophys. Res. Commun. 487 (2017), 62–67, 10.1016/j.bbrc.2017.04.013.
    • (2017) Biochem. Biophys. Res. Commun. , vol.487 , pp. 62-67
    • Aayadi, H.1    Mittal, S.P.K.2    Deshpande, A.3    Gore, M.4    Ghaskadbi, S.S.5
  • 13
    • 84870768499 scopus 로고    scopus 로고
    • Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity
    • Londhe, J.S., Devasagayam, T.P., Foo, L.Y., Shastry, P., Ghaskadbi, S.S., Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity. Fitoterapia 83 (2012), 1562–1568, 10.1016/j.fitote.2012.09.003.
    • (2012) Fitoterapia , vol.83 , pp. 1562-1568
    • Londhe, J.S.1    Devasagayam, T.P.2    Foo, L.Y.3    Shastry, P.4    Ghaskadbi, S.S.5
  • 14
    • 84882865770 scopus 로고    scopus 로고
    • In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii
    • Youn, K., Jun, M., In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii. Planta Med. 79 (2013), 1038–1042, 10.1055/s-0032-1328769.
    • (2013) Planta Med. , vol.79 , pp. 1038-1042
    • Youn, K.1    Jun, M.2
  • 15
    • 84930683137 scopus 로고    scopus 로고
    • Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway
    • Wang, P. et al., Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. Biochim. Biophys. Acta 1850 (2015), 1751–1761, 10.1016/j.bbagen.2015.04.010.
    • (2015) Biochim. Biophys. Acta , vol.1850 , pp. 1751-1761
    • Wang, P.1
  • 16
    • 84876361767 scopus 로고    scopus 로고
    • Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage
    • Bing, S.J. et al., Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage. Food Chem. Toxicol. 57 (2013), 147–153, 10.1016/j.fct.2013.03.022.
    • (2013) Food Chem. Toxicol. , vol.57 , pp. 147-153
    • Bing, S.J.1
  • 17
    • 0035159089 scopus 로고    scopus 로고
    • New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki
    • Okabe, S. et al., New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biol. Pharm. Bull. 24 (2001), 1145–1148.
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 1145-1148
    • Okabe, S.1
  • 18
    • 84992109043 scopus 로고    scopus 로고
    • Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21
    • Zhou, B., Wang, J., Zheng, G., Qiu, Z., Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21. Food Chem. Toxicol. 97 (2016), 375–384, 10.1016/j.fct.2016.10.005.
    • (2016) Food Chem. Toxicol. , vol.97 , pp. 375-384
    • Zhou, B.1    Wang, J.2    Zheng, G.3    Qiu, Z.4
  • 19
    • 84979519422 scopus 로고    scopus 로고
    • Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-alpha-dependent gene expression
    • Zhang, W. et al., Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-alpha-dependent gene expression. Mol. Nutr. Food Res. 60 (2016), 2387–2395, 10.1002/mnfr.201600048.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 2387-2395
    • Zhang, W.1
  • 20
    • 85021764255 scopus 로고    scopus 로고
    • Potential antiproliferative activity of polyphenol metabolites against human breast cancer cells and their urine excretion pattern in healthy subjects following acute intake of a polyphenol-rich juice of grumixama (Eugenia brasiliensis Lam.)
    • Teixeira, L.L. et al., Potential antiproliferative activity of polyphenol metabolites against human breast cancer cells and their urine excretion pattern in healthy subjects following acute intake of a polyphenol-rich juice of grumixama (Eugenia brasiliensis Lam.). Food Funct. 8 (2017), 2266–2274, 10.1039/c7fo00076f.
    • (2017) Food Funct. , vol.8 , pp. 2266-2274
    • Teixeira, L.L.1
  • 21
    • 84940773386 scopus 로고    scopus 로고
    • Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages
    • Piwowarski, J.P., Kiss, A.K., Granica, S., Moeslinger, T., Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages. Mol. Nutr. Food Res. 59 (2015), 2168–2177, 10.1002/mnfr.201500264.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2168-2177
    • Piwowarski, J.P.1    Kiss, A.K.2    Granica, S.3    Moeslinger, T.4
  • 22
    • 84905560024 scopus 로고    scopus 로고
    • Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials
    • Piwowarski, J.P. et al., Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. J. Ethnopharmacol. 155 (2014), 801–809, 10.1016/j.jep.2014.06.032.
    • (2014) J. Ethnopharmacol. , vol.155 , pp. 801-809
    • Piwowarski, J.P.1
  • 23
    • 84951908279 scopus 로고    scopus 로고
    • Macrophage development and polarization in chronic inflammation
    • Motwani, M.P., Gilroy, D.W., Macrophage development and polarization in chronic inflammation. Semin. Immunol. 27 (2015), 257–266, 10.1016/j.smim.2015.07.002.
    • (2015) Semin. Immunol. , vol.27 , pp. 257-266
    • Motwani, M.P.1    Gilroy, D.W.2
  • 24
    • 84988649474 scopus 로고    scopus 로고
    • Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production
    • Baseler, W.A. et al., Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biol. 10 (2016), 12–23, 10.1016/j.redox.2016.09.005.
    • (2016) Redox Biol. , vol.10 , pp. 12-23
    • Baseler, W.A.1
  • 25
    • 77952865796 scopus 로고    scopus 로고
    • Phagocyte partnership during the onset and resolution of inflammation
    • Soehnlein, O., Lindbom, L., Phagocyte partnership during the onset and resolution of inflammation. Nat. Rev. Immunol. 10 (2010), 427–439, 10.1038/nri2779.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 427-439
    • Soehnlein, O.1    Lindbom, L.2
  • 26
    • 84924368520 scopus 로고    scopus 로고
    • Tissue-resident macrophages: then and now
    • Davies, L.C., Taylor, P.R., Tissue-resident macrophages: then and now. Immunology 144 (2015), 541–548, 10.1111/imm.12451.
    • (2015) Immunology , vol.144 , pp. 541-548
    • Davies, L.C.1    Taylor, P.R.2
  • 27
    • 84906055605 scopus 로고    scopus 로고
    • Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
    • Esser, N., Legrand-Poels, S., Piette, J., Scheen, A.J., Paquot, N., Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res. Clin. Pract. 105 (2014), 141–150, 10.1016/j.diabres.2014.04.006.
    • (2014) Diabetes Res. Clin. Pract. , vol.105 , pp. 141-150
    • Esser, N.1    Legrand-Poels, S.2    Piette, J.3    Scheen, A.J.4    Paquot, N.5
  • 28
    • 85010208256 scopus 로고    scopus 로고
    • Alzheimer's disease: innate immunity gone awry?
    • VanItallie, T.B., Alzheimer's disease: innate immunity gone awry?. Metabolism 69S (2017), S41–S49, 10.1016/j.metabol.2017.01.014.
    • (2017) Metabolism , vol.69S , pp. S41-S49
    • VanItallie, T.B.1
  • 29
    • 85014637972 scopus 로고    scopus 로고
    • Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis-involvement of the miR-145/p70S6K1/HIF1alpha axis in vivo and in vitro
    • Kim, H. et al., Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis-involvement of the miR-145/p70S6K1/HIF1alpha axis in vivo and in vitro. J. Nutr. Biochem. 43 (2017), 107–115, 10.1016/j.jnutbio.2017.02.005.
    • (2017) J. Nutr. Biochem. , vol.43 , pp. 107-115
    • Kim, H.1
  • 30
    • 85028254772 scopus 로고    scopus 로고
    • Comparison of anti-inflammatory mechanisms of mango (Mangifera indica L.) and pomegranate (Punica granatum L.) in a preclinical model of colitis
    • Kim, H. et al., Comparison of anti-inflammatory mechanisms of mango (Mangifera indica L.) and pomegranate (Punica granatum L.) in a preclinical model of colitis. Mol. Nutr. Food Res. 60 (2016), 1912–1923, 10.1002/mnfr.201501008.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 1912-1923
    • Kim, H.1
  • 31
    • 84875052383 scopus 로고    scopus 로고
    • Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo
    • Kropat, C. et al., Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo. Mol. Nutr. Food Res. 57 (2013), 545–550, 10.1002/mnfr.201200504.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 545-550
    • Kropat, C.1
  • 32
    • 84969857864 scopus 로고    scopus 로고
    • Activated AMPK boosts the Nrf2/HO-1 signaling axis—a role for the unfolded protein response
    • Zimmermann, K. et al., Activated AMPK boosts the Nrf2/HO-1 signaling axis—a role for the unfolded protein response. Free Radic. Biol. Med. 88 (2015), 417–426, 10.1016/j.freeradbiomed.2015.03.030.
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 417-426
    • Zimmermann, K.1
  • 33
    • 84884684046 scopus 로고    scopus 로고
    • Honokiol: a non-adipogenic PPARgamma agonist from nature
    • Atanasov, A.G. et al., Honokiol: a non-adipogenic PPARgamma agonist from nature. Biochim. Biophys. Acta 1830 (2013), 4813–4819, 10.1016/j.bbagen.2013.06.021.
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 4813-4819
    • Atanasov, A.G.1
  • 34
    • 84894663300 scopus 로고    scopus 로고
    • Discovery of new liver X receptor agonists by pharmacophore modeling and shape-based virtual screening
    • Temml, V., Voss, C.V., Dirsch, V.M., Schuster, D., Discovery of new liver X receptor agonists by pharmacophore modeling and shape-based virtual screening. J. Chem. Inf. Model. 54 (2014), 367–371, 10.1021/ci400682b.
    • (2014) J. Chem. Inf. Model. , vol.54 , pp. 367-371
    • Temml, V.1    Voss, C.V.2    Dirsch, V.M.3    Schuster, D.4
  • 35
    • 84969528739 scopus 로고    scopus 로고
    • Inhibitory effects of geraniin on LPS-induced inflammation via regulating NF-kappaB and Nrf2 pathways in RAW 264.7 cells
    • Wang, P. et al., Inhibitory effects of geraniin on LPS-induced inflammation via regulating NF-kappaB and Nrf2 pathways in RAW 264.7 cells. Chem. Biol. Interact. 253 (2016), 134–142, 10.1016/j.cbi.2016.05.014.
    • (2016) Chem. Biol. Interact. , vol.253 , pp. 134-142
    • Wang, P.1
  • 36
    • 85029743545 scopus 로고    scopus 로고
    • Urolithin A mitigates cisplatin-induced nephrotoxicity by inhibiting renal inflammation and apoptosis in an experimental rat model
    • Guada, M., Ganugula, R., Vadhanam, M., Majeti, R.K., Urolithin A mitigates cisplatin-induced nephrotoxicity by inhibiting renal inflammation and apoptosis in an experimental rat model. J. Pharmacol. Exp. Ther., 2017, 10.1124/jpet.117.242420.
    • (2017) J. Pharmacol. Exp. Ther.
    • Guada, M.1    Ganugula, R.2    Vadhanam, M.3    Majeti, R.K.4
  • 37
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • Delerive, P., Fruchart, J.C., Staels, B., Peroxisome proliferator-activated receptors in inflammation control. J. Endocrinol. 169 (2001), 453–459.
    • (2001) J. Endocrinol. , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 38
    • 0033793133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation
    • Chinetti, G., Fruchart, J.C., Staels, B., Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm. Res. 49 (2000), 497–505, 10.1007/s000110050622.
    • (2000) Inflamm. Res. , vol.49 , pp. 497-505
    • Chinetti, G.1    Fruchart, J.C.2    Staels, B.3
  • 39
    • 85020376836 scopus 로고    scopus 로고
    • Liver X receptors link lipid metabolism and inflammation
    • Schulman, I.G., Liver X receptors link lipid metabolism and inflammation. FEBS Lett., 2017, 10.1002/1873-3468.12702.
    • (2017) FEBS Lett.
    • Schulman, I.G.1
  • 40
    • 33644652410 scopus 로고    scopus 로고
    • Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma
    • Li, N., Nel, A.E., Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. Antioxid. Redox Signal. 8 (2006), 88–98, 10.1089/ars.2006.8.88.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 88-98
    • Li, N.1    Nel, A.E.2
  • 41
    • 78049370987 scopus 로고    scopus 로고
    • Oxidative stress, inflammation, and cancer: how are they linked?
    • Reuter, S., Gupta, S.C., Chaturvedi, M.M., Aggarwal, B.B., Oxidative stress, inflammation, and cancer: how are they linked?. Free Radic. Biol. Med. 49 (2010), 1603–1616, 10.1016/j.freeradbiomed.2010.09.006.
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 1603-1616
    • Reuter, S.1    Gupta, S.C.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 42
    • 84978136448 scopus 로고    scopus 로고
    • Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
    • Ryu, D. et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22 (2016), 879–888, 10.1038/nm.4132.
    • (2016) Nat. Med. , vol.22 , pp. 879-888
    • Ryu, D.1
  • 43
    • 33646840681 scopus 로고    scopus 로고
    • Autophagy: a protective mechanism in response to stress and inflammation
    • Heymann, D., Autophagy: a protective mechanism in response to stress and inflammation. Curr. Opin. Investig. Drugs 7 (2006), 443–450.
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , pp. 443-450
    • Heymann, D.1
  • 44
    • 34548700796 scopus 로고    scopus 로고
    • Unveiling the roles of autophagy in innate and adaptive immunity
    • Levine, B., Deretic, V., Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 7 (2007), 767–777, 10.1038/nri2161.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 767-777
    • Levine, B.1    Deretic, V.2
  • 45
    • 70349924078 scopus 로고    scopus 로고
    • Links between autophagy, innate immunity, inflammation and Crohn's disease
    • Deretic, V., Links between autophagy, innate immunity, inflammation and Crohn's disease. Dig. Dis. 27 (2009), 246–251, 10.1159/000228557.
    • (2009) Dig. Dis. , vol.27 , pp. 246-251
    • Deretic, V.1
  • 46
    • 85013763791 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
    • Klionsky, D.J. et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12 (2016), 1–222, 10.1080/15548627.2015.1100356.
    • (2016) Autophagy , vol.12 , pp. 1-222
    • Klionsky, D.J.1
  • 47
    • 53549113031 scopus 로고    scopus 로고
    • The role of TOR in autophagy regulation from yeast to plants and mammals
    • Diaz-Troya, S., Perez-Perez, M.E., Florencio, F.J., Crespo, J.L., The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 4 (2008), 851–865.
    • (2008) Autophagy , vol.4 , pp. 851-865
    • Diaz-Troya, S.1    Perez-Perez, M.E.2    Florencio, F.J.3    Crespo, J.L.4
  • 48
    • 77950501014 scopus 로고    scopus 로고
    • mTOR regulation of autophagy
    • Jung, C.H., Ro, S.H., Cao, J., Otto, N.M., Kim, D.H., mTOR regulation of autophagy. FEBS Lett. 584 (2010), 1287–1295, 10.1016/j.febslet.2010.01.017.
    • (2010) FEBS Lett. , vol.584 , pp. 1287-1295
    • Jung, C.H.1    Ro, S.H.2    Cao, J.3    Otto, N.M.4    Kim, D.H.5
  • 49
    • 85018383859 scopus 로고    scopus 로고
    • The lysosome: a crucial hub for AMPK and mTORC1 signalling
    • Carroll, B., Dunlop, E.A., The lysosome: a crucial hub for AMPK and mTORC1 signalling. Biochem. J. 474 (2017), 1453–1466, 10.1042/BCJ20160780.
    • (2017) Biochem. J. , vol.474 , pp. 1453-1466
    • Carroll, B.1    Dunlop, E.A.2
  • 50
    • 84971554164 scopus 로고    scopus 로고
    • 5′-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
    • Yao, F., Zhang, M., Chen, L., 5′-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications. Acta Pharm. Sin. B 6 (2016), 20–25, 10.1016/j.apsb.2015.07.009.
    • (2016) Acta Pharm. Sin. B , vol.6 , pp. 20-25
    • Yao, F.1    Zhang, M.2    Chen, L.3
  • 51
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease. Cell 149 (2012), 274–293, 10.1016/j.cell.2012.03.017.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 52
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie, J.R., Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133 (2003), 2485S–2493S.
    • (2003) J. Nutr. , vol.133 , pp. 2485S-2493S
    • Davie, J.R.1
  • 53
    • 84995414949 scopus 로고    scopus 로고
    • Diet, microorganisms and their metabolites, and colon cancer
    • O'Keefe, S.J., Diet, microorganisms and their metabolites, and colon cancer. Nat. Rev. Gastroenterol. Hepatol. 13 (2016), 691–706, 10.1038/nrgastro.2016.165.
    • (2016) Nat. Rev. Gastroenterol. Hepatol. , vol.13 , pp. 691-706
    • O'Keefe, S.J.1
  • 54
    • 84881089726 scopus 로고    scopus 로고
    • Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies
    • Sangiovanni, E. et al., Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies. PLoS One, 8, 2013, e71762, 10.1371/journal.pone.0071762.
    • (2013) PLoS One , vol.8
    • Sangiovanni, E.1
  • 55
    • 84862168115 scopus 로고    scopus 로고
    • Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model
    • Jean-Gilles, D. et al., Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. J. Agric. Food Chem. 60 (2012), 5755–5762, 10.1021/jf203456w.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 5755-5762
    • Jean-Gilles, D.1
  • 56
    • 84977563497 scopus 로고    scopus 로고
    • Urolithins, the rescue of “old”metabolites to understand a “new” concept: metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status
    • Tomas-Barberan, F.A. et al., Urolithins, the rescue of “old”metabolites to understand a “new” concept: metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol. Nutr. Food Res., 61, 2017, xx, 10.1002/mnfr.201500901.
    • (2017) Mol. Nutr. Food Res. , vol.61 , pp. xx
    • Tomas-Barberan, F.A.1
  • 57
    • 84879387618 scopus 로고    scopus 로고
    • Biological significance of urolithins, the gut microbial ellagic-acid-derived metabolites: the evidence so far
    • Espin, J.C., Larrose, M., Garcia-Conesa, M.T., Tomas-Barberan, F., Biological significance of urolithins, the gut microbial ellagic-acid-derived metabolites: the evidence so far. Evid. Based Complement. Alternat. Med., 2013, 2013, 270418, 10.1155/2013/270418.
    • (2013) Evid. Based Complement. Alternat. Med. , vol.2013 , pp. 270418
    • Espin, J.C.1    Larrose, M.2    Garcia-Conesa, M.T.3    Tomas-Barberan, F.4
  • 58
    • 85021751510 scopus 로고    scopus 로고
    • In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats
    • Savi, M. et al., In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovasc. Diabetol., 16, 2017, 80, 10.1186/s12933-017-0561-3.
    • (2017) Cardiovasc. Diabetol. , vol.16 , pp. 80
    • Savi, M.1
  • 59
    • 85019259090 scopus 로고    scopus 로고
    • Phase II conjugates of urolithins isolated from human urine and potential role of β-glucuronidases in their disposition
    • Piwowarski, J.P., Stanisławska, I., Granica, S., Stefańska, J., Kiss, A.K., Phase II conjugates of urolithins isolated from human urine and potential role of β-glucuronidases in their disposition. Drug Metab. Dispos. 45 (2017), 657–665, 10.1124/dmd.117.075200.
    • (2017) Drug Metab. Dispos. , vol.45 , pp. 657-665
    • Piwowarski, J.P.1    Stanisławska, I.2    Granica, S.3    Stefańska, J.4    Kiss, A.K.5
  • 60
    • 85021980911 scopus 로고    scopus 로고
    • Punicalagin, a PTP1B inhibitor, induces M2c phenotype polarization via up-regulation of HO-1 in murine macrophages
    • Xu, X. et al., Punicalagin, a PTP1B inhibitor, induces M2c phenotype polarization via up-regulation of HO-1 in murine macrophages. Free Radic. Biol. Med. 110 (2017), 408–420, 10.1016/j.freeradbiomed.2017.06.014.
    • (2017) Free Radic. Biol. Med. , vol.110 , pp. 408-420
    • Xu, X.1
  • 61
    • 75649108606 scopus 로고    scopus 로고
    • Role of autophagy and autophagy genes in inflammatory bowel disease
    • Cadwell, K., Stappenbeck, T.S., Virgin, H.W., Role of autophagy and autophagy genes in inflammatory bowel disease. Curr. Top. Microbiol. Immunol. 335 (2009), 141–167, 10.1007/978-3-642-00302-8_7.
    • (2009) Curr. Top. Microbiol. Immunol. , vol.335 , pp. 141-167
    • Cadwell, K.1    Stappenbeck, T.S.2    Virgin, H.W.3
  • 63
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine, B., Mizushima, N., Virgin, H.W., Autophagy in immunity and inflammation. Nature 469 (2011), 323–335, 10.1038/nature09782.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 64
    • 85027940025 scopus 로고    scopus 로고
    • Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-gamma pathway
    • Han, Q.A. et al., Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-gamma pathway. Mol. Nutr. Food Res. 60 (2016), 1933–1943, 10.1002/mnfr.201500827.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 1933-1943
    • Han, Q.A.1
  • 65
    • 85016969413 scopus 로고    scopus 로고
    • Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-kappaB and activating Nrf2 signaling pathways
    • Zhu, G. et al., Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-kappaB and activating Nrf2 signaling pathways. Oncotarget 8 (2017), 22835–22841, 10.18632/oncotarget.15227.
    • (2017) Oncotarget , vol.8 , pp. 22835-22841
    • Zhu, G.1
  • 66
    • 85018784717 scopus 로고    scopus 로고
    • Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
    • Ip, W.K.E., Hoshi, N., Shouval, D.S., Snapper, S., Medzhitov, R., Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science 356 (2017), 513–519, 10.1126/science.aal3535.
    • (2017) Science , vol.356 , pp. 513-519
    • Ip, W.K.E.1    Hoshi, N.2    Shouval, D.S.3    Snapper, S.4    Medzhitov, R.5
  • 67
    • 85020871195 scopus 로고    scopus 로고
    • Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFkappaB pathways in autophagy- and p62-dependent manners
    • Ko, J.H., Yoon, S.O., Lee, H.J., Oh, J.Y., Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFkappaB pathways in autophagy- and p62-dependent manners. Oncotarget 8 (2017), 40817–40831, 10.18632/oncotarget.17256.
    • (2017) Oncotarget , vol.8 , pp. 40817-40831
    • Ko, J.H.1    Yoon, S.O.2    Lee, H.J.3    Oh, J.Y.4
  • 68
    • 85000428204 scopus 로고    scopus 로고
    • mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
    • Paschoal, V.A. et al., mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function. Immunobiology 222 (2017), 261–271, 10.1016/j.imbio.2016.09.014.
    • (2017) Immunobiology , vol.222 , pp. 261-271
    • Paschoal, V.A.1
  • 69
    • 85029409862 scopus 로고    scopus 로고
    • Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis
    • Chimin, P. et al., Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. J. Lipid Res., 2017, 10.1194/jlr.M074518.
    • (2017) J. Lipid Res.
    • Chimin, P.1
  • 70
    • 85016742201 scopus 로고    scopus 로고
    • Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway
    • Tang, L. et al., Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway. Biochem. Biophys. Res. Commun. 486 (2017), 774–780, 10.1016/j.bbrc.2017.03.119.
    • (2017) Biochem. Biophys. Res. Commun. , vol.486 , pp. 774-780
    • Tang, L.1
  • 71
    • 85025094662 scopus 로고    scopus 로고
    • Chemical composition of blackberry press cake, polyphenolic extract, and defatted seeds, and their effects on cecal fermentation, bacterial metabolites, and blood lipid profile in rats
    • Kosmala, M. et al., Chemical composition of blackberry press cake, polyphenolic extract, and defatted seeds, and their effects on cecal fermentation, bacterial metabolites, and blood lipid profile in rats. J. Agric. Food Chem. 65 (2017), 5470–5479, 10.1021/acs.jafc.7b01876.
    • (2017) J. Agric. Food Chem. , vol.65 , pp. 5470-5479
    • Kosmala, M.1
  • 72
    • 85020907718 scopus 로고    scopus 로고
    • Autophagy in cancer therapy
    • Fulda, S., Autophagy in cancer therapy. Front. Oncol., 7, 2017, 128, 10.3389/fonc.2017.00128.
    • (2017) Front. Oncol. , vol.7 , pp. 128
    • Fulda, S.1
  • 73
    • 85019766584 scopus 로고    scopus 로고
    • Autophagy and mitophagy in cardiovascular disease
    • Bravo-San Pedro, J.M., Kroemer, G., Galluzzi, L., Autophagy and mitophagy in cardiovascular disease. Circ. Res. 120 (2017), 1812–1824, 10.1161/CIRCRESAHA.117.311082.
    • (2017) Circ. Res. , vol.120 , pp. 1812-1824
    • Bravo-San Pedro, J.M.1    Kroemer, G.2    Galluzzi, L.3
  • 74
    • 85008330539 scopus 로고    scopus 로고
    • Autophagy in the liver: functions in health and disease
    • Ueno, T., Komatsu, M., Autophagy in the liver: functions in health and disease. Nat. Rev. Gastroenterol. Hepatol. 14 (2017), 170–184, 10.1038/nrgastro.2016.185.
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.14 , pp. 170-184
    • Ueno, T.1    Komatsu, M.2
  • 75
    • 85027556680 scopus 로고    scopus 로고
    • Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid
    • Heilman, J., Andreux, P., Tran, N., Rinsch, C., Blanco-Bose, W., Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food Chem. Toxicol., 2017, 10.1016/j.fct.2017.07.050.
    • (2017) Food Chem. Toxicol.
    • Heilman, J.1    Andreux, P.2    Tran, N.3    Rinsch, C.4    Blanco-Bose, W.5
  • 76
    • 85025806668 scopus 로고    scopus 로고
    • Regulation of inflammation by microbiota interactions with the host
    • Blander, J.M., Longman, R.S., Iliev, I.D., Sonnenberg, G.F., Artis, D., Regulation of inflammation by microbiota interactions with the host. Nat. Immunol. 18 (2017), 851–860, 10.1038/ni.3780.
    • (2017) Nat. Immunol. , vol.18 , pp. 851-860
    • Blander, J.M.1    Longman, R.S.2    Iliev, I.D.3    Sonnenberg, G.F.4    Artis, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.