In vitro BACE1 inhibitory activity of geraniin and corilagin from geranium thunbergii

Planta Medica

Volumn 79, Issue 12, 2013, Pages 1038-1042

  Youn, Kumju ^a   Jun, Mira ^a  

^a Dong A University   (South Korea)

Author keywords

secretase; Alzheimers disease; amyloid peptide; Geraniaceae; Geranium thunbergii

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CHYMOTRYPSIN; CORILAGIN; GERANIIN; RESVERATROL; TRYPSIN;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GERANIUM; GERANIUM THUNBERGII; IC 50; IN VITRO STUDY; INTESTINE FLORA; OXIDATIVE STRESS; SENILE PLAQUE;

GERANIACEAE; GERANIUM THUNBERGII;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GERANIUM; GLUCOSIDES; HUMANS; HYDROLYZABLE TANNINS; PLANTS, MEDICINAL;

EID: 84882865770     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328769     Document Type: Article

References (26)

1. Shimmyo Y., Kihara T., Akaike A., Niidome T., Sugimoto H. Flavonols and flavones as BACE1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta: 2008; 1780 819 825
2. Jin H., Liu T., Wang W. X., Xu J. H., Yang P. B., Lu H. X., Sun Q. R., Hu H. T. Protective effects of [Gly14]-humanin on β -amyloid-induced PC12 cell death by preventing mitochondrial dysfunction. Neurochem Int: 2010; 56 417 423
3. Efremov I. V., Vajdos F. F., Borzilleri K. A., Capetta S., Chen H., Dorff P. H., Dutra J. K., Goldstein S. W., Mansour M., McColl A., Noell S., Oborski C. E., OConnell T. N., OSullivan T. J., Pandit J., Wang H., Wei B. Q., Withka J. M. Discovery and optimization of a novel spiropyrrolidine inhibitor of β -secretase (BACE1) through fragment-based drug design. J Med Chem: 2012; 55 9069 9088
4. Luo Y., Bolon B., Kahn S., Bennett B. D., Khan S. B., Denis P., Fan W., Kha H., Zhang J., Gong Y., Martin L., Louis J. C., Yan Q., Richards W. G., Citron M., Vassar R. Mice deficient in BACE1, the Alzheimers β -secretase, have normal phenotype and abolished β -amyloid generation. Nature: 2001; 4 231 232 (Pubitemid 32194866)
5. Wolfe M. S. APP, notch and presenilin: molecular pieces in the puzzle of Alzheimers disease. Int Immunopharmacol: 2002; 2 1919 1929 (Pubitemid 35373932)
6. Liu Q. H., Jeong J. E., Choi E. J., Moon Y. H., Woo E. R. A new furofuran lignan from Geranium thunbergii Sieb. Et Zucc. Arch Pharm Res: 2006; 29 1109 1113
7. Okuda T., Mori K., Seno K., Hatano T. Constituents of Geranium thunbergii Sieb. Et Zucc.: VII. High-performance reversed-phase liquid chromatography of hydrolysable tannins and related polyphenols. J Chromatogr A: 1979; 171 313 320
8. Ito H., Hatano T., Namba O., Shirono T., Okuda T., Yoshida T. Constituents of Geranium thunbergii Sieb. Et Zucc. XV. Modified dehydroellagitannins, geraniic acids B and C, and phyllanthusiin F. Chem Pharm Bull: 1999; 47 1148 1151 (Pubitemid 29436770)
9. Ushino Y., Okuda T., Abe H. Effects of geraniin on morphology and function of macrophages. Int Arch Allergy Immunol: 1991; 96 224 230
10. Hiramatsu N., Xiufen W., Takechi R., Itoh Y., Mamo J., Pal S. Antimutagenicity of Japanese traditional herbs, gennoshoko, yomogi, senburi and iwa-tobacco. Biofactors: 2004; 22 123 125 (Pubitemid 40921773)
11. Sung Y. Y., Yoon T., Yang W. K., Kim S. J., Kim H. K. Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice. Mol Med Report: 2011; 4 1107 1113
12. Xiufen W., Hiramatsu N., Matsubara M. The antioxidative activity of traditional Japanese herbs. Biofactors: 2004; 21 281 284 (Pubitemid 40921869)
13. Adesina S. K., Idowu O., Ogundaini A. O., Oladimeji H., Olugbade T. A., Onawunmi G. O., Pais M. Antimicrobial constituents of the leaves of Acalypha wilkesiana and Acalypha hispida. Phytother Res: 2000; 14 371 374 (Pubitemid 30655527)
14. Marumoto S., Miyazawa M. β -Secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica. Phytother Res: 2010; 24 510 513
15. Youn K., Jun M. Inhibitory effects of key compounds isolated from Corni fructus on BACE1 activity. Phytother Res: 2012; 26 1714 1718
16. Dai J., Shen D., Yoshida W., Parrish S., Williams P. Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1. Planta Med: 2012; 78 1357 1362
17. Park I. H., Jeon S. Y., Lee H. J., Kim S. I., Song K. S. A β -secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus. Planta Med: 2004; 70 143 146
18. Je J. Y., Kim S. K. Water-soluble chitosan derivatives as a BACE1 inhibitor. Bioorg Med Chem: 2005; 13 6551 6555
19. Ito H. Metabolites of ellagitannins and their antioxidant activity. Planta Med: 2011; 77 1110 1115
20. Serrano J., Puupponen-Pimia R., Dauer A., Aura A., Saura-Calixto F. Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res: 2009; 53 S310 S329
21. Kwak H. M., Jeon Y. S., Sohng B. H., Kim J. G., Lee J. M., Lee K. B., Jeong H. H., Hur J. M., Kang Y. H., Song K. S. β -Secretase (BACE1) inhibitors from pomegranate (Punica granatum) Husk. Arch Pharm Res: 2005; 28 1328 1332
22. Prasain J. K., Peng N., Dai Y., Moore R., Arabshahi A., Wilson L., Barnes S., Wyss J. M., Kim H., Watts R. L. Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract. Phytomedicine: 2009; 16 233 243
23. Tamagno E., Bardini P., Guglielmotto M., Danni O., Tabaton M. The various aggregation state of β -amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression. Free Radic Biol Med: 2006; 41 202 212 (Pubitemid 43928492)
24. Thitilertdecha N., Teerawutgulrag A., Kilburn J. D., Rakariyatham N. Identification of major phenolic compounds from Nephelium lappaceum L. and their antioxidant activities. Molecules: 2010; 15 1453 1465
25. Chen Y., Chen C. Corilagin prevents tert-butyl hydroperoxide-induced oxidative stress injury in cultured N9 murine microglia cells. Neurochem Int: 2011; 59 290 296
26. Okabe S., Suganuma M., Imayoshi Y., Taniguchi S., Yoshida T., Fujiki H. New TNF- α releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biol Pharm Bull: 2001; 24 1145 1148 (Pubitemid 33049076)