메뉴 건너뛰기




Volumn 17, Issue 11, 2017, Pages 637-658

Understanding and targeting resistance mechanisms in NSCLC

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROTEIN KINASE SRC; PROTEIN TYROSINE KINASE; ROS1 PROTO ONCOGENE RECEPTOR TYROSINE KINASE; SCATTER FACTOR RECEPTOR; STAT PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 85032169104     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2017.84     Document Type: Review
Times cited : (710)

References (318)
  • 1
    • 84926432208 scopus 로고    scopus 로고
    • Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010
    • Meza, R., Meernik, C., Jeon, J. & Cote, M. L. Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS ONE 10, e0121323 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0121323
    • Meza, R.1    Meernik, C.2    Jeon, J.3    Cote, M.L.4
  • 2
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris, M. G. et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 311, 1998-2006 (2014).
    • (2014) JAMA , vol.311 , pp. 1998-2006
    • Kris, M.G.1
  • 3
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG 0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou, C. et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG 0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12, 735-742 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 735-742
    • Zhou, C.1
  • 4
    • 84918804764 scopus 로고    scopus 로고
    • First-line crizotinib versus chemotherapy in ALK-positive lung cancer
    • Solomon, B. J. et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N. Engl. J. Med. 371, 2167-2177 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2167-2177
    • Solomon, B.J.1
  • 5
    • 84911372597 scopus 로고    scopus 로고
    • Crizotinib in ROS1 rearranged non-small-cell lung cancer
    • Shaw, A. T. et al. Crizotinib in ROS1 rearranged non-small-cell lung cancer. N. Engl. J. Med. 371, 1963-1971 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1963-1971
    • Shaw, A.T.1
  • 6
    • 84991059363 scopus 로고    scopus 로고
    • Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: An open-label, multicentre phase 2 trial
    • Planchard, D. et al. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: An open-label, multicentre phase 2 trial. Lancet Oncol. 17, 984-993 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 984-993
    • Planchard, D.1
  • 7
    • 84966290869 scopus 로고    scopus 로고
    • A framework for understanding and targeting residual disease in oncogene-driven solid cancers
    • Bivona, T. G. & Doebele, R. C. A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Nat. Med. 22, 472-478 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 472-478
    • Bivona, T.G.1    Doebele, R.C.2
  • 8
    • 51049116207 scopus 로고    scopus 로고
    • Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
    • Wu, J. Y. et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin. Cancer Res. 14, 4877-4882 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4877-4882
    • Wu, J.Y.1
  • 9
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF κB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona, T. G. et al. FAS and NF κB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471, 523-526 (2011).
    • (2011) Nature , vol.471 , pp. 523-526
    • Bivona, T.G.1
  • 10
    • 84862777672 scopus 로고    scopus 로고
    • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
    • Ng, K. P. et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat. Med. 18, 521-528 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 521-528
    • Ng, K.P.1
  • 11
    • 77957039159 scopus 로고    scopus 로고
    • Small-cell carcinoma with an epidermal growth factor receptor mutation in a never-smoker with gefitinib-responsive adenocarcinoma of the lung
    • Alam, N. et al. Small-cell carcinoma with an epidermal growth factor receptor mutation in a never-smoker with gefitinib-responsive adenocarcinoma of the lung. Clin. Lung Cancer 11, E1-E4 (2010).
    • (2010) Clin. Lung Cancer , vol.11 , pp. E1-E4
    • Alam, N.1
  • 12
    • 84863336092 scopus 로고    scopus 로고
    • Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4 ALK lung cancer cells
    • Yamada, T. et al. Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4 ALK lung cancer cells. Clin. Cancer Res. 18, 3592-3602 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3592-3602
    • Yamada, T.1
  • 13
    • 84864127874 scopus 로고    scopus 로고
    • Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH dependent solubility the Achilles heel of targeted therapy?
    • Budha, N. R. et al. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH dependent solubility the Achilles heel of targeted therapy? Clin. Pharmacol. Ther. 92, 203-213 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 203-213
    • Budha, N.R.1
  • 14
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell, R. et al. Screening for epidermal growth factor receptor mutations in lung cancer. N. Engl. J. Med. 361, 958-967 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 958-967
    • Rosell, R.1
  • 15
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist, L. V. et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J. Clin. Oncol. 31, 3327-3334 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3327-3334
    • Sequist, L.V.1
  • 16
    • 85013382512 scopus 로고    scopus 로고
    • Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer
    • Mok, T. S. et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N. Engl. J. Med. 376, 629-640 (2017).
    • (2017) N. Engl. J. Med. , vol.376 , pp. 629-640
    • Mok, T.S.1
  • 17
    • 59449097754 scopus 로고    scopus 로고
    • Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy
    • Kancha, R. K., von Bubnoff, N., Peschel, C. & Duyster, J. Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. Clin. Cancer Res. 15, 460-467 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 460-467
    • Kancha, R.K.1    Von Bubnoff, N.2    Peschel, C.3    Duyster, J.4
  • 18
    • 84937158270 scopus 로고    scopus 로고
    • Impact of specific epidermal growth factor receptor (EGFR) mutations and clinical characteristics on outcomes after treatment with EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR-mutant lung cancer: A meta-Analysis
    • Lee, C. K. et al. Impact of specific epidermal growth factor receptor (EGFR) mutations and clinical characteristics on outcomes after treatment with EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR-mutant lung cancer: A meta-Analysis. J. Clin. Oncol. 33, 1958-1965 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1958-1965
    • Lee, C.K.1
  • 20
    • 84892631191 scopus 로고    scopus 로고
    • Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
    • Yasuda, H. et al. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci. Transl Med. 5, 216ra177 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 216ra177
    • Yasuda, H.1
  • 21
    • 85017940817 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02716116 (2017).
    • (2017) US National Library of Medicine
  • 22
    • 84893372504 scopus 로고    scopus 로고
    • Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing
    • Yu, H. A. et al. Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing. Ann. Oncol. 25, 423-428 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 423-428
    • Yu, H.A.1
  • 23
    • 84893344277 scopus 로고    scopus 로고
    • Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q
    • Watanabe, S. et al. Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q. J. Thorac. Oncol. 9, 189-194 (2014).
    • (2014) J. Thorac. Oncol. , vol.9 , pp. 189-194
    • Watanabe, S.1
  • 24
    • 84962919806 scopus 로고    scopus 로고
    • Examining treatment outcomes with erlotinib in patients with advanced non-small cell lung cancer whose tumors harbor uncommon EGFR mutations
    • Klughammer, B. et al. Examining treatment outcomes with erlotinib in patients with advanced non-small cell lung cancer whose tumors harbor uncommon EGFR mutations. J. Thorac. Oncol. 11, 545-555 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. 545-555
    • Klughammer, B.1
  • 25
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4 ALK fusion gene in non-small-cell lung cancer
    • Soda, M. et al. Identification of the transforming EML4 ALK fusion gene in non-small-cell lung cancer. Nature 448, 561-566 (2007).
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1
  • 26
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543-550 (2014).
    • (2014) Nature , vol.511 , pp. 543-550
  • 27
    • 4444319567 scopus 로고    scopus 로고
    • Differential effects of X ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells
    • Armstrong, F. et al. Differential effects of X ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. Oncogene 23, 6071-6082 (2004).
    • (2004) Oncogene , vol.23 , pp. 6071-6082
    • Armstrong, F.1
  • 28
    • 85011891356 scopus 로고    scopus 로고
    • Targeting ALK: Precision medicine takes on drug resistance
    • Lin, J. J., Riely, G. J. & Shaw, A. T. Targeting ALK: precision medicine takes on drug resistance. Cancer Discov. 7, 137-155 (2017).
    • (2017) Cancer Discov. , vol.7 , pp. 137-155
    • Lin, J.J.1    Riely, G.J.2    Shaw, A.T.3
  • 29
    • 84903466222 scopus 로고    scopus 로고
    • The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
    • Friboulet, L. et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov. 4, 662-673 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 662-673
    • Friboulet, L.1
  • 30
    • 84994065677 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to first-And second-generation ALK inhibitors in ALK-rearranged lung cancer
    • Gainor, J. F. et al. Molecular mechanisms of resistance to first-And second-generation ALK inhibitors in ALK-rearranged lung cancer. Cancer Discov. 6, 1118-1133 (2016).
    • (2016) Cancer Discov. , vol.6 , pp. 1118-1133
    • Gainor, J.F.1
  • 31
    • 84995934724 scopus 로고    scopus 로고
    • The potent ALK inhibitor Brigatinib (AP26113) overcomes mechanisms of resistance to first-And second-generation ALK inhibitors in preclinical models
    • Zhang, S. et al. The potent ALK inhibitor Brigatinib (AP26113) overcomes mechanisms of resistance to first-And second-generation ALK inhibitors in preclinical models. Clin. Cancer Res. 22, 5527-5538 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 5527-5538
    • Zhang, S.1
  • 32
    • 84902455683 scopus 로고    scopus 로고
    • Discovery of (10R)-7 amino 12 fluoro 2, 10, 16 trimethyl 15 oxo 10, 15, 16, 17 tetrahydro 2H 8, 4-(metheno)pyrazolo[4, 3 h][2, 5, 11]- benzoxadiazacyclotetradecine 3 carbonitrile (PF 06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations
    • Johnson, T. W. et al. Discovery of (10R)-7 amino 12 fluoro 2, 10, 16 trimethyl 15 oxo 10, 15, 16, 17 tetrahydro 2H 8, 4-(metheno)pyrazolo[4, 3 h][2, 5, 11]- benzoxadiazacyclotetradecine 3 carbonitrile (PF 06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J. Med. Chem. 57, 4720-4744 (2014).
    • (2014) J. Med. Chem. , vol.57 , pp. 4720-4744
    • Johnson, T.W.1
  • 33
    • 85003707690 scopus 로고    scopus 로고
    • Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: A single-Arm, open-label, phase 1/2 trial
    • Gettinger, S. N. et al. Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: A single-Arm, open-label, phase 1/2 trial. Lancet Oncol. 17, 1683-1696 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1683-1696
    • Gettinger, S.N.1
  • 34
    • 84995939711 scopus 로고    scopus 로고
    • Clinical activity of Alectinib in advanced RET-rearranged non-small cell lung cancer. J. Thorac
    • Lin, J. J. et al. Clinical activity of Alectinib in advanced RET-rearranged non-small cell lung cancer. J. Thorac. Oncol. 11, 2027-2032 (2016).
    • (2016) Oncol , vol.11 , pp. 2027-2032
    • Lin, J.J.1
  • 35
    • 84962505302 scopus 로고    scopus 로고
    • Clinical activity of ceritinib in ROS1 rearranged non-small cell lung cancer: Bench to bedside report
    • Subbiah, V., Hong, D. S. & Meric-Bernstam, F. Clinical activity of ceritinib in ROS1 rearranged non-small cell lung cancer: bench to bedside report. Proc. Natl Acad. Sci. USA 113, E1419-E1420 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E1419-E1420
    • Subbiah, V.1    Hong, D.S.2    Meric-Bernstam, F.3
  • 36
    • 85027524894 scopus 로고    scopus 로고
    • Alectinib versus Crizotinib in untreated ALK-positive non-small-cell lung cancer
    • Peters, S. et al. Alectinib versus Crizotinib in untreated ALK-positive non-small-cell lung cancer. N. Engl. J. Med. 377, 829-838 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 829-838
    • Peters, S.1
  • 37
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon, K. et al. ROS1 rearrangements define a unique molecular class of lung cancers. J. Clin. Oncol. 30, 863-870 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 863-870
    • Bergethon, K.1
  • 38
    • 84859794344 scopus 로고    scopus 로고
    • ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway
    • Ou, S. H., Tan, J., Yen, Y. & Soo, R. A. ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway. Expert Rev. Anticancer Ther. 12, 447-456 (2012).
    • (2012) Expert Rev. Anticancer Ther. , vol.12 , pp. 447-456
    • Ou, S.H.1    Tan, J.2    Yen, Y.3    Soo, R.A.4
  • 39
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik, P. K. et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J. Clin. Oncol. 29, 2046-2051 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2046-2051
    • Paik, P.K.1
  • 40
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107-1120 (2012).
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1
  • 41
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • Marchetti, A. et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J. Clin. Oncol. 29, 3574-3579 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3574-3579
    • Marchetti, A.1
  • 42
    • 84922228061 scopus 로고    scopus 로고
    • Clinical characteristics and course of 63 patients with BRAF mutant lung cancers
    • Litvak, A. M. et al. Clinical characteristics and course of 63 patients with BRAF mutant lung cancers. J. Thorac. Oncol. 9, 1669-1674 (2014).
    • (2014) J. Thorac. Oncol. , vol.9 , pp. 1669-1674
    • Litvak, A.M.1
  • 43
    • 84942319957 scopus 로고    scopus 로고
    • BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition
    • Yao, Z. et al. BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition. Cancer Cell 28, 370-383 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 370-383
    • Yao, Z.1
  • 44
    • 84964329499 scopus 로고    scopus 로고
    • Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: A single-Arm, multicentre, open-label, phase 2 trial
    • Planchard, D. et al. Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: A single-Arm, multicentre, open-label, phase 2 trial. Lancet. Oncol. 17, 642-650 (2016).
    • (2016) Lancet. Oncol. , vol.17 , pp. 642-650
    • Planchard, D.1
  • 45
    • 84939864059 scopus 로고    scopus 로고
    • Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
    • Hyman, D. M. et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N. Engl. J. Med. 373, 726-736 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 726-736
    • Hyman, D.M.1
  • 46
    • 84945243598 scopus 로고    scopus 로고
    • RAF inhibitors that evade paradoxical MAPK pathway activation
    • Zhang, C. et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature 526, 583-586 (2015).
    • (2015) Nature , vol.526 , pp. 583-586
    • Zhang, C.1
  • 47
    • 84996602583 scopus 로고    scopus 로고
    • Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer
    • Okimoto, R. A. et al. Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. Proc. Natl Acad. Sci. USA 113, 13456-13461 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 13456-13461
    • Okimoto, R.A.1
  • 48
    • 84923295009 scopus 로고    scopus 로고
    • Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer
    • Joshi, M., Rice, S. J., Liu, X., Miller, B. & Belani, C. P. Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer. PLoS ONE 10, e0118210 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0118210
    • Joshi, M.1    Rice, S.J.2    Liu, X.3    Miller, B.4    Belani, C.P.5
  • 49
    • 85019402929 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel compared with docetaxel alone and progression-free survival in patients with kras-mutant advanced non-small cell lung cancer: The SELECT-1 randomized clinical trial
    • Janne, P. A. et al. Selumetinib plus docetaxel compared with docetaxel alone and progression-free survival in patients with kras-mutant advanced non-small cell lung cancer: The SELECT-1 randomized clinical trial. JAMA 317, 1844-1853 (2017).
    • (2017) JAMA , vol.317 , pp. 1844-1853
    • Janne, P.A.1
  • 50
    • 84923123074 scopus 로고    scopus 로고
    • Antitumor activity in RAS-driven tumors by blocking AKT and MEK
    • Tolcher, A. W. et al. Antitumor activity in RAS-driven tumors by blocking AKT and MEK. Clin. Cancer Res. 21, 739-748 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 739-748
    • Tolcher, A.W.1
  • 51
    • 84979497068 scopus 로고    scopus 로고
    • A combinatorial strategy for treating KRAS-mutant lung cancer
    • Manchado, E. et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature 534, 647-651 (2016).
    • (2016) Nature , vol.534 , pp. 647-651
    • Manchado, E.1
  • 52
    • 84991717283 scopus 로고    scopus 로고
    • Phosphoproteomics reveals MAPK inhibitors enhance MET-And EGFR-driven AKT signaling in KRAS-mutant lung cancer
    • Kim, J. Y. et al. Phosphoproteomics reveals MAPK inhibitors enhance MET-And EGFR-driven AKT signaling in KRAS-mutant lung cancer. Mol. Cancer Res. 14, 1019-1029 (2016).
    • (2016) Mol. Cancer Res. , vol.14 , pp. 1019-1029
    • Kim, J.Y.1
  • 53
    • 84923957819 scopus 로고    scopus 로고
    • The Hippo effector YAP promotes resistance to RAF-And MEK-Targeted cancer therapies
    • Lin, L. et al. The Hippo effector YAP promotes resistance to RAF-And MEK-Targeted cancer therapies. Nat. Genet. 47, 250-256 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 250-256
    • Lin, L.1
  • 54
    • 84954485154 scopus 로고    scopus 로고
    • Coadministration of trametinib and palbociclib radiosensitizes KRAS-mutant non-small cell lung cancers in vitro and in vivo
    • Tao, Z. et al. Coadministration of trametinib and palbociclib radiosensitizes KRAS-mutant non-small cell lung cancers in vitro and in vivo. Clin. Cancer Res. 22, 122-133 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 122-133
    • Tao, Z.1
  • 55
    • 84947336844 scopus 로고    scopus 로고
    • Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with non-small cell lung cancer
    • Goldman, J. et al. Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with non-small cell lung cancer. J. Clin. Oncol. 35, 8026 (2014).
    • (2014) J. Clin. Oncol. , vol.35 , pp. 8026
    • Goldman, J.1
  • 56
    • 85017940817 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02152631 (2017).
    • (2017) US National Library of Medicine
  • 57
    • 85010654098 scopus 로고    scopus 로고
    • Prognostic and predictive value in KRAS in non-small-cell lung cancer: A review
    • Wood, K., Hensing, T., Malik, R. & Salgia, R. Prognostic and predictive value in KRAS in non-small-cell lung cancer: A review. JAMA Oncol. 2, 805-812 (2016).
    • (2016) JAMA Oncol. , vol.2 , pp. 805-812
    • Wood, K.1    Hensing, T.2    Malik, R.3    Salgia, R.4
  • 58
    • 84902603270 scopus 로고    scopus 로고
    • In situ selectivity profiling and crystal structure of SML 8 73 1, an active site inhibitor of oncogenic K Ras G12C
    • Hunter, J. C. et al. In situ selectivity profiling and crystal structure of SML 8 73 1, an active site inhibitor of oncogenic K Ras G12C. Proc. Natl Acad. Sci. USA 111, 8895-8900 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 8895-8900
    • Hunter, J.C.1
  • 59
    • 84957566931 scopus 로고    scopus 로고
    • Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
    • Lito, P., Solomon, M., Li, L. S., Hansen, R. & Rosen, N. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. Science 351, 604-608 (2016).
    • (2016) Science , vol.351 , pp. 604-608
    • Lito, P.1    Solomon, M.2    Li, L.S.3    Hansen, R.4    Rosen, N.5
  • 60
    • 84888639050 scopus 로고    scopus 로고
    • K Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
    • Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. & Shokat, K. M. K Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548-551 (2013).
    • (2013) Nature , vol.503 , pp. 548-551
    • Ostrem, J.M.1    Peters, U.2    Sos, M.L.3    Wells, J.A.4    Shokat, K.M.5
  • 61
    • 84938805958 scopus 로고    scopus 로고
    • Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
    • Frampton, G. M. et al. Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov. 5, 850-859 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 850-859
    • Frampton, G.M.1
  • 62
    • 0028084984 scopus 로고
    • Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
    • Gandino, L., Longati, P., Medico, E., Prat, M. & Comoglio, P. M. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J. Biol. Chem. 269, 1815-1820 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 1815-1820
    • Gandino, L.1    Longati, P.2    Medico, E.3    Prat, M.4    Comoglio, P.M.5
  • 63
    • 0035930341 scopus 로고    scopus 로고
    • Mutation of the c Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    • Peschard, P. et al. Mutation of the c Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell 8, 995-1004 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 995-1004
    • Peschard, P.1
  • 64
    • 85015268705 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients (pts) with advanced MET exon 14 altered non-small cell lung cancer (NSCLC)
    • Drilon, A. E. et al. Efficacy and safety of crizotinib in patients (pts) with advanced MET exon 14 altered non-small cell lung cancer (NSCLC). J. Clin. Oncol. 34, 108 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 108
    • Drilon, A.E.1
  • 65
    • 84938815085 scopus 로고    scopus 로고
    • Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
    • Paik, P. K. et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov. 5, 842-849 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 842-849
    • Paik, P.K.1
  • 66
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • Cappuzzo, F. et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J. Clin. Oncol. 27, 1667-1674 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1
  • 67
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato, R. et al. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J. Thorac. Oncol. 4, 5-11 (2009).
    • (2009) J. Thorac. Oncol. , vol.4 , pp. 5-11
    • Onozato, R.1
  • 68
    • 85015323244 scopus 로고    scopus 로고
    • Targeting MET in lung cancer: Will expectations finally be MET?
    • Drilon, A., Cappuzzo, F., Ou, S. I. & Camidge, D. R. Targeting MET in lung cancer: Will expectations finally be MET? J. Thorac. Oncol. 12, 15-26 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 15-26
    • Drilon, A.1    Cappuzzo, F.2    Ou, S.I.3    Camidge, D.R.4
  • 69
    • 84902811306 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced c MET-Amplified non-small cell lung cancer (NSCLC)
    • Camidge, D. R. et al. Efficacy and safety of crizotinib in patients with advanced c MET-Amplified non-small cell lung cancer (NSCLC). J. Clin. Oncol. 32, 8001 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 8001
    • Camidge, D.R.1
  • 70
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
    • Mazieres, J. et al. Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives. J. Clin. Oncol. 31, 1997-2003 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. 1997-2003
    • Mazieres, J.1
  • 71
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • Arcila, M. E. et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin. Cancer Res. 18, 4910-4918 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 4910-4918
    • Arcila, M.E.1
  • 72
    • 85017623620 scopus 로고    scopus 로고
    • ERBB2 mutated metastatic non-small cell lung cancer: Response and resistance to targeted therapies
    • Chuang, J. C. et al. ERBB2 mutated metastatic non-small cell lung cancer: Response and resistance to targeted therapies. J. Thorac. Oncol. 12, 833-842 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 833-842
    • Chuang, J.C.1
  • 73
    • 84961659480 scopus 로고    scopus 로고
    • Lung cancer patients with HER2 mutations treated with chemotherapy and HER2 targeted drugs: Results from the European EUHER2 cohort
    • Mazieres, J. et al. Lung cancer patients with HER2 mutations treated with chemotherapy and HER2 targeted drugs: Results from the European EUHER2 cohort. Ann. Oncol. 27, 281-286 (2016).
    • (2016) Ann. Oncol. , vol.27 , pp. 281-286
    • Mazieres, J.1
  • 74
    • 84946710397 scopus 로고    scopus 로고
    • Targeting HER2 aberrations as actionable drivers in lung cancers: Phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2 mutant or amplified tumors
    • Kris, M. G. et al. Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2 mutant or amplified tumors. Ann. Oncol. 26, 1421-1427 (2015).
    • (2015) Ann. Oncol. , vol.26 , pp. 1421-1427
    • Kris, M.G.1
  • 75
    • 85020217144 scopus 로고    scopus 로고
    • Response heterogeneity of EGFR and HER2 exon 20 insertions to covalent EGFR and HER2 inhibitors
    • Kosaka, T. et al. Response heterogeneity of EGFR and HER2 exon 20 insertions to covalent EGFR and HER2 inhibitors. Cancer Res. 77, 2712-2721 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 2712-2721
    • Kosaka, T.1
  • 76
    • 84876902448 scopus 로고    scopus 로고
    • Transitions to catalytically inactive conformations in EGFR kinase
    • Shan, Y., Arkhipov, A., Kim, E. T., Pan, A. C. & Shaw, D. E. Transitions to catalytically inactive conformations in EGFR kinase. Proc. Natl Acad. Sci. USA 110, 7270-7275 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 7270-7275
    • Shan, Y.1    Arkhipov, A.2    Kim, E.T.3    Pan, A.C.4    Shaw, D.E.5
  • 77
    • 84872288990 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition
    • Roskoski, R. Jr Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. Pharmacol. Res. 68, 68-94 (2013).
    • (2013) Pharmacol. Res. , vol.68 , pp. 68-94
    • Roskoski, R.1
  • 78
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist, L. V. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl Med. 3, 75ra26 (2011).
    • (2011) Sci. Transl Med. , vol.3 , pp. 75ra26
    • Sequist, L.V.1
  • 79
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • Yu, H. A. et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin. Cancer Res. 19, 2240-2247 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2240-2247
    • Yu, H.A.1
  • 80
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao, W. et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73 (2005).
    • (2005) PLoS Med. , vol.2 , pp. e73
    • Pao, W.1
  • 81
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi, S. et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 352, 786-792 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 786-792
    • Kobayashi, S.1
  • 82
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun, C. H. et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc. Natl Acad. Sci. USA 105, 2070-2075 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2070-2075
    • Yun, C.H.1
  • 83
    • 84978619027 scopus 로고    scopus 로고
    • Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
    • Hata, A. N. et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat. Med. 22, 262-269 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 262-269
    • Hata, A.N.1
  • 84
    • 84942942154 scopus 로고    scopus 로고
    • Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFR-Activating mutation using droplet digital PCR
    • Watanabe, M. et al. Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFR-Activating mutation using droplet digital PCR. Clin. Cancer Res. 21, 3552-3560 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 3552-3560
    • Watanabe, M.1
  • 85
    • 78049426513 scopus 로고    scopus 로고
    • EML4 ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • Choi, Y. L. et al. EML4 ALK mutations in lung cancer that confer resistance to ALK inhibitors. N. Engl. J. Med. 363, 1734-1739 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1734-1739
    • Choi, Y.L.1
  • 86
    • 85015856674 scopus 로고    scopus 로고
    • Resistance mechanisms to targeted therapies in ROS1+and ALK+non-small cell lung cancer
    • McCoach, C. E. et al. Resistance mechanisms to targeted therapies in ROS1+and ALK+non-small cell lung cancer. J. Clin. Oncol. 34, 9065 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 9065
    • McCoach, C.E.1
  • 87
    • 84991014974 scopus 로고    scopus 로고
    • Preclinical modeling of KIF5B RET fusion lung adenocarcinoma
    • Huang, Q. et al. Preclinical modeling of KIF5B RET fusion lung adenocarcinoma. Mol. Cancer Ther. 15, 2521-2529 (2016).
    • (2016) Mol. Cancer Ther. , vol.15 , pp. 2521-2529
    • Huang, Q.1
  • 88
    • 84904898065 scopus 로고    scopus 로고
    • AZD9291, an irreversible EGFR TKI, overcomes T790M mediated resistance to EGFR inhibitors in lung cancer
    • Cross, D. A. et al. AZD9291, an irreversible EGFR TKI, overcomes T790M mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 4, 1046-1061 (2014).
    • (2014) Cancer Discov. , vol.4 , pp. 1046-1061
    • Cross, D.A.1
  • 89
    • 84987849616 scopus 로고    scopus 로고
    • Acquired resistance of EGFR-mutant lung cancer to a T790M specific EGFR inhibitor: Emergence of a third mutation (C797S) in the EGFR tyrosine kinase domain
    • Yu, H. A. et al. Acquired resistance of EGFR-mutant lung cancer to a T790M specific EGFR inhibitor: Emergence of a third mutation (C797S) in the EGFR tyrosine kinase domain. JAMA Oncol. 1, 982-984 (2015).
    • (2015) JAMA Oncol. , vol.1 , pp. 982-984
    • Yu, H.A.1
  • 90
    • 84930755018 scopus 로고    scopus 로고
    • Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
    • Thress, K. S. et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat. Med. 21, 560-562 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 560-562
    • Thress, K.S.1
  • 91
    • 85018584810 scopus 로고    scopus 로고
    • Emergence of novel and dominant acquired EGFR solvent-front mutations at Gly796 (G796S/R) together with C797S/R and L792F/H mutations in one EGFR (L858R/T790M) NSCLC patient who progressed on osimertinib
    • Ou, S. I. et al. Emergence of novel and dominant acquired EGFR solvent-front mutations at Gly796 (G796S/R) together with C797S/R and L792F/H mutations in one EGFR (L858R/T790M) NSCLC patient who progressed on osimertinib. Lung Cancer 108, 228-231 (2017).
    • (2017) Lung Cancer , vol.108 , pp. 228-231
    • Ou, S.I.1
  • 92
    • 82555205478 scopus 로고    scopus 로고
    • ALK mutations conferring differential resistance to structurally diverse ALK inhibitors
    • Heuckmann, J. M. et al. ALK mutations conferring differential resistance to structurally diverse ALK inhibitors. Clin. Cancer Res. 17, 7394-7401 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7394-7401
    • Heuckmann, J.M.1
  • 93
    • 84908568858 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
    • Katayama, R. et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci. Transl Med. 4, 120ra117 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 120ra117
    • Katayama, R.1
  • 94
    • 84879088863 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib from a mutation in CD74 ROS1
    • Awad, M. M. et al. Acquired resistance to crizotinib from a mutation in CD74 ROS1. N. Engl. J. Med. 368, 2395-2401 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2395-2401
    • Awad, M.M.1
  • 95
    • 85015972296 scopus 로고    scopus 로고
    • Frequency and spectrum of ROS1 resistance mutations in ROS1 positive lung cancer patients progressing on crizotinib
    • Gainor, J. et al. Frequency and spectrum of ROS1 resistance mutations in ROS1 positive lung cancer patients progressing on crizotinib. J. Clin. Oncol. 34, 9072 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 9072
    • Gainor, J.1
  • 96
    • 84969257134 scopus 로고    scopus 로고
    • A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1 rearranged lung cancer
    • Drilon, A. et al. A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1 rearranged lung cancer. Clin. Cancer Res. 22, 2351-2358 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 2351-2358
    • Drilon, A.1
  • 97
    • 84954060726 scopus 로고    scopus 로고
    • Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer
    • Russo, M. et al. Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer. Cancer Discov. 6, 36-44 (2016).
    • (2016) Cancer Discov. , vol.6 , pp. 36-44
    • Russo, M.1
  • 98
    • 58149333768 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
    • Bean, J. et al. Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin. Cancer Res. 14, 7519-7525 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7519-7525
    • Bean, J.1
  • 99
    • 33751292685 scopus 로고    scopus 로고
    • Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
    • Balak, M. N. et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin. Cancer Res. 12, 6494-6501 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6494-6501
    • Balak, M.N.1
  • 100
    • 85019051749 scopus 로고    scopus 로고
    • Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A
    • Chiba, M. et al. Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A. BMC Cancer 17, 281 (2017).
    • (2017) BMC Cancer , vol.17 , pp. 281
    • Chiba, M.1
  • 101
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • Doebele, R. C. et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin. Cancer Res. 18, 1472-1482 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1472-1482
    • Doebele, R.C.1
  • 102
    • 78649475696 scopus 로고    scopus 로고
    • The neuroblastoma-Associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-Translocated cancers
    • Sasaki, T. et al. The neuroblastoma-Associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-Translocated cancers. Cancer Res. 70, 10038-10043 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 10038-10043
    • Sasaki, T.1
  • 103
    • 84917678260 scopus 로고    scopus 로고
    • Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
    • Katayama, R. et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin. Cancer Res. 20, 5686-5696 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5686-5696
    • Katayama, R.1
  • 104
    • 85007019439 scopus 로고    scopus 로고
    • Crizotinib-resistant ROS1 mutations reveal a predictive kinase inhibitor sensitivity model for ROS1-And ALK-rearranged lung cancers
    • Facchinetti, F. et al. Crizotinib-resistant ROS1 mutations reveal a predictive kinase inhibitor sensitivity model for ROS1-And ALK-rearranged lung cancers. Clin. Cancer Res. 22, 5983-5991 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 5983-5991
    • Facchinetti, F.1
  • 105
    • 84982161005 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib in NSCLC with MET exon 14 skipping
    • Heist, R. S. et al. Acquired resistance to crizotinib in NSCLC with MET exon 14 skipping. J. Thorac. Oncol. 11, 1242-1245 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. 1242-1245
    • Heist, R.S.1
  • 106
    • 85015316213 scopus 로고    scopus 로고
    • Emergence of preexisting MET Y1230C mutation as a resistance mechanism to crizotinib in NSCLC with MET exon 14 skipping
    • Ou, S. I. et al. Emergence of preexisting MET Y1230C mutation as a resistance mechanism to crizotinib in NSCLC with MET exon 14 skipping. J. Thorac. Oncol. 12, 137-140 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 137-140
    • Ou, S.I.1
  • 107
    • 84902449207 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinase MET in cancer: Small molecule inhibitors and clinical progress
    • Cui, J. J. Targeting receptor tyrosine kinase MET in cancer: small molecule inhibitors and clinical progress. J. Med. Chem. 57, 4427-4453 (2014).
    • (2014) J. Med. Chem. , vol.57 , pp. 4427-4453
    • Cui, J.J.1
  • 108
    • 85007401698 scopus 로고    scopus 로고
    • Acquired METD1228V mutation and resistance to MET inhibition in lung cancer
    • Bahcall, M. et al. Acquired METD1228V mutation and resistance to MET inhibition in lung cancer. Cancer Discov. 6, 1334-1341 (2016).
    • (2016) Cancer Discov , vol.6 , pp. 1334-1341
    • Bahcall, M.1
  • 109
    • 84880924426 scopus 로고    scopus 로고
    • LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-Tumor activities in mouse xenograft models
    • Yan, S. B. et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-Tumor activities in mouse xenograft models. Invest. New Drugs 31, 833-844 (2013).
    • (2013) Invest. New Drugs , vol.31 , pp. 833-844
    • Yan, S.B.1
  • 110
    • 85028050197 scopus 로고    scopus 로고
    • Acquired MET Y1248H and D1246N mutations mediate resistance to MET inhibitors in non-small cell lung cancer
    • Li, A. N. et al. Acquired MET Y1248H and D1246N mutations mediate resistance to MET inhibitors in non-small cell lung cancer. Clin. Cancer Res. 23, 4929-4937 (2017).
    • (2017) Clin. Cancer Res. , vol.23 , pp. 4929-4937
    • Li, A.N.1
  • 111
    • 84938196408 scopus 로고    scopus 로고
    • The allelic context of the C797S mutation acquired upon treatment with third-generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies
    • Niederst, M. J. et al. The allelic context of the C797S mutation acquired upon treatment with third-generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies. Clin. Cancer Res. 21, 3924-3933 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 3924-3933
    • Niederst, M.J.1
  • 112
    • 85015236659 scopus 로고    scopus 로고
    • Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer
    • Uchibori, K. et al. Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Nat. Commun. 8, 14768 (2017).
    • (2017) Nat. Commun. , vol.8 , pp. 14768
    • Uchibori, K.1
  • 113
    • 84973322897 scopus 로고    scopus 로고
    • Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
    • Jia, Y. et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature 534, 129-132 (2016).
    • (2016) Nature , vol.534 , pp. 129-132
    • Jia, Y.1
  • 114
    • 84954050562 scopus 로고    scopus 로고
    • Resensitization to crizotinib by the lorlatinib ALK resistance mutation L1198F
    • Shaw, A. T. et al. Resensitization to crizotinib by the lorlatinib ALK resistance mutation L1198F. N. Engl. J. Med. 374, 54-61 (2016).
    • (2016) N. Engl. J. Med. , vol.374 , pp. 54-61
    • Shaw, A.T.1
  • 115
    • 84948071403 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to AZD9291: A mutation-selective, irreversible EGFR inhibitor
    • Kim, T. M. et al. Mechanisms of acquired resistance to AZD9291: A mutation-selective, irreversible EGFR inhibitor. J. Thorac. Oncol. 10, 1736-1744 (2015).
    • (2015) J. Thorac. Oncol. , vol.10 , pp. 1736-1744
    • Kim, T.M.1
  • 116
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4 ALK
    • Katayama, R. et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4 ALK. Proc. Natl Acad. Sci. USA 108, 7535-7540 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7535-7540
    • Katayama, R.1
  • 117
    • 84894300510 scopus 로고    scopus 로고
    • Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer
    • Lin, L. et al. Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer. Proc. Natl Acad. Sci. USA 111, E748-E757 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E748-E757
    • Lin, L.1
  • 118
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi, K. et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc. Natl Acad. Sci. USA 109, E2127-E2133 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E2127-E2133
    • Ohashi, K.1
  • 119
    • 84899698299 scopus 로고    scopus 로고
    • Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer
    • de Bruin, E. C. et al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer Discov. 4, 606-619 (2014).
    • (2014) Cancer Discov. , vol.4 , pp. 606-619
    • De Bruin, E.C.1
  • 120
    • 84941786489 scopus 로고    scopus 로고
    • Combined EGFR/MEK inhibition prevents the emergence of resistance in EGFR mutant lung cancer
    • Tricker, E. M. et al. Combined EGFR/MEK inhibition prevents the emergence of resistance in EGFR mutant lung cancer. Cancer Discov. 5, 960-971 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 960-971
    • Tricker, E.M.1
  • 121
    • 84868010326 scopus 로고    scopus 로고
    • Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors
    • Ercan, D. et al. Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2, 934-947 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 934-947
    • Ercan, D.1
  • 122
    • 85015313813 scopus 로고    scopus 로고
    • Acquired BRAF V600E mutation as resistant mechanism after treatment with osimertinib
    • Ho, C. C. et al. Acquired BRAF V600E mutation as resistant mechanism after treatment with osimertinib. J. Thorac. Oncol. 12, 567-572 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 567-572
    • Ho, C.C.1
  • 123
    • 84941787370 scopus 로고    scopus 로고
    • Acquired resistance to the mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models
    • Eberlein, C. A. et al. Acquired resistance to the mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models. Cancer Res. 75, 2489-2500 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 2489-2500
    • Eberlein, C.A.1
  • 124
    • 84941013285 scopus 로고    scopus 로고
    • RAS-MAPK dependence underlies a rational polytherapy strategy in EML4 ALK-positive lung cancer
    • Hrustanovic, G. et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4 ALK-positive lung cancer. Nat. Med. 21, 1038-1047 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1038-1047
    • Hrustanovic, G.1
  • 125
    • 84919443958 scopus 로고    scopus 로고
    • Patient-derived models of acquired resistance can identify effective drug combinations for cancer
    • Crystal, A. S. et al. Patient-derived models of acquired resistance can identify effective drug combinations for cancer. Science 346, 1480-1486 (2014).
    • (2014) Science , vol.346 , pp. 1480-1486
    • Crystal, A.S.1
  • 126
    • 84924943550 scopus 로고    scopus 로고
    • Activation of RAS family members confers resistance to ROS1 targeting drugs
    • Cargnelutti, M. et al. Activation of RAS family members confers resistance to ROS1 targeting drugs. Oncotarget 6, 5182-5194 (2015).
    • (2015) Oncotarget , vol.6 , pp. 5182-5194
    • Cargnelutti, M.1
  • 127
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 128
    • 79953024710 scopus 로고    scopus 로고
    • Phosphoinositide 3 kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer
    • Ludovini, V. et al. Phosphoinositide 3 kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer. J. Thorac. Oncol. 6, 707-715 (2011).
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 707-715
    • Ludovini, V.1
  • 129
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • Sos, M. L. et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 69, 3256-3261 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3256-3261
    • Sos, M.L.1
  • 130
    • 84954560911 scopus 로고    scopus 로고
    • TGF β1 induces erlotinib resistance in non-small cell lung cancer by down-regulating PTEN
    • Shen, H. et al. TGF β1 induces erlotinib resistance in non-small cell lung cancer by down-regulating PTEN. Biomed. Pharmacother. 77, 1-6 (2016).
    • (2016) Biomed. Pharmacother. , vol.77 , pp. 1-6
    • Shen, H.1
  • 131
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-Amplified lung cancer
    • Engelman, J. A. et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-Amplified lung cancer. J. Clin. Invest. 116, 2695-2706 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2695-2706
    • Engelman, J.A.1
  • 132
    • 84948799794 scopus 로고    scopus 로고
    • Integrin β1 mediated acquired gefitinib resistance in non-small cell lung cancer cells occurs via the phosphoinositide 3 kinase-dependent pathway
    • Deng, Q. F. et al. Integrin β1 mediated acquired gefitinib resistance in non-small cell lung cancer cells occurs via the phosphoinositide 3 kinase-dependent pathway. Oncol. Lett. 11, 535-542 (2016).
    • (2016) Oncol. Lett. , vol.11 , pp. 535-542
    • Deng, Q.F.1
  • 133
    • 33644685228 scopus 로고    scopus 로고
    • The phosphatidylinositol 3 kinase inhibitor PX 866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts
    • Ihle, N. T. et al. The phosphatidylinositol 3 kinase inhibitor PX 866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol. Cancer Ther. 4, 1349-1357 (2005).
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1349-1357
    • Ihle, N.T.1
  • 134
    • 84949568982 scopus 로고    scopus 로고
    • BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer
    • Karachaliou, N. et al. BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer. Scientif. Rep. 5, 17499 (2015).
    • (2015) Scientif. Rep. , vol.5 , pp. 17499
    • Karachaliou, N.1
  • 135
    • 84903478069 scopus 로고    scopus 로고
    • Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M
    • Kawabata, S. et al. Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. Cell Rep. 7, 1824-1832 (2014).
    • (2014) Cell Rep , vol.7 , pp. 1824-1832
    • Kawabata, S.1
  • 136
    • 85029853942 scopus 로고    scopus 로고
    • MA04.02 neratinib ± temsirolimus in HER2 mutant lung cancers: An international, randomized phase II study
    • Gandhi, L. et al. MA04.02 neratinib ± temsirolimus in HER2 mutant lung cancers: An international, randomized phase II study. J. Thorac. Oncol. 12, S358-S359 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. S358-S359
    • Gandhi, L.1
  • 137
    • 84927695240 scopus 로고    scopus 로고
    • NF κB-Activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer
    • Blakely, C. M. et al. NF κB-Activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer. Cell Rep. 11, 98-110 (2015).
    • (2015) Cell Rep. , vol.11 , pp. 98-110
    • Blakely, C.M.1
  • 138
    • 84962750039 scopus 로고    scopus 로고
    • JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors
    • Gao, S. P. et al. JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors. Sci. Signal. 9, ra33 (2016).
    • (2016) Sci. Signal. , vol.9 , pp. ra33
    • Gao, S.P.1
  • 139
    • 85017265055 scopus 로고    scopus 로고
    • Co activation of STAT3 and YES-Associated protein 1 (YAP1) pathway in EGFR-mutant NSCLC
    • Chaib, I. et al. Co activation of STAT3 and YES-Associated protein 1 (YAP1) pathway in EGFR-mutant NSCLC. J. Natl Cancer Inst. http://dx.doi.org/10.1093/jnci/djx014 (2017).
    • (2017) J. Natl Cancer Inst
    • Chaib, I.1
  • 140
    • 84973278474 scopus 로고    scopus 로고
    • Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3
    • Shou, J. et al. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer Lett. 379, 124-133 (2016).
    • (2016) Cancer Lett. , vol.379 , pp. 124-133
    • Shou, J.1
  • 141
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling
    • Song, L., Rawal, B., Nemeth, J. A. & Haura, E. B. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling. Mol. Cancer Ther. 10, 481-494 (2011).
    • (2011) Mol. Cancer Ther , vol.10 , pp. 481-494
    • Song, L.1    Rawal, B.2    Nemeth, J.A.3    Haura, E.B.4
  • 142
    • 84867405669 scopus 로고    scopus 로고
    • Activation of IL 6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
    • Kim, S. M. et al. Activation of IL 6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol. Cancer Ther. 11, 2254-2264 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 2254-2264
    • Kim, S.M.1
  • 143
    • 85015292426 scopus 로고    scopus 로고
    • A phase 1/2 trial of ruxolitinib and erlotinib in patients with EGFR-mutant lung adenocarcinomas with acquired resistance to erlotinib
    • Yu, H. A. et al. A phase 1/2 trial of ruxolitinib and erlotinib in patients with EGFR-mutant lung adenocarcinomas with acquired resistance to erlotinib. J. Thorac. Oncol. 12, 102-109 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 102-109
    • Yu, H.A.1
  • 144
    • 84905726946 scopus 로고    scopus 로고
    • Drug resistance via feedback activation of Stat3 in oncogene-Addicted cancer cells
    • Lee, H. J. et al. Drug resistance via feedback activation of Stat3 in oncogene-Addicted cancer cells. Cancer Cell 26, 207-221 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 207-221
    • Lee, H.J.1
  • 145
    • 68449084677 scopus 로고    scopus 로고
    • The role of Src in solid tumors
    • Wheeler, D. L., Iida, M. & Dunn, E. F. The role of Src in solid tumors. Oncologist 14, 667-678 (2009).
    • (2009) Oncologist , vol.14 , pp. 667-678
    • Wheeler, D.L.1    Iida, M.2    Dunn, E.F.3
  • 146
    • 84886002801 scopus 로고    scopus 로고
    • Erlotinib resistance in lung cancer cells mediated by integrin beta1/Src/Akt-driven bypass signaling
    • Kanda, R. et al. Erlotinib resistance in lung cancer cells mediated by integrin beta1/Src/Akt-driven bypass signaling. Cancer Res. 73, 6243-6253 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 6243-6253
    • Kanda, R.1
  • 147
    • 71849120012 scopus 로고    scopus 로고
    • Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification
    • Yoshida, T. et al. Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification. Cancer Sci. 101, 167-172 (2010).
    • (2010) Cancer Sci. , vol.101 , pp. 167-172
    • Yoshida, T.1
  • 148
    • 84929914778 scopus 로고    scopus 로고
    • A phase I/II study combining erlotinib and dasatinib for non-small cell lung cancer
    • Gold, K. A. et al. A phase I/II study combining erlotinib and dasatinib for non-small cell lung cancer. Oncologist 19, 1040-1041 (2014).
    • (2014) Oncologist , vol.19 , pp. 1040-1041
    • Gold, K.A.1
  • 149
    • 85015235406 scopus 로고    scopus 로고
    • AZD0530 sensitizes drug-resistant ALK-positive lung cancer cells by inhibiting SRC signaling
    • Zhao, Y., Yang, Y., Xu, Y., Lu, S. & Jian, H. AZD0530 sensitizes drug-resistant ALK-positive lung cancer cells by inhibiting SRC signaling. FEBS Open Bio 7, 472-476 (2017).
    • (2017) FEBS Open Bio , vol.7 , pp. 472-476
    • Zhao, Y.1    Yang, Y.2    Xu, Y.3    Lu, S.4    Jian, H.5
  • 150
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino, L., Bertotti, A. & Comoglio, P. M. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 11, 834-848 (2010).
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 151
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean, J. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl Acad. Sci. USA 104, 20932-20937 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20932-20937
    • Bean, J.1
  • 152
    • 85015276627 scopus 로고    scopus 로고
    • Phase I results from a study of crizotinib in combination with erlotinib in patients with advanced nonsquamous non-small cell lung cancer
    • Ou, S. I. et al. Phase I results from a study of crizotinib in combination with erlotinib in patients with advanced nonsquamous non-small cell lung cancer. J. Thorac. Oncol. 12, 145-151 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 145-151
    • Ou, S.I.1
  • 153
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • Sequist, L. V. et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J. Clin. Oncol. 29, 3307-3315 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3307-3315
    • Sequist, L.V.1
  • 154
    • 84907561441 scopus 로고    scopus 로고
    • Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR-mutated (mut), MET-positive NSCLC: A single-Arm phase lb/ll study
    • Wu, Y.-L. et al. Safety and efficacy of INC280 in combination with gefitinib (gef) in patients with EGFR-mutated (mut), MET-positive NSCLC: A single-Arm phase lb/ll study. J. Clin. Oncol. 32, 8017 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 8017
    • Wu, Y.-L.1
  • 155
    • 84894553635 scopus 로고    scopus 로고
    • Crizotinib can overcome acquired resistance to CH5424802: Is amplification of the MET gene a key factor?
    • Gouji, T., Takashi, S., Mitsuhiro, T. & Yukito, I. Crizotinib can overcome acquired resistance to CH5424802: is amplification of the MET gene a key factor? J. Thorac. Oncol. 9, e27-e28 (2014).
    • (2014) J. Thorac. Oncol. , vol.9 , pp. e27-e28
    • Gouji, T.1    Takashi, S.2    Mitsuhiro, T.3    Yukito, I.4
  • 156
    • 84962297023 scopus 로고    scopus 로고
    • Molecular pathways: AXL, a membrane receptor mediator of resistance to therapy
    • Scaltriti, M., Elkabets, M. & Baselga, J. Molecular pathways: AXL, a membrane receptor mediator of resistance to therapy. Clin. Cancer Res. 22, 1313-1317 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1313-1317
    • Scaltriti, M.1    Elkabets, M.2    Baselga, J.3
  • 157
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer
    • Zhang, Z. et al. Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer. Nat. Genet. 44, 852-860 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 852-860
    • Zhang, Z.1
  • 158
    • 84871998076 scopus 로고    scopus 로고
    • An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers, L. A. et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin. Cancer Res. 19, 279-290 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 279-290
    • Byers, L.A.1
  • 159
    • 85017940817 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02424617 (2017).
    • (2017) US National Library of Medicine
  • 160
    • 84924266469 scopus 로고    scopus 로고
    • A functional landscape of resistance to ALK inhibition in lung cancer
    • Wilson, F. H. et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell 27, 397-408 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 397-408
    • Wilson, F.H.1
  • 161
    • 85027116112 scopus 로고    scopus 로고
    • Resistance to RET-inhibition in RET-rearranged NSCLC is mediated by reactivation of RAS/MAPK signaling
    • Nelson-Taylor, S. K. et al. Resistance to RET-inhibition in RET-rearranged NSCLC is mediated by reactivation of RAS/MAPK signaling. Mol. Cancer Ther. 16, 1623-1633(2017).
    • (2017) Mol. Cancer Ther , vol.16 , pp. 1623-1633
    • Nelson-Taylor, S.K.1
  • 162
    • 84963984183 scopus 로고    scopus 로고
    • Elucidation of resistance mechanisms to second-generation ALK inhibitors alectinib and ceritinib in non-small cell lung cancer cells
    • Dong, X., Fernandez-Salas, E., Li, E. & Wang, S. Elucidation of resistance mechanisms to second-generation ALK inhibitors alectinib and ceritinib in non-small cell lung cancer cells. Neoplasia 18, 162-171 (2016).
    • (2016) Neoplasia , vol.18 , pp. 162-171
    • Dong, X.1    Fernandez-Salas, E.2    Li, E.3    Wang, S.4
  • 163
    • 84930968377 scopus 로고    scopus 로고
    • Molecular changes associated with acquired resistance to crizotinib in ROS1 rearranged non-small cell lung cancer
    • Song, A. et al. Molecular changes associated with acquired resistance to crizotinib in ROS1 rearranged non-small cell lung cancer. Clin. Cancer Res. 21, 2379-2387 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 2379-2387
    • Song, A.1
  • 164
    • 84892655145 scopus 로고    scopus 로고
    • Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer
    • Davies, K. D. et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE 8, e82236 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e82236
    • Davies, K.D.1
  • 165
    • 85023752315 scopus 로고    scopus 로고
    • EGFR mediates responses to small molecule drugs targeting oncogenic fusion kinases
    • Vaishnavi, A. et al. EGFR mediates responses to small molecule drugs targeting oncogenic fusion kinases. Cancer Res. 77, 3551-3563 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 3551-3563
    • Vaishnavi, A.1
  • 166
    • 84958165970 scopus 로고    scopus 로고
    • Activation of EGFR bypass signaling by TGFα overexpression induces acquired resistance to alectinib in ALK-Translocated lung cancer cells
    • Tani, T. et al. Activation of EGFR bypass signaling by TGFα overexpression induces acquired resistance to alectinib in ALK-Translocated lung cancer cells. Mol. Cancer Ther. 15, 162-171 (2016).
    • (2016) Mol. Cancer Ther , vol.15 , pp. 162-171
    • Tani, T.1
  • 167
    • 85007483022 scopus 로고    scopus 로고
    • Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib-resistance of EML4 ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors
    • Taniguchi, H. et al. Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib-resistance of EML4 ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors. Cancer Sci. 108, 53-60 (2017).
    • (2017) Cancer Sci. , vol.108 , pp. 53-60
    • Taniguchi, H.1
  • 168
    • 84891738696 scopus 로고    scopus 로고
    • Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer
    • Yamaguchi, N. et al. Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer. Lung Cancer 83, 37-43 (2014).
    • (2014) Lung Cancer , vol.83 , pp. 37-43
    • Yamaguchi, N.1
  • 169
    • 84896091512 scopus 로고    scopus 로고
    • ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics
    • Arteaga, C. L. & Engelman, J. A. ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 25, 282-303 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 282-303
    • Arteaga, C.L.1    Engelman, J.A.2
  • 170
    • 84864015211 scopus 로고    scopus 로고
    • Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells
    • Tabara, K. et al. Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. PLoS ONE 7, e41017 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e41017
    • Tabara, K.1
  • 171
    • 0242442020 scopus 로고    scopus 로고
    • HER2 status in non-small cell lung cancer: Results from patient screening for enrollment to a phase II study of herceptin
    • Heinmoller, P. et al. HER2 status in non-small cell lung cancer: Results from patient screening for enrollment to a phase II study of herceptin. Clin. Cancer Res. 9, 5238-5243 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5238-5243
    • Heinmoller, P.1
  • 172
    • 84867760241 scopus 로고    scopus 로고
    • HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
    • Takezawa, K. et al. HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov. 2, 922-933 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 922-933
    • Takezawa, K.1
  • 173
    • 84869211206 scopus 로고    scopus 로고
    • Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4 ALK-positive non-small cell lung cancer
    • Tanizaki, J. et al. Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4 ALK-positive non-small cell lung cancer. Clin. Cancer Res. 18, 6219-6226 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6219-6226
    • Tanizaki, J.1
  • 174
    • 84982863876 scopus 로고    scopus 로고
    • Lung adenocarcinoma harboring concomitant SPTBN1 ALK fusion, c Met overexpression, and HER 2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy
    • Gu, F. F. et al. Lung adenocarcinoma harboring concomitant SPTBN1 ALK fusion, c Met overexpression, and HER 2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy. J. Hematol. Oncol. 9, 66 (2016).
    • (2016) J. Hematol. Oncol. , vol.9 , pp. 66
    • Gu, F.F.1
  • 175
    • 16844375982 scopus 로고    scopus 로고
    • Lack of trastuzumab activity in nonsmall cell lung carcinoma with overexpression of erb B2: 39810: A phase II trial of Cancer and Leukemia Group B
    • Clamon, G. et al. Lack of trastuzumab activity in nonsmall cell lung carcinoma with overexpression of erb B2: 39810: A phase II trial of Cancer and Leukemia Group B. Cancer 103, 1670-1675 (2005).
    • (2005) Cancer , vol.103 , pp. 1670-1675
    • Clamon, G.1
  • 176
    • 1542360632 scopus 로고    scopus 로고
    • Trastuzumab plus docetaxel in HER2/neu-positive non-small-cell lung cancer: A California Cancer Consortium screening and phase II trial
    • Lara, P. N. Jr et al. Trastuzumab plus docetaxel in HER2/neu-positive non-small-cell lung cancer: A California Cancer Consortium screening and phase II trial. Clin. Lung Cancer 5, 231-236 (2004).
    • (2004) Clin. Lung Cancer , vol.5 , pp. 231-236
    • Lara, P.N.1
  • 177
    • 2142762457 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of advanced non-small-cell lung cancer: Is there a role? Focus on Eastern Cooperative Oncology Group study 2598
    • Langer, C. J., Stephenson, P., Thor, A., Vangel, M. & Johnson, D. H. Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598. J. Clin. Oncol. 22, 1180-1187 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1180-1187
    • Langer, C.J.1    Stephenson, P.2    Thor, A.3    Vangel, M.4    Johnson, D.H.5
  • 178
    • 0942287963 scopus 로고    scopus 로고
    • Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2 positive non-small-cell lung cancer
    • Gatzemeier, U. et al. Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2 positive non-small-cell lung cancer. Ann. Oncol. 15, 19-27 (2004).
    • (2004) Ann. Oncol. , vol.15 , pp. 19-27
    • Gatzemeier, U.1
  • 179
    • 84880547779 scopus 로고    scopus 로고
    • Activation of the FGF2 FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC
    • Terai, H. et al. Activation of the FGF2 FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC. Mol. Cancer Res. 11, 759-767 (2013).
    • (2013) Mol. Cancer Res. , vol.11 , pp. 759-767
    • Terai, H.1
  • 180
    • 84958979098 scopus 로고    scopus 로고
    • EPHA2 blockade overcomes acquired resistance to EGFR kinase inhibitors in lung cancer
    • Amato, K. R. et al. EPHA2 blockade overcomes acquired resistance to EGFR kinase inhibitors in lung cancer. Cancer Res. 76, 305-318 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 305-318
    • Amato, K.R.1
  • 181
    • 84908363886 scopus 로고    scopus 로고
    • Rationale for co targeting IGF 1R and ALK in ALK fusion-positive lung cancer
    • Lovly, C. M. et al. Rationale for co targeting IGF 1R and ALK in ALK fusion-positive lung cancer. Nat. Med. 20, 1027-1034 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1027-1034
    • Lovly, C.M.1
  • 182
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • Morgillo, F., Woo, J. K., Kim, E. S., Hong, W. K. & Lee, H. Y. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res. 66, 10100-10111 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.Y.5
  • 183
    • 84982166645 scopus 로고    scopus 로고
    • An activating KIT mutation induces crizotinib resistance in ROS1 positive lung cancer
    • Dziadziuszko, R. et al. An activating KIT mutation induces crizotinib resistance in ROS1 positive lung cancer. J. Thorac. Oncol. 11, 1273-1281 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. 1273-1281
    • Dziadziuszko, R.1
  • 184
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong, Y. et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 4, e294 (2007).
    • (2007) PLoS Med , vol.4 , pp. e294
    • Gong, Y.1
  • 185
    • 85017202805 scopus 로고    scopus 로고
    • Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion-positive non-small cell lung cancer
    • Zhang, L. et al. Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion-positive non-small cell lung cancer. Cancer 123, 2927-2935 (2017).
    • (2017) Cancer , vol.123 , pp. 2927-2935
    • Zhang, L.1
  • 186
    • 85020935218 scopus 로고    scopus 로고
    • Histone deacetylase 3 inhibition overcomes BIM deletion polymorphism-mediated osimertinib resistance in EGFR-mutant lung cancer
    • Tanimoto, A. et al. Histone deacetylase 3 inhibition overcomes BIM deletion polymorphism-mediated osimertinib resistance in EGFR-mutant lung cancer. Clin. Cancer Res. 23, 3139-3149 (2016).
    • (2016) Clin. Cancer Res , vol.23 , pp. 3139-3149
    • Tanimoto, A.1
  • 187
    • 84898726862 scopus 로고    scopus 로고
    • The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial
    • Costa, C. et al. The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial. Clin. Cancer Res. 20, 2001-2010 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 2001-2010
    • Costa, C.1
  • 188
    • 85017940817 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02520778 (2017).
    • (2017) US National Library of Medicine
  • 189
  • 190
    • 84923183206 scopus 로고    scopus 로고
    • The emerging roles of YAP and TAZ in cancer
    • Moroishi, T., Hansen, C. G. & Guan, K. L. The emerging roles of YAP and TAZ in cancer. Nat. Rev. Cancer 15, 73-79 (2015).
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 73-79
    • Moroishi, T.1    Hansen, C.G.2    Guan, K.L.3
  • 191
    • 77953197857 scopus 로고    scopus 로고
    • Overexpression of yes-Associated protein contributes to progression and poor prognosis of non-small-cell lung cancer
    • Wang, Y. et al. Overexpression of yes-Associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci. 101, 1279-1285 (2010).
    • (2010) Cancer Sci. , vol.101 , pp. 1279-1285
    • Wang, Y.1
  • 192
    • 84964294731 scopus 로고    scopus 로고
    • Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance
    • Lee, J. E. et al. Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance. Biochem. Biophys. Res. Commun. 474, 154-160 (2016).
    • (2016) Biochem. Biophys. Res. Commun. , vol.474 , pp. 154-160
    • Lee, J.E.1
  • 193
    • 84982243161 scopus 로고    scopus 로고
    • YAP promotes erlotinib resistance in human non-small cell lung cancer cells
    • Hsu, P. C. et al. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget 7, 51922-51933 (2016).
    • (2016) Oncotarget , vol.7 , pp. 51922-51933
    • Hsu, P.C.1
  • 194
    • 73349128777 scopus 로고    scopus 로고
    • YAP-dependent induction of amphiregulin identifies a non-cell-Autonomous component of the Hippo pathway
    • Zhang, J. et al. YAP-dependent induction of amphiregulin identifies a non-cell-Autonomous component of the Hippo pathway. Nat. Cell Biol. 11, 1444 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1444
    • Zhang, J.1
  • 195
    • 84994895735 scopus 로고    scopus 로고
    • Coexistence of p16/CDKN2A homozygous deletions and activating EGFR mutations in lung adenocarcinoma patients signifies a poor response to EGFR-TKIs
    • Jiang, J. et al. Coexistence of p16/CDKN2A homozygous deletions and activating EGFR mutations in lung adenocarcinoma patients signifies a poor response to EGFR-TKIs. Lung Cancer 102, 101-107 (2016).
    • (2016) Lung Cancer , vol.102 , pp. 101-107
    • Jiang, J.1
  • 196
    • 85007439400 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors
    • Liu, M. et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors. Oncotarget 7, 84951-84964 (2016).
    • (2016) Oncotarget , vol.7 , pp. 84951-84964
    • Liu, M.1
  • 197
    • 84969753096 scopus 로고    scopus 로고
    • Case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib
    • Cha, Y. J., Cho, B. C., Kim, H. R., Lee, H. J. & Shim, H. S. A. Case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib. J. Thorac. Oncol. 11, e55-e58 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. e55-e58
    • Cha, Y.J.1    Cho, B.C.2    Kim, H.R.3    Lee, H.J.4    Shim, H.S.A.5
  • 198
    • 84924590266 scopus 로고    scopus 로고
    • RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
    • Niederst, M. J. et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat. Commun. 6, 6377 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6377
    • Niederst, M.J.1
  • 199
    • 84880894511 scopus 로고    scopus 로고
    • Transformation to sarcomatoid carcinoma in ALK-rearranged adenocarcinoma, which developed acquired resistance to crizotinib and received subsequent chemotherapies
    • Kobayashi, Y. et al. Transformation to sarcomatoid carcinoma in ALK-rearranged adenocarcinoma, which developed acquired resistance to crizotinib and received subsequent chemotherapies. J. Thorac. Oncol. 8, e75-e78 (2013).
    • (2013) J. Thorac. Oncol. , vol.8 , pp. e75-e78
    • Kobayashi, Y.1
  • 200
    • 84948798672 scopus 로고    scopus 로고
    • EMT is associated with, but does not drive resistance to ALK inhibitors among EML4 ALK non-small cell lung cancer
    • Gower, A., Hsu, W. H., Hsu, S. T., Wang, Y. & Giaccone, G. EMT is associated with, but does not drive resistance to ALK inhibitors among EML4 ALK non-small cell lung cancer. Mol. Oncol. 10, 601-609 (2016).
    • (2016) Mol. Oncol. , vol.10 , pp. 601-609
    • Gower, A.1    Hsu, W.H.2    Hsu, S.T.3    Wang, Y.4    Giaccone, G.5
  • 201
    • 84887994377 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4 ALK translocation
    • Kim, H. R. et al. Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4 ALK translocation. Mol. Oncol. 7, 1093-1102 (2013).
    • (2013) Mol. Oncol. , vol.7 , pp. 1093-1102
    • Kim, H.R.1
  • 202
    • 31544452076 scopus 로고    scopus 로고
    • Restoring E cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    • Witta, S. E. et al. Restoring E cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res. 66, 944-950 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 944-950
    • Witta, S.E.1
  • 203
    • 77957273623 scopus 로고    scopus 로고
    • TGF-β IL 6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
    • Yao, Z. et al. TGF-β IL 6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc. Natl Acad. Sci. USA 107, 15535-15540 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15535-15540
    • Yao, Z.1
  • 204
    • 84979752768 scopus 로고    scopus 로고
    • A genetic cell context-dependent role for ZEB1 in lung cancer
    • Zhang, T. et al. A genetic cell context-dependent role for ZEB1 in lung cancer. Nat. Commun. 7, 12231 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 12231
    • Zhang, T.1
  • 205
    • 84959255800 scopus 로고    scopus 로고
    • ZEB1 mediates acquired resistance to the epidermal growth factor receptor-Tyrosine kinase inhibitors in non-small cell lung cancer
    • Yoshida, T. et al. ZEB1 mediates acquired resistance to the epidermal growth factor receptor-Tyrosine kinase inhibitors in non-small cell lung cancer. PLoS ONE 11, e0147344 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0147344
    • Yoshida, T.1
  • 206
    • 84912101447 scopus 로고    scopus 로고
    • The role of Axl in drug resistance and epithelial-To mesenchymal transition of non-small cell lung carcinoma
    • Wu, F., Li, J., Jang, C., Wang, J. & Xiong, J. The role of Axl in drug resistance and epithelial-To mesenchymal transition of non-small cell lung carcinoma. Int. J. Clin. Exp. Pathol. 7, 6653-6661 (2014).
    • (2014) Int. J. Clin. Exp. Pathol. , vol.7 , pp. 6653-6661
    • Wu, F.1    Li, J.2    Jang, C.3    Wang, J.4    Xiong, J.5
  • 207
    • 84907495324 scopus 로고    scopus 로고
    • Overcoming EMT-Associated resistance to anti-cancer drugs via Src/FAK pathway inhibition
    • Wilson, C. et al. Overcoming EMT-Associated resistance to anti-cancer drugs via Src/FAK pathway inhibition. Oncotarget 5, 7328-7341 (2014).
    • (2014) Oncotarget , vol.5 , pp. 7328-7341
    • Wilson, C.1
  • 208
    • 84901036169 scopus 로고    scopus 로고
    • Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL 6 signaling and EMT reversal
    • Li, L. et al. Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL 6 signaling and EMT reversal. Clin. Cancer Res. 20, 2714-2726 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 2714-2726
    • Li, L.1
  • 209
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-Tolerant state in cancer cell subpopulations
    • Sharma, S. V. et al. A chromatin-mediated reversible drug-Tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1
  • 210
    • 84959122182 scopus 로고    scopus 로고
    • The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells
    • Greve, G. et al. The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells. BMC Cancer 15, 947 (2015).
    • (2015) BMC Cancer , vol.15 , pp. 947
    • Greve, G.1
  • 211
    • 84949651518 scopus 로고    scopus 로고
    • Crosstalk with cancer-Associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition
    • Choe, C. et al. Crosstalk with cancer-Associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition. Onco Targets Ther. 8, 3665-3678 (2015).
    • (2015) Onco Targets Ther. , vol.8 , pp. 3665-3678
    • Choe, C.1
  • 212
    • 84964297901 scopus 로고    scopus 로고
    • Podoplanin-positive cancer-Associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation
    • Yoshida, T. et al. Podoplanin-positive cancer-Associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation. Clin. Cancer Res. 21, 642-651 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 642-651
    • Yoshida, T.1
  • 213
    • 77953799106 scopus 로고    scopus 로고
    • Cancer-Associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs
    • Mink, S. R. et al. Cancer-Associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. Mol. Cancer Res. 8, 809-820 (2010).
    • (2010) Mol. Cancer Res. , vol.8 , pp. 809-820
    • Mink, S.R.1
  • 214
    • 70350721786 scopus 로고    scopus 로고
    • Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    • Wang, W. et al. Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin. Cancer Res. 15, 6630-6638 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6630-6638
    • Wang, W.1
  • 215
    • 84890812467 scopus 로고    scopus 로고
    • Chemotherapy activates cancer-Associated fibroblasts to maintain colorectal cancer-initiating cells by IL 17A
    • Lotti, F. et al. Chemotherapy activates cancer-Associated fibroblasts to maintain colorectal cancer-initiating cells by IL 17A. J. Exp. Med. 210, 2851-2872 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 2851-2872
    • Lotti, F.1
  • 216
    • 84995814749 scopus 로고    scopus 로고
    • EGF induced RET inhibitor resistance in CCDC6 RET lung cancer cells
    • Chang, H. et al. EGF induced RET inhibitor resistance in CCDC6 RET lung cancer cells. Yonsei Med. J. 58, 9-18 (2017).
    • (2017) Yonsei Med. J. , vol.58 , pp. 9-18
    • Chang, H.1
  • 217
    • 84876318874 scopus 로고    scopus 로고
    • Significance of cancer-Associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer
    • An, J. et al. Significance of cancer-Associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer. J. Cancer Res. Clin. Oncol. 139, 379-388 (2013).
    • (2013) J. Cancer Res. Clin. Oncol. , vol.139 , pp. 379-388
    • An, J.1
  • 218
    • 84983783161 scopus 로고    scopus 로고
    • Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions
    • Bae, S. Y., Park, H. J., Hong, J. Y., Lee, H. J. & Lee, S. K. Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions. Scientif. Rep. 6, 32258 (2016).
    • (2016) Scientif. Rep. , vol.6 , pp. 32258
    • Bae, S.Y.1    Park, H.J.2    Hong, J.Y.3    Lee, H.J.4    Lee, S.K.5
  • 219
    • 84872185689 scopus 로고    scopus 로고
    • N Cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells
    • Yamauchi, M. et al. N Cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. Am. J. Cancer Res. 1, 823-833 (2011).
    • (2011) Am. J. Cancer Res. , vol.1 , pp. 823-833
    • Yamauchi, M.1
  • 220
    • 79956093785 scopus 로고    scopus 로고
    • Interaction between neoplastic cells and cancer-Associated fibroblasts through the CXCL12/CXCR4 axis: Role in non-small cell lung cancer tumor proliferation
    • Wald, O. et al. Interaction between neoplastic cells and cancer-Associated fibroblasts through the CXCL12/CXCR4 axis: Role in non-small cell lung cancer tumor proliferation. J. Thorac. Cardiovasc. Surg. 141, 1503-1512 (2011).
    • (2011) J. Thorac. Cardiovasc. Surg. , vol.141 , pp. 1503-1512
    • Wald, O.1
  • 221
    • 85045349515 scopus 로고    scopus 로고
    • Abstract 4119: Cytoplasmic location of CXCR4 is correlated to loss of EMT marker and activation of downstream signaling pathway in non-small cell lung cancer
    • 4119
    • Wang, Y. et al. Abstract 4119: Cytoplasmic location of CXCR4 is correlated to loss of EMT marker and activation of downstream signaling pathway in non-small cell lung cancer. Cancer Res. 70, abstr. 4119 (2014).
    • (2014) Cancer Res. , vol.70
    • Wang, Y.1
  • 222
    • 85014634179 scopus 로고    scopus 로고
    • The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
    • Muz, B., de la Puente, P., Azab, F. & Azab, A. K. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia 3, 83-92 (2015).
    • (2015) Hypoxia , vol.3 , pp. 83-92
    • Muz, B.1    De La Puente, P.2    Azab, F.3    Azab, A.K.4
  • 223
    • 84900297049 scopus 로고    scopus 로고
    • Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor
    • Murakami, A. et al. Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor. PLoS ONE 9, e86459 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e86459
    • Murakami, A.1
  • 224
    • 84868212812 scopus 로고    scopus 로고
    • Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-Type epidermal growth factor receptors
    • Minakata, K. et al. Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-Type epidermal growth factor receptors. Cancer Sci. 103, 1946-1954 (2012).
    • (2012) Cancer Sci. , vol.103 , pp. 1946-1954
    • Minakata, K.1
  • 225
    • 84907462932 scopus 로고    scopus 로고
    • Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition
    • Kogita, A. et al. Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition. Int. J. Oncol. 45, 1430-1436 (2014).
    • (2014) Int. J. Oncol. , vol.45 , pp. 1430-1436
    • Kogita, A.1
  • 226
    • 84875846289 scopus 로고    scopus 로고
    • Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
    • Chatterjee, S. et al. Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J. Clin. Invest. 123, 1732-1740 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1732-1740
    • Chatterjee, S.1
  • 227
    • 84862811913 scopus 로고    scopus 로고
    • Tumor-Associated macrophages correlate with response to epidermal growth factor receptor-Tyrosine kinase inhibitors in advanced non-small cell lung cancer
    • Chung, F. T. et al. Tumor-Associated macrophages correlate with response to epidermal growth factor receptor-Tyrosine kinase inhibitors in advanced non-small cell lung cancer. Int. J. Cancer 131, E227-E235 (2012).
    • (2012) Int. J. Cancer , vol.131 , pp. E227-E235
    • Chung, F.T.1
  • 228
    • 84924554569 scopus 로고    scopus 로고
    • Transcriptome analysis of individual stromal cell populations identifies stroma-Tumor crosstalk in mouse lung cancer model
    • Choi, H. et al. Transcriptome analysis of individual stromal cell populations identifies stroma-Tumor crosstalk in mouse lung cancer model. Cell Rep. 10, 1187-1201 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 1187-1201
    • Choi, H.1
  • 229
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD 1 pathway contributes to immune escape in EGFR-driven lung tumors
    • Akbay, E. A. et al. Activation of the PD 1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 3, 1355-1363 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 1355-1363
    • Akbay, E.A.1
  • 230
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PD L1 expression by the EML4 ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer
    • Ota, K. et al. Induction of PD L1 expression by the EML4 ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer. Clin. Cancer Res. 21, 4014-4021 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 4014-4021
    • Ota, K.1
  • 231
    • 84990938506 scopus 로고    scopus 로고
    • EGFR mutations and ALK rearrangements are associated with low response rates to PD 1 pathway blockade in non-small cell lung cancer: A retrospective analysis
    • Gainor, J. F. et al. EGFR mutations and ALK rearrangements are associated with low response rates to PD 1 pathway blockade in non-small cell lung cancer: A retrospective analysis. Clin. Cancer Res. 22, 4585-4593 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 4585-4593
    • Gainor, J.F.1
  • 232
    • 85019668203 scopus 로고    scopus 로고
    • Tracking the evolution of non-small-cell lung cancer
    • Jamal-Hanjani, M. et al. Tracking the evolution of non-small-cell lung cancer. N. Engl. J. Med. 376, 2109-2121 (2017).
    • (2017) N. Engl. J. Med. , vol.376 , pp. 2109-2121
    • Jamal-Hanjani, M.1
  • 233
    • 84955152117 scopus 로고    scopus 로고
    • Heterogeneity in resistance mechanisms causes shorter duration of epidermal growth factor receptor kinase inhibitor treatment in lung cancer
    • Suda, K. et al. Heterogeneity in resistance mechanisms causes shorter duration of epidermal growth factor receptor kinase inhibitor treatment in lung cancer. Lung Cancer 91, 36-40 (2016).
    • (2016) Lung Cancer , vol.91 , pp. 36-40
    • Suda, K.1
  • 234
    • 84962222188 scopus 로고    scopus 로고
    • Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses
    • Sundaresan, T. K. et al. Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses. Clin. Cancer Res. 22, 1103-1110 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1103-1110
    • Sundaresan, T.K.1
  • 235
    • 84918789657 scopus 로고    scopus 로고
    • Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small cell lung cancer during treatment with erlotinib
    • Sorensen, B. S. et al. Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small cell lung cancer during treatment with erlotinib. Cancer 120, 3896-3901 (2014).
    • (2014) Cancer , vol.120 , pp. 3896-3901
    • Sorensen, B.S.1
  • 236
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • Oxnard, G. R. et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin. Cancer Res. 20, 1698-1705 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1698-1705
    • Oxnard, G.R.1
  • 237
    • 85019743651 scopus 로고    scopus 로고
    • Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
    • Abbosh, C. et al. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature 545, 446-451 (2017).
    • (2017) Nature , vol.545 , pp. 446-451
    • Abbosh, C.1
  • 238
    • 84958999430 scopus 로고    scopus 로고
    • Diverse drug-resistance mechanisms can emerge from drug-Tolerant cancer persister cells
    • Ramirez, M. et al. Diverse drug-resistance mechanisms can emerge from drug-Tolerant cancer persister cells. Nat. Commun. 7, 10690 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10690
    • Ramirez, M.1
  • 239
    • 85002622789 scopus 로고    scopus 로고
    • Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: A multicentre, randomised, controlled, phase 2 study
    • Gomez, D. R. et al. Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: A multicentre, randomised, controlled, phase 2 study. Lancet Oncol. 17, 1672-1682 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1672-1682
    • Gomez, D.R.1
  • 240
    • 85026741325 scopus 로고    scopus 로고
    • Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial
    • Mok, T. et al. Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial. J. Clin. Oncol. http://dx.doi.org/10.1200/jco.2017.35.18-suppl.lba9007 (2017).
    • (2017) J. Clin. Oncol.
    • Mok, T.1
  • 241
    • 84995428398 scopus 로고    scopus 로고
    • LBA1-PR: Osimertinb as first-line treatment for EGFR mutation-positive advanced NSCLC: Updated efficacy and safety results from two Phase I expansion cohorts
    • Ramalingam, S. et al. LBA1-PR: Osimertinb as first-line treatment for EGFR mutation-positive advanced NSCLC: updated efficacy and safety results from two Phase I expansion cohorts. J. Thorac. Oncol. 11, S152 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. S152
    • Ramalingam, S.1
  • 242
    • 85015214888 scopus 로고    scopus 로고
    • Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution
    • Jonsson, V. D. et al. Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution. Sci. Rep. 7, 44206 (2017).
    • (2017) Sci. Rep. , vol.7 , pp. 44206
    • Jonsson, V.D.1
  • 243
    • 84870317390 scopus 로고    scopus 로고
    • Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-Addicted non-small-cell lung cancer
    • Weickhardt, A. J. et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-Addicted non-small-cell lung cancer. J. Thorac. Oncol. 7, 1807-1814 (2012).
    • (2012) J. Thorac. Oncol. , vol.7 , pp. 1807-1814
    • Weickhardt, A.J.1
  • 244
    • 85018252710 scopus 로고    scopus 로고
    • Local therapy for oligoprogressive disease in patients with advanced stage non-small-cell lung cancer harboring epidermal growth factor receptor mutation
    • Qiu, B. et al. Local therapy for oligoprogressive disease in patients with advanced stage non-small-cell lung cancer harboring epidermal growth factor receptor mutation. Clin. Lung Cancer http://dx.doi.org/10.1016/j.cllc.2017.04.002 (2017).
    • (2017) Clin. Lung Cancer
    • Qiu, B.1
  • 245
    • 84960334957 scopus 로고    scopus 로고
    • An overview of the design and conduct of the BATTLE trials
    • Liu, S. & Lee, J. J. An overview of the design and conduct of the BATTLE trials. Chin. Clin. Oncol. 4, 33 (2015).
    • (2015) Chin. Clin. Oncol. , vol.4 , pp. 33
    • Liu, S.1    Lee, J.J.2
  • 246
    • 85017940817 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02465060 (2017).
    • (2017) US National Library of Medicine
  • 247
    • 84924579040 scopus 로고    scopus 로고
    • Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers
    • Rangachari, D. et al. Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers. Lung Cancer 88, 108-111 (2015).
    • (2015) Lung Cancer , vol.88 , pp. 108-111
    • Rangachari, D.1
  • 248
    • 34250177984 scopus 로고    scopus 로고
    • The blood-brain barrier and cancer: Transporters, treatment, and Trojan horses
    • Deeken, J. F. & Loscher, W. The blood-brain barrier and cancer: Transporters, treatment, and Trojan horses. Clin. Cancer Res. 13, 1663-1674 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1663-1674
    • Deeken, J.F.1    Loscher, W.2
  • 249
    • 77954427100 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI 420 in patients with central nervous system metastases of non-small cell lung cancer
    • Togashi, Y. et al. Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI 420 in patients with central nervous system metastases of non-small cell lung cancer. J. Thorac. Oncol. 5, 950-955 (2010).
    • (2010) J. Thorac. Oncol. , vol.5 , pp. 950-955
    • Togashi, Y.1
  • 250
    • 84866364723 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer
    • Togashi, Y. et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother. Pharmacol. 70, 399-405 (2012).
    • (2012) Cancer Chemother. Pharmacol. , vol.70 , pp. 399-405
    • Togashi, Y.1
  • 251
    • 84875235273 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma
    • Zhao, J. et al. Cerebrospinal fluid concentrations of gefitinib in patients with lung adenocarcinoma. Clin. Lung Cancer 14, 188-193 (2013).
    • (2013) Clin. Lung Cancer , vol.14 , pp. 188-193
    • Zhao, J.1
  • 252
    • 85039750626 scopus 로고    scopus 로고
    • OA08.05 Efficacy and cerebrospinal fluid concentration of afatinib in NSCLC patients with EGFR mutation developing leptomeningeal carcinomatosis
    • Tamiya, A. et al. OA08.05 Efficacy and cerebrospinal fluid concentration of afatinib in NSCLC patients with EGFR mutation developing leptomeningeal carcinomatosis. J. Thorac. Oncol. Abstr. 12, S273 (2017).
    • (2017) J. Thorac. Oncol. Abstr. , vol.12 , pp. S273
    • Tamiya, A.1
  • 253
    • 84926416449 scopus 로고    scopus 로고
    • Efficacy of the irreversible ERBB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)- pretreated non-small-cell lung cancer patients with brain metastases or leptomeningeal disease
    • Hoffknecht, P. et al. Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)- pretreated non-small-cell lung cancer patients with brain metastases or leptomeningeal disease. J. Thorac. Oncol. 10, 156-163 (2015).
    • (2015) J. Thorac. Oncol. , vol.10 , pp. 156-163
    • Hoffknecht, P.1
  • 254
    • 84991730676 scopus 로고    scopus 로고
    • Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity
    • Ballard, P. et al. Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity. Clin. Cancer Res. 22, 5130-5140 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 5130-5140
    • Ballard, P.1
  • 255
    • 79957487193 scopus 로고    scopus 로고
    • CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
    • Costa, D. B. et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J. Clin. Oncol. 29, e443-e445 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. e443-e445
    • Costa, D.B.1
  • 256
    • 85045325099 scopus 로고    scopus 로고
    • Novartis
    • Novartis. Zykadia prescribing information Novartis https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/zykadia.pdf (2016).
    • (2016) Zykadia Prescribing Information Novartis
  • 257
    • 84919779490 scopus 로고    scopus 로고
    • Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases
    • Kodama, T. et al. Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother. Pharmacol. 74, 1023-1028 (2014).
    • (2014) Cancer Chemother. Pharmacol. , vol.74 , pp. 1023-1028
    • Kodama, T.1
  • 258
    • 84949674090 scopus 로고    scopus 로고
    • Durable brain response with pulse-dose crizotinib and ceritinib in ALK-positive non-small cell lung cancer compared with brain radiotherapy
    • Dudnik, E. et al. Durable brain response with pulse-dose crizotinib and ceritinib in ALK-positive non-small cell lung cancer compared with brain radiotherapy. J. Clin. Neurosci. 26, 46-49 (2016).
    • (2016) J. Clin. Neurosci. , vol.26 , pp. 46-49
    • Dudnik, E.1
  • 259
    • 84895924837 scopus 로고    scopus 로고
    • Pulsed dosing of erlotinib for central nervous system progression in EGFR-mutant non-small cell lung cancer
    • Jackman, D. et al. Pulsed dosing of erlotinib for central nervous system progression in EGFR-mutant non-small cell lung cancer. J. Clin. Oncol. 31, 8116 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 8116
    • Jackman, D.1
  • 260
    • 85015823500 scopus 로고    scopus 로고
    • Superior efficacy and selectivity of novel small-molecule kinase inhibitors of T790M mutant EGFR in preclinical models of lung cancer
    • Rho, J. K. et al. Superior efficacy and selectivity of novel small-molecule kinase inhibitors of T790M mutant EGFR in preclinical models of lung cancer. Cancer Res. 77, 1200-1211 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 1200-1211
    • Rho, J.K.1
  • 261
    • 85013392619 scopus 로고    scopus 로고
    • Efficacy of bevacizumab and erlotinib combination for leptomeningeal carcinomatosis after failure of erlotinib
    • Ariyasu, R. et al. Efficacy of bevacizumab and erlotinib combination for leptomeningeal carcinomatosis after failure of erlotinib. Anticancer Drugs 28, 565-567 (2017).
    • (2017) Anticancer Drugs , vol.28 , pp. 565-567
    • Ariyasu, R.1
  • 262
    • 84891829654 scopus 로고    scopus 로고
    • Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar
    • Tang, S. C. et al. Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int. J. Cancer 134, 1484-1494 (2014).
    • (2014) Int. J. Cancer , vol.134 , pp. 1484-1494
    • Tang, S.C.1
  • 263
    • 0013574980 scopus 로고
    • Specific radiolabeling of a cell surface receptor for epidermal growth factor
    • Das, M. et al. Specific radiolabeling of a cell surface receptor for epidermal growth factor. Proc. Natl Acad. Sci. USA 74, 2790-2794 (1977).
    • (1977) Proc. Natl Acad. Sci. USA , vol.74 , pp. 2790-2794
    • Das, M.1
  • 264
    • 0021347296 scopus 로고
    • Isolation of transforming sequences of two human lung carcinomas: Structural and functional analysis of the activated c K ras oncogenes
    • Nakano, H. et al. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c K ras oncogenes. Proc. Natl Acad. Sci. USA 81, 71-75 (1984).
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 71-75
    • Nakano, H.1
  • 265
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi, M., Ritz, J. & Cooper, G. M. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42, 581-588 (1985).
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 266
    • 0028106163 scopus 로고
    • Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor
    • Ward, W. H. et al. Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor. Biochem. Pharmacol. 48, 659-666 (1994).
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 659-666
    • Ward, W.H.1
  • 267
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris, S. W. et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263, 1281-1284 (1994).
    • (1994) Science , vol.263 , pp. 1281-1284
    • Morris, S.W.1
  • 268
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 269
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 270
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • Stephens, P. et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 431, 525-526 (2004).
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1
  • 271
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274and small interfering RNA in non-small cell lung cancer
    • Ma, P. C. et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274and small interfering RNA in non-small cell lung cancer. Cancer Res. 65, 1479-1488 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 1479-1488
    • Ma, P.C.1
  • 272
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
    • Cappuzzo, F., Bemis, L. & Varella-Garcia, M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N. Engl. J. Med. 354, 2619-2621 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 273
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova, K. et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-1203 (2007).
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1
  • 274
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott, U. et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 68, 3389-3395 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3389-3395
    • McDermott, U.1
  • 275
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-Agent anti-programmed death 1 (MDX 1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer, J. R. et al. Phase I study of single-Agent anti-programmed death 1 (MDX 1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28, 3167-3175 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1
  • 276
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B RET fusions in lung adenocarcinoma
    • Kohno, T. et al. KIF5B RET fusions in lung adenocarcinoma. Nat. Med. 18, 375-377 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 375-377
    • Kohno, T.1
  • 277
    • 84862776857 scopus 로고    scopus 로고
    • Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
    • Lipson, D. et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat. Med. 18, 382-384 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 382-384
    • Lipson, D.1
  • 278
    • 84857985225 scopus 로고    scopus 로고
    • RET, ROS1 and ALK fusions in lung cancer
    • Takeuchi, K. et al. RET, ROS1 and ALK fusions in lung cancer. Nat. Med. 18, 378-381 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 378-381
    • Takeuchi, K.1
  • 279
    • 84866595717 scopus 로고    scopus 로고
    • A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib
    • Gautschi, O. et al. A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. J. Thorac. Oncol. 7, e23-e24 (2012).
    • (2012) J. Thorac. Oncol. , vol.7 , pp. e23-e24
    • Gautschi, O.1
  • 280
    • 84858002759 scopus 로고    scopus 로고
    • Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
    • De Greve, J. et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 76, 123-127 (2012).
    • (2012) Lung Cancer , vol.76 , pp. 123-127
    • De Greve, J.1
  • 281
    • 84887977876 scopus 로고    scopus 로고
    • Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M mediated resistance in NSCLC
    • Walter, A. O. et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M mediated resistance in NSCLC. Cancer Discov. 3, 1404-1415 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 1404-1415
    • Walter, A.O.1
  • 282
    • 84878858856 scopus 로고    scopus 로고
    • Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas
    • Drilon, A. et al. Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discov. 3, 630-635 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 630-635
    • Drilon, A.1
  • 283
    • 84887445619 scopus 로고    scopus 로고
    • Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
    • Vaishnavi, A. et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat. Med. 19, 1469-1472 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1469-1472
    • Vaishnavi, A.1
  • 284
    • 84948117368 scopus 로고    scopus 로고
    • Durable clinical response to entrectinib in NTRK1 rearranged non-small cell lung cancer
    • Farago, A. F. et al. Durable clinical response to entrectinib in NTRK1 rearranged non-small cell lung cancer. J. Thorac. Oncol. 10, 1670-1674 (2015).
    • (2015) J. Thorac. Oncol. , vol.10 , pp. 1670-1674
    • Farago, A.F.1
  • 285
    • 34548404210 scopus 로고    scopus 로고
    • Mechanisms for oncogenic activation of the epidermal growth factor receptor
    • Zandi, R., Larsen, A. B., Andersen, P., Stockhausen, M. T. & Poulsen, H. S. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell. Signal. 19, 2013-2023 (2007).
    • (2007) Cell. Signal. , vol.19 , pp. 2013-2023
    • Zandi, R.1    Larsen, A.B.2    Andersen, P.3    Stockhausen, M.T.4    Poulsen, H.S.5
  • 286
    • 84987677302 scopus 로고    scopus 로고
    • Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy
    • Kobayashi, Y. & Mitsudomi, T. Not all epidermal growth factor receptor mutations in lung cancer are created equal: perspectives for individualized treatment strategy. Cancer Sci. 107, 1179-1186 (2016).
    • (2016) Cancer Sci. , vol.107 , pp. 1179-1186
    • Kobayashi, Y.1    Mitsudomi, T.2
  • 287
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu, H. et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J. Natl Cancer Inst. 97, 339-346 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , pp. 339-346
    • Shigematsu, H.1
  • 288
    • 85011579204 scopus 로고    scopus 로고
    • The frequency and clinical impact of HER2 alterations in lung adenocarcinoma
    • Kim, E. K., Kim, K. A., Lee, C. Y. & Shim, H. S. The frequency and clinical impact of HER2 alterations in lung adenocarcinoma. PLoS ONE 12, e0171280 (2017).
    • (2017) PLoS ONE , vol.12 , pp. e0171280
    • Kim, E.K.1    Kim, K.A.2    Lee, C.Y.3    Shim, H.S.4
  • 289
    • 84863230117 scopus 로고    scopus 로고
    • A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
    • Ju, Y. S. et al. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. 22, 436-445 (2012).
    • (2012) Genome Res. , vol.22 , pp. 436-445
    • Ju, Y.S.1
  • 290
    • 85018282184 scopus 로고    scopus 로고
    • Targeting RET in patients with RET-rearranged lung cancers: Results from the global, multicenter RET registry
    • Gautschi, O. et al. Targeting RET in patients with RET-rearranged lung cancers: Results from the global, multicenter RET registry. J. Clin. Oncol. 35, 1403-1410 (2017).
    • (2017) J. Clin. Oncol. , vol.35 , pp. 1403-1410
    • Gautschi, O.1
  • 291
    • 85015270544 scopus 로고    scopus 로고
    • FRMD4A/RET: A novel RET oncogenic fusion variant in non-small cell lung carcinoma
    • Velcheti, V. et al. FRMD4A/RET: A novel RET oncogenic fusion variant in non-small cell lung carcinoma. J. Thorac. Oncol. 12, e15-e16 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. e15-e16
    • Velcheti, V.1
  • 292
    • 84870337408 scopus 로고    scopus 로고
    • Identification of CCDC6 RET fusion in the human lung adenocarcinoma cell line. LC 2/ad
    • Matsubara, D. et al. Identification of CCDC6 RET fusion in the human lung adenocarcinoma cell line. LC 2/ad. J. Thorac. Oncol. 7, 1872-1876 (2012).
    • (2012) J. Thorac. Oncol. , vol.7 , pp. 1872-1876
    • Matsubara, D.1
  • 293
    • 84978129582 scopus 로고    scopus 로고
    • Identification of a novel partner gene, KIAA1217, fused to RET: Functional characterization and inhibitor sensitivity of two isoforms in lung adenocarcinoma
    • Lee, M. S. et al. Identification of a novel partner gene, KIAA1217, fused to RET: functional characterization and inhibitor sensitivity of two isoforms in lung adenocarcinoma. Oncotarget 7, 36101-36114 (2016).
    • (2016) Oncotarget , vol.7 , pp. 36101-36114
    • Lee, M.S.1
  • 294
    • 84894066256 scopus 로고    scopus 로고
    • A single-Tube multiplexed assay for detecting ALK, ROS1, and RET fusions in lung cancer
    • Lira, M. E. et al. A single-Tube multiplexed assay for detecting ALK, ROS1, and RET fusions in lung cancer. J. Mol. Diagn. 16, 229-243 (2014).
    • (2014) J. Mol. Diagn. , vol.16 , pp. 229-243
    • Lira, M.E.1
  • 295
    • 84918504885 scopus 로고    scopus 로고
    • Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer
    • Kodama, T. et al. Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. Mol. Cancer Ther. 13, 2910-2918 (2014).
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2910-2918
    • Kodama, T.1
  • 297
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman, J. A. et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 14, 1351-1356 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1351-1356
    • Engelman, J.A.1
  • 298
    • 84977147460 scopus 로고    scopus 로고
    • Clinical and molecular characteristics of NF1 mutant lung cancer
    • Redig, A. J. et al. Clinical and molecular characteristics of NF1 mutant lung cancer. Clin. Cancer Res. 22, 3148-3156 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 3148-3156
    • Redig, A.J.1
  • 299
    • 84921610348 scopus 로고    scopus 로고
    • Phase I study of the MEK 1/2 inhibitor selumetinib (AZD6244) hydrogen sulfate in children and young adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas
    • Wildemann, B. C. et al. Phase I study of the MEK 1/2 inhibitor selumetinib (AZD6244) hydrogen sulfate in children and young adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas. J. Clin. Oncol. 32, 10018 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 10018
    • Wildemann, B.C.1
  • 300
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka, T. et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin. Cancer Res. 12, 5764-5769 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5764-5769
    • Kosaka, T.1
  • 301
    • 79960967335 scopus 로고    scopus 로고
    • A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients
    • Tiedt, R. et al. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res. 71, 5255-5264 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 5255-5264
    • Tiedt, R.1
  • 302
    • 84944802880 scopus 로고    scopus 로고
    • Preliminary results of TATTON, a multi-Arm phase Ib trial of AZD9291 combined with MEDI4736, AZD6094 or selumetinib in EGFR-mutant lung cancer
    • 2509
    • Oxnard, G. R. et al. Preliminary results of TATTON, a multi-Arm phase Ib trial of AZD9291 combined with MEDI4736, AZD6094 or selumetinib in EGFR-mutant lung cancer. J. Clin. Oncol. 33, abstr. 2509 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Oxnard, G.R.1
  • 303
    • 84894589324 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of the PI3K/mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors
    • Janne, P. A. et al. Phase I safety and pharmacokinetic study of the PI3K/mTOR inhibitor SAR245409 (XL765) in combination with erlotinib in patients with advanced solid tumors. J. Thorac. Oncol. 9, 316-323 (2014).
    • (2014) J. Thorac. Oncol. , vol.9 , pp. 316-323
    • Janne, P.A.1
  • 304
    • 84889089046 scopus 로고    scopus 로고
    • A phase Ib safety and tolerability study of a pan class I PI3K inhibitor buparlisib (BKM120) and gefitinib in EGFR TKI-resistance NSCLC
    • Tan, D. S. et al. A phase Ib safety and tolerability study of a pan class I PI3K inhibitor buparlisib (BKM120) and gefitinib in EGFR TKI-resistance NSCLC. J. Clin. Oncol. 31, 8107 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 8107
    • Tan, D.S.1
  • 305
    • 77958161544 scopus 로고    scopus 로고
    • Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer
    • Price, K. A. et al. Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer. J. Thorac. Oncol. 5, 1623-1629 (2010).
    • (2010) J. Thorac. Oncol. , vol.5 , pp. 1623-1629
    • Price, K.A.1
  • 306
    • 85045341520 scopus 로고    scopus 로고
    • P2.06 003 a phase Ib study of the combination of afatinib and ruxolitinib in EGFR mutant non-small cell lung cancer (NSCLC) progressed on EGFR-TKI
    • Park, J. S., Kim, H. R., Hong, M. H. & Cho, B. C. P2.06 003 a phase Ib study of the combination of afatinib and ruxolitinib in EGFR mutant non-small cell lung cancer (NSCLC) progressed on EGFR-TKI. J. Thorac. Oncol. 12, S1069-S1070 (2017).
    • (2017) J. Thorac. Oncol. , vol.12 , pp. S1069-S1070
    • Park, J.S.1    Kim, H.R.2    Hong, M.H.3    Cho, B.C.4
  • 307
    • 77950491674 scopus 로고    scopus 로고
    • Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer
    • Haura, E. B. et al. Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer. J. Clin. Oncol. 28, 1387-1394 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1387-1394
    • Haura, E.B.1
  • 308
    • 85016089304 scopus 로고    scopus 로고
    • A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer
    • Wakelee, H. A. et al. A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer. Cancer Chemother. Pharmacol. 79, 923-932 (2017).
    • (2017) Cancer Chemother. Pharmacol. , vol.79 , pp. 923-932
    • Wakelee, H.A.1
  • 309
    • 85003485962 scopus 로고    scopus 로고
    • Erlotinib, cabozantinib, or erlotinib plus cabozantinib as second-line or third-line treatment of patients with EGFR wild-Type advanced non-small-cell lung cancer (ECOG-ACRIN 1512): A randomised, controlled, open-label, multicentre, phase 2 trial
    • Neal, J. W. et al. Erlotinib, cabozantinib, or erlotinib plus cabozantinib as second-line or third-line treatment of patients with EGFR wild-Type advanced non-small-cell lung cancer (ECOG-ACRIN 1512): A randomised, controlled, open-label, multicentre, phase 2 trial. Lancet Oncol. 17, 1661-1671 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1661-1671
    • Neal, J.W.1
  • 310
    • 84890108571 scopus 로고    scopus 로고
    • Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
    • Spigel, D. R. et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 31, 4105-4114 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4105-4114
    • Spigel, D.R.1
  • 311
    • 84976212862 scopus 로고    scopus 로고
    • Phase 2 HERALD study of patritumab (P) with erlotinib (E) in advanced NSCLC subjects (SBJs)
    • Von Pawel, J. et al. Phase 2 HERALD study of patritumab (P) with erlotinib (E) in advanced NSCLC subjects (SBJs). J. Clin. Oncol. Abstr. 32, 8045 (2014).
    • (2014) J. Clin. Oncol. Abstr. , vol.32 , pp. 8045
    • Von Pawel, J.1
  • 312
    • 85017368927 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): An international, multicentre, single-Arm, phase 2 trial
    • Rosell, R. et al. Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): An international, multicentre, single-Arm, phase 2 trial. Lancet Respir. Med. 5, 435-444 (2017).
    • (2017) Lancet Respir. Med. , vol.5 , pp. 435-444
    • Rosell, R.1
  • 313
    • 84899471596 scopus 로고    scopus 로고
    • Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression
    • Reguart, N. et al. Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression. Lung Cancer 84, 161-167 (2014).
    • (2014) Lung Cancer , vol.84 , pp. 161-167
    • Reguart, N.1
  • 314
    • 84925536117 scopus 로고    scopus 로고
    • Phase I/II study of gefitinib (Iressa®) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer
    • Han, J. Y. et al. Phase I/II study of gefitinib (Iressa®) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 75, 475-483 (2015).
    • (2015) Cancer Chemother. Pharmacol. , vol.75 , pp. 475-483
    • Han, J.Y.1
  • 315
    • 84983102615 scopus 로고    scopus 로고
    • Activity of dalotuzumab, a selective anti IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: A phase I/II randomized trial
    • Moran, T. et al. Activity of dalotuzumab, a selective anti IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: A phase I/II randomized trial. Exp. Hematol. Oncol. 3, 26 (2014).
    • (2014) Exp. Hematol. Oncol. , vol.3 , pp. 26
    • Moran, T.1
  • 316
    • 84969850273 scopus 로고    scopus 로고
    • Combined pan-HER and ALK/ROS1/MET inhibition with dacomitinib and crizotinib in advanced non-small cell lung cancer: Results of a phase I study
    • Janne, P. A. et al. Combined pan-HER and ALK/ROS1/MET inhibition with dacomitinib and crizotinib in advanced non-small cell lung cancer: Results of a phase I study. J. Thorac. Oncol. 11, 737-747 (2016).
    • (2016) J. Thorac. Oncol. , vol.11 , pp. 737-747
    • Janne, P.A.1
  • 317
    • 84975320676 scopus 로고    scopus 로고
    • A phase 1 study of crizotinib and ganetespib (STA 9090) in ALK positive lung cancers
    • Riely, G. et al. A phase 1 study of crizotinib and ganetespib (STA 9090) in ALK positive lung cancers. J. Clin. Oncol. 33, 8064 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 8064
    • Riely, G.1
  • 318
    • 84996477970 scopus 로고    scopus 로고
    • Addition of HSP90 inhibitor onalespib to crizotinib prior to progression in patients with ALK-pos NSCLC: Results of a randomized phase 2 study [abstract]
    • Lee, J. et al. Addition of HSP90 inhibitor onalespib to crizotinib prior to progression in patients with ALK-pos NSCLC: Results of a randomized phase 2 study [abstract]. J. Clin. Oncol. 34, 9059 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 9059
    • Lee, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.